Detailed information for compound 1452138

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 363.451 | Formula: C19H29N3O4
  • H donors: 2 H acceptors: 2 LogP: 1.16 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1C(=O)NCC(=O)NCC(N1CCOCC1)(C)C
  • InChi: 1S/C19H29N3O4/c1-4-26-16-8-6-5-7-15(16)18(24)20-13-17(23)21-14-19(2,3)22-9-11-25-12-10-22/h5-8H,4,9-14H2,1-3H3,(H,20,24)(H,21,23)
  • InChiKey: HXENZVZUZIQBEV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA, U transporter 1 0.0099 0.1374 0.1929
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0413 0.0393
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.1318 0.1299
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0162 0.4048
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.036 0.0339
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0342 0.0322
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.041 0.3802
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0717 0.0697
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0272 0.0323
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0421 0.0401
Schistosoma mansoni tar DNA-binding protein 0.0257 0.3753 0.374
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.036 0.2156
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0369 0.0465
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0369 0.3424
Schistosoma mansoni tar DNA-binding protein 0.0257 0.3753 0.374
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0252 0.0232
Plasmodium falciparum importin beta, putative 0.0035 0.041 0.2773
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0244 0.3245
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.1318 0.1299
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.1078 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.1318 0.1847
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0369 0.0465
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0272 0.1281
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.015
Schistosoma mansoni smad1 5 8 and 0.0024 0.0252 0.0232
Leishmania major GTP-binding protein, putative 0.0026 0.0272 0.1198
Loa Loa (eye worm) transcription factor SMAD2 0.0357 0.5248 0.7574
Echinococcus granulosus c-Jun N-terminal kinases 0.0468 0.6913 0.6906
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0244 1
Brugia malayi hypothetical protein 0.0051 0.0656 0.0883
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0717 0.0697
Brugia malayi MH1 domain containing protein 0.0024 0.0252 0.0294
Schistosoma mansoni hypothetical protein 0.0372 0.547 0.546
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0244 0.3245
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0139 0.3381
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0252 0.0232
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0272 0.2522
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0272 1
Brugia malayi Pre-SET motif family protein 0.0219 0.3182 0.4563
Echinococcus granulosus Smad4 0.0024 0.0252 0.0232
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0717 0.0697
Loa Loa (eye worm) RNA binding protein 0.0257 0.3753 0.5396
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0244 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0717 0.0697
Loa Loa (eye worm) hypothetical protein 0.0031 0.036 0.0451
Echinococcus granulosus tar DNA binding protein 0.0257 0.3753 0.374
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0252 0.0232
Schistosoma mansoni hypothetical protein 0.0035 0.0413 0.0393
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.036 0.0339
Brugia malayi MH2 domain containing protein 0.0024 0.0252 0.0294
Echinococcus granulosus snurportin 1 0.0372 0.547 0.546
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0272 0.1198
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.3182 0.4563
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0272 0.0323
Toxoplasma gondii LsmAD domain-containing protein 0.0079 0.1078 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0162 0.039
Trypanosoma brucei PAB1-binding protein , putative 0.0079 0.1078 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.1318 0.1299
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0717 0.0971
Loa Loa (eye worm) hypothetical protein 0.0024 0.0244 0.0282
Brugia malayi MH2 domain containing protein 0.0024 0.0252 0.0294
Schistosoma mansoni hypothetical protein 0.0095 0.1318 0.1299
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0301 0.4409 0.6352
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0369 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.005 0.0029
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0311 0.1626
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0244 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.041 0.0524
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0421 0.0401
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.1318 0.1847
Schistosoma mansoni smad1 5 8 and 0.0024 0.0252 0.0232
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0252 0.0294
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0369 0.2333
Echinococcus multilocularis tumor protein p63 0.0338 0.4969 0.4958
Schistosoma mansoni ran 0.0026 0.0272 0.0251
