Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.2389 | 0.3074 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0051 | 0.2389 | 0.2389 |
Echinococcus granulosus | GPCR family 2 | 0.0051 | 0.2389 | 0.3074 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.2389 | 0.3074 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.7774 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.8471 | 0.8471 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2389 | 0.3074 |
Brugia malayi | RNA binding protein | 0.013 | 0.7774 | 0.7774 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.6477 | 0.8332 |
Brugia malayi | hypothetical protein | 0.0092 | 0.5188 | 0.5188 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5188 | 0.5188 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0162 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2389 | 0.3074 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2389 | 0.3074 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.7774 | 0.7774 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2389 | 0.3074 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.6477 | 0.6477 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.013 | 0.7774 | 0.7774 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0051 | 0.2389 | 0.2389 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.7774 | 0.7774 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.7774 | 0.7774 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.2389 | 0.3074 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.8471 | 0.8471 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7774 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.8471 | 0.8471 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | eyes absent homolog | 0.0092 | 0.5188 | 0.6673 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5188 | 0.5188 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0051 | 0.2389 | 0.2389 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2389 | 0.2389 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7774 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0111 | 0.6477 | 0.6477 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.7774 | 0.7774 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.2389 | 0.3074 |
Echinococcus multilocularis | GPCR, family 2 | 0.0051 | 0.2389 | 0.3074 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7774 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0017 | 0 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.7774 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5012 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.