Detailed information for compound 1452275

Basic information

Technical information
  • TDR Targets ID: 1452275
  • Name: 4-[2-(2-dimethylaminopropyl)phenyl]sulfanylph enol; ethanol; hydrochloride
  • MW: 369.949 | Formula: C19H28ClNO2S
  • H donors: 2 H acceptors: 2 LogP: 5.08 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)Sc1ccccc1CC(N(C)C)C.CCO.Cl
  • InChi: 1S/C17H21NOS.C2H6O.ClH/c1-13(18(2)3)12-14-6-4-5-7-17(14)20-16-10-8-15(19)9-11-16;1-2-3;/h4-11,13,19H,12H2,1-3H3;3H,2H2,1H3;1H
  • InChiKey: VUUBFUHNOZBTFH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[2-(2-dimethylaminopropyl)phenyl]thio]phenol; ethanol; hydrochloride
  • 4-({2-[2-(dimethylamino)propyl]phenyl}sulfanyl)phenol
  • MLS000540150
  • SMR000161825

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.086 0.4477 0.4477
Leishmania major cyclic nucleotide-binding protein-like protein 0.002 0.0045 0.0865
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0126 0.2397
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0686 0.0686
Echinococcus multilocularis Protein son of sevenless 0.0033 0.0113 0.0181
Mycobacterium tuberculosis Conserved protein 0.0036 0.0126 0.1019
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0179 0.0529
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0021
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0036 0.0036
Schistosoma mansoni ap endonuclease 0.0019 0.0036 0.0083
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.002 0.0045 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0045 0.0865
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0033
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0138 0.0138
Loa Loa (eye worm) latrophilin receptor protein 2 0.0272 0.1374 0.1374
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0041 0.015
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0138 0.0138
Brugia malayi regulator of G-protein signaling egl-10 0.0046 0.0183 0.0183
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0297 0.0965
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0066 0.0491
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0074 0.4092
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.0074 0.0122
Onchocerca volvulus 0.0023 0.0058 0.0087
Echinococcus granulosus chromobox protein 1 0.0068 0.0297 0.0642
Brugia malayi beta-lactamase 0.0036 0.0126 0.0126
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.0045 0.0048
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.002 0.0045 0.0865
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.002 0.0045 0.5
Mycobacterium ulcerans hypothetical protein 0.002 0.0045 0.0166
Loa Loa (eye worm) DOMON domain-containing protein 0.0015 0.0015 0.0015
Leishmania major hypothetical protein, conserved 0.0067 0.029 0.5519
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.002 0.0045 0.0865
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Schistosoma mansoni kinase 0.0047 0.0186 0.0429
Schistosoma mansoni inositol transporter 0.0075 0.0334 0.0771
Schistosoma mansoni hypothetical protein 0.004 0.0151 0.0348
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0065 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0113 0.1601
Brugia malayi latrophilin 2 splice variant baaae 0.0588 0.3041 0.3041
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0074 0.0562
Loa Loa (eye worm) hypothetical protein 0.0033 0.0113 0.0113
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0033 0.0113 0.0283
Schistosoma mansoni hypothetical protein 0.0272 0.1374 0.3176
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.002 0.0045 0.0307
Echinococcus granulosus ras GTP exchange factor 0.0033 0.0113 0.0213
Echinococcus multilocularis regulator of G protein signaling 7 0.0046 0.0183 0.0319
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0126 0.8193
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.002 0.0045 0.1068
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0074 0.0562
Trypanosoma cruzi PAB1-binding protein , putative 0.0111 0.0525 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0155 0.0438
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0126 0.0332
Loa Loa (eye worm) RNA binding protein 0.0548 0.2833 0.2833
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0138 0.0319
Trichomonas vaginalis glutaminase, putative 0.0531 0.2743 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0046 0.0183 0.0319
Echinococcus granulosus expressed conserved protein 0.0091 0.0421 0.0929
Echinococcus granulosus chromobox protein 1 0.0068 0.0297 0.0642
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0033
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0033 0.0113 0.0181
Brugia malayi N-terminal motif family protein 0.0033 0.0113 0.0113
Echinococcus granulosus segment polarity protein dishevelled 0.0046 0.0183 0.0377
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0138 0.2632
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.002 0.0045 0.0865
Brugia malayi hypothetical protein 0.0072 0.0317 0.0317
Brugia malayi RasGEF domain containing protein 0.0033 0.0113 0.0113
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.002 0.0045 0.0057
Brugia malayi hypothetical protein 0.0018 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0081 0.0164
Treponema pallidum cyclic nucleotide binding protein 0.002 0.0045 1
Echinococcus granulosus sodium:glucose cotransporter 0.0075 0.0334 0.0726
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0067 0.029 0.5519
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0066 0.0242
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0045 0.0865
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0045 0.0045
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0272 0.1374 0.266
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.002 0.0045 0.0045
Onchocerca volvulus 0.0033 0.0113 0.0199
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0173 0.33
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0036 0.003
Schistosoma mansoni tar DNA-binding protein 0.0548 0.2833 0.6548
