Detailed information for compound 1452723

Basic information

Technical information
  • TDR Targets ID: 1452723
  • Name: 3-[(6-methylquinazolin-4-yl)amino]propanoic a cid hydrochloride
  • MW: 267.711 | Formula: C12H14ClN3O2
  • H donors: 2 H acceptors: 4 LogP: 3.07 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCNc1ncnc2c1cc(C)cc2.Cl
  • InChi: 1S/C12H13N3O2.ClH/c1-8-2-3-10-9(6-8)12(15-7-14-10)13-5-4-11(16)17;/h2-3,6-7H,4-5H2,1H3,(H,16,17)(H,13,14,15);1H
  • InChiKey: LNXPQPMHSDRZAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[(6-methyl-4-quinazolinyl)amino]propanoic acid hydrochloride
  • 3-[(6-methylquinazolin-4-yl)amino]propionic acid hydrochloride
  • 3-(6-Methyl-quinazolin-4-ylamino)-propionic acid
  • SMR000123204
  • MLS000523226

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0559 0.0559
Brugia malayi mbt repeat family protein 0.0058 0.0667 0.0667
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.079 0.079
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0106 0.1419 0.3485
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0083 0.1056 0.1056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0559 0.0559
Echinococcus multilocularis GPCR, family 2 0.011 0.1472 0.1472
Brugia malayi Isocitrate dehydrogenase 0.0083 0.1056 0.1056
Echinococcus granulosus tar DNA binding protein 0.0661 1 1
Brugia malayi MH2 domain containing protein 0.0018 0.0053 0.0053
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0106 0.1419 1
Loa Loa (eye worm) RNA binding protein 0.0661 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0667 0.0617
Brugia malayi mbt repeat family protein 0.0058 0.0667 0.0667
Loa Loa (eye worm) TAR-binding protein 0.0661 1 1
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0424 0.4012
Leishmania major trypanothione reductase 0.0042 0.0424 0.4012
Loa Loa (eye worm) hypothetical protein 0.0043 0.0448 0.0397
Brugia malayi Latrophilin receptor protein 2 0.011 0.1472 0.1472
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0098 0.218
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0096 0.1254 0.8301
Loa Loa (eye worm) Smad1 0.004 0.0397 0.0346
Toxoplasma gondii ABC1 family protein 0.0043 0.0448 0.4242
Loa Loa (eye worm) nuclear factor I 0.0022 0.0119 0.0066
Loa Loa (eye worm) hypothetical protein 0.0043 0.0448 0.0397
Schistosoma mansoni smad1 5 8 and 0.004 0.0397 0.0397
Schistosoma mansoni ap endonuclease 0.0021 0.0098 0.0098
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0559 0.0559
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0448 0.0448
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0448 0.11
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.079 0.079
Schistosoma mansoni Smad4 0.0018 0.0053 0.0053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0559 0.0559
Brugia malayi glutathione reductase 0.0042 0.0424 0.0424
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0448 0.11
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0083 0.1056 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0667 0.0667
Brugia malayi Smad1 0.004 0.0397 0.0397
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0448 0.11
Schistosoma mansoni hypothetical protein 0.011 0.1472 0.1472
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0448 0.4242
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.079 0.079
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0667 0.0617
Echinococcus granulosus GPCR family 2 0.011 0.1472 0.1472
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0053 0.0053
Loa Loa (eye worm) glutathione reductase 0.0042 0.0424 0.0372
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0667 0.0667
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0559 0.0559
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0098 0.0045
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0096 0.1254 0.308
Echinococcus multilocularis isocitrate dehydrogenase 0.0083 0.1056 0.1056
Echinococcus multilocularis TGF beta signal transducer SmadC 0.004 0.0397 0.0397
Toxoplasma gondii isocitrate dehydrogenase 0.0083 0.1056 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.4073 1
Schistosoma mansoni tar DNA-binding protein 0.0661 1 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0053 0.0053
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0083 0.1056 1
Schistosoma mansoni tar DNA-binding protein 0.0661 1 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0098 0.218
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0096 0.1254 0.308
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0667 0.0667
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0098 0.0098
Leishmania major hypothetical protein, conserved 0.0043 0.0448 0.4242
Plasmodium falciparum glutathione reductase 0.0042 0.0424 0.4012
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0106 0.1419 0.3485
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.1056 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0448 0.11
