Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.1635 | 0.1635 |
Echinococcus multilocularis | neuroligin | 0.0314 | 0.1635 | 0.1635 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.1635 | 0.1635 |
Onchocerca volvulus | 0.0314 | 0.1635 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.1635 | 0.1635 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0314 | 0.1635 | 0.1635 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0233 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.1635 | 0.1635 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0314 | 0.1635 | 0.1635 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0233 | 0.0233 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0314 | 0.1635 | 0.1635 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0233 | 0.0233 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0314 | 0.1635 | 0.1635 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0314 | 0.1635 | 0.1635 |
Brugia malayi | Carboxylesterase family protein | 0.0314 | 0.1635 | 0.1635 |
Schistosoma mansoni | gliotactin | 0.0314 | 0.1635 | 0.1635 |
Onchocerca volvulus | 0.0314 | 0.1635 | 1 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0314 | 0.1635 | 0.1635 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1861 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.1635 | 0.1635 |
Loa Loa (eye worm) | carboxylesterase | 0.0314 | 0.1635 | 0.1635 |
Schistosoma mansoni | acetylcholinesterase | 0.0314 | 0.1635 | 0.1635 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0314 | 0.1635 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0314 | 0.1635 | 0.1635 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0314 | 0.1635 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0314 | 0.1635 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0314 | 0.1635 | 0.1635 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0314 | 0.1635 | 0.5 |
Onchocerca volvulus | 0.0314 | 0.1635 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0314 | 0.1635 | 0.1635 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.1635 | 0.1635 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0314 | 0.1635 | 0.1635 |
Brugia malayi | hypothetical protein | 0.0314 | 0.1635 | 0.1635 |
Loa Loa (eye worm) | carboxylesterase | 0.1861 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0233 | 0.0233 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0314 | 0.1635 | 0.1635 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0233 | 0.0233 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0233 | 0.0233 |
Echinococcus multilocularis | acetylcholinesterase | 0.1861 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0233 | 0.0233 |
Echinococcus granulosus | acetylcholinesterase | 0.1861 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1861 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1861 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1861 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1861 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0314 | 0.1635 | 0.1635 |
Onchocerca volvulus | 0.0314 | 0.1635 | 1 | |
Onchocerca volvulus | 0.0314 | 0.1635 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.1861 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.1635 | 0.1635 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0314 | 0.1635 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0233 | 0.0233 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0314 | 0.1635 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0314 | 0.1635 | 0.1635 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0233 | 0.0233 |
Echinococcus granulosus | neuroligin | 0.0314 | 0.1635 | 0.1635 |
Loa Loa (eye worm) | hypothetical protein | 0.1861 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0314 | 0.1635 | 0.1635 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0314 | 0.1635 | 0.1635 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1861 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1861 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 33.5875 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.