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0138 0.0231
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0023 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0066 0.0242
Loa Loa (eye worm) hypothetical protein 0.101 0.5268 0.5268
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0036 0.0686
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.002 0.0045 0.0048
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.002 0.0045 0.0307
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0425 0.1438
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0138 0.0272
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0657 0.1519
Loa Loa (eye worm) hepatopoietin HPO2 0.0067 0.029 0.029
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0018 0.0033 0.0076
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0126 0.0126
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.0045 0.0057
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0033 0.0113 0.0199
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0067 0.029 0.5519
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0297 0.0297
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0065 0.028 0.028
Schistosoma mansoni similar to Protein C20orf152 homolog 0.002 0.0045 0.0105
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0452 0.0848
Trypanosoma cruzi Flagellar Member 6 0.002 0.0045 0.0865
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0425 0.1438
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.001
Brugia malayi CHE-14 protein 0.0042 0.0158 0.0158
Brugia malayi TAR-binding protein 0.0548 0.2833 0.2833
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0138 0.0504
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0173 0.33
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0173 0.2864
Schistosoma mansoni smad1 5 8 and 0.013 0.0623 0.1441
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0149 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.005 0.0203 0.0423
Entamoeba histolytica hypothetical protein 0.0109 0.0515 1
Echinococcus multilocularis tar DNA binding protein 0.0548 0.2833 0.5529
Giardia lamblia Kinase, PLK 0.0092 0.0425 1
Brugia malayi glutaminase DH11.1 0.0531 0.2743 0.2743
Onchocerca volvulus 0.0016 0.0021 0.0012
Echinococcus multilocularis segment polarity protein dishevelled 0.0046 0.0183 0.0319
Schistosoma mansoni sodium/solute symporter 0.0075 0.0334 0.0771
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0126 0.0459
Schistosoma mansoni inositol monophosphatase 0.0045 0.0173 0.0401
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0033 0.0113 0.0181
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.002 0.0042 0.0794
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.016 0.3051
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0515 0.1148
Echinococcus multilocularis TGF beta signal transducer SmadC 0.013 0.0623 0.1184
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0063 0.0271 0.517
Schistosoma mansoni hypothetical protein 0.0015 0.0015 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0425 0.0983
Trypanosoma brucei isocitrate dehydrogenase, putative 0.005 0.0203 0.3863
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0158 0.045
Onchocerca volvulus 0.0036 0.0126 0.0226
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.016 0.3051
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.0045 0.0048
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.0045 0.0301
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0045 0.0307
Brugia malayi RNA recognition motif domain containing protein 0.0548 0.2833 0.2833
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0063 0.0271 0.517
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0033
Trichomonas vaginalis esterase, putative 0.0036 0.0126 0.0332
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0126 0.2397
Loa Loa (eye worm) isocitrate dehydrogenase 0.005 0.0203 0.0203
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.002 0.0045 0.0865
Loa Loa (eye worm) hypothetical protein 0.068 0.3526 0.3526
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.002 0.0045 0.0057
Schistosoma mansoni DNA polymerase eta 0.0038 0.0138 0.0319
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0046 0.0183 0.0319
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.002 0.0045 0.0057
Loa Loa (eye worm) hypothetical protein 0.0033 0.0113 0.0113
Trypanosoma cruzi hypothetical protein 0.0033 0.0113 0.2147
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0425 0.0795
Brugia malayi RasGEF domain containing protein 0.0033 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0109 0.0515 0.1191
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0173 0.0507
Echinococcus multilocularis mothers against decapentaplegic 2 0.0058 0.0244 0.0439
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0017 0.003 0.0171
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0065 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0588 0.3041 0.3041
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0045 0.0035
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0045 0.0105
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0113 0.1601
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.002 0.0045 0.0048
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0126
Loa Loa (eye worm) beta-lactamase 0.0036 0.0126 0.0126
Echinococcus granulosus Protein son of sevenless 0.0033 0.0113 0.0213
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0425 0.0836
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.002 0.0045 0.0105
Trichomonas vaginalis ras GTP exchange factor, putative 0.0033 0.0113 0.0283
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0036 0.0686
Echinococcus multilocularis expressed conserved protein 0.0021 0.0047 0.0051
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.0029 0.0557
Mycobacterium ulcerans transmembrane transport protein 0.002 0.0045 0.0166
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0012 0.0003 0.0052
