Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | adrenoceptor beta 2, surface | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.648 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0106 | 0.648 | 0.6435 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4355 | 0.4355 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0094 | 0.5574 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.2394 | 0.2251 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4355 | 0.597 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1207 | 0.1207 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.2394 | 0.4295 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.2394 | 0.2394 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.2394 | 0.4295 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1207 | 0.2166 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0094 | 0.5574 | 0.5574 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0094 | 0.5574 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0094 | 0.5574 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.2394 | 0.2251 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0124 | 0.0124 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1207 | 0.2166 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.2394 | 0.2251 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1207 | 0.2166 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1207 | 0.2166 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.5574 | 0.8283 |
Onchocerca volvulus | 0.0033 | 0.1207 | 0.5 | |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4355 | 0.7813 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4355 | 0.597 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.648 | 0.648 |
Onchocerca volvulus | 0.0033 | 0.1207 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1165 | 0.1165 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.2394 | 0.2251 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4355 | 0.4355 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1207 | 0.1097 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4355 | 0.597 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.2394 | 0.4295 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0094 | 0.5574 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4355 | 0.597 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1207 | 0.1207 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.5574 | 0.8283 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.2394 | 0.2299 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.2394 | 0.2299 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4355 | 0.4284 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1207 | 0.1097 |
Echinococcus granulosus | lamin | 0.0033 | 0.1207 | 0.2166 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4355 | 0.7813 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0155 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4355 | 0.597 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2394 | 0.2394 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1207 | 0.2166 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4355 | 0.4284 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.2394 | 0.4295 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1207 | 0.1207 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.5574 | 0.8283 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.2394 | 0.4295 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4355 | 0.4355 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.2394 | 0.4295 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0094 | 0.5574 | 0.5519 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4355 | 0.4284 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.5821 uM | PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor: Hit Validation with GloSensor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485386] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID504448, AID504454, AID504459] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.