Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0149 | 1 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0053 | 0.1797 | 0.4287 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.1643 | 0.3919 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.4192 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0053 | 0.1797 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.4192 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.4192 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.4192 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.1278 | 0.3048 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3782 | 0.6343 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3782 | 0.6343 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0081 | 0.4192 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.5963 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0081 | 0.4192 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0102 | 0.5963 | 0.5963 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.4192 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1278 | 0.2143 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.4192 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0053 | 0.1797 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.4192 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0051 | 0.1643 | 0.3919 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1278 | 0.2143 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1278 | 0.1278 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3782 | 0.3782 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0081 | 0.4192 | 1 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0083 | 0.0083 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.1278 | 0.3048 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3782 | 0.3782 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.1643 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3782 | 0.3782 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.1278 | 0.3048 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1278 | 0.2143 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3782 | 0.6343 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.4192 | 0.4192 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.1278 | 0.3048 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0051 | 0.1643 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3782 | 0.9023 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1643 | 0.1643 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3782 | 0.3782 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.1278 | 0.3048 |
Leishmania major | hypothetical protein, conserved | 0.0051 | 0.1643 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3782 | 0.6343 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0081 | 0.4192 | 0.703 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3782 | 0.3782 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0053 | 0.1797 | 0.4287 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.1278 | 0.1278 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0149 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1278 | 0.2143 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.1278 | 0.1278 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0051 | 0.1643 | 0.3919 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.5963 | 0.5963 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.1278 | 0.3048 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.1643 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0081 | 0.4192 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3782 | 0.6343 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0051 | 0.1643 | 0.1643 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.1278 | 0.1278 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.1643 | 0.3919 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3782 | 0.3782 |
Brugia malayi | Probable ClpP-like protease | 0.0081 | 0.4192 | 0.4192 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0081 | 0.4192 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3782 | 0.9023 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0081 | 0.4192 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0657 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 1.2589 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (binding) | 39.8107 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.