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0673 0.1514
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.016 0.0274
Echinococcus granulosus voltage gated potassium channel 0.002 0.0045 0.0057
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0066 0.0242
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.0074 0.0104
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.016 0.0324
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0074 0.1414
Schistosoma mansoni chromobox protein 0.0068 0.0297 0.0687
Loa Loa (eye worm) RasGEF domain-containing protein 0.0033 0.0113 0.0113
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0046 0.0183 0.0343
Mycobacterium ulcerans polyketide synthase Pks13 0.0036 0.013 0.0473
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0021
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0067 0.029 0.5519
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0033 0.0113 0.0261
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.016 0.0274
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.0074 0.0074
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0158 0.032
Trypanosoma brucei protein kinase A regulatory subunit 0.002 0.0045 0.0865
Brugia malayi Muscle positioning protein 4 0.0015 0.0015 0.0015
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0158 0.3005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0045 0.0035
Mycobacterium ulcerans transcriptional regulatory protein 0.002 0.0045 0.0166
Echinococcus granulosus son of sevenless 1 0.0033 0.0113 0.0213
Mycobacterium ulcerans glutaminase 0.0531 0.2743 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0045 0.0035
Onchocerca volvulus 0.0036 0.0126 0.0226
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0425 0.1438
Schistosoma mansoni hypothetical protein 0.0831 0.4326 1
Plasmodium vivax ataxin-2 like protein, putative 0.0111 0.0525 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0045 0.0105
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0045 0.0057
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0169 0.0314
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0113 0.1601
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0033 0.0113 0.0261
Loa Loa (eye worm) MH1 domain-containing protein 0.0058 0.0244 0.0244
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0155 0.0284
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.0181 0.0181
Echinococcus multilocularis solute carrier family 5 0.0075 0.0334 0.0615
Echinococcus granulosus segment polarity protein dishevelled 0.0046 0.0183 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0081 0.0164
Brugia malayi RNA binding protein 0.0548 0.2833 0.2833
Brugia malayi Isocitrate dehydrogenase 0.005 0.0203 0.0203
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0138 0.2632
Leishmania major DNA polymerase eta, putative 0.0038 0.0138 0.2632
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0158
Echinococcus multilocularis isocitrate dehydrogenase 0.005 0.0203 0.0358
Echinococcus multilocularis expressed conserved protein 0.0091 0.0421 0.0786
Schistosoma mansoni Smad4 0.0058 0.0244 0.0565
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0113 0.1601
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0067 0.029 0.5519
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0047 0.0109
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0045 0.0057
Brugia malayi beta-lactamase family protein 0.0036 0.0126 0.0126
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.002 0.0045 0.0105
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.1139 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.005 0.0203 0.3863
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0138
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0033 0.0113 0.2147
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0126 0.0332
Brugia malayi photoreceptor-specific nuclear receptor 0.0241 0.1208 0.1208
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0074 0.4092
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0113 0.1601
Mycobacterium ulcerans polyketide synthase 0.0024 0.0066 0.0242
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0045 0.0105
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0126 0.1019
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0045 0.0105
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0139 0.3279
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0126 0.0291
Schistosoma mansoni dep domain containing protein 0.0046 0.0183 0.0423
Trypanosoma brucei PAB1-binding protein , putative 0.0111 0.0525 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.016 0.016
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0425 0.1438
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.002 0.0045 0.0045
Echinococcus multilocularis dna polymerase eta 0.0038 0.0138 0.0231
Echinococcus multilocularis voltage gated potassium channel 0.002 0.0045 0.0048
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0075 0.0334 0.6352
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0126 0.1019
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0158 0.032
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0067 0.029 0.0529
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0113 0.1601
Schistosoma mansoni patched 1 0.0042 0.0158 0.0366
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0074 0.4092
Loa Loa (eye worm) hypothetical protein 0.0041 0.0154 0.0154
Brugia malayi Sodium:solute symporter family protein 0.0075 0.0334 0.0334
Onchocerca volvulus 0.0075 0.0334 0.0649
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0138 0.2632
Loa Loa (eye worm) hypothetical protein 0.0944 0.4924 0.4924
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.0066 0.3458
Schistosoma mansoni TGF-beta signal transducer Smad2 0.013 0.0623 0.1441
Leishmania major hypothetical protein, conserved 0.002 0.0045 0.0865
Schistosoma mansoni hypothetical protein 0.0272 0.1374 0.3176
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0045 0.0035
