Detailed information for compound 1453100

Basic information

Technical information
  • TDR Targets ID: 1453100
  • Name: 2-[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]-N -propan-2-ylbenzamide
  • MW: 341.792 | Formula: C18H16ClN3O2
  • H donors: 1 H acceptors: 3 LogP: 4.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NC(=O)c1ccccc1c1onc(n1)c1ccccc1Cl)C
  • InChi: 1S/C18H16ClN3O2/c1-11(2)20-17(23)12-7-3-4-8-13(12)18-21-16(22-24-18)14-9-5-6-10-15(14)19/h3-11H,1-2H3,(H,20,23)
  • InChiKey: FERFOUTWABYQAB-UHFFFAOYSA-N  


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Synonyms

  • 2-[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]-N-isopropyl-benzamide
  • 2-[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]-N-isopropylbenzamide
  • 2-[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]-N-propan-2-yl-benzamide
  • STOCK5S-08040
  • SMR000046602
  • ZINC02351523
  • MLS000042198

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni jumonji/arid domain-containing protein 0.0196 0.2847 0.4193
Loa Loa (eye worm) hypothetical protein 0.0096 0.1176 0.1128
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0301 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0301 0.0415
Loa Loa (eye worm) jmjC domain-containing protein 0.0055 0.05 0.0448
Mycobacterium ulcerans beta-lactamase 0.0043 0.0301 0.0618
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0311 0.0237
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.2047 0.4203
Brugia malayi jmjC domain containing protein 0.0055 0.05 0.0448
Onchocerca volvulus 0.003 0.0078 0.0045
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0301 0.0596
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0434 0.4601
Echinococcus multilocularis lamin dm0 0.003 0.0078 0.0043
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0055 0.05 0.5416
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0202 0.0161
Echinococcus multilocularis GPCR, family 2 0.0198 0.2875 0.7809
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0198 0.2875 0.7809
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0301 0.0661
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0301 0.0618
Schistosoma mansoni hypothetical protein 0.0118 0.1548 0.2237
Echinococcus granulosus JmjC domain containing protein 4 0.0055 0.05 0.1212
Plasmodium vivax JmjC domain containing protein 0.0078 0.0868 1
Brugia malayi TAR-binding protein 0.0199 0.2884 0.2845
Loa Loa (eye worm) intermediate filament protein 0.003 0.0078 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2884 0.4249
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0434 0.0504
Brugia malayi beta-lactamase 0.0043 0.0301 0.0249
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0148 0.2045 0.5503
Leishmania major mitochondrial DNA polymerase beta 0.0313 0.4797 1
Echinococcus granulosus lamin 0.003 0.0078 0.0043
Schistosoma mansoni hypothetical protein 0.0428 0.6702 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0199 0.2884 0.2845
Giardia lamblia PHD finger protein 15 0.0029 0.0063 0.5
Echinococcus granulosus lysine specific demethylase 6a 0.0089 0.1061 0.2772
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0581 0.0529
Brugia malayi intermediate filament protein 0.003 0.0078 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2884 0.4249
Echinococcus multilocularis lysine specific demethylase 5A 0.0195 0.282 0.7655
Leishmania major hypothetical protein, conserved 0.0055 0.05 0.094
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.2047 0.4016
Trypanosoma brucei RNA helicase, putative 0.0118 0.1548 0.293
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0078 0.0025
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.2393 0.2352
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2884 0.4249
Loa Loa (eye worm) hypothetical protein 0.0043 0.0301 0.0249
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0253 0.0529
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0301 0.0596
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0202 0.0149
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0198 0.2875 0.7809
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0081 0.0923 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0354 0.5468 1
Mycobacterium ulcerans lipase LipD 0.0043 0.0301 0.0618
Loa Loa (eye worm) hypothetical protein 0.0051 0.0434 0.0382
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0301 0.0216
Brugia malayi Pax transcription factor protein 2 0.0237 0.3525 0.349
Brugia malayi hypothetical protein 0.0033 0.013 0.0076
Loa Loa (eye worm) RNA binding protein 0.0199 0.2884 0.2845
Brugia malayi jmjC domain containing protein 0.0055 0.05 0.0448
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0202 0.0161
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0301 0.0359
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0025
Loa Loa (eye worm) hypothetical protein 0.003 0.0069 0.0015
Schistosoma mansoni hypothetical protein 0.0198 0.2875 0.4235
Brugia malayi hypothetical protein 0.0245 0.3664 0.363
Brugia malayi Bromodomain containing protein 0.0029 0.0063 0.0009
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.3664 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0301 0.0596
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0301 0.0596
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.2047 0.4016
Brugia malayi N-terminal motif family protein 0.0354 0.5468 0.5443
