Detailed information for compound 1452380

Basic information

Technical information
  • TDR Targets ID: 1452380
  • Name: 5-(2-chlorophenyl)-7-(3,4-dimethoxyphenyl)-1, 5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimi dine
  • MW: 370.833 | Formula: C19H19ClN4O2
  • H donors: 1 H acceptors: 2 LogP: 4.18 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C1CC(Nc2n1ncn2)c1ccccc1Cl
  • InChi: 1S/C19H19ClN4O2/c1-25-17-8-7-12(9-18(17)26-2)16-10-15(13-5-3-4-6-14(13)20)23-19-21-11-22-24(16)19/h3-9,11,15-16H,10H2,1-2H3,(H,21,22,23)
  • InChiKey: IWLZNVQGZISRKT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(2-Chloro-phenyl)-7-(3,4-dimethoxy-phenyl)-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidine
  • STOCK4S-08465
  • SMR000013925
  • MLS000075099
  • BAS 06762801

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable esterase LipL 0.0185 0.1428 0.1389
Loa Loa (eye worm) hypothetical protein 0.0185 0.1428 0.2636
Trypanosoma brucei ISWI complex protein 0.0032 0.0109 0.059
Loa Loa (eye worm) hypothetical protein 0.0094 0.0645 0.1191
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0096 0.05
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0028 0.0002
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0331 0.0566
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0096 0.05
Schistosoma mansoni apoferritin-2 0.0069 0.043 0.0748
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0193
Loa Loa (eye worm) hypothetical protein 0.0099 0.069 0.1275
Brugia malayi mbt repeat family protein 0.0058 0.0331 0.0566
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0388 0.317 0.356
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0096 0.0079
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.04 0.0693
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0407 0.3331 0.3742
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0194 0.019
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.1428 0.3429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0299 0.0719
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0041 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0254 0.0611
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0104 0.0145
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.009 0.0611 0.4172
Brugia malayi Bromodomain containing protein 0.0083 0.0553 0.0977
Brugia malayi hypothetical protein 0.0024 0.0041 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0045 0.0107
Loa Loa (eye worm) hypothetical protein 0.0185 0.1428 0.2636
Echinococcus multilocularis cpg binding protein 0.0035 0.014 0.0129
Schistosoma mansoni gabp alpha 0.0075 0.0484 0.0849
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0185 0.1428 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0667 0.1231
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0104 0.0145
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0053 0.0295 0.0708
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0045 0.0057
Entamoeba histolytica hypothetical protein 0.0407 0.3331 1
Brugia malayi nuclear receptor NHR-88 0.0031 0.0104 0.0145
Brugia malayi Latrophilin receptor protein 2 0.0111 0.0792 0.142
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0193
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.014 0.0129
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.014 0.0211
Brugia malayi latrophilin 2 splice variant baaae 0.024 0.19 0.3477
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0076
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0096 0.0079
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0253 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0096 0.0232
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0096 0.05
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0104 0.0088
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0194 0.0359
Mycobacterium tuberculosis Conserved protein 0.0185 0.1428 0.1389
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0387 0.0669
Echinococcus granulosus tar DNA binding protein 0.065 0.5416 0.6104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0413 0.0991
Onchocerca volvulus 0.0185 0.1428 0.3363
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0053 0.0295 0.1916
Mycobacterium tuberculosis Probable hydrolase 0.0185 0.1428 0.1389
Brugia malayi Calcitonin receptor-like protein seb-1 0.0352 0.2855 0.5249
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0104 0.0088
Echinococcus granulosus histone acetyltransferase KAT2B 0.0053 0.0295 0.0304
Trichomonas vaginalis esterase, putative 0.0185 0.1428 0.3429
Schistosoma mansoni importin beta-1 0.003 0.0095 0.0126
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0417 0.2919
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0193
Plasmodium vivax hypothetical protein, conserved 0.0185 0.1428 1
Echinococcus multilocularis tar DNA binding protein 0.065 0.5416 0.6104
Leishmania major hypothetical protein, conserved 0.0185 0.1428 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0072 0.0453 0.3046
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0331 0.0566
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0104 0.0153
