Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.1279 | 0.1279 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0206 | 0.7463 | 0.7463 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.4601 | 0.4601 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0078 | 0.1837 | 0.1837 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.1837 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.1837 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0846 | 0.0846 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1837 | 0.1083 |
Schistosoma mansoni | tar DNA-binding protein | 0.0263 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0078 | 0.1837 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0263 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0206 | 0.7463 | 0.7463 |
Echinococcus granulosus | tar DNA binding protein | 0.0263 | 1 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0051 | 0.0659 | 0.0659 |
Loa Loa (eye worm) | RNA binding protein | 0.0263 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0065 | 0.1279 | 0.1279 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0846 | 0.0846 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0846 | 0.0846 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.1837 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.1279 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.7463 | 0.7229 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0206 | 0.7463 | 0.7229 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.1279 | 0.1279 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0051 | 0.0659 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0846 | 0.0846 |
Loa Loa (eye worm) | TAR-binding protein | 0.0263 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0263 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0263 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0141 | 0.4601 | 0.4601 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0065 | 0.1279 | 0.0473 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0263 | 1 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.1837 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.1279 | 0.1279 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.1837 | 0.1837 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.1837 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0051 | 0.0659 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0846 | 0.0846 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.1837 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0065 | 0.1279 | 0.1279 |
Schistosoma mansoni | tar DNA-binding protein | 0.0263 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.1837 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0846 | 0.0846 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0051 | 0.0659 | 0.0659 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.1279 | 0.1279 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.1279 | 0.1279 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Brugia malayi | Probable ClpP-like protease | 0.0078 | 0.1837 | 0.1837 |
Brugia malayi | TAR-binding protein | 0.0263 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.1279 | 0.1279 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0263 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.1837 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0065 | 0.1279 | 0.1279 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.1279 | 0.1279 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.1837 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0263 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.4601 | 0.4102 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0846 | 0.0846 |
Echinococcus multilocularis | GPCR, family 2 | 0.0065 | 0.1279 | 0.1279 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0846 | 0.0846 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0078 | 0.1837 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1279 | 0.0473 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.1837 | 0.1837 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7943 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Saccharomyces cerevisiae | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.