Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0068 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.2242 | 0.1394 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0985 | 0.022 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.2242 | 0.5 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0683 | 0.1458 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0985 | 0.3369 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.2242 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2925 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.2242 | 0.7397 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.2242 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2242 | 0.7664 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2821 | 0.9646 |
Brugia malayi | hypothetical protein | 0.0028 | 0.2556 | 0.8593 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0027 | 0.2242 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.2925 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.2242 | 0.1583 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.2242 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0985 | 0.3369 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0985 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.2242 | 0.1394 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.03 | 0.1026 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.2925 | 0.2925 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.2556 | 1 |
Onchocerca volvulus | 0.003 | 0.2925 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.2556 | 0.8738 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.2925 | 0.2925 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.2925 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.2242 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.2242 | 0.7397 |
Echinococcus multilocularis | lamin | 0.003 | 0.2925 | 0.2925 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0985 | 0.3369 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.2242 | 0.1394 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.2242 | 0.1394 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.2556 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0985 | 0.3369 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.2556 | 0.5 |
Echinococcus multilocularis | musashi | 0.003 | 0.2925 | 0.2925 |
Onchocerca volvulus | 0.003 | 0.2925 | 1 | |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.2242 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2242 | 0.7664 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0985 | 0.3369 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.2925 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.2242 | 0.5 |
Brugia malayi | intermediate filament protein | 0.003 | 0.2925 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.2556 | 0.0405 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.2242 | 0.7397 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.2925 | 0.2925 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2242 | 0.7664 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.2242 | 0.1583 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.2556 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.2556 | 1 |
Echinococcus granulosus | lamin | 0.003 | 0.2925 | 0.2925 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.2556 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.2242 | 0.1394 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.5733 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.