Detailed information for compound 1452885

Basic information

Technical information
  • TDR Targets ID: 1452885
  • Name: (Z)-2-(1H-benzimidazol-2-yl)-3-(5-nitrofuran- 2-yl)prop-2-enenitrile
  • MW: 280.238 | Formula: C14H8N4O3
  • H donors: 1 H acceptors: 4 LogP: 2.57 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C/c1ccc(o1)[N+](=O)[O-])/c1nc2c([nH]1)cccc2
  • InChi: 1S/C14H8N4O3/c15-8-9(7-10-5-6-13(21-10)18(19)20)14-16-11-3-1-2-4-12(11)17-14/h1-7H,(H,16,17)/b9-7-
  • InChiKey: LISLUXJODLGWGJ-CLFYSBASSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (Z)-2-(1H-benzimidazol-2-yl)-3-(5-nitro-2-furyl)prop-2-enenitrile
  • (Z)-2-(1H-benzimidazol-2-yl)-3-(5-nitro-2-furyl)acrylonitrile
  • ZINC04725898

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0226 0.3259
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0309 0.0308
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0117 0.0358
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0056 0.0056
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0097 0.0577 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.072 0.0719
Echinococcus granulosus snurportin 1 0.0372 0.2402 0.2401
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0511 0.051
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0011 0.0008
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0011 0.0033
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.01 0.0836
Echinococcus granulosus neuropeptide s receptor 0.0558 0.3644 0.3643
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0327 0.0324
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0061 0.009
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0226 0.3259
Brugia malayi Inositol-1 0.0045 0.0226 0.0226
Brugia malayi Thioredoxin reductase 0.0057 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0097 0.0574 0.0573
Echinococcus granulosus carboxylesterase 5A 0.1514 1 1
Schistosoma mansoni hypothetical protein 0.0013 0.0014 0.0011
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0011 0.0008
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.3644 0.3643
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0226 0.0225
Plasmodium falciparum thioredoxin reductase 0.002 0.0061 0.0153
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.072 0.072
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0061 0.0153
Mycobacterium ulcerans monoamine oxidase 0.0065 0.0364 0.0502
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.01 0.0836
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0511 0.051
Brugia malayi hypothetical protein 0.0011 0.0003 0.0003
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0438 0.0438
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.01 0.1355
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0011 0.0011
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0226 0.3113
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0097 0.0577 1
Loa Loa (eye worm) bZIP transcription factor family protein 0.0011 0.0003 0.0002
Brugia malayi hypothetical protein 0.0365 0.2357 0.2357
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0065 0.0364 1
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0061 0.0147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0297 0.0296
Schistosoma mansoni cpg binding protein 0.0037 0.0173 0.0171
Brugia malayi Cell death specification protein 2 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0065 0.0364 0.0363
Loa Loa (eye worm) cell death specification protein 2 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Echinococcus granulosus tumor protein p63 0.0408 0.2643 0.2643
Schistosoma mansoni amine oxidase 0.0065 0.0364 0.0361
Entamoeba histolytica hypothetical protein 0.0043 0.0219 0.3006
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0011 0.001
Brugia malayi Ets-domain containing protein 0.0087 0.0511 0.0511
Schistosoma mansoni ran 0.0026 0.01 0.0097
Schistosoma mansoni neuroligin 3 (S09 family) 0.0256 0.1631 0.1629
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.0014 0.0013
Onchocerca volvulus 0.0012 0.0011 0.0033
Loa Loa (eye worm) hypothetical protein 0.0256 0.1631 0.163
Loa Loa (eye worm) hypothetical protein 0.0119 0.072 0.0719
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Loa Loa (eye worm) inositol-1 0.0045 0.0226 0.0225
Brugia malayi steroid hormone receptor 0.0012 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0011 0.0011
Mycobacterium ulcerans dehydrogenase 0.0065 0.0364 0.0502
Trichomonas vaginalis ran, putative 0.0026 0.01 0.0247
Echinococcus multilocularis dual specificity 0.0097 0.0577 0.0576
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0161 0.201
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0256 0.1631 0.1629
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0256 0.1631 0.163
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.016 0.0159
Onchocerca volvulus 0.0256 0.1631 0.6917
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0056 0.0054
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.01 0.1417
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2402 0.2401
Schistosoma mansoni gabp alpha 0.0087 0.0511 0.0508
Echinococcus granulosus dual specificity 0.0097 0.0577 0.0576
Echinococcus granulosus X box binding protein 1 0.0348 0.2243 0.2243
Loa Loa (eye worm) hypothetical protein 0.0097 0.0574 0.0573
Loa Loa (eye worm) hypothetical protein 0.0365 0.2357 0.2356
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0297 0.0296
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.072 0.0719
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0226 0.3259
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0256 0.1631 0.2809
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0061 0.009
Plasmodium vivax importin-beta 2, putative 0.0035 0.0161 0.3406
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0056 0.0056
