Detailed information for compound 1452148

Basic information

Technical information
  • TDR Targets ID: 1452148
  • Name: 6-methyl-3-[[4-(phenylmethyl)piperazin-1-yl]m ethyl]chromen-4-one
  • MW: 348.438 | Formula: C22H24N2O2
  • H donors: 0 H acceptors: 1 LogP: 3.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)c(=O)c(co2)CN1CCN(CC1)Cc1ccccc1
  • InChi: 1S/C22H24N2O2/c1-17-7-8-21-20(13-17)22(25)19(16-26-21)15-24-11-9-23(10-12-24)14-18-5-3-2-4-6-18/h2-8,13,16H,9-12,14-15H2,1H3
  • InChiKey: CYVDIPIBMANUKY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-methyl-3-[[4-(phenylmethyl)-1-piperazinyl]methyl]-4-chromenone
  • 3-[[4-(benzyl)piperazin-1-yl]methyl]-6-methyl-chromone
  • 3-[(4-benzyl-1-piperazinyl)methyl]-6-methyl-4H-chromen-4-one
  • MLS000532909
  • SMR000140347
  • Oprea1_345063

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens galactosidase, alpha Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Glycoside hydrolase, family 27 Get druggable targets OG5_127620 All targets in OG5_127620
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Alpha-N-acetylgalactosaminidase precursor, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii melibiase subfamily protein Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Melibiase family protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Alpha-tubulin 0.0094 0.0445 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0094 0.0445 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0057 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0043 0.0183
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Echinococcus granulosus Glycosyl transferase family 8 0.0073 0.0318 0.0799
Echinococcus granulosus tubulin alpha 0.0085 0.0392 0.0983
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.0248 0.0248
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0013 0.0034
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0342 0.0859
Plasmodium vivax tubulin epsilon chain, putative 0.0085 0.0392 0.1933
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0628 0.0925
Plasmodium falciparum tubulin epsilon chain, putative 0.0085 0.0392 0.1933
Toxoplasma gondii beta-tubulin, putative 0.0085 0.0392 0.1933
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0031 0.012
Echinococcus multilocularis TGF beta signal transducer SmadC 0.011 0.0544 0.1364
Trypanosoma brucei epsilon tubulin 0.0085 0.0392 0.1933
Brugia malayi Isocitrate dehydrogenase 0.0346 0.2 0.2
Echinococcus granulosus Tubulin beta 2C chain 0.0085 0.0392 0.0983
Brugia malayi hypothetical protein 0.0029 0.0047 0.0047
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.0248 0.0248
Brugia malayi MH2 domain containing protein 0.011 0.0544 0.0544
Trichomonas vaginalis tubulin, putative 0.0085 0.0392 0.8798
Trichomonas vaginalis tubulin, putative 0.0037 0.0095 0.2013
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0083 0.038 0.0954
Plasmodium falciparum alpha tubulin 2 0.0094 0.0445 0.2197
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Brugia malayi nuclear hormone receptor 0.0029 0.0047 0.0047
Brugia malayi tubulin alpha-2 chain 0.0094 0.0445 0.0445
Leishmania major alpha tubulin 0.0094 0.0445 0.2197
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0043 0.1086
Loa Loa (eye worm) hypothetical protein 0.0521 0.3073 0.3073
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0342 0.1684
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0049 0.0169 0.6645
Echinococcus granulosus Tubulin alpha 1 chain 0.0094 0.0445 0.1115
Trypanosoma cruzi epsilon tubulin, putative 0.0085 0.0392 0.1933
Echinococcus multilocularis Tubulin alpha 1 chain 0.0094 0.0445 0.1115
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0013 0.0013
Brugia malayi Glycosyl transferase family 8 protein 0.0073 0.0318 0.0318
Echinococcus multilocularis Tubulin beta 2C chain 0.0085 0.0392 0.0983
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0047 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0095 0.2013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0346 0.2 0.5017
Schistosoma mansoni tar DNA-binding protein 0.058 0.3437 0.506
Loa Loa (eye worm) hypothetical protein 0.0094 0.0445 0.0445
Brugia malayi MH1 domain containing protein 0.0061 0.0241 0.0241
Schistosoma mansoni smad1 5 8 and 0.011 0.0544 0.08
Echinococcus multilocularis Glycosyl transferase, family 8 0.0073 0.0318 0.0799
Brugia malayi hypothetical protein 0.0033 0.0068 0.0068
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0346 0.2 1
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0071 0.0304 0.0763
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0031 0.0714
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0047 0.0069
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0047 0.0117
Schistosoma mansoni tubulin subunit delta 0.0037 0.0095 0.014
Trypanosoma brucei beta tubulin 0.0085 0.0392 0.1933
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Toxoplasma gondii beta-1 tubulin, putative 0.0085 0.0392 0.1933
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0346 0.2 0.5017
Echinococcus multilocularis beta tubulin 0.0085 0.0392 0.0983
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0043 0.0183
