Detailed information for compound 1451858

Basic information

Technical information
  • TDR Targets ID: 1451858
  • Name: 6-(4-chlorophenyl)-2-(di(phenyl)amino)-5,6-di hydro-1,3-thiazin-4-one
  • MW: 392.901 | Formula: C22H17ClN2OS
  • H donors: 0 H acceptors: 1 LogP: 5.5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C1CC(=O)N=C(S1)N(c1ccccc1)c1ccccc1
  • InChi: 1S/C22H17ClN2OS/c23-17-13-11-16(12-14-17)20-15-21(26)24-22(27-20)25(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-14,20H,15H2
  • InChiKey: WBGDAEALUNLTLQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS000722067
  • SMR000236663

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone binding protein No references
Homo sapiens corticotropin releasing hormone receptor 2 No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 2 438 aa 383 aa 26.1 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis GPCR, family 2 0.02 0.2191 0.214
Loa Loa (eye worm) hypothetical protein 0.0045 0.0326 0.0326
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0385 0.4411 0.4374
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0369 0.0306
Schistosoma mansoni smad1 5 8 and 0.0051 0.0403 0.0341
Loa Loa (eye worm) MH2 domain-containing protein 0.0051 0.0403 0.0403
Brugia malayi MH2 domain containing protein 0.0051 0.0403 0.0403
Brugia malayi hypothetical protein 0.01 0.0989 0.0989
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0069 0.0623 0.0562
Onchocerca volvulus 0.0033 0.0181 0.0567
Loa Loa (eye worm) hypothetical protein 0.0033 0.0181 0.0181
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0181 0.0181
Brugia malayi MH2 domain containing protein 0.0023 0.0065 0.0065
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0326 0.0263
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0326 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.6484 0.6461
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.02 0.2191 0.214
Schistosoma mansoni intermediate filament proteins 0.0033 0.0181 0.0117
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3214 0.3169
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0326 0.0263
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0326 0.5
Schistosoma mansoni hypothetical protein 0.02 0.2191 0.214
Brugia malayi Calcitonin receptor-like protein seb-1 0.0633 0.7377 0.7377
Echinococcus granulosus lamin dm0 0.0033 0.0181 0.0117
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0326 0.0263
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0852 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0326 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.013 0.013
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0326 0.0263
Brugia malayi intermediate filament protein 0.0033 0.0181 0.0181
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0326 0.0263
Loa Loa (eye worm) hypothetical protein 0.0155 0.1647 0.1647
Toxoplasma gondii LsmAD domain-containing protein 0.0155 0.1647 1
Brugia malayi hypothetical protein 0.0155 0.1647 0.1647
Loa Loa (eye worm) nuclear factor I 0.0028 0.013 0.013
Brugia malayi RNA recognition motif domain containing protein 0.0852 1 1
Schistosoma mansoni smad1 5 8 and 0.0051 0.0403 0.0341
Brugia malayi Smad1 0.0051 0.0403 0.0403
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0818 0.9596 0.9596
Schistosoma mansoni tar DNA-binding protein 0.0852 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0385 0.4411 0.4374
Echinococcus multilocularis smad 0.0051 0.0403 0.0341
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0369 0.0306
Schistosoma mansoni hypothetical protein 0.0433 0.4976 0.4944
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.6484 0.6461
Brugia malayi hypothetical protein 0.0286 0.3214 0.3214
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0369 0.0323
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0326 0.5
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0369 0.0306
Brugia malayi mothers against decapentaplegic homolog 3 0.0023 0.0065 0.0065
Schistosoma mansoni lamin 0.0033 0.0181 0.0117
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0326 0.0326
Schistosoma mansoni lamin 0.0033 0.0181 0.0117
Loa Loa (eye worm) hypothetical protein 0.0286 0.3214 0.3214
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0051 0.0403 0.0341
Schistosoma mansoni hypothetical protein 0.0069 0.0623 0.0562
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0051 0.0403 0.0341
Loa Loa (eye worm) hypothetical protein 0.0154 0.1637 0.1637
Echinococcus granulosus lamin 0.0033 0.0181 0.0117
Brugia malayi MH1 domain containing protein 0.0051 0.0403 0.0403
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0326 0.0263
Echinococcus granulosus GPCR family 2 0.02 0.2191 0.214
Onchocerca volvulus 0.0033 0.0181 0.0567
Schistosoma mansoni tar DNA-binding protein 0.0852 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.02 0.2191 0.214
Echinococcus granulosus tar DNA binding protein 0.0852 1 1
Schistosoma mansoni hypothetical protein 0.02 0.2191 0.214
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0633 0.7377 0.7377
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0181 0.0181