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2884 0.4249
Brugia malayi Latrophilin receptor protein 2 0.0198 0.2875 0.2836
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.2393 0.647
Loa Loa (eye worm) hypothetical protein 0.0034 0.0139 0.0085
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.4797 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0202 0.0161
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0311 0.0237
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0301 0.0216
Brugia malayi glutaminase DH11.1 0.0269 0.4056 0.4024
Brugia malayi MH2 domain containing protein 0.012 0.1568 0.1522
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0434 0.0504
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0055 0.05 0.0648
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0202 0.0386
Echinococcus granulosus GPCR family 2 0.0198 0.2875 0.7809
Loa Loa (eye worm) hypothetical protein 0.0089 0.1061 0.1013
Loa Loa (eye worm) hypothetical protein 0.0043 0.0301 0.0249
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0301 0.0661
Loa Loa (eye worm) hypothetical protein 0.0626 1 1
Onchocerca volvulus 0.003 0.0078 0.0045
Loa Loa (eye worm) hypothetical protein 0.0198 0.2875 0.2836
Schistosoma mansoni alpha glucosidase 0.0038 0.0202 0.0209
Schistosoma mansoni glutaminase 0.0269 0.4056 0.6014
Loa Loa (eye worm) hypothetical protein 0.0354 0.5468 0.5443
Schistosoma mansoni hypothetical protein 0.0198 0.2875 0.4235
Brugia malayi jmjC domain containing protein 0.0089 0.1061 0.1013
Schistosoma mansoni alpha-glucosidase 0.0146 0.2001 0.2919
Trichomonas vaginalis glutaminase, putative 0.0269 0.4056 1
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0139 0.5727
Brugia malayi beta-lactamase family protein 0.0043 0.0301 0.0249
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0301 0.0596
Brugia malayi follicle stimulating hormone receptor 0.028 0.4235 0.4204
Loa Loa (eye worm) jmjC domain-containing protein 0.0055 0.05 0.0448
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0311 0.0237
Echinococcus multilocularis tar DNA binding protein 0.0199 0.2884 0.7833
Mycobacterium ulcerans hypothetical protein 0.0043 0.0301 0.0618
Schistosoma mansoni jumonji domain containing protein 0.0184 0.2634 0.3873
Onchocerca volvulus 0.0043 0.0301 0.0457
Toxoplasma gondii ABC1 family protein 0.0043 0.0301 0.3266
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0202 0.0161
Echinococcus granulosus lamin dm0 0.003 0.0078 0.0043
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0202 0.0161
Mycobacterium ulcerans glutaminase 0.0269 0.4056 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0472 0.0587
Echinococcus multilocularis lamin 0.003 0.0078 0.0043
Echinococcus multilocularis JmjC domain containing protein 4 0.0055 0.05 0.1212
Loa Loa (eye worm) pax transcription factor protein 2 0.0237 0.3525 0.349
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0411 0.0359
Loa Loa (eye worm) hypothetical protein 0.0043 0.0301 0.0249
Echinococcus granulosus tar DNA binding protein 0.0199 0.2884 0.7833
Leishmania major hypothetical protein, conserved 0.0043 0.0301 0.0521
Onchocerca volvulus Alhambra homolog 0.0029 0.0063 0.0017
Loa Loa (eye worm) glutaminase 2 0.0269 0.4056 0.4024
Brugia malayi RNA binding protein 0.0199 0.2884 0.2845
Leishmania major hypothetical protein, conserved 0.0051 0.0434 0.08
Schistosoma mansoni phd/f-box containing protein 0.0055 0.05 0.0658
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0202 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0626 1 1
Toxoplasma gondii PLU-1 family protein 0.0044 0.0303 0.3288
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0055 0.05 0.0648
Echinococcus multilocularis jumonji domain containing 1A 0.0055 0.05 0.1212
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0198 0.2875 0.7809
Trichomonas vaginalis esterase, putative 0.0043 0.0301 0.0415
Brugia malayi PHD-finger family protein 0.0029 0.0063 0.0009
Onchocerca volvulus 0.005 0.0411 0.0659
Schistosoma mansoni jumonji domain containing protein 0.0055 0.05 0.0658
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0203 0.2962 0.8049
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0301 0.0596
Schistosoma mansoni phosphatidylserine receptor 0.0055 0.05 0.0658
Loa Loa (eye worm) hypothetical protein 0.0055 0.05 0.0448
Onchocerca volvulus 0.0043 0.0301 0.0457
Loa Loa (eye worm) hypothetical protein 0.0029 0.0063 0.0009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0301 0.0249
Loa Loa (eye worm) jmjC domain-containing protein 0.024 0.3573 0.3538
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.2393 0.2352
Echinococcus granulosus intermediate filament protein 0.003 0.0078 0.0043
Echinococcus multilocularis lysine specific demethylase 6a 0.0089 0.1061 0.2772
Loa Loa (eye worm) hypothetical protein 0.0034 0.0139 0.0085
Echinococcus granulosus lysine specific demethylase 5A 0.0196 0.2847 0.7731
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0198 0.2875 0.2836
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.2326 0.5477
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0311 0.0237
Schistosoma mansoni survival motor neuron protein 0.005 0.0411 0.0524
Schistosoma mansoni hypothetical protein 0.005 0.0411 0.0524
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0202 0.0161
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0301 0.0596
Brugia malayi jmjC domain containing protein 0.0055 0.05 0.0448