Onchocerca volvulus 0.0185 0.1428 0.3363
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.009 0.0611 0.4172
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0104 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0413 0.0991
Loa Loa (eye worm) hypothetical protein 0.024 0.19 0.3509
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0041 0.0076
Schistosoma mansoni ferritin light chain 0.0069 0.043 0.0748
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.106 0.117
Echinococcus multilocularis snurportin 1 0.032 0.2587 0.2901
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0053 0.0295 0.2066
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0104 0.0088
Giardia lamblia GTOR 0.009 0.0611 1
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0104 0.0153
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0104 0.0145
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0263 0.169
Schistosoma mansoni thyroid hormone receptor 0.0419 0.3437 0.6329
Schistosoma mansoni ferritin 0.0069 0.043 0.0748
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.009 0.0611 0.1769
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0104 0.0145
Leishmania major hypothetical protein, conserved 0.005 0.0263 0.169
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0045 0.0057
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0185 0.1428 0.2636
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0096 0.05
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0104 0.0193
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0331 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0104 0.0145
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0667 0.0725
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0026 0.0185
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0099 0.069 0.0752
Brugia malayi RNA binding protein 0.065 0.5416 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.1428 0.2636
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0476 0.051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0045 0.0084
Schistosoma mansoni apoferritin-2 0.0069 0.043 0.0748
Trypanosoma cruzi ISWI complex protein 0.0032 0.0109 0.059
Schistosoma mansoni zinc finger protein 0.0046 0.0234 0.0386
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.009 0.0611 0.4172
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0667 0.0725
Echinococcus granulosus snurportin 1 0.032 0.2587 0.2901
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0041 0.0017
Schistosoma mansoni hypothetical protein 0.0022 0.0028 0.0003
Schistosoma mansoni ets-related 0.0229 0.1801 0.3293
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0263 0.169
Brugia malayi nuclear hormone receptor 0.0031 0.0104 0.0145
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0095 0.0662
Brugia malayi RNA recognition motif domain containing protein 0.065 0.5416 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0028 0.0002
Brugia malayi Pre-SET motif family protein 0.0443 0.3639 0.6703
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0104 0.0088
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0095 0.0486
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0331 0.0345
Echinococcus granulosus tumor protein p63 0.105 0.8856 1
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0069 0.043 0.278
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.106 0.117
Schistosoma mansoni zinc finger protein 0.0032 0.0109 0.0153
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0331 0.0704
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0331 0.0345
Echinococcus granulosus cpg binding protein 0.0035 0.014 0.0129
Onchocerca volvulus 0.0504 0.4163 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0111 0.0792 0.1462
Loa Loa (eye worm) hypothetical protein 0.0024 0.0045 0.0084
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0218 0.3279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0453 0.1087
Echinococcus multilocularis smad 0.0042 0.0194 0.019
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.017 0.1293 0.1435
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0331 0.0612
Loa Loa (eye worm) hypothetical protein 0.0024 0.0045 0.0084
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0203 0.126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.069 0.1232
Toxoplasma gondii target of rapamycin (TOR), putative 0.0067 0.0413 0.2891
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0339 0.0815
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0104 0.0088
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0253 0.0256
Echinococcus multilocularis RUN 0.0024 0.0041 0.0017
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0041 0.0017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0407 0.3331 0.3742
Schistosoma mansoni hypothetical protein 0.0111 0.0792 0.142
Loa Loa (eye worm) acetyltransferase 0.017 0.1293 0.2388
Schistosoma mansoni bromodomain containing protein 0.0137 0.1012 0.1829
Schistosoma mansoni ferritin light chain 0.0069 0.043 0.0748
Trichomonas vaginalis set domain proteins, putative 0.0504 0.4163 1
Brugia malayi Smad1 0.0042 0.0194 0.0311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0104 0.0193
