Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0262 | 0.9133 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0262 | 0.9133 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0148 | 0.2645 | 0.2896 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0262 | 0.9133 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0262 | 0.9133 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0262 | 0.9133 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5862 | 0.6418 |
Loa Loa (eye worm) | TAR-binding protein | 0.0262 | 0.9133 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0262 | 0.9133 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0262 | 0.9133 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0262 | 0.9133 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.2645 | 0.2896 |
Brugia malayi | TAR-binding protein | 0.0262 | 0.9133 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5862 | 0.6418 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0148 | 0.2645 | 0.2896 |
Brugia malayi | RNA binding protein | 0.0262 | 0.9133 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0262 | 0.9133 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0262 | 0.9133 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0148 | 0.2645 | 0.2896 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0083 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.092 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 1 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.