Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0076 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.1055 | 0.6457 | 0.6457 |
Echinococcus multilocularis | GPCR, family 2 | 0.0504 | 0.2841 | 0.3507 |
Schistosoma mansoni | tar DNA-binding protein | 0.1305 | 0.8101 | 1 |
Brugia malayi | hypothetical protein | 0.0148 | 0.05 | 0.05 |
Brugia malayi | isocitrate dehydrogenase | 0.01 | 0.0185 | 0.0185 |
Brugia malayi | MH2 domain containing protein | 0.1055 | 0.6457 | 0.6457 |
Echinococcus granulosus | GPCR family 2 | 0.0504 | 0.2841 | 0.3507 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.001 | 0.0012 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.1594 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.01 | 0.0185 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0504 | 0.2841 | 0.3507 |
Schistosoma mansoni | hypothetical protein | 0.0504 | 0.2841 | 0.3507 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0504 | 0.2841 | 0.3507 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0504 | 0.2841 | 0.2841 |
Schistosoma mansoni | tar DNA-binding protein | 0.1305 | 0.8101 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.05 | 0.05 |
Brugia malayi | RNA binding protein | 0.1305 | 0.8101 | 0.8101 |
Brugia malayi | Isocitrate dehydrogenase | 0.01 | 0.0185 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.109 | 0.6687 | 0.6687 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.01 | 0.0185 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.1055 | 0.6457 | 0.6457 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.01 | 0.0185 | 0.0229 |
Brugia malayi | hypothetical protein | 0.0482 | 0.2696 | 0.2696 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.01 | 0.0185 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.01 | 0.0185 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.01 | 0.0185 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.2696 | 0.2696 |
Echinococcus multilocularis | tar DNA binding protein | 0.1305 | 0.8101 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.1305 | 0.8101 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.01 | 0.0185 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1594 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.1594 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.1305 | 0.8101 | 0.8101 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.1305 | 0.8101 | 0.8101 |
Schistosoma mansoni | hypothetical protein | 0.0504 | 0.2841 | 0.3507 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.01 | 0.0185 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.2841 | 0.2841 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.01 | 0.0185 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0076 | 0.0025 | 0.0904 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.01 | 0.0185 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.01 | 0.0185 | 0.0229 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.01 | 0.0185 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.1305 | 0.8101 | 0.8101 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0504 | 0.2841 | 0.3507 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0076 | 0.0025 | 0.0904 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0504 | 0.2841 | 0.2841 |
Echinococcus granulosus | tar DNA binding protein | 0.1305 | 0.8101 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.05 | 0.05 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.01 | 0.0185 | 0.0229 |
Schistosoma mansoni | hypothetical protein | 0.109 | 0.6687 | 0.8254 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.01 | 0.0185 | 0.0229 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.001 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.001 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.01 | 0.0185 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.1305 | 0.8101 | 0.8101 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.01 | 0.0185 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0025 | 0.0025 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.01 | 0.0185 | 0.0229 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.001 | 0.0012 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.001 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.1305 | 0.8101 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0504 | 0.2841 | 0.2841 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0504 | 0.2841 | 0.3507 |
Schistosoma mansoni | hypothetical protein | 0.0504 | 0.2841 | 0.3507 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0504 | 0.2841 | 0.3507 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.001 | 0.0012 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.001 | 0.0012 |
Onchocerca volvulus | 0.0482 | 0.2696 | 1 | |
Brugia malayi | TAR-binding protein | 0.1305 | 0.8101 | 0.8101 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.109 | 0.6687 | 0.6687 |
Schistosoma mansoni | tar DNA-binding protein | 0.1305 | 0.8101 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.01 | 0.0185 | 0.0229 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.