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0045 0.0035
Echinococcus granulosus RUN 0.0024 0.0041 0.0017
Plasmodium vivax importin-beta 2, putative 0.003 0.0095 0.0486
Loa Loa (eye worm) hypothetical protein 0.0111 0.0792 0.1462
Mycobacterium tuberculosis Probable lipase LipD 0.0185 0.1428 0.1389
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0104 0.0088
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0185 0.1428 0.26
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0104 0.0145
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0204 0.0377
Brugia malayi PHD-finger family protein 0.0057 0.0329 0.0562
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0041 0.0017
Brugia malayi Bromodomain containing protein 0.0161 0.1221 0.2216
Loa Loa (eye worm) Smad1 0.0042 0.0194 0.0359
Brugia malayi RNA, U transporter 1 0.0085 0.057 0.1008
Entamoeba histolytica hypothetical protein 0.0024 0.0046 0.0058
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0045 0.0035
Onchocerca volvulus 0.0154 0.1157 0.2707
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.0484 0.0894
Entamoeba histolytica hypothetical protein 0.0407 0.3331 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0045 0.0035
Brugia malayi hypothetical protein 0.005 0.0263 0.0439
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.04 0.0423
Echinococcus multilocularis Smad4 0.0042 0.0194 0.019
Schistosoma mansoni thyroid hormone receptor 0.0419 0.3437 0.6329
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0295 0.0708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0453 0.1087
Trichomonas vaginalis ran, putative 0.0022 0.0026 0.0064
Brugia malayi MH1 domain containing protein 0.0023 0.0035 0.0015
Brugia malayi Ets-domain containing protein 0.0075 0.0484 0.0849
Brugia malayi hypothetical protein 0.0024 0.0041 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.1428 0.3429
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0041 0.0017
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0104 0.0145
Brugia malayi Doublecortin family protein 0.0024 0.0041 0.0027
Schistosoma mansoni tar DNA-binding protein 0.065 0.5416 1
Loa Loa (eye worm) hypothetical protein 0.008 0.052 0.096
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0111 0.0792 0.142
Brugia malayi hypothetical protein 0.0032 0.0112 0.0159
Loa Loa (eye worm) hypothetical protein 0.0088 0.0597 0.1101
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0104 0.0193
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0185 0.1428 0.26
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0026 0.0049
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.0484 0.0518
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0072 0.0453 0.3046
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0104 0.0088
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.0484 0.0518
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.009 0.0611 0.0662
Brugia malayi Ets-domain containing protein 0.0075 0.0484 0.0849
Echinococcus multilocularis zinc finger protein 0.0046 0.0234 0.0236
Onchocerca volvulus 0.0185 0.1428 0.3363
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0263 0.169
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0185 0.1428 0.1389
Brugia malayi beta-lactamase family protein 0.0185 0.1428 0.26
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0254 0.0611
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0111 0.0792 0.0867
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0129 0.0949 0.1044
Schistosoma mansoni hypothetical protein 0.0111 0.0792 0.142
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0194 0.019
Entamoeba histolytica hypothetical protein 0.0407 0.3331 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0104 0.0153
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0096 0.05
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0361 0.0379
Brugia malayi acetyltransferase, GNAT family protein 0.017 0.1293 0.2351
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.04 0.0423
Brugia malayi hypothetical protein 0.0407 0.3331 0.6131
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0111 0.0792 0.0867
Schistosoma mansoni transcription factor LCR-F1 0.0407 0.3331 0.6131
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0104 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0255 0.0612
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0193
Mycobacterium tuberculosis Conserved protein 0.0185 0.1428 0.1389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0295 0.0708
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0046 0.011
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.009 0.0611 0.4172
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0667 0.0725
Schistosoma mansoni cpg binding protein 0.0035 0.014 0.0211
Echinococcus granulosus histone acetyltransferase KAT2B 0.016 0.1212 0.1342
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.1428 0.3429
Brugia malayi beta-lactamase 0.0185 0.1428 0.26
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0096 0.05
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0253 0.042