Schistosoma mansoni smad1 5 8 and 0.004 0.0397 0.0397
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0098 0.0925
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0448 0.4242
Loa Loa (eye worm) transcription factor SMAD2 0.059 0.8903 0.8897
Schistosoma mansoni smad 0.004 0.0397 0.0397
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0559 0.0559
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0448 0.0448
Brugia malayi Calcitonin receptor-like protein seb-1 0.0347 0.5137 0.5137
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0098 1
Brugia malayi MH1 domain containing protein 0.004 0.0397 0.0397
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0667 0.0667
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.079 0.079
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0432 0.0432
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0231 0.3353 0.3353
Loa Loa (eye worm) hypothetical protein 0.0237 0.3441 0.3406
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0424 0.0372
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0096 0.1254 0.308
Schistosoma mansoni smad 0.0018 0.0053 0.0053
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0098 1
Mycobacterium ulcerans lipase LipD 0.0043 0.0448 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0106 0.1419 0.3485
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0098 0.0925
Brugia malayi latrophilin 2 splice variant baaae 0.0237 0.3441 0.3441
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0667 0.0667
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0448 0.11
Onchocerca volvulus 0.0043 0.0448 0.1545
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0098 0.0098
Brugia malayi MH2 domain containing protein 0.059 0.8903 0.8903
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0448 1
Plasmodium vivax glutathione reductase, putative 0.0042 0.0424 0.4012
Schistosoma mansoni hypothetical protein 0.011 0.1472 0.1472
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.1056 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0083 0.1056 0.1056
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0098 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.004 0.0397 0.0346
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0083 0.1056 1
Brugia malayi TAR-binding protein 0.0661 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.1056 0.1056
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0 0.5
Onchocerca volvulus 0.0058 0.0667 0.2401
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0559 0.0559
Loa Loa (eye worm) MH1 domain-containing protein 0.004 0.0397 0.0346
Schistosoma mansoni Smad4 0.004 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0183 0.2608 0.2568
Onchocerca volvulus 0.0043 0.0448 0.1545
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.011 0.1472 0.1472
Echinococcus granulosus mothers against decapentaplegic 5 0.004 0.0397 0.0397
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0448 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0098 0.0925
Echinococcus multilocularis smad 0.004 0.0397 0.0397
Onchocerca volvulus 0.0043 0.0448 0.1545
Brugia malayi beta-lactamase family protein 0.0043 0.0448 0.0448
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0448 0.4242
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0448 0.4242
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0448 0.0448
Schistosoma mansoni ap endonuclease 0.0021 0.0098 0.0098
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.1056 0.1056
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.1056 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.1056 0.1056
Loa Loa (eye worm) hypothetical protein 0.0043 0.0448 0.0397
Mycobacterium ulcerans beta-lactamase 0.0043 0.0448 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.011 0.1472 0.1426
Mycobacterium tuberculosis Conserved protein 0.0043 0.0448 0.11
Trypanosoma brucei trypanothione reductase 0.0042 0.0424 0.4012
Schistosoma mansoni TGF-beta signal transducer Smad2 0.004 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.011 0.1472 0.1426
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0347 0.5137 0.5111
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0098 0.0925
Schistosoma mansoni Smad4 0.0018 0.0053 0.0053
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0448 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0096 0.1254 0.308
Brugia malayi MH1 domain containing protein 0.004 0.0397 0.0397
Mycobacterium tuberculosis Conserved protein 0.0043 0.0448 0.11
Brugia malayi beta-lactamase family protein 0.0043 0.0448 0.0448
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0448 0.0448
Mycobacterium ulcerans hypothetical protein 0.0043 0.0448 1
Schistosoma mansoni tar DNA-binding protein 0.0661 1 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0448 0.0448
