Detailed information for compound 1453161

Basic information

Technical information
  • TDR Targets ID: 1453161
  • Name: 3-(2-fluorophenoxy)-N-methyl-N-(phenylmethyl) propan-1-amine; oxalic acid
  • MW: 363.38 | Formula: C19H22FNO5
  • H donors: 2 H acceptors: 4 LogP: 1.35 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(=O)O.CN(Cc1ccccc1)CCCOc1ccccc1F
  • InChi: 1S/C17H20FNO.C2H2O4/c1-19(14-15-8-3-2-4-9-15)12-7-13-20-17-11-6-5-10-16(17)18;3-1(4)2(5)6/h2-6,8-11H,7,12-14H2,1H3;(H,3,4)(H,5,6)
  • InChiKey: QRMKNAHVZUNQBR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • benzyl-[3-(2-fluorophenoxy)propyl]-methyl-amine; oxalic acid
  • ethanedioic acid; 3-(2-fluorophenoxy)-N-methyl-N-(phenylmethyl)propan-1-amine
  • MLS000974888
  • N-benzyl-3-(2-fluorophenoxy)-N-methyl-1-propanamine oxalate
  • SMR000497592

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0018 0.0032 0.0025
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0228 0.3143
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.0444 0.0437
Entamoeba histolytica tartrate dehydrogenase, putative 0.0036 0.0173 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0444 0.0437
Brugia malayi TAR-binding protein 0.0335 0.2464 0.2459
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.0444 0.0934
Loa Loa (eye worm) MH2 domain-containing protein 0.1196 0.9064 0.9064
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.002 0.0051 0.0108
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0103 0.0442
Brugia malayi MH2 domain containing protein 0.0081 0.0519 0.0513
Echinococcus multilocularis isocitrate dehydrogenase 0.0299 0.2189 0.4608
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0291 0.4744
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.0102
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0256 0.1224
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.025
Schistosoma mansoni growth factor receptor-bound protein 0.0018 0.0032 0.0037
Echinococcus multilocularis RUN 0.0015 0.0007 0.0014
Brugia malayi jmjC domain containing protein 0.0044 0.0231 0.0225
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.0185 0.0389
Brugia malayi isocitrate dehydrogenase 0.0299 0.2189 0.2183
Echinococcus granulosus chromobox protein 1 0.0084 0.054 0.1136
Brugia malayi Variant SH3 domain containing protein 0.0018 0.0032 0.0025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0185 0.0178
Onchocerca volvulus 0.0034 0.0153 0.0734
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0072 0.0444 0.0936
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0417 0.3092 0.3087
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.0185 0.0262
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0299 0.2189 0.4608
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0072 0.0444 0.0643
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.0102
Schistosoma mansoni adapter molecule crk 0.0018 0.0032 0.0037
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0452 0.0446
Brugia malayi hypothetical protein 0.0034 0.0153 0.0147
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0072 0.0444 0.0934
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0291 0.0587
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0228 0.1677
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0417 0.3092 0.651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0072 0.0444 0.0437
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0072 0.0444 0.0934
Brugia malayi beta-lactamase family protein 0.0043 0.0228 0.0221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0444 0.0644
Echinococcus multilocularis Glycosyltransferase protein LARGE1 0.0052 0.0296 0.0622
Brugia malayi AT16019p 0.0018 0.0034 0.0027
Echinococcus multilocularis peregrin 0.0035 0.0164 0.0346
Echinococcus multilocularis smad 0.0081 0.0519 0.1093
Echinococcus multilocularis Glycosyl transferase, family 8 0.007 0.0435 0.0916
Echinococcus multilocularis tar DNA binding protein 0.0335 0.2464 0.5189
Schistosoma mansoni glycosyltransferase-related 0.007 0.0435 0.063
Echinococcus granulosus TGF beta signal transducer SmadC 0.0081 0.0519 0.1093
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0068 0.0418 0.088
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0597 0.0869
Brugia malayi MH1 domain containing protein 0.0045 0.024 0.0233
Loa Loa (eye worm) hypothetical protein 0.0043 0.0228 0.0221
Toxoplasma gondii ABC1 family protein 0.0043 0.0228 0.0598
Loa Loa (eye worm) hypothetical protein 0.0043 0.0228 0.0221
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0036 0.0173 0.0746
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0068 0.0418 0.088
Loa Loa (eye worm) hypothetical protein 0.0038 0.0185 0.0178