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0095 0.0486
Schistosoma mansoni polycystin 1-related 0.0024 0.0041 0.0027
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0194 0.019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0104 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0453 0.1087
Schistosoma mansoni Smad4 0.0042 0.0194 0.0311
Schistosoma mansoni tar DNA-binding protein 0.065 0.5416 1
Echinococcus multilocularis ferritin 0.0069 0.043 0.0457
Schistosoma mansoni hypothetical protein 0.024 0.19 0.3477
Treponema pallidum bacterioferrin (TpF1) 0.0069 0.043 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.069 0.1232
Echinococcus multilocularis beta LACTamase domain containing family member 0.0185 0.1428 0.1587
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.065 0.5416 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.04 0.0693
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0104 0.0193
Brugia malayi MH1 domain containing protein 0.0023 0.0035 0.0015
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0096 0.013
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.009 0.0611 0.1085
Loa Loa (eye worm) hypothetical protein 0.0066 0.04 0.0738
Schistosoma mansoni hypothetical protein 0.0423 0.3468 0.6386
Schistosoma mansoni rab6-interacting 0.0024 0.0041 0.0027
Schistosoma mansoni tar DNA-binding protein 0.065 0.5416 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0419 0.3437 0.3863
Mycobacterium ulcerans hypothetical protein 0.0185 0.1428 1
Trichomonas vaginalis ferritin, putative 0.0069 0.043 0.1032
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.009 0.0611 0.1769
Schistosoma mansoni hypothetical protein 0.0024 0.0041 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0498 0.1196
Plasmodium falciparum importin beta, putative 0.003 0.0095 0.2874
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.1786 0.1993
Loa Loa (eye worm) fli-1 protein 0.0229 0.1801 0.3326
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0041 0.0625
Echinococcus granulosus zinc finger protein 0.0046 0.0234 0.0236
Mycobacterium ulcerans lipase LipD 0.0185 0.1428 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0095 0.0175
Echinococcus multilocularis GPCR, family 2 0.0111 0.0792 0.0867
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0096 0.013
Brugia malayi mbt repeat family protein 0.0058 0.0331 0.0566
Schistosoma mansoni cellular tumor antigen P53 0.0154 0.1157 0.2098
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0104 0.0145
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0185 0.1428 0.1389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0254 0.0611
Schistosoma mansoni cpg binding protein 0.003 0.0092 0.0121
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0104 0.0145
Loa Loa (eye worm) hypothetical protein 0.0185 0.1428 0.2636
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0413 0.0991
Schistosoma mansoni hypothetical protein 0.0111 0.0792 0.142
Loa Loa (eye worm) hypothetical protein 0.0185 0.1428 0.2636
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0413 0.0991
Schistosoma mansoni cpg binding protein 0.0035 0.014 0.0211
Echinococcus granulosus histone lysine methyltransferase setb 0.0099 0.069 0.0752
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0218 0.8096
Brugia malayi Importin beta-1 subunit 0.003 0.0095 0.0126
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0045 0.0057
Schistosoma mansoni smad1 5 8 and 0.0042 0.0194 0.0311
Trypanosoma cruzi target of rapamycin kinase 3 0.0072 0.0453 0.3046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0255 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0453 0.1087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0667 0.1188
Schistosoma mansoni hypothetical protein 0.0032 0.0109 0.0153
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.009 0.0611 0.4172
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0611 0.1128
Loa Loa (eye worm) RNA binding protein 0.065 0.5416 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0104 0.0145
Trichomonas vaginalis penicillin-binding protein, putative 0.0185 0.1428 0.3429
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0046 0.011
Schistosoma mansoni rab6-interacting 0.0024 0.0041 0.0027
Brugia malayi MH1 domain containing protein 0.0042 0.0194 0.0311
Mycobacterium ulcerans bacterioferritin BfrB 0.0069 0.043 0.278
Loa Loa (eye worm) hypothetical protein 0.005 0.0263 0.0486
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0263 0.169
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0096 0.0232
Schistosoma mansoni hypothetical protein 0.035 0.2843 0.5227
Schistosoma mansoni tar DNA-binding protein 0.065 0.5416 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0104 0.0145
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0104 0.0088
Loa Loa (eye worm) MBCTL1 0.0066 0.04 0.0738
Echinococcus granulosus beta LACTamase domain containing family member 0.0185 0.1428 0.1587
Loa Loa (eye worm) hypothetical protein 0.0352 0.2855 0.5272
Mycobacterium ulcerans beta-lactamase 0.0185 0.1428 1
Loa Loa (eye worm) beta-lactamase 0.0185 0.1428 0.2636
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0104 0.0145
