Detailed information for compound 1453108

Basic information

Technical information
  • TDR Targets ID: 1453108
  • Name: N-(3,4-dimethylphenyl)-4-[2-(3-nitrobenzoyl)h ydrazinyl]-4-oxobutanamide
  • MW: 384.386 | Formula: C19H20N4O5
  • H donors: 3 H acceptors: 5 LogP: 2.01 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NNC(=O)c1cccc(c1)[N+](=O)[O-])CCC(=O)Nc1ccc(c(c1)C)C
  • InChi: 1S/C19H20N4O5/c1-12-6-7-15(10-13(12)2)20-17(24)8-9-18(25)21-22-19(26)14-4-3-5-16(11-14)23(27)28/h3-7,10-11H,8-9H2,1-2H3,(H,20,24)(H,21,25)(H,22,26)
  • InChiKey: BCUJRKKGAPYPQU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3,4-dimethylphenyl)-4-[N'-(3-nitrobenzoyl)hydrazino]-4-oxo-butanamide
  • N-(3,4-dimethylphenyl)-4-[N'-[(3-nitrophenyl)-oxomethyl]hydrazino]-4-oxobutanamide
  • N-(3,4-dimethylphenyl)-4-keto-4-[N'-(3-nitrobenzoyl)hydrazino]butyramide
  • N-(3,4-dimethylphenyl)-4-[2-(3-nitrophenyl)carbonylhydrazinyl]-4-oxo-butanamide
  • ZINC02134310
  • STK028647
  • MLS000538763
  • N-(3,4-dimethylphenyl)-4-(2-{3-nitrobenzoyl}hydrazino)-4-oxobutanamide
  • SMR000160593
  • AN-329/40760464
  • ARONIS000377