Brugia malayi DIX domain containing protein 0.0046 0.0183 0.0183
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0046 0.0183 0.0183
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.0203 0.3863
Loa Loa (eye worm) hypothetical protein 0.0046 0.0183 0.0183
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0139 0.2158
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.005 0.0201 0.0419
Brugia malayi Latrophilin receptor protein 2 0.0272 0.1374 0.1374
Brugia malayi Smad1 0.013 0.0623 0.0623
Plasmodium falciparum ataxin-2 like protein, putative 0.0111 0.0525 1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0021 0.0403
Trypanosoma cruzi cAMP response protein 1 0.002 0.0045 0.0865
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.016 0.3767
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0138 0.2132
Loa Loa (eye worm) hypothetical protein 0.0241 0.1208 0.1208
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0036 0.0686
Brugia malayi Cyclic-nucleotide gated cation channel 0.002 0.0045 0.0045
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0173 1
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0045 0.0105
Plasmodium falciparum cGMP-dependent protein kinase 0.0021 0.0047 0.0895
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0058 0.0058
Loa Loa (eye worm) inositol-1 0.0045 0.0173 0.0173
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.002 0.0045 0.0048
Mycobacterium ulcerans hypothetical protein 0.002 0.0045 0.0166
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0042 0.0794
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0425 0.0939
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0033 0.0113 0.0283
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0041 0.1463
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0036 0.0686
Brugia malayi hypothetical protein 0.0046 0.0183 0.0183
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0686 0.1307
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.005 0.0203 0.0469
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0138 0.2632
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0047 0.0109
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.016 0.0324
Mycobacterium ulcerans polyketide synthase 0.0026 0.0074 0.0271
Trypanosoma brucei cAMP response protein 1, putative 0.002 0.0045 0.0865
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0422 0.2165 0.4216
Loa Loa (eye worm) hypothetical protein 0.0072 0.0317 0.0317
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0063 0.0271 0.4913
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.5107 1
Schistosoma mansoni tar DNA-binding protein 0.0548 0.2833 0.6548
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.002 0.0045 0.0105
Echinococcus granulosus expressed protein 0.0065 0.028 0.0601
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.0045 0.0048
Trichomonas vaginalis rotamase, putative 0.0065 0.028 0.09
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0046 0.0183 0.0423
Schistosoma mansoni chromobox protein 0.0068 0.0297 0.0687
Loa Loa (eye worm) RasGEF domain-containing protein 0.0033 0.0113 0.0113
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Schistosoma mansoni hypothetical protein 0.0272 0.1374 0.3176
Mycobacterium ulcerans thioesterase TesA 0.002 0.0045 0.0164
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.005 0.0203 0.0358
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0058 0.0058
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0045 0.0105
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0138 0.2632
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0045 0.0045
Echinococcus granulosus sodium:glucose cotransporter 2 0.0075 0.0334 0.0726
Echinococcus granulosus cGMP dependent protein kinase 1 0.0021 0.0047 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0139 0.0382
Loa Loa (eye worm) hypothetical protein 0.0111 0.0525 0.0525
Mycobacterium ulcerans beta-lactamase 0.0036 0.0126 0.0459
Schistosoma mansoni tar DNA-binding protein 0.0548 0.2833 0.6548
Toxoplasma gondii peptidylprolyl isomerase 0.0063 0.0271 0.517
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.005 0.0201 0.0355
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0425 0.1438
Entamoeba histolytica hypothetical protein 0.0109 0.0515 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0126 0.0332
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0045 0.0048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.0203 0.0358
Loa Loa (eye worm) hypothetical protein 0.0272 0.1374 0.1374
Schistosoma mansoni dishevelled 0.0046 0.0183 0.0423
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0058 0.0416
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.002 0.0045 0.0105
Brugia malayi Protein kinase domain containing protein 0.0016 0.0021 0.0021
Onchocerca volvulus 0.002 0.0045 0.0062
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0036 0.0035
Schistosoma mansoni ap endonuclease 0.0019 0.0036 0.0083
Echinococcus granulosus sodium:myo inositol cotransporter 0.0075 0.0334 0.0726
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0045 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.016 0.0459
Mycobacterium ulcerans hypothetical protein 0.002 0.0045 0.0166
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0126 0.0244
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0425 0.1438
Trypanosoma brucei polo-like protein kinase 0.0092 0.0425 0.8099
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0045 0.0865
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0139 0.2656
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.0203 0.3863
Leishmania major DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Trypanosoma brucei Flagellar Member 6 0.002 0.0045 0.0865
Onchocerca volvulus 0.0042 0.0161 0.0298
Schistosoma mansoni hypothetical protein 0.004 0.0151 0.0348
Trypanosoma cruzi cAMP response protein 1, putative 0.002 0.0045 0.0865
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0173 0.0507
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0036 0.0131