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0387 0.0669
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0331 0.0345
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.014 0.0129
Brugia malayi beta-lactamase family protein 0.0185 0.1428 0.26
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0045 0.0135
Schistosoma mansoni hypothetical protein 0.0388 0.317 0.5833
Echinococcus granulosus Smad4 0.0042 0.0194 0.019
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0194 0.0311
Echinococcus multilocularis importin subunit beta 1 0.003 0.0095 0.0077
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.017 0.1293 0.2351
Schistosoma mansoni hypothetical protein 0.0043 0.0204 0.033
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0129 0.0949 0.1044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0443 0.3639 0.6719
Schistosoma mansoni loxhd1 0.0024 0.0041 0.0027
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0096 0.0178
Echinococcus granulosus GPCR family 2 0.0111 0.0792 0.0867
Echinococcus multilocularis expressed protein 0.0069 0.043 0.0457
Schistosoma mansoni tar DNA-binding protein 0.065 0.5416 1
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0104 0.0193
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0398 0.0689
Trypanosoma cruzi ISWI complex protein 0.0032 0.0109 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0299 0.0719
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0611 0.1468
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0096 0.0232
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0263 1
Schistosoma mansoni smad 0.0042 0.0194 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0413 0.0991
Schistosoma mansoni coup transcription factor 0.0031 0.0104 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0104 0.0145
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.3468 0.3898
Brugia malayi ecdysteroid receptor 0.0031 0.0104 0.0145
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0387 0.0408
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0104 0.0088
Loa Loa (eye worm) MH2 domain-containing protein 0.0611 0.5083 0.9386
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0104 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0356 0.0855
Trypanosoma brucei hypothetical protein, conserved 0.0185 0.1428 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0104 0.0088
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0194 0.0359
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0667 0.1188
Mycobacterium ulcerans bacterioferritin BfrA 0.0069 0.043 0.278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0453 0.1087
Mycobacterium leprae Probable lipase LipE 0.0185 0.1428 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0104 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0096 0.0232
Schistosoma mansoni hypothetical protein 0.032 0.2587 0.4752
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.04 0.0423
Echinococcus multilocularis tumor protein p63 0.105 0.8856 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0185 0.1428 0.26
Loa Loa (eye worm) nuclear factor I 0.0023 0.0035 0.0064
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0069 0.043 0.0386
Mycobacterium ulcerans esterase/lipase LipP 0.0185 0.1428 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0104 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0104 0.0193
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0041 0.0017
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0076
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0193
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0092 0.0169
Onchocerca volvulus 0.003 0.0092 0.0123
Brugia malayi MH2 domain containing protein 0.0042 0.0194 0.0311
Schistosoma mansoni hypothetical protein 0.0111 0.0792 0.142
Schistosoma mansoni hypothetical protein 0.0407 0.3331 0.6131
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0104 0.0145
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0104 0.0145
Plasmodium vivax SET domain protein, putative 0.0064 0.0387 0.2573
Schistosoma mansoni lipoxygenase 0.0142 0.106 0.1917
Brugia malayi Pre-SET motif family protein 0.0064 0.0387 0.0669
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.2587 0.4778
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0104 0.0145
Loa Loa (eye worm) hypothetical protein 0.0154 0.1157 0.2136
Echinococcus granulosus importin subunit beta 1 0.003 0.0095 0.0077
Leishmania major hypothetical protein, conserved 0.0032 0.0109 0.059
Echinococcus granulosus smad 0.0042 0.0194 0.019
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0263 1
Leishmania major importin beta-1 subunit, putative 0.0024 0.0046 0.0138
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0388 0.317 0.356
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0476 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0611 0.1468
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0158 0.0942
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.04 0.0423
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0046 0.0138
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0111 0.0792 0.0867