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0035 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.0141 0.1652 0.2367
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0234 0.2989 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0234 0.2989 1
Echinococcus multilocularis smad 0.0049 0.0338 0.0484
Brugia malayi RNA recognition motif domain containing protein 0.0511 0.698 0.698
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0327 0.0468
Schistosoma mansoni hypothetical protein 0.0141 0.1652 0.2367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0426 0.061
Echinococcus multilocularis tar DNA binding protein 0.0511 0.698 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0327 0.0327
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0327 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0153 0.1832 0.4744
Entamoeba histolytica hypothetical protein 0.0109 0.1201 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0327 1
Brugia malayi MH1 domain containing protein 0.0049 0.0338 0.0338
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0234 0.2989 0.4282
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0327 0.1093
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0153 0.1832 1
Entamoeba histolytica hypothetical protein 0.0109 0.1201 1
Schistosoma mansoni tar DNA-binding protein 0.0511 0.698 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0444 0.6017 0.6017
Entamoeba histolytica hypothetical protein 0.0109 0.1201 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0444 0.6017 0.6017
Toxoplasma gondii hypothetical protein 0.008 0.0788 0.2637
Schistosoma mansoni hypothetical protein 0.0141 0.1652 0.2367
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0327 0.0468
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0426 0.0426
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0426 0.061
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0327 0.0468
Schistosoma mansoni smad1 5 8 and 0.0049 0.0338 0.0484
Loa Loa (eye worm) Smad1 0.0049 0.0338 0.0338
Loa Loa (eye worm) transcription factor SMAD2 0.0721 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0141 0.1652 0.1652
Loa Loa (eye worm) hypothetical protein 0.0027 0.0022 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0426 0.061
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4976 0.4976
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0132 0.0442
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0412 0.555 0.7951
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0049 0.0338 0.0484
Leishmania major importin beta-1 subunit, putative 0.0028 0.0037 0.1147
Schistosoma mansoni smad1 5 8 and 0.0049 0.0338 0.0484
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0141 0.1652 0.2367
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0234 0.2989 0.5
Echinococcus granulosus mothers against decapentaplegic 5 0.0049 0.0338 0.0484
Schistosoma mansoni tar DNA-binding protein 0.0511 0.698 1
Schistosoma mansoni hypothetical protein 0.0372 0.4976 0.7128
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0234 0.2989 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0234 0.2989 0.5
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.0338 0.0338
Echinococcus granulosus tar DNA binding protein 0.0511 0.698 1
Brugia malayi TAR-binding protein 0.0511 0.698 0.698
Plasmodium falciparum importin beta, putative 0.0035 0.0132 0.0442
Echinococcus multilocularis Smad4 0.0049 0.0338 0.0484
Brugia malayi Latrophilin receptor protein 2 0.0141 0.1652 0.1652
Schistosoma mansoni importin beta-1 0.0035 0.0132 0.0189
Loa Loa (eye worm) nuclear factor I 0.0027 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0141 0.1652 0.2367
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0327 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0412 0.555 0.7951
Schistosoma mansoni smad1 5 8 and 0.0049 0.0338 0.0484
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0327 0.0468
Loa Loa (eye worm) MH2 domain-containing protein 0.0721 1 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0132 0.0442
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0037 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0141 0.1652 0.2367
Loa Loa (eye worm) RNA binding protein 0.0511 0.698 0.698
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.0327 0.1093
Brugia malayi MH2 domain containing protein 0.0049 0.0338 0.0338
Brugia malayi MH1 domain containing protein 0.0027 0.0022 0.0022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0141 0.1652 0.2367
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.0327 0.1093
Entamoeba histolytica hypothetical protein 0.0028 0.0037 0.0312
Schistosoma mansoni tar DNA-binding protein 0.0511 0.698 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0132 0.4045
Brugia malayi Probable ClpP-like protease 0.0234 0.2989 0.2989
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0153 0.1832 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0327 0.0468
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0426 0.061
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.1201 0.172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0426 0.061
Loa Loa (eye worm) hypothetical protein 0.0304 0.3997 0.3997
Schistosoma mansoni Smad4 0.0049 0.0338 0.0484
Brugia malayi isocitrate dehydrogenase 0.0048 0.0327 0.0327
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0049 0.0338 0.0484
Echinococcus granulosus snurportin 1 0.0372 0.4976 0.7128
Echinococcus granulosus Smad4 0.0049 0.0338 0.0484
Loa Loa (eye worm) latrophilin receptor protein 2 0.0141 0.1652 0.1652
Brugia malayi Smad1 0.0049 0.0338 0.0338
Echinococcus multilocularis GPCR, family 2 0.0141 0.1652 0.2367
Schistosoma mansoni tar DNA-binding protein 0.0511 0.698 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0234 0.2989 1
Brugia malayi MH1 domain containing protein 0.0049 0.0338 0.0338
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0132 0.0189
Entamoeba histolytica hypothetical protein 0.0109 0.1201 1
Echinococcus granulosus GPCR family 2 0.0141 0.1652 0.2367
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0 0.5
Echinococcus granulosus peptidase Clp S14 family 0.0153 0.1832 0.2625
Echinococcus multilocularis peptidase Clp (S14 family) 0.0153 0.1832 0.2625
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.1201 0.172
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0788 0.2637
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0788 0.2637
Brugia malayi RNA binding protein 0.0511 0.698 0.698
Schistosoma mansoni tar DNA-binding protein 0.0511 0.698 1
Schistosoma mansoni hypothetical protein 0.0109 0.1201 0.172
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0234 0.2989 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0327 1
Echinococcus multilocularis snurportin 1 0.0372 0.4976 0.7128
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0234 0.2989 1
Brugia malayi RNA, U transporter 1 0.0099 0.1055 0.1055
Brugia malayi latrophilin 2 splice variant baaae 0.0304 0.3997 0.3997
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.1201 0.172
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0327 0.0468
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0234 0.2989 0.4282
Schistosoma mansoni smad 0.0049 0.0338 0.0484
Echinococcus granulosus importin subunit beta 1 0.0035 0.0132 0.0189
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0234 0.2989 0.5
Loa Loa (eye worm) TAR-binding protein 0.0511 0.698 0.698
Loa Loa (eye worm) hypothetical protein 0.0141 0.1652 0.1652
Schistosoma mansoni hypothetical protein 0.0304 0.3997 0.5726
Echinococcus granulosus smad 0.0049 0.0338 0.0484
Brugia malayi hypothetical protein 0.0109 0.1201 0.1201
Brugia malayi Calcitonin receptor-like protein seb-1 0.0444 0.6017 0.6017
Echinococcus granulosus TGF beta signal transducer SmadC 0.0049 0.0338 0.0484
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0426 0.061
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0141 0.1652 0.2367
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0426 0.061
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0037 1
Brugia malayi MH1 domain containing protein 0.0027 0.0022 0.0022
Schistosoma mansoni peptidase Clp (S14 family) 0.0234 0.2989 0.4282
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0327 0.0468
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0444 0.6017 0.6017
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0234 0.2989 0.5
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0327 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.0338 0.0338
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0037 1
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0327 0.1093
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0132 0.4045
Loa Loa (eye worm) hypothetical protein 0.0234 0.2989 0.2989
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0234 0.2989 0.5
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0327 0.0327
Echinococcus multilocularis mothers against decapentaplegic 5 0.0049 0.0338 0.0484
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0511 0.698 0.698
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0037 0.1147
Brugia malayi MH2 domain containing protein 0.0049 0.0338 0.0338

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8199 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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