Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Neospora caninum | Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma japonicum | ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.3713 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.2052 | 0.1704 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3713 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3713 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.3713 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8854 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.2052 | 0.372 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0531 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3713 | 0.3984 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2052 | 0.2052 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.2052 | 0.372 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.042 | 0.5 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4619 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3713 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.2052 | 0.372 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4619 | 0.4619 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5275 | 0.616 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5275 | 0.5275 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5275 | 0.615 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.8052 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0014 | 0.1265 | 0.1796 |
Onchocerca volvulus | 0.0035 | 0.4331 | 0.5 | |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.2052 | 0.372 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.2052 | 0.1681 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.3713 | 0.4001 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.2052 | 0.1704 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.042 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.3713 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.2052 | 0.1681 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3713 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4331 | 0.4856 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.042 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.2052 | 0.372 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2052 | 0.2052 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4331 | 0.4331 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4331 | 0.4842 |
Brugia malayi | hypothetical protein | 0.002 | 0.214 | 0.1826 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4619 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2052 | 0.2052 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.8052 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4619 | 0.4619 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0839 | 0.0754 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.2052 | 0.372 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.1265 | 0.1265 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.8052 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0014 | 0.1265 | 0.1796 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2052 | 0.2052 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0839 | 0.0754 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.8052 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5973 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 21.1923 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.