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.0203 0.0358
Toxoplasma gondii LsmAD domain-containing protein 0.0111 0.0525 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.016 0.0324
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0066 0.0491
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.0657 0.0657
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0021 0.0047 0.0051
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0067 0.029 0.0625
Echinococcus multilocularis mothers against decapentaplegic 6 0.0058 0.0244 0.0439
Mycobacterium tuberculosis Conserved protein 0.002 0.0045 0.0307
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0138 0.1129
Loa Loa (eye worm) hypothetical protein 0.0075 0.0334 0.0334
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.0045 0.1756
Schistosoma mansoni hypothetical protein 0.004 0.0151 0.0348
Loa Loa (eye worm) MH1 domain-containing protein 0.013 0.0623 0.0623
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.002 0.0045 0.0048
Echinococcus multilocularis ras GTP exchange factor 0.0033 0.0113 0.0181
Schistosoma mansoni smad 0.0058 0.0244 0.0565
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0452 0.8682
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0272 0.1374 0.1374
Echinococcus granulosus regulator of G protein signaling 7 0.0046 0.0183 0.0377
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.005 0.0203 0.3863
Onchocerca volvulus 0.002 0.0045 0.0062
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.002 0.0045 0.0045
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.002 0.0045 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0548 0.2833 0.6548
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.002 0.0045 0.0045
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0138 0.0504
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0126
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0173 0.0507
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0126 0.1019
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0623 0.0623
Brugia malayi MH2 domain containing protein 0.0058 0.0244 0.0244
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0425 0.8099
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0045 0.0105
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0033 0.0113 0.0213
Brugia malayi hypothetical protein 0.0111 0.0525 0.0525
Echinococcus granulosus high affinity choline transporter 1 0.068 0.3526 0.8142
Echinococcus granulosus dna polymerase kappa 0.0038 0.0138 0.0272
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0113 0.1601
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0173 0.0632
Loa Loa (eye worm) nuclear factor I 0.0072 0.0317 0.0317
Schistosoma mansoni inositol transporter 0.0075 0.0334 0.0771
Echinococcus multilocularis GPCR, family 2 0.0272 0.1374 0.266
Leishmania major regulatory subunit of protein kinase a-like protein 0.002 0.0045 0.0865
Echinococcus granulosus mothers against decapentaplegic 6 0.0058 0.0244 0.0519
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0944 0.4924 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0126 0.0459
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.002 0.0045 0.0048
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0045 0.0865
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0046 0.0183 0.0183
Trichomonas vaginalis rotamase, putative 0.0063 0.0271 0.087
Schistosoma mansoni Smad4 0.013 0.0623 0.1441
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0075 0.0334 0.0615
Schistosoma mansoni hypothetical protein 0.005 0.0201 0.0465
Brugia malayi SEA domain containing protein 0.0015 0.0015 0.0015
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0126 0.1019
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0074 0.0562
Loa Loa (eye worm) hypothetical protein 0.003 0.0096 0.0096
Schistosoma mansoni smad 0.013 0.0623 0.1441
Echinococcus multilocularis protein patched 0.0042 0.0158 0.0271
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0045 0.0048
Onchocerca volvulus 0.0026 0.0074 0.0119
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0673 0.1281
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.016 0.037
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0173 0.33
Echinococcus multilocularis mothers against decapentaplegic 5 0.013 0.0623 0.1184
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.002 0.0045 0.0865
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Leishmania major protein kinase, putative 0.0021 0.0047 0.0895
Echinococcus granulosus Pleckstrin G protein interacting region 0.0046 0.0183 0.0377
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0045 0.0105
Leishmania major hypothetical protein, conserved 0.0036 0.0126 0.2397
Brugia malayi hypothetical protein 0.0026 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0042 0.016 0.016
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0126 0.0332
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0045 0.0105
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.002 0.0045 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0425 0.1438
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0158 0.0452
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0138 0.0138
Echinococcus granulosus mothers against decapentaplegic 5 0.013 0.0623 0.1399
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0158 0.3005
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.0203 0.3863
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.002 0.0045 0.0865
Loa Loa (eye worm) hypothetical protein 0.0051 0.0208 0.0208
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0126 0.0291
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0126 0.1019
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0665 0.1496
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0422 0.2165 0.4981
Schistosoma mansoni z-protein (S1r protein) 0.0046 0.0183 0.0423
Echinococcus multilocularis Smad4 0.013 0.0623 0.1184
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.002 0.0045 0.0865