Echinococcus granulosus protocadherin 11 0.0011 0.0003 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0011 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0011 0.0011
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0893 0.1492
Schistosoma mansoni acetylcholinesterase 0.0256 0.1631 0.1629
Brugia malayi amine oxidase, flavin-containing family protein 0.0065 0.0364 0.0364
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.0014 0.0013
Toxoplasma gondii histone lysine-specific demethylase 0.0065 0.0364 0.9562
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0061 0.009
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0065 0.0364 0.0361
Loa Loa (eye worm) hypothetical protein 0.1514 1 1
Brugia malayi Ets-domain containing protein 0.0087 0.0511 0.0511
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0364 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0364 0.0363
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0117 0.0358
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0065 0.0364 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0011 0.0011
Trypanosoma cruzi UDP-galactopyranose mutase 0.0065 0.0364 0.5901
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0061 0.009
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0927 0.6096 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0065 0.0364 0.0548
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0061 0.009
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0011 0.0033
Echinococcus multilocularis protein patched 0.0051 0.0269 0.0268
Loa Loa (eye worm) hypothetical protein 0.1514 1 1
Loa Loa (eye worm) hypothetical protein 0.0256 0.1631 0.163
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0438 0.0437
Loa Loa (eye worm) hypothetical protein 0.006 0.0327 0.0326
Echinococcus granulosus BC026374 protein S09 family 0.0256 0.1631 0.163
Brugia malayi glutathione reductase 0.0057 0.0309 0.0309
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0269 0.0268
Schistosoma mansoni hypothetical protein 0.0494 0.3215 0.3213
Mycobacterium tuberculosis Possible oxidoreductase 0.0065 0.0364 0.0548
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0011 0.001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0065 0.0364 0.0363
Onchocerca volvulus 0.0256 0.1631 0.6917
Echinococcus multilocularis protein dispatched 1 0.0058 0.0317 0.0316
Schistosoma mansoni hypothetical protein 0.0372 0.2402 0.24
Echinococcus multilocularis carboxylesterase 5A 0.1514 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0419 0.0416
Loa Loa (eye worm) hypothetical protein 0.0065 0.0364 0.0363
Brugia malayi hypothetical protein 0.0043 0.0219 0.0219
Brugia malayi MH2 domain containing protein 0.0144 0.0888 0.0888
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0893 0.1492
Echinococcus multilocularis expressed conserved protein 0.0112 0.0672 0.0671
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0061 0.6001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.0011 0.0003 0.0002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0011 0.001
Entamoeba histolytica hypothetical protein 0.0028 0.0117 0.1596
Brugia malayi nuclear hormone receptor 0.0012 0.0011 0.0011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0011 0.0003 0.0002
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0065 0.0364 0.0363
Schistosoma mansoni importin beta-1 0.0035 0.0161 0.0158
Entamoeba histolytica hypothetical protein 0.0043 0.0219 0.3006
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0061 0.0153
Schistosoma mansoni gliotactin 0.0256 0.1631 0.1629
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0011 0.0003 0.0002
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0065 0.0364 1
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0364 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.0438 0.0437
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0011 0.0033
Echinococcus multilocularis neuroligin 0.0256 0.1631 0.163
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0011 0.0008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0367 0.9648
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0061 0.009
Echinococcus multilocularis geminin 0.0205 0.1291 0.129
Mycobacterium tuberculosis Probable reductase 0.013 0.0796 0.1319
Schistosoma mansoni hypothetical protein 0.0058 0.0317 0.0314
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0011 0.001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0226 0.1051
Brugia malayi TAR-binding protein 0.0076 0.0438 0.0438
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0226 0.5282
Loa Loa (eye worm) hypothetical protein 0.0286 0.1829 0.1828
Schistosoma mansoni ets 0.0013 0.0014 0.0011
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.01 0.1417
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0888 0.0888
Echinococcus multilocularis X box binding protein 1 0.0348 0.2243 0.2243
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0297 0.0297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0011 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0011 0.001
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0011 0.0008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0297 0.0296
Loa Loa (eye worm) acetylcholinesterase 1 0.1514 1 1
Schistosoma mansoni hypothetical protein 0.0049 0.0257 0.0254
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0014 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0061 0.009
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.106 0.1059
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0219 0.0216
Onchocerca volvulus 0.0256 0.1631 0.6917
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0888 0.0888
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0195 0.0247
Brugia malayi Ets-domain containing protein 0.0013 0.0014 0.0014
Schistosoma mansoni ets-related 0.0265 0.1695 0.1693
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0256 0.1631 0.1629