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0244 1
Trichomonas vaginalis set domain proteins, putative 0.025 0.3637 1
Schistosoma mansoni tar DNA-binding protein 0.0257 0.3753 0.374
Schistosoma mansoni tar DNA-binding protein 0.0257 0.3753 0.374
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0162 0.0141
Onchocerca volvulus 0.0031 0.036 0.0862
Echinococcus multilocularis Smad4 0.0024 0.0252 0.0232
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0717 0.0697
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0468 0.6913 0.6906
Brugia malayi latrophilin 2 splice variant baaae 0.0206 0.2978 0.4267
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.036 0.0339
Entamoeba histolytica hypothetical protein 0.0035 0.0413 1
Brugia malayi Latrophilin receptor protein 2 0.0095 0.1318 0.1847
Schistosoma mansoni Smad4 0.0011 0.005 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0257 0.3753 0.374
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0369 0.0349
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.1078 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.015
Schistosoma mansoni serine/threonine protein kinase 0.0468 0.6913 0.6906
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0162 0.0093
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0272 0.0251
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.015
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0244 0.089
Brugia malayi hypothetical protein 0.0035 0.0413 0.0529
Entamoeba histolytica hypothetical protein 0.0035 0.0413 1
Leishmania major importin beta-1 subunit, putative 0.0028 0.0311 0.1626
Schistosoma mansoni hypothetical protein 0.0095 0.1318 0.1299
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0369 0.2333
Brugia malayi Pre-SET motif family protein 0.0031 0.036 0.0451
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0369 0.2261
Echinococcus granulosus smad 0.0024 0.0252 0.0232
Schistosoma mansoni hypothetical protein 0.0095 0.1318 0.1299
Echinococcus multilocularis smad 0.0024 0.0252 0.0232
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.036 0.0339
Loa Loa (eye worm) hypothetical protein 0.0206 0.2978 0.4267
Brugia malayi Importin beta-1 subunit 0.0035 0.041 0.0524
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0162 0.0093
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0162 0.6335
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0162 0.0163
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.005 0.0029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0244 0.3245
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0468 0.6913 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0244 0.0282
Brugia malayi MH1 domain containing protein 0.0013 0.0089 0.0056
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0369 0.0349
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0153 0.5
Loa Loa (eye worm) nuclear factor I 0.0013 0.0089 0.0056
Echinococcus multilocularis importin subunit beta 1 0.0035 0.041 0.039
Echinococcus granulosus GPCR family 2 0.0095 0.1318 0.1299
Loa Loa (eye worm) hypothetical protein 0.0013 0.0089 0.0056
Brugia malayi MH2 domain containing protein 0.0357 0.5248 0.7574
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0369 0.0349
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0369 0.0349
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.015
Schistosoma mansoni hypothetical protein 0.0095 0.1318 0.1299
Entamoeba histolytica Ran family GTPase 0.0026 0.0272 0.4373
Schistosoma mansoni smad 0.0024 0.0252 0.0232
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.1078 1
Schistosoma mansoni smad 0.0011 0.005 0.0029
Onchocerca volvulus 0.025 0.3637 1
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0631 0.0611
Onchocerca volvulus 0.0024 0.0244 0.0539
Entamoeba histolytica hypothetical protein 0.0028 0.0311 0.5932
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0257 0.3753 0.5396
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0244 0.639
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0413 0.0393
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0244 0.089
Brugia malayi Smad1 0.0024 0.0252 0.0294
Brugia malayi MH1 domain containing protein 0.0013 0.0089 0.0056
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0301 0.4409 0.6352
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0244 0.0282
Mycobacterium ulcerans hypothetical protein 0.0024 0.0244 1
Onchocerca volvulus 0.005 0.0631 0.1619
Brugia malayi hypothetical protein 0.0079 0.1078 0.1498
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0311 0.0802
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0272 0.1281
Schistosoma mansoni smad1 5 8 and 0.0024 0.0252 0.0232
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.005 0.0029
Loa Loa (eye worm) hypothetical protein 0.005 0.0631 0.0846
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0369 0.0349
Schistosoma mansoni hypothetical protein 0.0036 0.0421 0.0401
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0369 0.2261
Echinococcus multilocularis tar DNA binding protein 0.0257 0.3753 0.374
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0369 0.2261