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0301 0.2958
Loa Loa (eye worm) jmjC domain-containing protein 0.0055 0.05 0.0448
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0063 0.0009
Onchocerca volvulus 0.0237 0.3525 0.6411
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0434 0.4601
Loa Loa (eye worm) hypothetical protein 0.0043 0.0301 0.0249
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0434 0.47
Brugia malayi hypothetical protein 0.0051 0.0434 0.0382
Toxoplasma gondii hypothetical protein 0.0051 0.0419 0.4542
Loa Loa (eye worm) latrophilin receptor protein 2 0.0198 0.2875 0.2836
Schistosoma mansoni jumonji/arid domain-containing protein 0.0196 0.2847 0.4193
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1568 0.1522
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1568 0.1522
Schistosoma mansoni alpha-glucosidase 0.0146 0.2001 0.2919
Schistosoma mansoni intermediate filament proteins 0.003 0.0078 0.0023
Loa Loa (eye worm) hypothetical protein 0.0428 0.6702 0.6684
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2884 0.4249
Loa Loa (eye worm) glutaminase 0.0269 0.4056 0.4024
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0434 0.0504
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0202 0.0161
Brugia malayi RNA recognition motif domain containing protein 0.0199 0.2884 0.2845
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0301 0.0618
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0203 0.2962 0.8049
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.4797 1
Schistosoma mansoni lamin 0.003 0.0078 0.0023
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0055 0.05 0.0648
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0202 0.2189
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0063 0.0684
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.2393 0.647
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0301 0.0415
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0301 0.0415
Mycobacterium leprae Probable lipase LipE 0.0043 0.0301 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.2393 0.647
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0434 0.4601
Mycobacterium tuberculosis Conserved protein 0.0043 0.0301 0.0596
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0626 1 1
Echinococcus granulosus jumonji domain containing 1A 0.0055 0.05 0.1212
Plasmodium falciparum JmjC domain-containing protein, putative 0.0078 0.0868 1
Schistosoma mansoni hypothetical protein 0.0198 0.2875 0.4235
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0301 0.0415
Loa Loa (eye worm) beta-lactamase 0.0043 0.0301 0.0249
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.4203 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0301 0.0596
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0301 0.0415
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0301 0.0596
Loa Loa (eye worm) TAR-binding protein 0.0199 0.2884 0.2845
Onchocerca volvulus 0.0098 0.1206 0.2127
Brugia malayi latrophilin 2 splice variant baaae 0.0428 0.6702 0.6684
Mycobacterium ulcerans hypothetical protein 0.0165 0.2326 0.5678
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0078 0.0025
Loa Loa (eye worm) hypothetical protein 0.0043 0.0301 0.0249
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0202 0.0149
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0198 0.2875 0.7809
Echinococcus multilocularis musashi 0.003 0.0078 0.0043
Schistosoma mansoni hypothetical protein 0.0198 0.2875 0.4235
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0202 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.4235 0.4204
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0301 0.0359
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0253 0.0529
Brugia malayi beta-lactamase family protein 0.0043 0.0301 0.0249
Echinococcus multilocularis phd:f box containing protein 0.0055 0.05 0.1212
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0063 0.0684
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0202 0.0161
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0148 0.2045 0.5503
Brugia malayi jmjC domain containing protein 0.024 0.3573 0.3538
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0313 0.4797 1
Onchocerca volvulus 0.0043 0.0301 0.0457
Schistosoma mansoni lamin 0.003 0.0078 0.0023
Loa Loa (eye worm) hypothetical protein 0.0245 0.3664 0.363
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.3664 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0202 0.0161
Brugia malayi jmjC domain containing protein 0.0203 0.2962 0.2923
Loa Loa (eye worm) hypothetical protein 0.0043 0.0301 0.0249
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0301 0.0249
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0202 0.0386
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0202 0.0312
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0301 0.0216
Echinococcus granulosus phd:f box containing protein 0.0055 0.05 0.1212
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0089 0.1061 0.1503
Schistosoma mansoni protein phosphatase 2C 0.0055 0.05 0.0658

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Firefly Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 2309 (Probe Summary for Inhibitors and Stabilizers of Firefly Luciferase)] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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