Loa Loa (eye worm) MH2 domain-containing protein 0.0081 0.0519 0.0513
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0153 0.0734
Brugia malayi Probable ClpP-like protease 0.0079 0.05 0.0494
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0068 0.0418 0.088
Brugia malayi CXXC zinc finger family protein 0.0023 0.0068 0.0062
Loa Loa (eye worm) hypothetical protein 0.0417 0.3092 0.3087
Schistosoma mansoni isocitrate dehydrogenase 0.0036 0.0173 0.0245
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0228 0.1677
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0072 0.0444 0.0437
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0228 0.048
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0072 0.0444 0.0438
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0284 0.1279
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0336 0.0708
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0164 0.0158
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.05 0.0726
Schistosoma mansoni tyrosine kinase 0.0624 0.4679 0.6876
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0045 0.024 0.0334
Brugia malayi CHD4 protein 0.0015 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0147
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.0153 0.0323
Schistosoma mansoni chromobox protein 0.0084 0.054 0.0784
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0231 0.033
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0147
Loa Loa (eye worm) TAR-binding protein 0.0335 0.2464 0.2459
Trichomonas vaginalis esterase, putative 0.0043 0.0228 0.1011
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0175 0.0247
Echinococcus granulosus lipoxygenase domain containing protein 0.0015 0.0007 0.0014
Brugia malayi Isocitrate dehydrogenase 0.0299 0.2189 0.2183
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0072 0.0444 0.0437
Brugia malayi mothers against decapentaplegic homolog 3 0.0036 0.0174 0.0167
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.05 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0072 0.0444 0.0437
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0028 0.0113 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0072 0.0444 0.0437
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0036 0.0043
Loa Loa (eye worm) hypothetical protein 0.0043 0.0228 0.0221
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0397 0.0391
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.05 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.054 0.1136
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0228 0.0221
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0171
Echinococcus granulosus Polycystic kidney disease protein 0.0015 0.0007 0.0014
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0038 0.0185 0.0178
Schistosoma mansoni hypothetical protein 0.0035 0.0164 0.0232
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0336 0.0485
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0164 0.0232
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0164 0.0346
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0299 0.2189 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.0102
Echinococcus granulosus c src tyrosine kinase 0.002 0.0051 0.0108
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.0153 0.0147
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0336 0.0485
Brugia malayi Glycosyl transferase family 8 protein 0.007 0.0435 0.0429
Brugia malayi Tyrosine-protein kinase abl-1 0.0258 0.1873 0.1868
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0779 0.164
Loa Loa (eye worm) hypothetical protein 0.0038 0.0185 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0072 0.0444 0.0437
Loa Loa (eye worm) RNA binding protein 0.0335 0.2464 0.2459
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0335 0.2464 0.2459
Echinococcus multilocularis conserved hypothetical protein 0.0052 0.0296 0.0622
Onchocerca volvulus 0.005 0.028 0.134
Echinococcus granulosus tyrosine protein kinase Lyn 0.002 0.0051 0.0108
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.0153 0.0323
Leishmania major hypothetical protein, conserved 0.0043 0.0228 0.0272
Loa Loa (eye worm) hypothetical protein 0.0901 0.6803 0.68
Mycobacterium ulcerans lipase LipD 0.0043 0.0228 0.1677
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.0102
Leishmania major hypothetical protein, conserved 0.0126 0.0858 0.34
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0228 0.0221
Loa Loa (eye worm) hypothetical protein 0.0072 0.0444 0.0437
Schistosoma mansoni coup transcription factor 0.0072 0.0444 0.0643
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.05 0.1904
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0164 0.0723
