Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0832 | 0.022 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.7065 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0077 | 0.7065 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.7065 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.7065 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0051 | 0.3352 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.7065 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0832 | 0.022 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0832 | 0.032 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0832 | 0.022 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 1 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0077 | 0.7065 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0832 | 0.032 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.6963 | 0.676 |
Onchocerca volvulus | 0.0033 | 0.0832 | 0.5 | |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0051 | 0.3352 | 0.4744 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.6963 | 0.676 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 1 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.7065 | 1 |
Onchocerca volvulus | 0.0033 | 0.0832 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.5661 | 0.5371 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0832 | 0.022 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.7065 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.0832 | 0.032 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0832 | 0.022 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.7065 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6963 | 0.9841 |
Brugia malayi | RNA binding protein | 0.0076 | 0.6963 | 0.676 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.7065 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0077 | 0.7065 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.7065 | 0.5 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0051 | 0.3352 | 0.4233 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.6963 | 0.676 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0051 | 0.3352 | 0.4233 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.6963 | 0.9841 |
Echinococcus granulosus | lamin | 0.0033 | 0.0832 | 0.032 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0051 | 0.3352 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.7065 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.6963 | 0.676 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0748 | 0.0131 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0832 | 0.032 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.7065 | 0.687 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5661 | 0.5371 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6963 | 0.9841 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6963 | 0.9841 |
Brugia malayi | Probable ClpP-like protease | 0.0077 | 0.7065 | 0.687 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0832 | 0.032 |
Schistosoma mansoni | lamin | 0.0033 | 0.0832 | 0.032 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.6963 | 0.676 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0832 | 0.032 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0832 | 0.032 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.7065 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.5661 | 0.7819 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.6963 | 0.9841 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6963 | 0.9841 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6963 | 0.9841 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0928 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.