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0042 0.0126 0.0185
Leishmania major alpha tubulin 0.0094 0.0445 0.2197
Loa Loa (eye worm) MH2 domain-containing protein 0.1613 0.9799 0.9799
Echinococcus multilocularis GPCR, family 2 0.0521 0.3073 0.7709
Schistosoma mansoni alpha tubulin 0.0094 0.0445 0.0654
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0047 0.0069
Brugia malayi Tubulin alpha chain 0.0094 0.0445 0.0445
Plasmodium falciparum tubulin delta chain, putative 0.0037 0.0095 0.0442
Entamoeba histolytica tubulin gamma chain 0.0085 0.0392 0.8798
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0068
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.0248 0.0622
Brugia malayi beta-tubulin, identical 0.0085 0.0392 0.0392
Trypanosoma brucei alpha tubulin 0.0094 0.0445 0.2197
Trichomonas vaginalis tubulin alpha chain, putative 0.0085 0.0392 0.8798
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.0248 1
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.0445 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0744 0.1866
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0013 0.0034
Loa Loa (eye worm) hypothetical protein 0.1125 0.6794 0.6794
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0342 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0037 0.0095 0.2013
Plasmodium vivax tubulin alpha chain, putative 0.0094 0.0445 0.2197
Schistosoma mansoni tubulin subunit alpha 0.0094 0.0445 0.0654
Echinococcus multilocularis p2X purinoceptor 4 0.0078 0.0344 0.0863
Giardia lamblia Epsilon tubulin 0.0037 0.0095 0.2013
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Trichomonas vaginalis tubulin alpha chain, putative 0.0048 0.0164 0.3592
Trypanosoma cruzi beta tubulin, putative 0.0085 0.0392 0.1933
Trypanosoma cruzi tubulin gamma chain 0.0085 0.0392 0.1933
Echinococcus multilocularis RUN 0.0024 0.0013 0.0034
Loa Loa (eye worm) nuclear hormone receptor 0.049 0.2881 0.2881
Toxoplasma gondii melibiase subfamily protein 0.0124 0.0628 0.3119
Echinococcus multilocularis geminin 0.0205 0.1127 0.2826
Trypanosoma brucei beta tubulin 0.0085 0.0392 0.1933
Loa Loa (eye worm) hypothetical protein 0.0493 0.2902 0.2902
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.0248 0.0248
Trypanosoma brucei epsilon tubulin 0.0085 0.0392 0.1933
Echinococcus granulosus Tubulin beta 2C chain 0.0085 0.0392 0.0983
Trichomonas vaginalis tubulin gamma chain, putative 0.0037 0.0095 0.2013
Trichomonas vaginalis tubulin beta chain, putative 0.0048 0.0164 0.3592
Echinococcus multilocularis tubulin delta chain 0.0037 0.0095 0.0238
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0346 0.2 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0248 0.0622
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0248 0.0248
Trypanosoma brucei epsilon tubulin 0.0085 0.0392 0.1933
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0248 0.0248
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0071 0.0304 0.0763
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0043 0.1086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0047 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.0248 0.0248
Schistosoma mansoni tubulin subunit alpha 0.0094 0.0445 0.0654
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0043 0.0043
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0375 0.0551
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0124 0.0628 0.1576
Echinococcus multilocularis Tubulin beta 2C chain 0.0085 0.0392 0.0983
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.0248 0.0622
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0068 0.0171
Echinococcus multilocularis tubulin alpha chain 0.0094 0.0445 0.1115
Toxoplasma gondii alpha-tubulin I, putative 0.0094 0.0445 0.2197
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0042 0.0126 0.3553
Trypanosoma cruzi alpha tubulin, putative 0.0094 0.0445 0.2197
Loa Loa (eye worm) tubulin beta-4 chain 0.0085 0.0392 0.0392
Echinococcus multilocularis isocitrate dehydrogenase 0.0346 0.2 0.5017
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0043 0.0183
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0048 0.0164 0.3592
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.0248 0.0365
Echinococcus granulosus mothers against decapentaplegic 2 0.0049 0.0169 0.0425
Schistosoma mansoni hypothetical protein 0.0521 0.3073 0.4523
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0013
Brugia malayi Melibiase family protein 0.0082 0.0375 0.0375
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0043 0.0043
Leishmania major gamma-tubulin 0.0085 0.0392 0.1933
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0157 0.344
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0178 0.0448
Schistosoma mansoni tubulin subunit beta 0.0085 0.0392 0.0577
Brugia malayi nuclear receptor RXR 0.0029 0.0047 0.0047
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0047 0.0047
Loa Loa (eye worm) MH1 domain-containing protein 0.011 0.0544 0.0544
Schistosoma mansoni tyrosine kinase 0.0659 0.3927 0.578
Echinococcus multilocularis tubulin alpha chain 0.0094 0.0445 0.1115
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.0248 0.0622
