Detailed information for compound 1452496

Basic information

Technical information
  • TDR Targets ID: 1452496
  • Name: 2-dimethylamino-6-(4-fluorophenyl)-8-(thiophe n-2-ylmethyl)pteridin-7-one
  • MW: 381.427 | Formula: C19H16FN5OS
  • H donors: 0 H acceptors: 3 LogP: 2.91 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)c1nc2cnc(nc2n(c1=O)Cc1cccs1)N(C)C
  • InChi: 1S/C19H16FN5OS/c1-24(2)19-21-10-15-17(23-19)25(11-14-4-3-9-27-14)18(26)16(22-15)12-5-7-13(20)8-6-12/h3-10H,11H2,1-2H3
  • InChiKey: YNTMJKZTGPMHGY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-dimethylamino-6-(4-fluorophenyl)-8-(2-thienylmethyl)pteridin-7-one
  • 2-dimethylamino-6-(4-fluorophenyl)-8-(2-thienylmethyl)-7-pteridinone
  • NCGC00012842
  • PCOP-954004

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens caspase 1, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens caspase 7, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus caspase 8 caspase 1, apoptosis-related cysteine peptidase 383 aa 312 aa 26.6 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Brugia malayi Cell death protein 3 precursor caspase 7, apoptosis-related cysteine peptidase 303 aa 256 aa 37.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0094 0.225 0.4306
Brugia malayi latrophilin 2 splice variant baaae 0.0204 0.5226 0.5226
Plasmodium falciparum metacaspase-like protein 0.0053 0.1137 0.5
Schistosoma mansoni tar DNA-binding protein 0.0134 0.3335 0.6383
Schistosoma mansoni smad1 5 8 and 0.0026 0.0389 0.0744
Loa Loa (eye worm) hypothetical protein 0.0298 0.779 0.779
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0094 0.225 0.6386
Brugia malayi N-terminal motif family protein 0.0186 0.4746 0.4746
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.1137 1
Trypanosoma brucei metacaspase 5, putative 0.0053 0.1137 1
Echinococcus multilocularis caspase 8 0.0053 0.1137 0.3228
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0094 0.225 0.6386
Trypanosoma cruzi metacaspase, putative 0.0053 0.1137 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0053 0.1137 0.2176
Echinococcus multilocularis apoptotic protease activating factor 1 0.005 0.1038 0.2945
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.1137 1
Echinococcus granulosus GPCR family 2 0.0094 0.225 0.6386
Loa Loa (eye worm) latrophilin receptor protein 2 0.0094 0.225 0.225
Echinococcus granulosus caspase 3 0.0088 0.2072 0.5881
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0053 0.1137 0.1137
Schistosoma mansoni hypothetical protein 0.005 0.1038 0.1986
Echinococcus granulosus caspase 8 0.0053 0.1137 0.3228
Onchocerca volvulus Cell death protein 3 homolog 0.0103 0.2489 0.5245
Brugia malayi MH1 domain containing protein 0.0014 0.0075 0.0075
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.01 0.2403 0.682
Schistosoma mansoni smad 0.0026 0.0389 0.0744
Leishmania major metacaspase, putative 0.0053 0.1137 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.1137 1
Trypanosoma brucei metacaspase MCA3 0.0053 0.1137 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0899 0.0899
Loa Loa (eye worm) nuclear factor I 0.0014 0.0075 0.0075
Echinococcus granulosus apoptotic protease activating factor 1 0.005 0.1038 0.2945
Trypanosoma cruzi metacaspase, putative 0.0053 0.1137 1
Schistosoma mansoni smad1 5 8 and 0.0026 0.0389 0.0744
Loa Loa (eye worm) hypothetical protein 0.005 0.1038 0.1038
Trypanosoma brucei metacaspase 0.0053 0.1137 1
Plasmodium vivax hypothetical protein, conserved 0.0053 0.1137 0.5
Echinococcus multilocularis caspase 0.0141 0.3523 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0141 0.3523 1
Onchocerca volvulus 0.005 0.1038 0.2186
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0389 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.1137 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0094 0.225 0.6386
Trypanosoma brucei metacaspase MCA2 0.0053 0.1137 1
Echinococcus multilocularis GPCR, family 2 0.0094 0.225 0.6386
Echinococcus multilocularis caspase 3 0.0088 0.2072 0.5881
Loa Loa (eye worm) MH2 domain-containing protein 0.038 1 1
Schistosoma mansoni hypothetical protein 0.0204 0.5226 1
Brugia malayi TAR-binding protein 0.0134 0.3335 0.3335
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0094 0.225 0.6386
Loa Loa (eye worm) hypothetical protein 0.0204 0.5226 0.5226
Loa Loa (eye worm) hypothetical protein 0.0053 0.1137 0.1137
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.1137 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.01 0.2403 0.682
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.1137 1
Brugia malayi MH2 domain containing protein 0.0026 0.0389 0.0389
Schistosoma mansoni caspase-7 (C14 family) 0.0141 0.3523 0.6742
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0389 0.1103
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.1137 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.3335 0.3335
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0899 0.1721