Schistosoma mansoni smad1 5 8 and 0.013 0.0623 0.1441
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0046 0.0183 0.0183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.101 0.5268 0.5268
Echinococcus multilocularis chromobox protein 1 0.0068 0.0297 0.0544
Entamoeba histolytica hypothetical protein 0.0033 0.0113 0.1601
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0155 0.0438
Echinococcus multilocularis son of sevenless 1 0.0033 0.0113 0.0181
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0297 0.0965
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0033 0.0113 0.0261
Brugia malayi MH2 domain containing protein 0.013 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0126
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0043 0.0284
Onchocerca volvulus 0.0036 0.0126 0.0226
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.0066 0.3458
Toxoplasma gondii Erv1 / Alr family protein 0.0067 0.029 0.5519
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0173 0.33
Echinococcus granulosus TGF beta signal transducer SmadC 0.013 0.0623 0.1399
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0686 0.1585
Brugia malayi hypothetical protein 0.0046 0.0183 0.0183
Loa Loa (eye worm) Smad1 0.013 0.0623 0.0623
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0425 0.8099
Leishmania major hypothetical protein, conserved 0.002 0.0045 0.0865
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.002 0.0045 0.0865
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0126
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.005 0.0203 0.1702
Echinococcus granulosus cGMP dependent protein kinase 0.0021 0.0047 0.0061
Brugia malayi hypothetical protein 0.0016 0.0021 0.0021
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0042 0.0794
Trypanosoma cruzi hypothetical protein 0.0033 0.0113 0.2147
Brugia malayi MH1 domain containing protein 0.0072 0.0317 0.0317
Toxoplasma gondii exonuclease III APE 0.0019 0.0036 0.0686
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0126 0.0126
Leishmania major hypothetical protein, conserved 0.002 0.0045 0.0865
Leishmania major hypothetical protein, conserved 0.0111 0.0525 1
Echinococcus granulosus GPCR family 2 0.0272 0.1374 0.3143
Schistosoma mansoni rotamase 0.0065 0.028 0.0646
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0657 0.1251
Brugia malayi N-terminal motif family protein 0.0944 0.4924 0.4924
Echinococcus multilocularis expressed protein 0.0065 0.028 0.0508
Schistosoma mansoni hypothetical protein 0.0831 0.4326 1
Brugia malayi hypothetical protein 0.0018 0.0033 0.0033
Mycobacterium ulcerans thioesterase 0.002 0.0045 0.0164
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0033 0.0113 0.0213
Echinococcus multilocularis geminin 0.0831 0.4326 0.8464
Schistosoma mansoni smad1 5 8 and 0.013 0.0623 0.1441
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0018 0.0033 0.0033
Brugia malayi MH1 domain containing protein 0.0072 0.0317 0.0317
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0113 0.1601
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0075 0.0334 0.0615
Schistosoma mansoni tar DNA-binding protein 0.0548 0.2833 0.6548
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0032 0.0104 0.0241
Onchocerca volvulus 0.0046 0.0183 0.0343
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.016 0.0459
Echinococcus granulosus patatin phospholipase domain containing protein 0.002 0.0045 0.0057
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0036 0.013 0.1054
Loa Loa (eye worm) transcription factor SMAD2 0.1906 1 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.046 0.1063
Loa Loa (eye worm) hypothetical protein 0.0058 0.0244 0.0244
Loa Loa (eye worm) DIX domain-containing protein 0.0046 0.0183 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0047 0.0109
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0158 0.045
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0046 0.0183 0.0183
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0036 0.0847
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.016 0.2591
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0425 0.0425
Brugia malayi Inositol-1 0.0045 0.0173 0.0173
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0036 0.0686
Brugia malayi Augmenter of liver regeneration 0.0067 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.016 0.0459
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Echinococcus multilocularis protein dispatched 1 0.0048 0.019 0.0332
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0045 0.0865
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0158 0.0318
Schistosoma mansoni ras GTP exchange factor 0.0033 0.0113 0.0261
Mycobacterium leprae Probable lipase LipE 0.0036 0.0126 0.8193
Echinococcus granulosus tar DNA binding protein 0.0548 0.2833 0.6532
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.002 0.0045 0.0105
Brugia malayi hypothetical protein 0.0109 0.0515 0.0515
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0452 0.1001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0657 0.1478
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0138 0.1129
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0425 0.8099
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.002 0.0045 0.0045
Brugia malayi beta-lactamase family protein 0.0036 0.0126 0.0126
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0045 0.0105
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0515 0.1191
Toxoplasma gondii Erv1 / Alr family protein 0.0067 0.029 0.5519
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0548 0.2833 0.2833
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0113 0.1601
Loa Loa (eye worm) TK/ALK protein kinase 0.0016 0.0021 0.0021
Loa Loa (eye worm) AGC/PKG protein kinase 0.0021 0.0047 0.0047
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0045 0.0035
Entamoeba histolytica hypothetical protein 0.0109 0.0515 1
Loa Loa (eye worm) TAR-binding protein 0.0548 0.2833 0.2833