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0011 0.0011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0219 0.0218
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0014 0.0013
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0061 0.006
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0011 0.001
Entamoeba histolytica protein kinase, putative 0.0097 0.0577 0.8006
Echinococcus multilocularis snurportin 1 0.0372 0.2402 0.2401
Leishmania major importin beta-1 subunit, putative 0.0028 0.0117 0.1169
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0011 0.0008
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.0011 0.0003 0.0002
Echinococcus granulosus para nitrobenzyl esterase 0.0256 0.1631 0.163
Plasmodium falciparum glutathione reductase 0.002 0.0061 0.0153
Brugia malayi hypothetical protein 0.0256 0.1631 0.1631
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0297 0.0294
Brugia malayi transcription factor E74 isoform 0.0013 0.0014 0.0014
Entamoeba histolytica hypothetical protein 0.0043 0.0219 0.3006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0056 0.0056
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0097 0.0577 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0256 0.1631 0.2602
Leishmania major trypanothione reductase 0.0057 0.0309 0.4855
Echinococcus granulosus protocadherin 11 0.0011 0.0003 0.0002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0056 0.0056
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0065 0.0364 0.0361
Schistosoma mansoni cpg binding protein 0.0035 0.016 0.0157
Echinococcus multilocularis tumor protein p63 0.0408 0.2643 0.2643
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0014 0.0013
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0011 0.001
Loa Loa (eye worm) carboxylesterase 0.0256 0.1631 0.163
Plasmodium vivax glutathione reductase, putative 0.0057 0.0309 0.8228
Schistosoma mansoni coup transcription factor 0.0012 0.0011 0.0008
Brugia malayi SWIRM domain containing protein 0.0065 0.0364 0.0364
Brugia malayi Carboxylesterase family protein 0.0256 0.1631 0.1631
Echinococcus multilocularis acetylcholinesterase 0.1514 1 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0256 0.1631 0.163
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0061 0.009
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0226 0.3259
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0011 0.001
Echinococcus granulosus lysine specific histone demethylase 1A 0.0065 0.0364 0.0363
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0061 0.009
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0309 0.0451
Trichomonas vaginalis spcc417.12 protein, putative 0.0256 0.1631 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0427 0.0426
Loa Loa (eye worm) hypothetical protein 0.0065 0.0364 0.0363
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0117 0.1169
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0161 0.201
Brugia malayi Carboxylesterase family protein 0.0256 0.1631 0.1631
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0011 0.0003 0.0002
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.3644 0.3643
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.0011 0.0003 0.0002
Brugia malayi Carboxylesterase family protein 0.1514 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0011 0.0008
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0011 0.0011
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0011 0.001
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0309 0.0308
Echinococcus multilocularis protoporphyrinogen oxidase 0.0065 0.0364 0.0363
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0893 0.1492
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0011 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0011 0.0011
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0161 0.016
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0438 0.0437
Schistosoma mansoni elf1 0.0013 0.0014 0.0011
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0014 0.0013
Schistosoma mansoni inositol monophosphatase 0.0045 0.0226 0.0223
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0796 0.1319
Brugia malayi hypothetical protein 0.0065 0.0364 0.0364
Brugia malayi Hepatic leukemia factor 0.0011 0.0003 0.0003
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0862 0.5661 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0438 0.0436
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0061 0.009
Loa Loa (eye worm) hypothetical protein 0.0035 0.0161 0.016
Brugia malayi Cell death specification protein 2 0.0011 0.0003 0.0003
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0269 0.0268
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0061 0.006
Plasmodium falciparum protoporphyrinogen oxidase 0.0065 0.0364 1
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1829 0.1828
Loa Loa (eye worm) hypothetical protein 0.0065 0.0364 0.0363
Brugia malayi Protein kinase domain containing protein 0.0097 0.0577 0.0577
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0061 0.009
Schistosoma mansoni patched 1 0.0051 0.0269 0.0266
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0014 0.0013
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0348 0.2243 0.2241
Loa Loa (eye worm) carboxylesterase 0.0256 0.1631 0.163
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0269 0.1323
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0097 0.0577 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0061 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0011 0.001
Echinococcus granulosus expressed conserved protein 0.0112 0.0672 0.0671
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0011 0.0011
Entamoeba histolytica Ran family GTPase 0.0026 0.01 0.1354
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0061 0.0008
Echinococcus granulosus protein C ets 2 0.0013 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0056 0.0056