Schistosoma mansoni hypothetical protein 0.0094 0.225 0.4306
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0389 0.1103
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0094 0.225 0.225
Schistosoma mansoni tar DNA-binding protein 0.0134 0.3335 0.6383
Echinococcus granulosus tar DNA binding protein 0.0134 0.3335 0.9467
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.1137 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.1137 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.1137 1
Brugia malayi MH1 domain containing protein 0.0026 0.0389 0.0389
Brugia malayi MH1 domain containing protein 0.0026 0.0389 0.0389
Echinococcus granulosus Smad4 0.0026 0.0389 0.1103
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0899 0.1721
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0899 0.2552
Schistosoma mansoni caspase-7 (C14 family) 0.0103 0.2489 0.4763
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0899 0.0899
Brugia malayi hypothetical protein 0.005 0.1038 0.1038
Schistosoma mansoni tar DNA-binding protein 0.0134 0.3335 0.6383
Trypanosoma cruzi metacaspase, putative 0.0053 0.1137 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.1137 1
Loa Loa (eye worm) TAR-binding protein 0.0134 0.3335 0.3335
Brugia malayi Cell death protein 3 precursor 0.0103 0.2489 0.2489
Schistosoma mansoni smad1 5 8 and 0.0026 0.0389 0.0744
Loa Loa (eye worm) transcription factor SMAD2 0.038 1 1
Echinococcus multilocularis Smad4 0.0026 0.0389 0.1103
Brugia malayi MH1 domain containing protein 0.0014 0.0075 0.0075
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0899 0.5
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0899 0.2552
Loa Loa (eye worm) hypothetical protein 0.0094 0.225 0.225
Brugia malayi MH2 domain containing protein 0.0026 0.0389 0.0389
Loa Loa (eye worm) Smad1 0.0026 0.0389 0.0389
Schistosoma mansoni tar DNA-binding protein 0.0134 0.3335 0.6383
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0899 0.2552
Echinococcus multilocularis smad 0.0026 0.0389 0.1103
Brugia malayi Steroid receptor seven-up type 2 0.01 0.2403 0.2403
Loa Loa (eye worm) RNA binding protein 0.0134 0.3335 0.3335
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0103 0.2489 0.2489
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.1137 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0899 0.2552
Trypanosoma brucei Metacaspase-4 0.0053 0.1137 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0075
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.1137 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0298 0.779 0.779
Trypanosoma cruzi metacaspase, putative 0.0053 0.1137 1
Schistosoma mansoni hypothetical protein 0.0094 0.225 0.4306
Schistosoma mansoni hypothetical protein 0.0094 0.225 0.4306
Schistosoma mansoni caspase-3 (C14 family) 0.0141 0.3523 0.6742
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.1137 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0899 0.2552
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.4746 1
Brugia malayi RNA binding protein 0.0134 0.3335 0.3335
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.3335 0.3335
Echinococcus multilocularis tar DNA binding protein 0.0134 0.3335 0.9467
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.1137 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0298 0.779 0.779
Schistosoma mansoni Smad4 0.0026 0.0389 0.0744
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.1137 1
Brugia malayi Latrophilin receptor protein 2 0.0094 0.225 0.225
Plasmodium falciparum metacaspase 1 0.0053 0.1137 0.5
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0899 0.5
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0141 0.3523 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.2273 0.2273
Schistosoma mansoni tar DNA-binding protein 0.0134 0.3335 0.6383
Brugia malayi Smad1 0.0026 0.0389 0.0389
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0389 0.1103
Echinococcus granulosus smad 0.0026 0.0389 0.1103
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.1137 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0389 0.0744
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.1137 0.5
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.1137 0.5
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.1137 1
Plasmodium vivax metacaspase 1, putative 0.0053 0.1137 0.5
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0389 0.1103
Echinococcus granulosus caspase 2 0.0103 0.2489 0.7064
Loa Loa (eye worm) hypothetical protein 0.0186 0.4746 0.4746
Loa Loa (eye worm) nuclear hormone receptor 0.0095 0.2258 0.2258
Brugia malayi Calcitonin receptor-like protein seb-1 0.0298 0.779 0.779
Echinococcus granulosus caspase 0.0141 0.3523 1
Echinococcus multilocularis caspase 2 0.0103 0.2489 0.7064
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0899 0.2552

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 25.11886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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