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0228 0.1011
Echinococcus multilocularis ecdysone induced protein 78C 0.0072 0.0444 0.0934
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0228 0.0325
Loa Loa (eye worm) hypothetical protein 0.024 0.1736 0.1731
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0228 0.0272
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0049 0.0274 0.0393
Echinococcus granulosus GPCR family 2 0.0417 0.3092 0.651
Echinococcus granulosus mothers against decapentaplegic 5 0.0081 0.0519 0.1093
Schistosoma mansoni hypothetical protein 0.035 0.258 0.3787
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0397 0.0837
Trichomonas vaginalis chromobox protein, putative 0.0084 0.054 0.2514
Brugia malayi Latrophilin receptor protein 2 0.0417 0.3092 0.3087
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0231 0.033
Loa Loa (eye worm) beta-lactamase 0.0043 0.0228 0.0221
Echinococcus granulosus RUN 0.0015 0.0007 0.0014
Schistosoma mansoni smad1 5 8 and 0.0081 0.0519 0.0754
Loa Loa (eye worm) Smad1 0.0081 0.0519 0.0513
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.027 0.0569
Schistosoma mansoni retinoic acid receptor RXR 0.0072 0.0444 0.0643
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0072 0.0444 0.0437
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.0444 0.0934
Loa Loa (eye worm) hypothetical protein 0.0037 0.0175 0.0168
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0299 0.2189 0.4608
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0072 0.0444 0.0934
Brugia malayi MH1 domain containing protein 0.0081 0.0519 0.0513
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0147
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.0153 0.0323
Loa Loa (eye worm) hypothetical protein 0.0072 0.0444 0.0437
Schistosoma mansoni hypothetical protein 0.0417 0.3092 0.454
Brugia malayi Bromodomain containing protein 0.0035 0.0164 0.0158
Schistosoma mansoni thyroid hormone receptor 0.0072 0.0444 0.0643
Echinococcus multilocularis mothers against decapentaplegic 6 0.0036 0.0174 0.0366
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.05 0.1053
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0072 0.0444 0.0437
Schistosoma mansoni RAR-like nuclear receptor 0.0072 0.0444 0.0643
Mycobacterium tuberculosis Conserved protein 0.0043 0.0228 0.0272
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0036 0.0173 0.0364
Brugia malayi beta-lactamase family protein 0.0043 0.0228 0.0221
Brugia malayi nuclear hormone receptor 0.0034 0.0153 0.0147
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.0153 0.0323
Mycobacterium ulcerans aldehyde dehydrogenase 0.0045 0.024 0.2055
Echinococcus multilocularis mothers against decapentaplegic 5 0.0081 0.0519 0.1093
Plasmodium vivax ataxin-2 like protein, putative 0.0126 0.0858 0.3903
Mycobacterium tuberculosis Conserved protein 0.0043 0.0228 0.0272
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0291 0.0614
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.05 0.5
Loa Loa (eye worm) DR-78 0.0034 0.0153 0.0147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0153 0.0323
Onchocerca volvulus Alhambra homolog 0.0035 0.0164 0.0786
Brugia malayi Probable isocitrate dehydrogenase 0.0036 0.0173 0.0166
Loa Loa (eye worm) steroid hormone receptor 0.0072 0.0444 0.0437
Loa Loa (eye worm) nuclear hormone receptor 0.0485 0.3618 0.3614
Schistosoma mansoni cpg binding protein 0.0024 0.0078 0.0106
Schistosoma mansoni nck2/grb4 0.0018 0.0032 0.0037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0021 0.0014
Brugia malayi MH2 domain containing protein 0.0081 0.0519 0.0513
Toxoplasma gondii aldehyde dehydrogenase 0.0045 0.024 0.0658
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0072 0.0444 0.0437
Schistosoma mansoni hypothetical protein 0.0028 0.0113 0.0156
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0153 0.0323
Trichomonas vaginalis chromobox protein, putative 0.0084 0.054 0.2514
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0147
Loa Loa (eye worm) MH1 domain-containing protein 0.0081 0.0519 0.0513
Loa Loa (eye worm) hypothetical protein 0.0489 0.3649 0.3645
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0336 0.0708
Brugia malayi SET domain containing protein 0.0016 0.0014 0.0007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0175 0.0343
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.0153 0.0147
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0072 0.0444 0.0934
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0228 0.1011
Schistosoma mansoni tyrosine kinase 0.002 0.0051 0.0066
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.0153 0.0147