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0013 0.0034
Trichomonas vaginalis tubulin gamma chain, putative 0.0085 0.0392 0.8798
Echinococcus multilocularis tubulin beta 1 chain 0.0085 0.0392 0.0983
Leishmania major alpha tubulin 0.0094 0.0445 0.2197
Schistosoma mansoni P2X receptor subunit 0.0078 0.0344 0.0507
Loa Loa (eye worm) tubulin alpha-2 chain 0.0094 0.0445 0.0445
Brugia malayi Probable ClpP-like protease 0.0077 0.0342 0.0342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.0248 0.0248
Echinococcus granulosus Tubulin beta 2C chain 0.0085 0.0392 0.0983
Schistosoma mansoni tar DNA-binding protein 0.058 0.3437 0.506
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0042 0.0126 0.0126
Mycobacterium tuberculosis Cell division protein FtsZ 0.0037 0.0095 0.0442
Trypanosoma cruzi zeta tubulin, putative 0.0037 0.0095 0.0442
Entamoeba histolytica tubulin family protein 0.0085 0.0392 0.8798
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0346 0.2 0.5017
Echinococcus multilocularis tubulin alpha 0.0085 0.0392 0.0983
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0178 0.4744
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0184 0.0461
Echinococcus granulosus tubulin alpha 1C chain 0.0094 0.0445 0.1115
Treponema pallidum cell division protein FtsZ 0.0037 0.0095 0.2627
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0042 0.0126 0.0316
Trypanosoma cruzi epsilon tubulin, putative 0.0085 0.0392 0.1933
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.0169 0.0169
Leishmania major alpha tubulin 0.0094 0.0445 0.2197
Echinococcus multilocularis tubulin subunit beta 0.0085 0.0392 0.0983
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0248 0.0248
Echinococcus multilocularis tar DNA binding protein 0.058 0.3437 0.8624
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0043 0.1086
Schistosoma mansoni smad1 5 8 and 0.011 0.0544 0.08
Brugia malayi MH2 domain containing protein 0.0049 0.0169 0.0169
Leishmania major alpha tubulin 0.0094 0.0445 0.2197
Loa Loa (eye worm) hypothetical protein 0.0042 0.0126 0.0126
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0184 0.4043
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0085 0.0392 0.1933
Brugia malayi hypothetical protein 0.0033 0.0068 0.0068
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0042 0.0126 0.0316
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.0445 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Brugia malayi Tubulin beta chain 0.0048 0.0164 0.0164
Schistosoma mansoni coup transcription factor 0.0062 0.0248 0.0365
Schistosoma mansoni nuclear receptor 0.0029 0.0047 0.0069
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0184 0.0888
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.0248 0.0365
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0007 0.0017
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0047 0.0047
Echinococcus multilocularis hypothetical protein 0.0094 0.0445 0.1115
Schistosoma mansoni tar DNA-binding protein 0.058 0.3437 0.506
Trichomonas vaginalis tubulin epsilon chain, putative 0.0094 0.0445 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0085 0.0392 0.0983
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0914 0.2293
Echinococcus granulosus smad 0.011 0.0544 0.1364
Loa Loa (eye worm) hypothetical protein 0.0082 0.0375 0.0375
Brugia malayi mothers against decapentaplegic homolog 3 0.0049 0.0169 0.0169
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0047 0.0047
Loa Loa (eye worm) tubulin beta-2A chain 0.0085 0.0392 0.0392
Loa Loa (eye worm) nuclear factor I 0.0061 0.0241 0.0241
Schistosoma mansoni tubulin subunit beta 0.0085 0.0392 0.0577
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0047 0.0117
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.0248 0.0365
Brugia malayi Tubulin gamma chain 0.0085 0.0392 0.0392
Trypanosoma brucei tubulin gamma chain 0.0085 0.0392 0.1933
Schistosoma mansoni alpha tubulin 0.0094 0.0445 0.0654
Loa Loa (eye worm) tubulin alpha chain 0.0094 0.0445 0.0445
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0248 0.0248
Echinococcus multilocularis thyroid hormone receptor alpha 0.0062 0.0248 0.0622
Loa Loa (eye worm) alpha-tubulin 0.0094 0.0445 0.0445
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0522 0.3082 0.7732
Schistosoma mansoni nuclear receptor 0.0029 0.0047 0.0069
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0043 0.1086
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.0169 0.0169
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0184 0.0888
Trypanosoma brucei alpha tubulin 0.0094 0.0445 0.2197
Brugia malayi photoreceptor-specific nuclear receptor 0.0299 0.1707 0.1707
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0248 0.0248
Giardia lamblia Alpha-tubulin 0.0094 0.0445 1
Echinococcus multilocularis tubulin alpha chain 0.0094 0.0445 0.1115
Echinococcus granulosus tubulin alpha 1C chain 0.0094 0.0445 0.1115
Trypanosoma brucei alpha tubulin 0.0094 0.0445 0.2197
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Loa Loa (eye worm) hypothetical protein 0.0077 0.0342 0.0342
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0522 0.3082 0.7732
Schistosoma mansoni tubulin subunit beta 0.0085 0.0392 0.0577