Onchocerca volvulus 0.0256 0.1631 0.6917
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0061 0.0153
Schistosoma mansoni hypothetical protein 0.0205 0.1291 0.1288
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0796 0.1319
Schistosoma mansoni hypothetical protein 0.0049 0.0257 0.0254
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.01 0.0836
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0438 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0011 0.0011
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0511 0.051
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0013
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0226 1
Brugia malayi bZIP transcription factor family protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) glutathione reductase 0.0057 0.0309 0.0308
Schistosoma mansoni BC026374 protein (S09 family) 0.0256 0.1631 0.1629
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0061 0.009
Echinococcus multilocularis protein C ets 2 0.0013 0.0014 0.0013
Schistosoma mansoni hypothetical protein 0.0049 0.0257 0.0254
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0014 0.0011
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0317 0.0317
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0097 0.0577 0.0576
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0438 0.0436
Loa Loa (eye worm) hypothetical protein 0.0256 0.1631 0.163
Schistosoma mansoni cpg binding protein 0.0037 0.0173 0.0171
Brugia malayi ecdysteroid receptor 0.0012 0.0011 0.0011
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0438 0.0437
Entamoeba histolytica protein kinase, putative 0.0097 0.0577 0.8006
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1514 1 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5472 0.5472
Brugia malayi Fli-1 protein 0.0265 0.1695 0.1695
Echinococcus granulosus acetylcholinesterase 0.1514 1 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.0317 0.0314
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0065 0.0364 1
Trypanosoma brucei trypanothione reductase 0.0057 0.0309 0.4855
Schistosoma mansoni ran 0.0026 0.01 0.0097
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0056 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0011 0.001
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0011 0.0008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0297 0.0296
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0796 0.1319
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0014 0.0013
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0011 0.001
Echinococcus multilocularis para nitrobenzyl esterase 0.0256 0.1631 0.163
Onchocerca volvulus 0.0065 0.0364 0.1533
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.01 0.0099
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0226 0.0274
Loa Loa (eye worm) hypothetical protein 0.0256 0.1631 0.163
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0011 0.0008
Brugia malayi hypothetical protein 0.0286 0.1829 0.1829
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0161 0.3257
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5472 0.5472
Chlamydia trachomatis protoporphyrinogen oxidase 0.0065 0.0364 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0161 0.0161
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0026 0.0026
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0067 0.0378 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0061 0.009
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0014 0.0013
Schistosoma mansoni hypothetical protein 0.0205 0.1291 0.1288
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0011 0.001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0226 0.1051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0297 0.0294
Echinococcus granulosus neuroligin 0.0256 0.1631 0.163
Onchocerca volvulus 0.0058 0.0317 0.1334
Echinococcus granulosus dnaJ subfamily B 0.0494 0.3215 0.3214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0011 0.001
Schistosoma mansoni hypothetical protein 0.0049 0.0257 0.0254
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0733 0.073
Treponema pallidum NADH oxidase 0.002 0.0061 0.5
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.0014 0.0013
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0014 0.0013
Onchocerca volvulus 0.006 0.0327 0.1376
Loa Loa (eye worm) hypothetical protein 0.0062 0.0345 0.0344
Onchocerca volvulus 0.0365 0.2357 1
Schistosoma mansoni hypothetical protein 0.0043 0.0219 0.0216
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Schistosoma mansoni amine oxidase 0.0065 0.0364 0.0361
Entamoeba histolytica hypothetical protein 0.0043 0.0219 0.3006
Echinococcus multilocularis cpg binding protein 0.0037 0.0173 0.0172
Brugia malayi RNA, U transporter 1 0.0099 0.0588 0.0588
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0226 0.1051
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0011 0.001
Echinococcus granulosus importin subunit beta 1 0.0035 0.0161 0.016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0011 0.001
Echinococcus granulosus geminin 0.0205 0.1291 0.129
Echinococcus multilocularis ets variant gene 4 0.0013 0.0014 0.0013
Entamoeba histolytica hypothetical protein 0.0097 0.0577 0.8006
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0309 0.8228
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0796 0.1319
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0014 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0438 0.0436
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0061 0.0153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0297 0.0294
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0796 0.8614
Echinococcus multilocularis protocadherin 11 0.0011 0.0003 0.0002
Brugia malayi Carboxylesterase family protein 0.0256 0.1631 0.1631
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0256 0.1631 1