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0231 0.0225
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0072 0.0444 0.0934
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.002 0.0051 0.0108
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.0153 0.0147
Brugia malayi mbt repeat family protein 0.0058 0.0336 0.033
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0299 0.2189 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0045 0.024 0.0506
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0039 0.0102
Schistosoma mansoni tyrosine kinase 0.002 0.0051 0.0066
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0041 0.0209 0.044
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.028 0.0403
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0072 0.0444 0.212
Echinococcus multilocularis tyrosine protein kinase Fyn 0.002 0.0051 0.0108
Echinococcus granulosus tyrosine protein kinase Src42A 0.002 0.0051 0.0108
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0228 0.0272
Echinococcus multilocularis dnaJ subfamily B 0.0323 0.2374 0.4999
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.0185 0.0389
Brugia malayi Probable isocitrate dehydrogenase 0.0036 0.0173 0.0166
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0103 0.0442
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0336 0.0708
Schistosoma mansoni hypothetical protein 0.0901 0.6803 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0299 0.2189 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0164 0.0294
Brugia malayi hypothetical protein 0.0034 0.0153 0.0147
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0417 0.3092 0.651
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0039 0.0102
Schistosoma mansoni smad 0.0036 0.0174 0.0246
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.002 0.0051 0.0108
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.0153 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0021 0.0014
Schistosoma mansoni transcription factor LCR-F1 0.0028 0.0113 0.0156
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0299 0.2189 0.4608
Mycobacterium ulcerans hypothetical protein 0.0043 0.0228 0.1677
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.0444 0.0934
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.05 1
Onchocerca volvulus 0.0037 0.0178 0.0851
Loa Loa (eye worm) hypothetical protein 0.0066 0.0397 0.0391
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.002 0.0051 0.0108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.0102
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.001 0.0021
Onchocerca volvulus 0.0072 0.0444 0.212
Loa Loa (eye worm) MH2 domain-containing protein 0.0036 0.0174 0.0167
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.05 1
Onchocerca volvulus 0.0023 0.0068 0.0327
Loa Loa (eye worm) hypothetical protein 0.0072 0.0444 0.0437
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0072 0.0444 0.0437
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0147
Schistosoma mansoni nuclear receptor 0.0034 0.0153 0.0216
Loa Loa (eye worm) MH1 domain-containing protein 0.0036 0.0174 0.0167
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0072 0.0444 0.0643
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0153 0.0147
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0336 0.0708
Brugia malayi Tyrosine-protein kinase abl-1 0.0384 0.2838 0.2833
Loa Loa (eye worm) hypothetical protein 0.0058 0.0336 0.033
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.05 0.2262
Schistosoma mansoni tar DNA-binding protein 0.0335 0.2464 0.3616
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0175 0.0247
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0336 0.0485
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0153 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0151 0.0638
Brugia malayi PHD-finger family protein 0.0035 0.0164 0.0158
Schistosoma mansoni cpg binding protein 0.0023 0.0068 0.0091
Echinococcus multilocularis chromobox protein 1 0.0084 0.054 0.1136
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0228 0.0272
Schistosoma mansoni tyrosine kinase 0.002 0.0051 0.0066
Brugia malayi MH2 domain containing protein 0.1196 0.9064 0.9064
Plasmodium vivax SET domain protein, putative 0.0037 0.0175 0.077
Echinococcus multilocularis tyrosine protein kinase Fgr 0.002 0.0051 0.0108
Mycobacterium ulcerans aldehyde dehydrogenase 0.0045 0.024 0.2055
Schistosoma mansoni hypothetical protein 0.0323 0.2374 0.3484
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.0153 0.0147
Schistosoma mansoni hypothetical protein 0.0417 0.3092 0.454
Schistosoma mansoni Smad4 0.0036 0.0174 0.0246
Echinococcus multilocularis c src tyrosine kinase 0.002 0.0051 0.0108