Echinococcus granulosus regulator of G protein signaling 7 0.0046 0.0183 0.0377
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0138 0.0319
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0113 0.1601
Brugia malayi N-terminal motif family protein 0.0033 0.0113 0.0113
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0067 0.029 0.5519
Toxoplasma gondii hypothetical protein 0.0046 0.0183 0.3489
Brugia malayi isocitrate dehydrogenase 0.005 0.0203 0.0203
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.016 0.3051
Mycobacterium tuberculosis Conserved protein 0.0036 0.0126 0.1019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0657 0.1519
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0063 0.0271 0.517
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0066 0.0066
Trypanosoma cruzi cAMP binding protein, putative 0.002 0.0045 0.0865
Loa Loa (eye worm) hypothetical protein 0.0097 0.0452 0.0452
Mycobacterium ulcerans regulatory protein 0.002 0.0045 0.0166
Schistosoma mansoni hypothetical protein 0.0588 0.3041 0.7029
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0158 0.0158
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0045 0.0105
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0042 0.0794
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0126 0.1019
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0036 0.0686
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0062 0.0456
Toxoplasma gondii isocitrate dehydrogenase 0.005 0.0203 0.3863
Toxoplasma gondii ABC1 family protein 0.0036 0.0126 0.2397
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0076 0.1447
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0126
Schistosoma mansoni hypothetical protein 0.0016 0.0021 0.0048
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.002 0.0045 0.0105
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0038 0.0139 0.0139
Echinococcus granulosus cGMP dependent protein kinase 1 0.0021 0.0047 0.0061
Brugia malayi MH2 domain containing protein 0.013 0.0623 0.0623
Leishmania major hypothetical protein, unknown function 0.002 0.0045 0.0865
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Brugia malayi GH02984p 0.068 0.3526 0.3526
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0138 0.2632
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.002 0.0045 0.0035
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.0045 0.0057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0657 0.1478
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Schistosoma mansoni hypothetical protein 0.0272 0.1374 0.3176
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0113 0.1601
Brugia malayi mothers against decapentaplegic homolog 3 0.0058 0.0244 0.0244
Brugia malayi MH1 domain containing protein 0.013 0.0623 0.0623
Loa Loa (eye worm) MH2 domain-containing protein 0.1906 1 1
Onchocerca volvulus Protein cycle homolog 0.0018 0.0033 0.0036
Mycobacterium ulcerans hypothetical protein 0.0036 0.0126 0.0459
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0126 0.0206
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0066 0.0242
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.002 0.0045 0.0105
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0126 0.2397
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0066 0.0491
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0113 0.1601
Brugia malayi chromobox protein homolog 3 0.0038 0.0139 0.0139
Echinococcus multilocularis chromobox protein 1 0.0068 0.0297 0.0544
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0272 0.1374 0.3143
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.002 0.0045 0.0057
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0036 0.013 0.1054
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0173 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0076 0.1447
Brugia malayi MH1 domain containing protein 0.013 0.0623 0.0623
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0425 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0076 0.1447
Schistosoma mansoni hypothetical protein 0.0016 0.0021 0.0048
Echinococcus granulosus Smad4 0.013 0.0623 0.1399
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0126 0.2397
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.002 0.0045 0.0035
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0173 0.33
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0045 0.0035
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0515 0.0972
Toxoplasma gondii isocitrate dehydrogenase 0.005 0.0203 0.3863
Trypanosoma brucei cAMP binding protein, putative 0.002 0.0045 0.0865
Echinococcus multilocularis patatin phospholipase domain containing protein 0.002 0.0045 0.0048
Trypanosoma cruzi PAB1-binding protein , putative 0.0111 0.0525 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0058 0.0244 0.0467
Mycobacterium leprae Conserved hypothetical protein 0.002 0.0045 0.1802
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0425 0.8124
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.028 0.09
Schistosoma mansoni inositol monophosphatase 0.0045 0.0173 0.0401
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0018 0.0033 0.0033
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0173 0.0354
Mycobacterium leprae Polyketide synthase Pks13 0.0036 0.013 0.8508
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0036 0.0223
Brugia malayi RasGEF domain containing protein 0.0033 0.0113 0.0113
Schistosoma mansoni Smad4 0.0058 0.0244 0.0565
Treponema pallidum cyclic nucleotide binding protein 0.002 0.0045 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.086 0.4477 0.4477
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0021 0.0047 0.0895
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0126 0.1019
Echinococcus granulosus dna polymerase eta 0.0038 0.0138 0.0272
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0138 0.0377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0657 0.1251
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0045 0.0307
