Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4927 | 0.4927 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0099 | 0.6612 | 0.6612 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4927 | 0.4927 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Treponema pallidum | DNA ligase (lig) | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.7882 | 0.7882 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0145 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0046 | 0.268 | 0.5439 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4927 | 0.4927 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0046 | 0.268 | 0.5439 |
Giardia lamblia | Replication factor C, subunit 1 | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0145 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.268 | 0.4053 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4927 | 0.4927 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.6612 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4927 | 0.7452 |
Chlamydia trachomatis | DNA ligase | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4927 | 0.7452 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.268 | 0.268 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0046 | 0.268 | 0.268 |
Echinococcus multilocularis | GPCR, family 2 | 0.0046 | 0.268 | 0.5439 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4927 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4927 | 0.7452 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0 | 0.5 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.001 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4927 | 0.4927 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0046 | 0.268 | 0.268 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.268 | 0.4053 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4927 | 0.7452 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0046 | 0.268 | 0.268 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0046 | 0.268 | 0.5439 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.7882 | 0.7882 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4927 | 0.4927 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.6612 | 0.6612 |
Echinococcus granulosus | GPCR family 2 | 0.0046 | 0.268 | 0.5439 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4927 | 1 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.268 | 0.4053 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4927 | 0.7452 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0046 | 0.268 | 0.5439 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.001 | 0 | 0.5 |
Toxoplasma gondii | ATPase, AAA family protein | 0.001 | 0 | 0.5 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.001 | 0 | 0.5 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.001 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.001 | 0 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.7882 | 0.7882 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.268 | 0.4053 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5012 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 23.7558 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.