Onchocerca volvulus 0.0043 0.0228 0.1089
Onchocerca volvulus 0.0034 0.0153 0.0734
Loa Loa (eye worm) TK/ABL protein kinase 0.0633 0.4749 0.4746
Schistosoma mansoni growth factor receptor-bound protein 0.0018 0.0032 0.0037
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0523 0.3908 0.8229
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0072 0.0444 0.0437
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0153 0.0323
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.05 0.1904
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0072 0.0444 0.0643
Brugia malayi Steroid receptor seven-up type 2 0.0523 0.3908 0.3904
Echinococcus granulosus mothers against decapentaplegic 2 0.0036 0.0174 0.0366
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.001 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0335 0.2464 0.3616
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0397 0.0837
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0072 0.0444 0.0643
Toxoplasma gondii isocitrate dehydrogenase 0.0299 0.2189 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.002 0.0051 0.0108
Giardia lamblia PHD finger protein 15 0.0035 0.0164 0.5
Schistosoma mansoni chromobox protein 0.0084 0.054 0.0784
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0228 0.048
Loa Loa (eye worm) MBCTL1 0.0066 0.0397 0.0391
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0036 0.0173 0.0166
Echinococcus multilocularis geminin 0.0205 0.1464 0.3083
Brugia malayi mbt repeat family protein 0.0058 0.0336 0.033
Loa Loa (eye worm) hypothetical protein 0.0043 0.0228 0.0221
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0228 0.0272
Echinococcus multilocularis growth factor receptor bound protein 2 0.0018 0.0032 0.0067
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0291 0.0614
Onchocerca volvulus 0.0058 0.0336 0.1607
Loa Loa (eye worm) hypothetical protein 0.0038 0.0185 0.0178
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.001 0.0003
Loa Loa (eye worm) SRC-1 0.002 0.0051 0.0045
Echinococcus granulosus Glycosyl transferase family 8 0.007 0.0435 0.0916
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0072 0.0444 0.0934
Brugia malayi RNA recognition motif domain containing protein 0.0335 0.2464 0.2459
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0153 0.0216
Schistosoma mansoni cpg binding protein 0.0024 0.0078 0.0106
Loa Loa (eye worm) hypothetical protein 0.0043 0.0228 0.0221
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0228 0.0325
Loa Loa (eye worm) hypothetical protein 0.0036 0.0173 0.0166
Loa Loa (eye worm) hypothetical protein 0.0018 0.0032 0.0025
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0081 0.0519 0.1093
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0228 0.0272
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.0068 0.0062
Brugia malayi hypothetical protein 0.0038 0.0185 0.0178
Brugia malayi RNA binding protein 0.0335 0.2464 0.2459
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0228 0.1011
Echinococcus granulosus tyrosine protein kinase Btk29A 0.002 0.0051 0.0108
Onchocerca volvulus 0.0043 0.0228 0.1089
Toxoplasma gondii LsmAD domain-containing protein 0.0126 0.0858 0.3622
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0299 0.2189 0.4608
Echinococcus multilocularis tyrosine protein kinase Src42A 0.002 0.0051 0.0108
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0231 0.0487
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0147
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0185 0.0178
Echinococcus granulosus ecdysone induced protein 78C 0.0072 0.0444 0.0934
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.05 0.2262
Schistosoma mansoni smad1 5 8 and 0.0081 0.0519 0.0754
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.002 0.0051 0.0066
Echinococcus multilocularis Polycystic kidney disease protein 0.0015 0.0007 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0444 0.0644
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0299 0.2189 0.4608
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0018 0.0032 0.0025
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0175 0.0368
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0397 0.0837
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0153 0.0323
Schistosoma mansoni lipoxygenase 0.0041 0.0209 0.0297
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.002 0.0051 0.0108
Echinococcus multilocularis lipoxygenase domain containing protein 0.0015 0.0007 0.0014
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0036 0.0174 0.083
Echinococcus granulosus NCK adaptor protein 0.0018 0.0032 0.0067
Mycobacterium tuberculosis Conserved protein 0.0043 0.0228 0.0272