Entamoeba histolytica tubulin alpha chain, putative 0.0094 0.0445 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0013
Brugia malayi MH1 domain containing protein 0.011 0.0544 0.0544
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0521 0.3073 0.4523
Echinococcus multilocularis smad 0.011 0.0544 0.1364
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0521 0.3073 0.7709
Schistosoma mansoni Smad4 0.011 0.0544 0.08
Echinococcus multilocularis Tubulin beta 2C chain 0.0085 0.0392 0.0983
Plasmodium falciparum ataxin-2 like protein, putative 0.0186 0.1012 0.5042
Echinococcus granulosus p2X purinoceptor 4 0.0078 0.0344 0.0863
Plasmodium vivax tubulin gamma chain, putative 0.0085 0.0392 0.1933
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0342 0.5
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0007 0.0007
Brugia malayi nuclear receptor NHR-88 0.0029 0.0047 0.0047
Leishmania major delta tubulin, putative 0.0037 0.0095 0.0442
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0248 0.0365
Schistosoma mansoni hypothetical protein 0.0521 0.3073 0.4523
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Echinococcus granulosus mothers against decapentaplegic 6 0.0049 0.0169 0.0425
Toxoplasma gondii isocitrate dehydrogenase 0.0346 0.2 1
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0047 0.0047
Loa Loa (eye worm) transcription factor SMAD2 0.1613 0.9799 0.9799
Brugia malayi Cell division protein ftsZ 0.0037 0.0095 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.0248 0.0248
Brugia malayi Tubulin beta chain 0.0037 0.0095 0.0095
Mycobacterium ulcerans hypothetical protein 0.0029 0.0043 0.1086
Brugia malayi nuclear hormone receptor 0.0062 0.0248 0.0248
Schistosoma mansoni P2X receptor subunit 0.0078 0.0344 0.0507
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0628 0.0925
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0042 0.0126 0.0126
Schistosoma mansoni ap endonuclease 0.0023 0.0007 0.001
Brugia malayi MH1 domain containing protein 0.0061 0.0241 0.0241
Loa Loa (eye worm) BEN-1 protein 0.0085 0.0392 0.0392
Brugia malayi Probable isocitrate dehydrogenase 0.0042 0.0126 0.0126
Loa Loa (eye worm) tubulin alpha chain 0.0094 0.0445 0.0445
Echinococcus granulosus tubulin epsilon chain 0.0085 0.0392 0.0983
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0521 0.3073 0.3073
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.0248 0.0365
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0521 0.3073 0.7709
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0248 0.0365
Trichomonas vaginalis tubulin alpha chain, putative 0.0048 0.0164 0.3592
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0007 0.0017
Echinococcus granulosus tubulin alpha chain 0.0094 0.0445 0.1115
Schistosoma mansoni ap endonuclease 0.0023 0.0007 0.001
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0085 0.0392 0.0983
Trichomonas vaginalis tubulin alpha chain, putative 0.0048 0.0164 0.3592
Schistosoma mansoni smad 0.0049 0.0169 0.0249
Echinococcus granulosus tubulin alpha chain 0.0094 0.0445 0.1115
Echinococcus granulosus peroxisome assembly protein 26 0.0094 0.0445 0.1115
Leishmania major alpha tubulin 0.0094 0.0445 0.2197
Schistosoma mansoni polycystin 1-related 0.0024 0.0013 0.002
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0042 0.0126 0.3553
Onchocerca volvulus 0.0029 0.0047 0.1416
Echinococcus granulosus FTZ F1 alpha 0.0062 0.0248 0.0622
Echinococcus granulosus tubulin alpha 3 chain 0.0094 0.0445 0.1115
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0037 0.0095 0.0442
Trypanosoma cruzi zeta tubulin, putative 0.0037 0.0095 0.0442
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.0445 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0085 0.0392 0.0983
Loa Loa (eye worm) hypothetical protein 0.0062 0.0248 0.0248
Echinococcus granulosus tubulin alpha chain 0.0094 0.0445 0.1115
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0043 0.0832
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0013 0.0034
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Schistosoma mansoni P2X receptor subunit 0.0078 0.0344 0.0507
Loa Loa (eye worm) isocitrate dehydrogenase 0.0346 0.2 0.2
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0042 0.0126 0.0316
Onchocerca volvulus 0.0029 0.0047 0.1416
Onchocerca volvulus 0.0048 0.0164 0.6416
Echinococcus granulosus tubulin delta chain 0.0037 0.0095 0.0238
Brugia malayi RNA binding protein 0.058 0.3437 0.3437
Loa Loa (eye worm) tubulin alpha-3 chain 0.0046 0.0147 0.0147
Trypanosoma brucei zeta tubulin, putative 0.0037 0.0095 0.0442
Loa Loa (eye worm) hypothetical protein 0.0062 0.0248 0.0248
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0346 0.2 0.2943
Brugia malayi nuclear receptor NHR-88 0.0062 0.0248 0.0248
Schistosoma mansoni hypothetical protein 0.1125 0.6794 1
Brugia malayi Tubulin beta-1 chain 0.0085 0.0392 0.0392
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.0248 0.0365
Brugia malayi Probable isocitrate dehydrogenase 0.0042 0.0126 0.0126
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0346 0.2 1
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0047 0.0069
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0071 0.0304 0.0763
