Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.4827 | 0.4827 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.2488 | 0.5143 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0395 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.2488 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0395 | 0.0384 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0395 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.2488 | 0.5143 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4827 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.4827 | 0.4821 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0395 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0245 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0395 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1697 | 0.3501 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.2488 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2488 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0395 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4827 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1697 | 0.3501 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.4827 | 0.4821 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2488 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0395 | 0.0395 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0395 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1697 | 0.3501 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1697 | 0.3501 |
Brugia malayi | Smad1 | 0.0017 | 0.0011 | 0.0011 |
Brugia malayi | RNA binding protein | 0.0127 | 0.4827 | 0.4827 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4827 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0011 | 0.0011 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1697 | 0.3501 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1697 | 0.3501 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.2488 | 0.5143 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.4827 | 0.4821 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.2488 | 0.5143 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.4827 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1697 | 0.1688 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1697 | 0.3501 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0011 | 0.0011 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2488 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0011 | 0.0011 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.2488 | 1 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.4827 | 0.4827 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0011 | 0.0011 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4827 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4827 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1697 | 0.1697 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0245 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.4827 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.