Loa Loa (eye worm) glycosyl transferase family 8 protein 0.007 0.0435 0.0429
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0036 0.0173 0.0364
Loa Loa (eye worm) hypothetical protein 0.0036 0.0174 0.0167
Echinococcus granulosus tyrosine protein kinase Src64B 0.002 0.0051 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0072 0.0444 0.0437
Schistosoma mansoni smad 0.0081 0.0519 0.0754
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0417 0.3092 0.651
Schistosoma mansoni tyrosine kinase 0.002 0.0051 0.0066
Toxoplasma gondii histone lysine methyltransferase SET1 0.0044 0.0234 0.063
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0164 0.0294
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0299 0.2189 1
Brugia malayi nuclear receptor NHR-88 0.0034 0.0153 0.0147
Loa Loa (eye worm) hypothetical protein 0.0035 0.0164 0.0158
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0046 0.0039
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0185 0.0178
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0153 0.0323
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.0102
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0036 0.0173 0.0166
Brugia malayi tailless protein 0.0034 0.0153 0.0147
Trypanosoma cruzi PAB1-binding protein , putative 0.0126 0.0858 0.3216
Brugia malayi nuclear hormone receptor 0.0072 0.0444 0.0437
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1318 1 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0015 0.0007 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0175 0.0247
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0299 0.2189 1
Schistosoma mansoni tar DNA-binding protein 0.0335 0.2464 0.3616
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.1826 0.182
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0041 0.0209 0.044
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0185 0.0262
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0523 0.3908 0.8229
Brugia malayi steroid hormone receptor 0.0072 0.0444 0.0437
Schistosoma mansoni Smad4 0.0081 0.0519 0.0754
Brugia malayi Heterochromatin protein 1 0.0084 0.054 0.0533
Onchocerca volvulus 0.0015 0.0007 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0444 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0256 0.1147
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.0153 0.0216
Plasmodium falciparum ataxin-2 like protein, putative 0.0126 0.0858 0.3903
Brugia malayi hypothetical protein 0.0081 0.0517 0.051
Brugia malayi Smad1 0.0081 0.0519 0.0513
Echinococcus multilocularis tyrosine protein kinase Src64B 0.002 0.0051 0.0108
Schistosoma mansoni nuclear receptor 0.0034 0.0153 0.0216
Echinococcus granulosus tyrosine protein kinase Fyn 0.002 0.0051 0.0108
Brugia malayi Pre-SET motif family protein 0.0252 0.1826 0.182
Loa Loa (eye worm) nuclear factor I 0.0045 0.024 0.0233
Loa Loa (eye worm) isocitrate dehydrogenase 0.0299 0.2189 0.2183
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.0444 0.0934
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0036 0.0173 0.0364
Echinococcus multilocularis lipoxygenase domain containing protein 0.0015 0.0007 0.0014
Brugia malayi nuclear receptor RXR 0.0038 0.0185 0.0178
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0299 0.2189 0.3211
Echinococcus granulosus tyrosine protein kinase ABL1 0.0633 0.4749 1
Echinococcus multilocularis NCK adaptor protein 0.0018 0.0032 0.0067
Echinococcus multilocularis mothers against decapentaplegic 2 0.0036 0.0174 0.0366
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0072 0.0444 0.0437
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0147
Brugia malayi chromobox protein homolog 3 0.0047 0.0256 0.025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0072 0.0444 0.0936
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0153 0.0323
Loa Loa (eye worm) hypothetical protein 0.0045 0.024 0.0233
Echinococcus granulosus growth factor receptor bound protein 2 0.0018 0.0032 0.0067
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0164 0.0346
Schistosoma mansoni steroid hormone receptor ad4bp 0.0072 0.0444 0.0643
Schistosoma mansoni smad1 5 8 and 0.0081 0.0519 0.0754
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.1635 0.3444
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.1635 0.3444
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0299 0.2189 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0284 0.1355
Echinococcus multilocularis tyrosine protein kinase Fyn 0.002 0.0051 0.0108
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0072 0.0444 0.0936
Brugia malayi MH1 domain containing protein 0.0045 0.024 0.0233
Schistosoma mansoni Smad4 0.0036 0.0174 0.0246
Brugia malayi hypothetical protein 0.0028 0.0113 0.0106