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0448 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0098 0.218
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0347 0.5137 0.5137
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.011 0.1472 0.1472
Brugia malayi Thioredoxin reductase 0.0042 0.0424 0.0424
Schistosoma mansoni hypothetical protein 0.0237 0.3441 0.3441
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0098 0.0098
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0231 0.3353 0.3353
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0432 0.0432
Trichomonas vaginalis esterase, putative 0.0043 0.0448 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0098 0.0925
Loa Loa (eye worm) hypothetical protein 0.0066 0.079 0.0741
Brugia malayi N-terminal motif family protein 0.0183 0.2608 0.2608
Brugia malayi RNA recognition motif domain containing protein 0.0661 1 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0448 0.11
Loa Loa (eye worm) MH2 domain-containing protein 0.059 0.8903 0.8897
Brugia malayi MH1 domain containing protein 0.0022 0.0119 0.0119
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0661 1 1
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0667 0.0667
Brugia malayi isocitrate dehydrogenase 0.0083 0.1056 0.1056
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0098 0.0925
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0448 0.11
Mycobacterium tuberculosis Probable reductase 0.0096 0.1254 0.308
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0053 0.0053
Mycobacterium tuberculosis Probable dehydrogenase 0.0096 0.1254 0.308
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0098 0.024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0559 0.0559
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0667 0.2401
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0448 1
Brugia malayi MH2 domain containing protein 0.004 0.0397 0.0397
Brugia malayi beta-lactamase 0.0043 0.0448 0.0448
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0424 0.104
Brugia malayi MH1 domain containing protein 0.0022 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0022 0.0119 0.0066
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.011 0.1472 0.1472
Schistosoma mansoni tar DNA-binding protein 0.0661 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.011 0.1472 0.1472
Loa Loa (eye worm) hypothetical protein 0.0347 0.5137 0.5111
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.011 0.1472 0.1472
Echinococcus multilocularis tar DNA binding protein 0.0661 1 1
Plasmodium falciparum thioredoxin reductase 0.0042 0.0424 0.4012
Loa Loa (eye worm) beta-lactamase 0.0043 0.0448 0.0397
Schistosoma mansoni hypothetical protein 0.011 0.1472 0.1472
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0098 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0448 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0053 0.0053
Toxoplasma gondii exonuclease III APE 0.0021 0.0098 0.0925
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.079 0.079
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0053 0.0053
Loa Loa (eye worm) isocitrate dehydrogenase 0.0083 0.1056 0.1008
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0448 0.0397
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0083 0.1056 0.1056
Loa Loa (eye worm) MBCTL1 0.0066 0.079 0.0741
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.079 0.079
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0183 0.2608 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0448 0.0397
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0448 0.11
Loa Loa (eye worm) hypothetical protein 0.0043 0.0448 0.0397
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0448 1
Schistosoma mansoni smad1 5 8 and 0.004 0.0397 0.0397
Schistosoma mansoni hypothetical protein 0.011 0.1472 0.1472
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0424 0.4012
Echinococcus granulosus smad 0.004 0.0397 0.0397
Schistosoma mansoni hypothetical protein 0.0354 0.5259 0.5259
Brugia malayi MH2 domain containing protein 0.004 0.0397 0.0397
Echinococcus granulosus TGF beta signal transducer SmadC 0.004 0.0397 0.0397
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0559 0.0509
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0667 0.0667
Toxoplasma gondii isocitrate dehydrogenase 0.0083 0.1056 1
Toxoplasma gondii thioredoxin reductase 0.0042 0.0424 0.4012
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0083 0.1056 0.2593
Echinococcus granulosus Smad4 0.004 0.0397 0.0397
Echinococcus multilocularis mothers against decapentaplegic 5 0.004 0.0397 0.0397
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0083 0.1056 1
Echinococcus multilocularis Smad4 0.004 0.0397 0.0397
Schistosoma mansoni tar DNA-binding protein 0.0661 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0448 0.0397

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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