TDR Targets

Basic information

Technical information

TDR Targets ID: 1453229
Name: N-(3-chlorophenyl)-5-oxo-6,7-dihydro-1H-[1,2, 4]triazolo[5,1-b]pyrimidine-7-carboxamide
MW: 291.693 | Formula: C12H10ClN5O2
H donors: 2 H acceptors: 4 LogP: 0.89 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1Nc2ncnn2C(C1)C(=O)Nc1cccc(c1)Cl
InChi: 1S/C12H10ClN5O2/c13-7-2-1-3-8(4-7)16-11(20)9-5-10(19)17-12-14-6-15-18(9)12/h1-4,6,9H,5H2,(H,16,20)(H,14,15,17,19)
InChiKey: NWBLLQJYTIBDGU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-chlorophenyl)-5-keto-6,7-dihydro-1H-[1,2,4]triazolo[5,1-b]pyrimidine-7-carboxamide
MLS000719122
SMR000291390
STK210561
BAS 11133250

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	lipase LipD	0.0036	0.0954	0.1231
Onchocerca volvulus		0.0033	0.0776	0.4436
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0105	0.4094	0.5822
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0029	0.0635	0.0635
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0086	0.0086
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.5121	0.7736
Toxoplasma gondii	ABC1 family protein	0.0036	0.0954	0.1231
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0954	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0954	0.0954
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0029	0.0635	0.0903
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0029	0.0635	0.0959
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0037	0.0972	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1026	0.1026
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0029	0.0635	0.0959
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0954	0.0814
Schistosoma mansoni	hypothetical protein	0.0018	0.0093	0.0141
Echinococcus multilocularis	lamin	0.0033	0.0776	0.1104
Echinococcus granulosus	ecdysone induced protein 78C	0.0029	0.0635	0.0903
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0954	0.0814
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0093	0.0132
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0954	0.1231
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0029	0.0635	0.0635
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0029	0.0635	0.0635
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0035	0.0868	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0635	0.0635
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0029	0.0635	0.0959
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0954	0.0954
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0037	0.0972	0.0972
Brugia malayi	TAR-binding protein	0.0128	0.5121	0.5121
Echinococcus multilocularis	musashi	0.0033	0.0776	0.1104
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0029	0.0635	0.0903
Brugia malayi	ecdysteroid receptor	0.0029	0.0635	0.0635
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.016	0.662	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0954	0.1441
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0055	0.1815	0.1519
Schistosoma mansoni	ap endonuclease	0.0019	0.0159	0.024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0029	0.0635	0.0635
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0029	0.0635	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0635	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0056	0.183	0.183
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Onchocerca volvulus		0.0036	0.0954	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0954	1
Onchocerca volvulus		0.0036	0.0954	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0954	0.1441
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0954	0.1231
Brugia malayi	MH2 domain containing protein	0.0086	0.3198	0.3198
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0954	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0954	0.0954
Echinococcus multilocularis	survival motor neuron protein 1	0.017	0.7032	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.183	0.183
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.016	0.662	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0093	0.0141
Brugia malayi	beta-lactamase family protein	0.0036	0.0954	0.0954
Trichomonas vaginalis	esterase, putative	0.0036	0.0954	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0776	0.0776
Loa Loa (eye worm)	hypothetical protein	0.016	0.662	0.662
Brugia malayi	nuclear receptor NHR-88	0.0029	0.0635	0.0635
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0029	0.0635	0.0635
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0159	0.0159
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.016	0.662	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0093	0.0093
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0954	0.0954
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.0972	0.1468
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0105	0.4094	0.4029
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.016	0.662	0.9414
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0954	0.1357
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0029	0.0635	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0635	0.0635
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.5121	0.7736
Loa Loa (eye worm)	TAR-binding protein	0.0128	0.5121	0.5121
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0093	0.0132
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0055	0.1815	0.2563
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0635	0.0635
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0093	0.0132
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.183	0.183
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0776	0.1173
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0093	0.0093
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0159	0.5
Brugia malayi	steroid hormone receptor	0.0029	0.0635	0.0635
Schistosoma mansoni	coup transcription factor	0.0029	0.0635	0.0959
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0029	0.0635	0.0903
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0954	0.1231
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.183	0.183
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0029	0.0635	0.0635
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0954	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0029	0.0635	0.0959
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.016	0.662	0.5
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0029	0.0635	0.0635
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.016	0.662	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0954	0.0954
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0954	0.1231
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.1026	0.1026
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.016	0.662	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.016	0.662	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0159	0.0159
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.0972	0.1468
Echinococcus granulosus	GPCR family 2	0.0018	0.0093	0.0132
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0233	0.9927	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0029	0.0635	0.0903
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0029	0.0635	0.0903
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0954	1
Toxoplasma gondii	hypothetical protein	0.0055	0.1815	0.2563
Schistosoma mansoni	ap endonuclease	0.0019	0.0159	0.024
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0029	0.0635	0.0635
Echinococcus multilocularis	lamin dm0	0.0033	0.0776	0.1104
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0029	0.0635	0.0635
Brugia malayi	beta-lactamase	0.0036	0.0954	0.0954
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0055	0.1815	0.2563