Echinococcus multilocularis FTZ F1 alpha 0.0072 0.0444 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0151 0.0638
Loa Loa (eye worm) hypothetical protein 0.1318 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0072 0.0444 0.0934
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0028 0.0113 0.0237
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0228 0.1011
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0036 0.0173 0.0166
Plasmodium falciparum ataxin-2 like protein, putative 0.0126 0.0858 0.3903
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2025 0.9189
Loa Loa (eye worm) hypothetical protein 0.0072 0.0444 0.0437
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0147
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0633 0.4749 1
Echinococcus multilocularis GPCR, family 2 0.0417 0.3092 0.651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0072 0.0444 0.0437
Echinococcus multilocularis cpg binding protein 0.0024 0.0078 0.0165
Brugia malayi conserved hypotetical protein 0.0034 0.0153 0.0147
Echinococcus multilocularis thyroid hormone receptor alpha 0.0072 0.0444 0.0934
Loa Loa (eye worm) transcription factor SMAD2 0.1196 0.9064 0.9064
Onchocerca volvulus 0.0287 0.2092 1
Echinococcus granulosus dnaJ subfamily B 0.0323 0.2374 0.4999
Brugia malayi photoreceptor-specific nuclear receptor 0.0558 0.4174 0.417
Echinococcus granulosus FTZ F1 alpha 0.0072 0.0444 0.0934
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.0153 0.0216
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0779 0.164
Onchocerca volvulus Bile acid receptor homolog 0.0072 0.0444 0.212
Brugia malayi nuclear receptor NHR-67 0.0034 0.0153 0.0147
Schistosoma mansoni aldehyde dehydrogenase 0.0045 0.024 0.0344
Echinococcus granulosus chromobox protein 1 0.0084 0.054 0.1136
Echinococcus multilocularis Smad4 0.0081 0.0519 0.1093
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.0153 0.0216
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0147
Loa Loa (eye worm) latrophilin receptor protein 2 0.0417 0.3092 0.3087
Onchocerca volvulus 0.0043 0.0228 0.1089
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0397 0.0837
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.05 0.1053
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0336 0.033
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0045 0.024 0.0506
Loa Loa (eye worm) hypothetical protein 0.0072 0.0444 0.0437
Loa Loa (eye worm) hypothetical protein 0.0043 0.0228 0.0221
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0045 0.024 0.0334
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0221 0.0466
Loa Loa (eye worm) hypothetical protein 0.006 0.0357 0.0351
Brugia malayi Calcitonin receptor-like protein seb-1 0.1318 1 1
Schistosoma mansoni nuclear hormone receptor 0.0072 0.0444 0.0643
Echinococcus granulosus smad 0.0081 0.0519 0.1093
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0018 0.0032 0.0037
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0397 0.0575
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0228 0.1011
Brugia malayi MH2 domain containing protein 0.0036 0.0174 0.0167
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0072 0.0444 0.0936
Schistosoma mansoni hypothetical protein 0.0417 0.3092 0.454
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0336 0.1607
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0036 0.0173 0.0364
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0147
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0147
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0291 0.0587
Brugia malayi ecdysteroid receptor 0.0072 0.0444 0.0437
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0072 0.0444 0.0437
Schistosoma mansoni hypothetical protein 0.0417 0.3092 0.454
Brugia malayi nuclear receptor RXR 0.0034 0.0153 0.0147
Brugia malayi Variant SH3 domain containing protein 0.0018 0.0032 0.0025
Brugia malayi MH1 domain containing protein 0.0081 0.0519 0.0513
Schistosoma mansoni zinc finger protein 0.0034 0.0153 0.0216
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.054 0.0533
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0175 0.0368
Toxoplasma gondii isocitrate dehydrogenase 0.0299 0.2189 1
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0036 0.0173 0.0245
Loa Loa (eye worm) hypothetical protein 0.0079 0.05 0.0494
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0417 0.3092 0.651
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0228 0.1014
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0081 0.0519 0.0754
Echinococcus granulosus tar DNA binding protein 0.0335 0.2464 0.5189
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0056 0.0327 0.0688
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.0153 0.0323