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.0657 0.0657
Loa Loa (eye worm) hypothetical protein 0.0046 0.0183 0.0183
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.0045 0.0048
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0075 0.0334 0.0615
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.002 0.0045 0.0307
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0126 0.0332
Plasmodium falciparum ataxin-2 like protein, putative 0.0111 0.0525 1
Trypanosoma cruzi protein kinase A regulatory subunit 0.002 0.0045 0.0865
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0074 0.0271
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0018 0.0033 0.0033
Brugia malayi Heterochromatin protein 1 0.0068 0.0297 0.0297
Schistosoma mansoni high-affinity choline transporter 0.068 0.3526 0.815
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.002 0.0042 0.0794
Loa Loa (eye worm) glutaminase 0.0531 0.2743 0.2743
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0126
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0045 0.0048
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0075 0.0334 0.0726
Treponema pallidum catabolite gene activator (Crp) 0.002 0.0045 1
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0033 0.0113 0.0261
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0018 0.0033 0.0033
Mycobacterium ulcerans lipase LipD 0.0036 0.0126 0.0459
Trypanosoma brucei unspecified product 0.0038 0.0138 0.2632
Echinococcus granulosus mothers against decapentaplegic 2 0.0058 0.0244 0.0519
Echinococcus granulosus geminin 0.0831 0.4326 1
Echinococcus multilocularis high affinity choline transporter 1 0.068 0.3526 0.6891
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0021 0.0047 0.0051
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0062 0.0456
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0138 0.0377
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0045 0.0057
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0041 0.015
Schistosoma mansoni dishevelled 0.0046 0.0183 0.0423
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.002 0.0045 0.0045
Echinococcus multilocularis segment polarity protein dishevelled 0.0046 0.0183 0.0319
Leishmania major protein kinase A regulatory subunit, putative 0.002 0.0045 0.0865
Treponema pallidum catabolite gene activator 0.002 0.0045 1
Schistosoma mansoni regulator of G protein signaling 0.0046 0.0183 0.0423
Echinococcus multilocularis smad 0.013 0.0623 0.1184
Mycobacterium tuberculosis Conserved protein 0.0036 0.0126 0.1019
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0023 0.0083
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.016 0.3051
Onchocerca volvulus 0.0016 0.0021 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0045 0.0035
Mycobacterium ulcerans hypothetical protein 0.002 0.0045 0.0166
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0158 0.3005
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.005 0.0203 0.3863
Schistosoma mansoni glutaminase 0.0531 0.2743 0.634
Leishmania major protein kinase, putative 0.0028 0.0088 0.1672
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0138 0.2632
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0139 0.0382
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0158 0.0271
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0139 0.0253
Schistosoma mansoni hypothetical protein 0.004 0.0151 0.0348
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0452 0.0452
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.002 0.0045 0.0865
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0036 0.0036
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.002 0.0045 0.0307
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0033 0.0113 0.1601
Onchocerca volvulus 0.003 0.0096 0.0165
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.016 0.037
Loa Loa (eye worm) glutaminase 2 0.0531 0.2743 0.2743
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0067 0.029 0.5519
Schistosoma mansoni hypothetical protein 0.002 0.0045 0.0105
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.0203 0.0358
Loa Loa (eye worm) acetyltransferase 0.0142 0.0686 0.0686
Brugia malayi Egg laying defective protein 4 0.0021 0.0047 0.0047
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.002 0.0042 0.0413
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.0045 0.0057
Loa Loa (eye worm) MH2 domain-containing protein 0.0058 0.0244 0.0244
Trichomonas vaginalis ras GTP exchange factor, putative 0.0033 0.0113 0.0283
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0179 0.0529
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0138 0.0231
Echinococcus granulosus solute carrier family 5 0.0075 0.0334 0.0726
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0021
Entamoeba histolytica hypothetical protein 0.0109 0.0515 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0063 0.0271 0.517
Trypanosoma brucei unspecified product 0.0026 0.0076 0.1447
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.0045 0.0057
Loa Loa (eye worm) RasGEF domain-containing protein 0.0033 0.0113 0.0113
Giardia lamblia DINP protein human, muc B family 0.0038 0.0138 0.3249
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.016 0.0274
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0074 0.0271
Echinococcus granulosus smad 0.013 0.0623 0.1399
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0657 0.1519
Trypanosoma brucei unspecified product 0.0026 0.0076 0.1447
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0149 0.1221

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 50 uM PUBCHEM_BIOASSAY: Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1903, AID1909, AID2501, AID2615, AID2775, AID435001, AID449729, AID485276, AID485288] ChEMBL. No reference
IC50 (functional) 71.88 uM PUBCHEM_BIOASSAY: Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1909, AID2102, AID2501, AID2615, AID2775, AID449729, AID485276, AID485288] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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