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0342 0.0859
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0047 0.0117
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0037 0.0095 0.2013
Mycobacterium ulcerans cell division protein FtsZ 0.0037 0.0095 0.2627
Echinococcus granulosus tubulin alpha 3 chain 0.0094 0.0445 0.1115
Loa Loa (eye worm) BEN-1 protein 0.0085 0.0392 0.0392
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0342 1
Plasmodium falciparum tubulin gamma chain 0.0085 0.0392 0.1933
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.0248 0.0248
Schistosoma mansoni Smad4 0.0049 0.0169 0.0249
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Echinococcus multilocularis tubulin alpha chain 0.0094 0.0445 0.1115
Schistosoma mansoni hypothetical protein 0.0024 0.0013 0.002
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0346 0.2 0.5017
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0068
Trypanosoma brucei zeta tubulin 0.0037 0.0095 0.0442
Echinococcus multilocularis tubulin alpha 3 chain 0.0094 0.0445 0.1115
Brugia malayi MH1 domain containing protein 0.011 0.0544 0.0544
Leishmania major alpha tubulin 0.0094 0.0445 0.2197
Giardia lamblia Beta tubulin 0.0085 0.0392 0.8798
Schistosoma mansoni Smad4 0.0049 0.0169 0.0249
Schistosoma mansoni glycosyltransferase-related 0.0073 0.0318 0.0469
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0342 0.1684
Echinococcus multilocularis tyrosine protein kinase Abl 0.0273 0.1546 0.3879
Schistosoma mansoni tubulin subunit alpha 0.0037 0.0095 0.014
Loa Loa (eye worm) acetyltransferase 0.0175 0.0944 0.0944
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0037 0.0095 0.2627
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Echinococcus granulosus glycosyltransferase protein LARGE2 0.0071 0.0304 0.0763
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0342 0.1684
Leishmania major isocitrate dehydrogenase, putative 0.0042 0.0126 0.0598
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0521 0.3073 0.7709
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0043 0.04
Schistosoma mansoni smad 0.011 0.0544 0.08
Echinococcus granulosus p2X purinoceptor 4 0.0078 0.0344 0.0863
Loa Loa (eye worm) hypothetical protein 0.0062 0.0248 0.0248
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0042 0.0126 0.0598
Brugia malayi conserved hypotetical protein 0.0029 0.0047 0.0047
Trichomonas vaginalis tubulin, putative 0.0048 0.0164 0.3592
Schistosoma mansoni tubulin subunit gamma 0.0085 0.0392 0.0577
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0047 0.0117
Brugia malayi Latrophilin receptor protein 2 0.0521 0.3073 0.3073
Brugia malayi tubulin alpha chain - mouse 0.0094 0.0445 0.0445
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0047 0.0117
Loa Loa (eye worm) glycosyl transferase family 8 protein 0.0073 0.0318 0.0318
Trypanosoma brucei tubulin delta chain 0.0037 0.0095 0.0442
Echinococcus granulosus beta tubulin 0.0085 0.0392 0.0983
Trichomonas vaginalis tubulin beta chain, putative 0.0085 0.0392 0.8798
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0047 0.1416
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0342 0.1684
Giardia lamblia Beta tubulin 0.0085 0.0392 0.8798
Trypanosoma cruzi PAB1-binding protein , putative 0.0186 0.1012 0.5042
Brugia malayi Doublecortin family protein 0.0024 0.0013 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0248 0.0248
Loa Loa (eye worm) beta-tubulin 0.0085 0.0392 0.0392
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0043 0.0832
Echinococcus granulosus Tubulin beta 2C chain 0.0085 0.0392 0.0983
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0375 0.0551
Schistosoma mansoni isocitrate dehydrogenase 0.0042 0.0126 0.0185
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0013 0.0034
Brugia malayi hypothetical protein 0.012 0.0606 0.0606
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0047 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0248 0.0622
Schistosoma mansoni alpha tubulin 0.0094 0.0445 0.0654
Echinococcus granulosus tubulin subunit beta 0.0085 0.0392 0.0983
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0043 0.0832
Brugia malayi follicle stimulating hormone receptor 0.0282 0.1604 0.1604
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.0248 0.0622
Onchocerca volvulus 0.0029 0.0043 0.1265
Loa Loa (eye worm) latrophilin receptor protein 2 0.0521 0.3073 0.3073
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0047 0.0047
Schistosoma mansoni tar DNA-binding protein 0.058 0.3437 0.506
Echinococcus granulosus tubulin alpha chain 0.0094 0.0445 0.1115
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0178 0.0862
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0031 0.012
Toxoplasma gondii alpha tubulin TUBA1 0.0094 0.0445 0.2197
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0068 0.0171
Loa Loa (eye worm) TAR-binding protein 0.058 0.3437 0.3437
Echinococcus granulosus tyrosine protein kinase ABL1 0.0669 0.3986 1
Loa Loa (eye worm) alpha-tubulin 0.0094 0.0445 0.0445
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0342 0.5
Loa Loa (eye worm) tubulin alpha 2 0.0057 0.0217 0.0217
