Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.3586 | 0.4164 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3586 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.3586 | 0.4164 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.8611 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3586 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3586 | 1 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.3586 | 0.4164 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.3586 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 1 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0126 | 0.3586 | 0.4164 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.3586 | 0.4164 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.3586 | 0.4164 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.3586 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.8611 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3586 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3586 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.