Loa Loa (eye worm) RNA binding protein 0.0852 1 1
Echinococcus granulosus Smad4 0.0051 0.0403 0.0341
Onchocerca volvulus 0.0058 0.0489 0.2064
Trypanosoma cruzi PAB1-binding protein , putative 0.0155 0.1647 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0369 0.0323
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0369 0.0306
Loa Loa (eye worm) MH2 domain-containing protein 0.075 0.8777 0.8777
Brugia malayi Latrophilin receptor protein 2 0.02 0.2191 0.2191
Schistosoma mansoni smad 0.0051 0.0403 0.0341
Brugia malayi N-terminal motif family protein 0.0194 0.2121 0.2121
Brugia malayi TAR-binding protein 0.0852 1 1
Schistosoma mansoni tar DNA-binding protein 0.0852 1 1
Schistosoma mansoni hypothetical protein 0.0058 0.0489 0.0427
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.02 0.2191 0.2191
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0369 0.0323
Schistosoma mansoni hypothetical protein 0.02 0.2191 0.214
Schistosoma mansoni survival motor neuron protein 0.0058 0.0489 0.0427
Echinococcus granulosus TGF beta signal transducer SmadC 0.0051 0.0403 0.0341
Loa Loa (eye worm) Smad1 0.0051 0.0403 0.0403
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0369 0.0306
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.0065 0.0065
Plasmodium falciparum ataxin-2 like protein, putative 0.0155 0.1647 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3214 0.3169
Echinococcus multilocularis lamin 0.0033 0.0181 0.0117
Schistosoma mansoni tar DNA-binding protein 0.0852 1 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.0369 0.5
Echinococcus granulosus mothers against decapentaplegic 5 0.0051 0.0403 0.0341
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0069 0.0623 0.0562
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0326 0.5
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0369 0.0306
Echinococcus multilocularis Smad4 0.0051 0.0403 0.0341
Loa Loa (eye worm) hypothetical protein 0.0032 0.0174 0.0174
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.0065 0.0065
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0369 0.0323
Echinococcus granulosus intermediate filament protein 0.0033 0.0181 0.0117
Trypanosoma brucei PAB1-binding protein , putative 0.0155 0.1647 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0155 0.1647 1
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0369 0.0369
Schistosoma mansoni Smad4 0.0051 0.0403 0.0341
Schistosoma mansoni hypothetical protein 0.02 0.2191 0.214
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0369 0.0369
Echinococcus granulosus smad 0.0051 0.0403 0.0341
Brugia malayi MH1 domain containing protein 0.0028 0.013 0.013
Echinococcus multilocularis musashi 0.0033 0.0181 0.0117
Loa Loa (eye worm) hypothetical protein 0.02 0.2191 0.2191
Echinococcus multilocularis mothers against decapentaplegic 5 0.0051 0.0403 0.0341
Plasmodium falciparum ataxin-2 like protein, putative 0.0155 0.1647 1
Loa Loa (eye worm) TAR-binding protein 0.0852 1 1
Brugia malayi hypothetical protein 0.0154 0.1637 0.1637
Schistosoma mansoni tar DNA-binding protein 0.0852 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.6484 0.6461
Plasmodium vivax ataxin-2 like protein, putative 0.0155 0.1647 1
Brugia malayi MH2 domain containing protein 0.0051 0.0403 0.0403
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0369 0.0306
Brugia malayi MH2 domain containing protein 0.075 0.8777 0.8777
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0181 0.0181
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0369 0.0323
Loa Loa (eye worm) transcription factor SMAD2 0.075 0.8777 0.8777
Brugia malayi MH1 domain containing protein 0.0028 0.013 0.013
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0065
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0194 0.2121 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0326 0.0263
Loa Loa (eye worm) hypothetical protein 0.0194 0.2121 0.2121
Leishmania major hypothetical protein, conserved 0.0155 0.1647 1
Loa Loa (eye worm) hypothetical protein 0.0433 0.4976 0.4976
Brugia malayi latrophilin 2 splice variant baaae 0.0433 0.4976 0.4976
Echinococcus multilocularis tar DNA binding protein 0.0852 1 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0051 0.0403 0.0403
Brugia malayi MH1 domain containing protein 0.0051 0.0403 0.0403
Onchocerca volvulus 0.0154 0.1637 0.7651
Loa Loa (eye worm) latrophilin receptor protein 2 0.02 0.2191 0.2191
Echinococcus multilocularis lamin dm0 0.0033 0.0181 0.0117
Loa Loa (eye worm) hypothetical protein 0.0818 0.9596 0.9596
Brugia malayi isocitrate dehydrogenase 0.0048 0.0369 0.0369
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0326 0.0263
Schistosoma mansoni smad1 5 8 and 0.0051 0.0403 0.0341
Echinococcus granulosus neuropeptide s receptor 0.0558 0.6484 0.6461

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 53 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 13.8 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: Ub-rhodamine 110 based assay for inhibitors Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2281, AID463106, AID463254] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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