Schistosoma mansoni rab6-interacting 0.0024 0.0013 0.002
Loa Loa (eye worm) tubulin alpha 2 0.0057 0.0217 0.0217
Trichomonas vaginalis tubulin gamma chain, putative 0.0085 0.0392 0.8798
Leishmania major alpha tubulin 0.0094 0.0445 0.2197
Toxoplasma gondii beta tubulin 0.0085 0.0392 0.1933
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0013 0.0034
Echinococcus multilocularis Tubulin alpha 1 chain 0.0094 0.0445 0.1115
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0184 0.0888
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.0248 0.0622
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0068 0.0068
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0669 0.3986 1
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0299 0.1707 0.1707
Loa Loa (eye worm) hypothetical protein 0.0062 0.0248 0.0248
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.0248 0.0248
Brugia malayi hypothetical protein 0.0024 0.0013 0.0013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0346 0.2 0.5017
Echinococcus multilocularis tubulin alpha 1C chain 0.0094 0.0445 0.1115
Leishmania major zeta tubulin, putative 0.0037 0.0095 0.0442
Echinococcus multilocularis Smad4 0.011 0.0544 0.1364
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Schistosoma mansoni tubulin subunit beta 0.0037 0.0095 0.014
Plasmodium vivax ataxin-2 like protein, putative 0.0186 0.1012 0.5042
Echinococcus multilocularis conserved hypothetical protein 0.0054 0.0202 0.0506
Echinococcus granulosus mothers against decapentaplegic 5 0.011 0.0544 0.1364
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.0248 0.0622
Trypanosoma cruzi PAB1-binding protein , putative 0.0186 0.1012 0.5042
Brugia malayi Smad1 0.011 0.0544 0.0544
Loa Loa (eye worm) DR-78 0.0029 0.0047 0.0047
Trypanosoma brucei beta tubulin 0.0085 0.0392 0.1933
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0628 0.0925
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0043 0.0183
Trypanosoma brucei beta tubulin 0.0085 0.0392 0.1933
Brugia malayi RNA recognition motif domain containing protein 0.058 0.3437 0.3437
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0248 0.0365
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0342 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0013 0.0034
Brugia malayi hypothetical protein 0.0186 0.1012 0.1012
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0346 0.2 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.0248 0.0365
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0346 0.2 1
Brugia malayi hypothetical protein 0.0029 0.0047 0.0047
Schistosoma mansoni rab6-interacting 0.0024 0.0013 0.002
Brugia malayi Calcitonin receptor-like protein seb-1 0.1646 1 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0944 0.2369
Brugia malayi alpha-tubulin 0.0094 0.0445 0.0445
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0157 0.0756
Loa Loa (eye worm) hypothetical protein 0.0062 0.0248 0.0248
Echinococcus multilocularis mothers against decapentaplegic 2 0.0049 0.0169 0.0425
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0037 0.0095 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0095 0.2013
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0043 0.1086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0248 0.0622
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.0248 0.0622
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.0248 0.0248
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0282 0.1604 0.1604
Brugia malayi ecdysteroid receptor 0.0062 0.0248 0.0248
Giardia lamblia Beta tubulin 0.0085 0.0392 0.8798
Loa Loa (eye worm) RNA binding protein 0.058 0.3437 0.3437
Echinococcus granulosus TGF beta signal transducer SmadC 0.011 0.0544 0.1364
Trypanosoma cruzi tubulin delta chain 0.0037 0.0095 0.0442
Brugia malayi Tubulin alpha-2 chain 0.0094 0.0445 0.0445
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.0248 1
Trypanosoma brucei beta tubulin 0.0085 0.0392 0.1933
Plasmodium vivax delta tubulin, putative 0.0037 0.0095 0.0442
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.0248 0.0622
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0047 0.0117
Echinococcus multilocularis tubulin gamma 1 chain 0.0085 0.0392 0.0983
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0068 0.01
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0342 1
Schistosoma mansoni zinc finger protein 0.0029 0.0047 0.0069
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.0248 0.0622
Brugia malayi Tubulin alpha chain 0.0037 0.0095 0.0095
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0094 0.0445 1
Echinococcus granulosus RUN 0.0024 0.0013 0.0034
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.0248 0.0365
Loa Loa (eye worm) hypothetical protein 0.0062 0.0248 0.0248
Brugia malayi Tyrosine-protein kinase abl-1 0.0273 0.1546 0.1546
Loa Loa (eye worm) MH2 domain-containing protein 0.011 0.0544 0.0544
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0043 0.0183
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0178 0.0448
Brugia malayi MH2 domain containing protein 0.011 0.0544 0.0544
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0068 0.0068
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0013 0.0034