Schistosoma mansoni	hypothetical protein	0.0035	0.0868	0.1312
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0029	0.0635	0.0635
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0235	1	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0159	0.0226
Schistosoma mansoni	lamin	0.0033	0.0776	0.1173
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0776	0.0776
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0105	0.4094	0.4029
Schistosoma mansoni	peptidase Clp (S14 family)	0.016	0.662	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0105	0.4094	0.5542
Schistosoma mansoni	thyroid hormone receptor	0.0029	0.0635	0.0959
Brugia malayi	RNA binding protein	0.0128	0.5121	0.5121
Brugia malayi	photoreceptor-specific nuclear receptor	0.0029	0.0635	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0749	0.0749
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0954	0.0814
Schistosoma mansoni	lamin	0.0033	0.0776	0.1173
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0029	0.0635	0.0635
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.016	0.662	0.9414
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0093	0.0132
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0954	0.0954
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0029	0.0635	0.0635
Brugia malayi	intermediate filament protein	0.0033	0.0776	0.0776
Echinococcus granulosus	FTZ F1 alpha	0.0029	0.0635	0.0903
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0029	0.0635	0.0635
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0029	0.0635	0.0635
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0029	0.0635	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0635	0.0635
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0954	0.0814
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0037	0.0972	0.0972
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0037	0.0972	0.1382
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0093	0.0093
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0954	1
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0954	0.0814
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0635	0.0635
Echinococcus multilocularis	tar DNA binding protein	0.0128	0.5121	0.7283
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0029	0.0635	0.0903
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0954	0.0814
Onchocerca volvulus		0.0035	0.0868	0.7316
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0029	0.0635	0.0903
Echinococcus granulosus	tar DNA binding protein	0.0128	0.5121	0.7283
Loa Loa (eye worm)	transcription factor SMAD2	0.0086	0.3198	0.3198
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0635	0.0635
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0029	0.0635	0.0903
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0029	0.0635	0.0959
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.016	0.662	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0029	0.0635	0.0959
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0029	0.0635	0.0903
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0037	0.0972	0.1382
Brugia malayi	beta-lactamase family protein	0.0036	0.0954	0.0954
Leishmania major	hypothetical protein, conserved	0.0036	0.0954	1
Brugia malayi	hypothetical protein	0.017	0.7032	0.7032
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0029	0.0635	0.0959
Echinococcus granulosus	lamin dm0	0.0033	0.0776	0.1104
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0954	0.0814
Schistosoma mansoni	nuclear hormone receptor	0.0029	0.0635	0.0959
Brugia malayi	nuclear hormone receptor	0.0029	0.0635	0.0635
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0954	0.1357
Schistosoma mansoni	RAR-like nuclear receptor	0.0029	0.0635	0.0959
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0159	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0954	0.1231
Schistosoma mansoni	hypothetical protein	0.0018	0.0093	0.0141
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.5121	0.7736
Loa Loa (eye worm)	MH2 domain-containing protein	0.0086	0.3198	0.3198
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0029	0.0635	0.0903
Loa Loa (eye worm)	steroid hormone receptor	0.0029	0.0635	0.0635
Onchocerca volvulus		0.0033	0.0776	0.4436
Brugia malayi	Probable ClpP-like protease	0.016	0.662	0.662
Echinococcus granulosus	survival motor neuron protein 1	0.017	0.7032	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.016	0.662	1
Echinococcus granulosus	peptidase Clp S14 family	0.0105	0.4094	0.5822
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0093	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0954	0.0954
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0954	0.0954
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0037	0.0972	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0954	0.0954
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.0972	0.1468
Echinococcus granulosus	lamin	0.0033	0.0776	0.1104
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0776	0.0776
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0029	0.0635	0.0903
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0776	0.0776
Echinococcus granulosus	intermediate filament protein	0.0033	0.0776	0.1104
Brugia malayi	RNA recognition motif domain containing protein	0.0128	0.5121	0.5121
Schistosoma mansoni	survival motor neuron protein	0.0035	0.0868	0.1312
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0954	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0954	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0029	0.0635	0.0959
Schistosoma mansoni	thyroid hormone receptor	0.0029	0.0635	0.0959
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0029	0.0635	0.0903
Echinococcus multilocularis	FTZ F1 alpha	0.0029	0.0635	0.0903
Echinococcus multilocularis	ecdysone induced protein 78C	0.0029	0.0635	0.0903
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.5121	0.7736
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0128	0.5121	0.5121
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0029	0.0635	0.0903
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0016	0.0007	0.001
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0029	0.0635	0.0635
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.5121	0.7736
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.016	0.662	1
Loa Loa (eye worm)	RNA binding protein	0.0128	0.5121	0.5121
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0635	0.0635
Onchocerca volvulus		0.0036	0.0954	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0029	0.0635	0.0635
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0954	0.0814
Brugia malayi	Steroid receptor seven-up type 2	0.0029	0.0635	0.0635
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.016	0.662	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0029	0.0635	0.0635
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0159	0.0226
Schistosoma mansoni	hypothetical protein	0.0038	0.1026	0.155
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0055	0.1815	0.2563
Schistosoma mansoni	hypothetical protein	0.0018	0.0093	0.0141
Brugia malayi	Nuclear hormone receptor-like 1	0.0029	0.0635	0.0635
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0029	0.0635	0.0635
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0954	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0954	0.0814
Loa Loa (eye worm)	hypothetical protein	0.017	0.7032	0.7032
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0016	0.0007	0.001

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.02 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.2753 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1583521

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1453229