Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.4248 | 0.5844 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.727 | 0.727 |
Onchocerca volvulus | 0.005 | 0.727 | 1 | |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.005 | 0.727 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.005 | 0.727 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.005 | 0.727 | 0.727 |
Brugia malayi | AMP-binding enzyme family protein | 0.005 | 0.727 | 0.727 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.4248 | 0.5844 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0037 | 0.4668 | 1 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0015 | 0 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.005 | 0.727 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.005 | 0.727 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0037 | 0.4668 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.005 | 0.727 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.4668 | 0.4668 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.4668 | 0.4668 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.005 | 0.727 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.727 | 0.727 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.005 | 0.727 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.4248 | 0.5844 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.005 | 0.727 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0015 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.4248 | 0.5844 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.005 | 0.727 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.005 | 0.727 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.005 | 0.727 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.005 | 0.727 | 0.727 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.4668 | 0.4668 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0015 | 0 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.005 | 0.727 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.4668 | 0.4668 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0037 | 0.4668 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.005 | 0.727 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.727 | 0.727 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.005 | 0.727 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.005 | 0.727 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.005 | 0.727 | 1 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.4668 | 0.4668 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0015 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0063 | 1 | 1 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0037 | 0.4668 | 0.6421 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0037 | 0.4668 | 0.6421 |
Toxoplasma gondii | propionate-CoA ligase | 0.0015 | 0 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.005 | 0.727 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.005 | 0.727 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.