Trichomonas vaginalis tubulin, putative 0.0048 0.0164 0.3592
Schistosoma mansoni hypothetical protein 0.0521 0.3073 0.4523
Leishmania major alpha tubulin 0.0094 0.0445 0.2197
Echinococcus granulosus tubulin gamma 1 chain 0.0085 0.0392 0.0983
Trichomonas vaginalis tubulin epsilon chain, putative 0.0085 0.0392 0.8798
Echinococcus granulosus Tubulin alpha 1 chain 0.0094 0.0445 0.1115
Loa Loa (eye worm) hypothetical protein 0.0046 0.0147 0.0147
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0157 0.344
Echinococcus multilocularis tubulin epsilon chain 0.0085 0.0392 0.0983
Brugia malayi Steroid receptor seven-up type 2 0.0522 0.3082 0.3082
Brugia malayi steroid hormone receptor 0.0062 0.0248 0.0248
Plasmodium falciparum tubulin beta chain 0.0085 0.0392 0.1933
Echinococcus multilocularis p2X purinoceptor 4 0.0078 0.0344 0.0863
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0068 0.01
Schistosoma mansoni TGF-beta signal transducer Smad2 0.011 0.0544 0.08
Loa Loa (eye worm) hypothetical protein 0.1646 1 1
Echinococcus multilocularis tubulin alpha chain 0.0094 0.0445 0.1115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0248 0.0622
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0047 0.0069
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0083 0.038 0.0954
Echinococcus granulosus tubulin beta 1 chain 0.0085 0.0392 0.0983
Schistosoma mansoni tubulin subunit beta 0.0085 0.0392 0.0577
Echinococcus multilocularis peroxisome assembly protein 26 0.0094 0.0445 0.1115
Trichomonas vaginalis tubulin epsilon chain, putative 0.0085 0.0392 0.8798
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.0445 1
Giardia lamblia Gamma tubulin 0.0085 0.0392 0.8798
Loa Loa (eye worm) tubulin beta-1 chain 0.0085 0.0392 0.0392
Brugia malayi ecdysone receptor 0.0029 0.0047 0.0047
Echinococcus granulosus beta tubulin 0.0085 0.0392 0.0983
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0342 0.0504
Schistosoma mansoni smad1 5 8 and 0.011 0.0544 0.08
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Loa Loa (eye worm) Smad1 0.011 0.0544 0.0544
Echinococcus granulosus GPCR family 2 0.0521 0.3073 0.7709
Loa Loa (eye worm) hypothetical protein 0.0057 0.0217 0.0217
Trypanosoma brucei alpha tubulin, putative 0.0048 0.0164 0.0789
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Plasmodium falciparum alpha tubulin 1 0.0094 0.0445 0.2197
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0178 0.0862
Toxoplasma gondii hypothetical protein 0.0027 0.0031 0.012
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0124 0.0628 0.1576
Brugia malayi nuclear receptor NHR-67 0.0029 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0061 0.0241 0.0241
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.058 0.3437 0.3437
Leishmania major alpha tubulin 0.0094 0.0445 0.2197
Brugia malayi MH2 domain containing protein 0.1613 0.9799 0.9799
Loa Loa (eye worm) hypothetical protein 0.0254 0.1429 0.1429
Brugia malayi Tubulin alpha-2 chain 0.0094 0.0445 0.0445
Brugia malayi isocitrate dehydrogenase 0.0346 0.2 0.2
Echinococcus granulosus tar DNA binding protein 0.058 0.3437 0.8624
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0042 0.0126 0.3058
Schistosoma mansoni tubulin subunit alpha 0.0094 0.0445 0.0654
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0046 0.0147 0.3216
Echinococcus granulosus Tubulin alpha 1 chain 0.0094 0.0445 0.1115
Echinococcus granulosus geminin 0.0205 0.1127 0.2826
Loa Loa (eye worm) TK/ABL protein kinase 0.0669 0.3986 0.3986
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0184 0.4043
Brugia malayi tailless protein 0.0029 0.0047 0.0047
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.0248 0.0622
Schistosoma mansoni lipoxygenase 0.0142 0.0744 0.1095
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0042 0.0126 0.2723
Schistosoma mansoni unc-13 (munc13) 0.0042 0.0126 0.0185
Trypanosoma brucei alpha tubulin 0.0094 0.0445 0.2197
Entamoeba histolytica tartrate dehydrogenase, putative 0.0042 0.0126 0.2723
Echinococcus multilocularis p2X purinoceptor 4 0.0078 0.0344 0.0863
Leishmania major alpha tubulin 0.0094 0.0445 0.2197
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1646 1 1
Leishmania major epsilon tubulin, putative 0.0085 0.0392 0.1933
Echinococcus granulosus tubulin alpha chain 0.0094 0.0445 0.1115
Mycobacterium leprae cell division protein FtsZ 0.0037 0.0095 0.206
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.0248 0.0365
Schistosoma mansoni lipoxygenase 0.01 0.048 0.0706
Toxoplasma gondii LsmAD domain-containing protein 0.0186 0.1012 0.5042
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0346 0.2 1
Loa Loa (eye worm) tubulin beta chain 0.0085 0.0392 0.0392
Leishmania major hypothetical protein, conserved 0.0186 0.1012 0.5042
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0068 0.0068
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Giardia lamblia Delta tubulin 0.0037 0.0095 0.2013
Echinococcus multilocularis Glycosyltransferase protein LARGE1 0.0054 0.0202 0.0506
Echinococcus granulosus Tubulin beta 2C chain 0.0085 0.0392 0.0983
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0047 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.0248 0.0248