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0072 0.0444 0.0643
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.001 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0072 0.0444 0.0437
Schistosoma mansoni thyroid hormone receptor 0.0072 0.0444 0.0643
Onchocerca volvulus 0.0015 0.0007 0.0032
Schistosoma mansoni hypothetical protein 0.0205 0.1464 0.2144
Mycobacterium ulcerans beta-lactamase 0.0043 0.0228 0.1677
Brugia malayi Sex muscle abnormal protein 5 0.0018 0.0032 0.0025
Loa Loa (eye worm) hypothetical protein 0.0072 0.0444 0.0437
Trichomonas vaginalis set domain proteins, putative 0.0287 0.2092 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.002 0.0051 0.0108
Echinococcus granulosus mothers against decapentaplegic 6 0.0036 0.0174 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0072 0.0444 0.0437
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0153 0.0216
Brugia malayi latrophilin 2 splice variant baaae 0.0901 0.6803 0.68
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0284 0.1279
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.05 1
Schistosoma mansoni tar DNA-binding protein 0.0335 0.2464 0.3616
Mycobacterium ulcerans aldehyde dehydrogenase 0.0045 0.024 0.2055
Onchocerca volvulus Protein ultraspiracle homolog 0.0072 0.0444 0.212
Brugia malayi nuclear receptor NHR-88 0.0072 0.0444 0.0437
Loa Loa (eye worm) hypothetical protein 0.0034 0.0153 0.0147
Brugia malayi jmjC domain containing protein 0.0115 0.0779 0.0773
Loa Loa (eye worm) hypothetical protein 0.0558 0.4174 0.417
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.05 1
Brugia malayi ecdysone receptor 0.0034 0.0153 0.0147
Brugia malayi Pre-SET motif family protein 0.0037 0.0175 0.0168
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0153 0.0734
Echinococcus granulosus jumonji domain containing protein 0.0049 0.027 0.0569
Schistosoma mansoni unc-13 (munc13) 0.0036 0.0173 0.0245
Trypanosoma cruzi PAB1-binding protein , putative 0.0126 0.0858 0.3216
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0072 0.0444 0.0643
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0036 0.0173 0.1762
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0027
Echinococcus multilocularis tyrosine protein kinase Abl 0.0258 0.1873 0.3945
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0299 0.2189 1
Brugia malayi beta-lactamase 0.0043 0.0228 0.0221
Brugia malayi SRC-1 0.002 0.0051 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0256 0.1147
Loa Loa (eye worm) hypothetical protein 0.0126 0.0858 0.0852
Schistosoma mansoni aldehyde dehydrogenase 0.0045 0.024 0.0344
Echinococcus granulosus cpg binding protein 0.0024 0.0078 0.0165
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0161 0.0338
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0072 0.0444 0.0438
Echinococcus granulosus tyrosine protein kinase Fyn 0.002 0.0051 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0072 0.0444 0.0437
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0072 0.0444 0.0437
Schistosoma mansoni hypothetical protein 0.0205 0.1464 0.2144
Echinococcus granulosus Glycosyltransferase protein LARGE1 0.0052 0.0296 0.0622
Trypanosoma brucei PAB1-binding protein , putative 0.0126 0.0858 0.3216
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0299 0.2189 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0175 0.0368
Schistosoma mansoni tar DNA-binding protein 0.0335 0.2464 0.3616
Echinococcus granulosus geminin 0.0205 0.1464 0.3083
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0056 0.0327 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0072 0.0444 0.0437
Brugia malayi hypothetical protein 0.0126 0.0858 0.0852
Mycobacterium leprae Probable lipase LipE 0.0043 0.0228 0.3143
Echinococcus granulosus glycosyltransferase protein LARGE2 0.0068 0.0418 0.088
Echinococcus granulosus peregrin 0.0035 0.0164 0.0346
Plasmodium falciparum phd finger protein, putative 0.0035 0.0164 0.0723
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0036 0.0173 0.0166
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0228 0.0272
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0228 0.0272
Brugia malayi hypothetical protein 0.0038 0.0185 0.0178
Echinococcus granulosus Smad4 0.0081 0.0519 0.1093
Echinococcus granulosus tyrosine protein kinase Fyn 0.002 0.0051 0.0108
Schistosoma mansoni hypothetical protein 0.0056 0.0327 0.0471
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.0153 0.0323

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2311 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (binding) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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