Mycobacterium ulcerans oxidoreductase 0.0065 0.0364 0.0502
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0011 0.001
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0011 0.001
Entamoeba histolytica protein kinase domain containing protein 0.0097 0.0577 0.8006
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0117 0.0358
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0256 0.1631 0.2809
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0011 0.001
Echinococcus granulosus cpg binding protein 0.0037 0.0173 0.0172
Brugia malayi CXXC zinc finger family protein 0.0035 0.016 0.016
Echinococcus multilocularis acetylcholinesterase 0.1514 1 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0256 0.1631 0.163
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0796 0.1319
Onchocerca volvulus 0.0256 0.1631 0.6917
Loa Loa (eye worm) hypothetical protein 0.0256 0.1631 0.163
Loa Loa (eye worm) fli-1 protein 0.0265 0.1695 0.1695
Brugia malayi CHE-14 protein 0.0051 0.0269 0.0269
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0014 0.0013
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0014 0.0013
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0226 0.0225
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0269 0.0268
Brugia malayi nuclear receptor NHR-88 0.0012 0.0011 0.0011
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0061 0.009
Trypanosoma cruzi UDP-galactopyranose mutase 0.0065 0.0364 0.5901
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.01 0.01
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0438 0.0436
Leishmania major UDP-galactopyranose mutase 0.0065 0.0364 0.5901
Plasmodium falciparum importin beta, putative 0.0035 0.0161 0.3406
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0893 1
Echinococcus granulosus acetylcholinesterase 0.1514 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0056 0.0056
Echinococcus granulosus lysine specific histone demethylase 1A 0.0065 0.0364 0.0363
Echinococcus multilocularis 0.0065 0.0364 0.0363
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0061 0.009
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0309 0.0308
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0061 0.0058
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0011 0.0011
Brugia malayi Cell death specification protein 2 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0035 0.016 0.0668
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0011 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0219 0.0218
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0065 0.0364 0.0502
Loa Loa (eye worm) hypothetical protein 0.0051 0.0269 0.0268
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0061 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0011 0.0011
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0309 0.4855
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0061 0.009
Brugia malayi isocitrate dehydrogenase 0.0019 0.0056 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0011 0.0011
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0014 0.0014
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0269 0.0268
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0011 0.001
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.3215 0.3214
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1829 0.1828
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0256 0.1631 0.163
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0061 0.0061
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.01 0.0099
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0011 0.0008
Leishmania major GTP-binding protein, putative 0.0026 0.01 0.0836
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.3644 0.3643
Echinococcus granulosus ccaat enhancer binding protein delta 0.0011 0.0003 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0011 0.001
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.01 0.0099
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0577 0.0575
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.072 1
Plasmodium falciparum glutathione reductase 0.0057 0.0309 0.8228
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0927 0.6096 1
Echinococcus granulosus tar DNA binding protein 0.0076 0.0438 0.0437
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Brugia malayi Carboxylesterase family protein 0.0256 0.1631 0.1631
Loa Loa (eye worm) carboxylesterase 0.1514 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0297 0.0296
Toxoplasma gondii thioredoxin reductase 0.0057 0.0309 0.7868
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.106 0.1059
Echinococcus multilocularis protocadherin 11 0.0011 0.0003 0.0002
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0014 0.0013
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Schistosoma mansoni ets-related 0.0013 0.0014 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0011 0.0011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0011 0.0008
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0011 0.001
Schistosoma mansoni inositol monophosphatase 0.0045 0.0226 0.0223
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5472 0.5471
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0013
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.01 1
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.0014 0.0013
Mycobacterium tuberculosis Carboxylesterase LipT 0.0256 0.1631 0.2809
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0256 0.1631 0.163
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0256 0.1631 0.1629
Schistosoma mansoni hypothetical protein 0.0013 0.0014 0.0011
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0065 0.0364 0.2419
Plasmodium falciparum thioredoxin reductase 0.0057 0.0309 0.8228
Brugia malayi RNA binding protein 0.0076 0.0438 0.0438

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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