Echinococcus granulosus p2X purinoceptor 4 0.0078 0.0344 0.0863
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0047 0.0117
Echinococcus multilocularis mothers against decapentaplegic 5 0.011 0.0544 0.1364
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.0248 1
Schistosoma mansoni hypothetical protein 0.0083 0.038 0.056
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.0248 0.0248
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0248 0.0248
Schistosoma mansoni tubulin subunit beta 0.0085 0.0392 0.0577
Echinococcus multilocularis beta tubulin 0.0085 0.0392 0.0983
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Schistosoma mansoni tubulin subunit epsilon 0.0085 0.0392 0.0577
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0944 0.139
Loa Loa (eye worm) tubulin gamma chain 0.0085 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0186 0.1012 0.1012
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0124 0.0628 0.1576
Plasmodium vivax tubulin beta chain, putative 0.0085 0.0392 0.1933
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0521 0.3073 0.7709
Loa Loa (eye worm) hypothetical protein 0.0062 0.0248 0.0248
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0346 0.2 1
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.0445 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0186 0.1012 0.5042
Echinococcus multilocularis tubulin alpha 3 chain 0.0094 0.0445 0.1115
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0043 0.1086
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0042 0.0126 0.0126
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0744 0.1866
Entamoeba histolytica tubulin family protein 0.0085 0.0392 0.8798
Trypanosoma cruzi tubulin delta chain 0.0037 0.0095 0.0442
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0248 0.0365
Echinococcus multilocularis Tubulin beta 2C chain 0.0085 0.0392 0.0983
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.0375 0.8403
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0346 0.2 1
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0042 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.0248 0.0248
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0205 0.1127 0.1658
Echinococcus multilocularis tubulin alpha 1C chain 0.0094 0.0445 0.1115
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0944 0.0944
Onchocerca volvulus 0.0062 0.0248 1
Echinococcus granulosus Glycosyltransferase protein LARGE1 0.0054 0.0202 0.0506
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0042 0.0126 0.0316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.0248 0.0248
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0628 0.0925
Brugia malayi TAR-binding protein 0.058 0.3437 0.3437
Echinococcus multilocularis mothers against decapentaplegic 6 0.0049 0.0169 0.0425
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0047 0.0117
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.0445 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0094 0.0445 0.1115
Brugia malayi hypothetical protein 0.0024 0.0013 0.0013
Toxoplasma gondii isocitrate dehydrogenase 0.0346 0.2 1
Plasmodium vivax tubulin alpha chain, putative 0.0094 0.0445 0.2197
Echinococcus granulosus tubulin subunit TubB 0.0094 0.0445 0.1115
Trichomonas vaginalis tubulin gamma chain, putative 0.0085 0.0392 0.8798
Leishmania major beta tubulin 0.0085 0.0392 0.1933
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0047 0.0069
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0043
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0057 0.0217 0.4794
Brugia malayi latrophilin 2 splice variant baaae 0.1125 0.6794 0.6794
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.0248 0.0248
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0043 0.1086
Leishmania major alpha tubulin 0.0094 0.0445 0.2197
Brugia malayi nuclear receptor RXR 0.0033 0.0068 0.0068
Echinococcus granulosus alpha tubulin 0.0094 0.0445 0.1115
Loa Loa (eye worm) tubulin beta chain 0.0037 0.0095 0.0095
Schistosoma mansoni hypothetical protein 0.0205 0.1127 0.1658
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0047 0.0117
Trypanosoma brucei PAB1-binding protein , putative 0.0186 0.1012 0.5042
Schistosoma mansoni P2X receptor subunit 0.0078 0.0344 0.0507
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0047 0.1416
Entamoeba histolytica tubulin alpha-1 chain 0.0094 0.0445 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0043 0.04
Schistosoma mansoni tubulin subunit beta 0.0085 0.0392 0.0577
Trichomonas vaginalis tubulin alpha chain, putative 0.0085 0.0392 0.8798
Brugia malayi Tyrosine-protein kinase abl-1 0.0406 0.2364 0.2364
Echinococcus granulosus Smad4 0.011 0.0544 0.1364
Echinococcus multilocularis tubulin subunit TubB 0.0094 0.0445 0.1115
Loa Loa (eye worm) hypothetical protein 0.0049 0.0169 0.0169
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0342 1
Schistosoma mansoni tar DNA-binding protein 0.058 0.3437 0.506
Schistosoma mansoni loxhd1 0.0024 0.0013 0.002

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1778 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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