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0104 0.0088
Onchocerca volvulus 0.0058 0.0331 0.0704
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0045 0.0135
Schistosoma mansoni lipoxygenase 0.01 0.0692 0.1234
Toxoplasma gondii ABC1 family protein 0.0185 0.1428 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0069 0.043 0.0386
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0387 0.2711
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0104 0.0145
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0104 0.0145
Loa Loa (eye worm) bromodomain containing protein 0.0041 0.0186 0.0343
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0667 0.0725
Loa Loa (eye worm) hypothetical protein 0.0147 0.1096 0.2023
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0069 0.043 0.5
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0046 0.011
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0104 0.0145
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0104 0.0088
Brugia malayi MH2 domain containing protein 0.0042 0.0194 0.0311
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0185 0.1428 0.1389
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0194 0.019
Mycobacterium tuberculosis Conserved protein 0.0185 0.1428 0.1389
Brugia malayi steroid hormone receptor 0.0031 0.0104 0.0145
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0218 0.058
Onchocerca volvulus 0.0064 0.0387 0.0839
Loa Loa (eye worm) hypothetical protein 0.0185 0.1428 0.2636
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.1786 0.1993
Brugia malayi CXXC zinc finger family protein 0.003 0.0092 0.0121
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0193
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.1428 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0185 0.1428 0.3429
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0331 0.0566
Schistosoma mansoni smad1 5 8 and 0.0042 0.0194 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0611 0.1468
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0352 0.2855 0.5272
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0104 0.0088
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0611 0.1085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0255 0.0612
Brugia malayi MH2 domain containing protein 0.0611 0.5083 0.9383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0255 0.0612
Trichomonas vaginalis bromodomain-containing protein, putative 0.0053 0.0295 0.0708
Mycobacterium leprae conserved hypothetical protein 0.0185 0.1428 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0667 0.1188
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0111 0.0792 0.0867
Onchocerca volvulus 0.0024 0.0045 0.001
Schistosoma mansoni ferritin 0.0069 0.043 0.0748
Loa Loa (eye worm) TAR-binding protein 0.065 0.5416 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0352 0.2855 0.5249
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.009 0.0611 0.4172
Schistosoma mansoni ferritin 0.0069 0.043 0.0748
Brugia malayi TAR-binding protein 0.065 0.5416 1
Loa Loa (eye worm) transcription factor SMAD2 0.0611 0.5083 0.9386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0413 0.0991
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0041 0.0106
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0104 0.0088
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0104 0.0088
Brugia malayi MH1 domain containing protein 0.0042 0.0194 0.0311
Echinococcus granulosus ferritin 0.0069 0.043 0.0457
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0104 0.0145
Echinococcus granulosus expressed protein 0.0069 0.043 0.0457
Entamoeba histolytica hypothetical protein 0.0407 0.3331 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0299 0.0719
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0104 0.0145
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0263 0.1844
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0053 0.0295 0.2066
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0045 0.0135
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.009 0.0611 0.0662
Schistosoma mansoni smad1 5 8 and 0.0042 0.0194 0.0311
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0104 0.0088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0667 0.1188
Brugia malayi Fli-1 protein 0.0229 0.1801 0.3293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0413 0.0991
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0104 0.0145
Loa Loa (eye worm) hypothetical protein 0.0058 0.0331 0.0612
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0104 0.0193
Mycobacterium tuberculosis Probable lipase LipE 0.0185 0.1428 0.1389
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0096 0.0232
Echinococcus granulosus dnaJ subfamily B 0.0423 0.3468 0.3898
Schistosoma mansoni ferritin 0.0069 0.043 0.0748
Onchocerca volvulus 0.0031 0.0104 0.0153
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.014 0.0211
Loa Loa (eye worm) hypothetical protein 0.0064 0.039 0.072
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.1428 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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