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0717 0.0697
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.041 0.2705
Echinococcus multilocularis GPCR, family 2 0.0095 0.1318 0.1299
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0717 0.0697
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0244 1
Plasmodium vivax SET domain protein, putative 0.0031 0.036 0.2229
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0244 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.547 0.7897
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0162 0.1503
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.015
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0717 0.0971
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0162 0.0141
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0252 0.0232
Brugia malayi Calcitonin receptor-like protein seb-1 0.0301 0.4409 0.6352
Leishmania major hypothetical protein, conserved 0.0079 0.1078 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0244 0.089
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0162 1
Schistosoma mansoni ran 0.0026 0.0272 0.0251
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0139 0.3381
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0162 0.0163
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0153 0.3799
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0162 0.039
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0369 0.0349
Loa Loa (eye worm) MH2 domain-containing protein 0.0357 0.5248 0.7574
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0244 0.639
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0244 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0244 0.0282
Loa Loa (eye worm) hypothetical protein 0.0095 0.1318 0.1847
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0272 0.1198
Loa Loa (eye worm) TAR-binding protein 0.0257 0.3753 0.5396
Brugia malayi TAR-binding protein 0.0257 0.3753 0.5396
Brugia malayi isocitrate dehydrogenase 0.0032 0.0369 0.0465
Schistosoma mansoni Smad4 0.0024 0.0252 0.0232
Entamoeba histolytica hypothetical protein 0.0035 0.0413 1
Plasmodium vivax ataxin-2 like protein, putative 0.0079 0.1078 1
Echinococcus multilocularis microtubule associated protein 2 0.0673 1 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0252 0.0232
Brugia malayi RNA binding protein 0.0257 0.3753 0.5396
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0413 0.0393
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0272 0.1198
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0272 0.0251
Schistosoma mansoni ap endonuclease 0.0018 0.0162 0.0141
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0369 0.2261
Schistosoma mansoni ap endonuclease 0.0018 0.0162 0.0141
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0311 0.0802
Brugia malayi RNA recognition motif domain containing protein 0.0257 0.3753 0.5396
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0153 0.5946
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.005 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0244 0.0282
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0244 0.0282
Plasmodium vivax importin-beta 2, putative 0.0035 0.041 0.2773
Schistosoma mansoni Smad4 0.0011 0.005 0.0029
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0369 0.2261
Schistosoma mansoni importin beta-1 0.0035 0.041 0.039
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0244 1
Schistosoma mansoni microtubule-associated protein tau 0.0673 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0311 0.0802
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0139 0.3381
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.036 0.0339
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.041 0.3802
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0252 0.0294
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.1318 0.1299
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0369 0.3424
Brugia malayi Stress-activated protein kinase jnk-1 0.0468 0.6913 1
Echinococcus multilocularis snurportin 1 0.0372 0.547 0.546
Echinococcus granulosus tumor protein p63 0.0338 0.4969 0.4958
Entamoeba histolytica hypothetical protein 0.0035 0.0413 1
Schistosoma mansoni hypothetical protein 0.0206 0.2978 0.2963
Echinococcus granulosus importin subunit beta 1 0.0035 0.041 0.039
Loa Loa (eye worm) hypothetical protein 0.0079 0.1078 0.1498
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0244 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.036 0.0339
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0139 0.3381
Loa Loa (eye worm) Smad1 0.0024 0.0252 0.0294
Trichomonas vaginalis ran, putative 0.0026 0.0272 0.0693
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.1078 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0162 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.036 0.0339
Brugia malayi MH1 domain containing protein 0.0024 0.0252 0.0294
Loa Loa (eye worm) hypothetical protein 0.0301 0.4409 0.6352
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0369 0.0349

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2311 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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