TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 231.699 | Formula: C10H16ClN2O2-
H donors: 2 H acceptors: 3 LogP: 2.27 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CCCCCCc1nc[nH]c1.[Cl-]
InChi: 1S/C10H16N2O2.ClH/c13-10(14)6-4-2-1-3-5-9-7-11-8-12-9;/h7-8H,1-6H2,(H,11,12)(H,13,14);1H/p-1
InChiKey: URRMBPXZTPMGFB-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	DNA polymerase eta, putative	0.007	0.1947	0.6755
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.04	0.1304
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0071	0.1981	0.1981
Schistosoma mansoni	adenoreceptor	0.0095	0.2727	0.5287
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0043	0.1106	0.2109
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Echinococcus granulosus	Carboxy terminal domain RNA polymerase II	0.0013	0.0186	0.0306
Brugia malayi	RE15519p	0.0095	0.2727	0.2705
Echinococcus multilocularis	dna polymerase eta	0.0099	0.2868	0.5565
Onchocerca volvulus		0.0095	0.2727	0.1868
Schistosoma mansoni	blooms syndrome DNA helicase	0.002	0.0405	0.0735
Echinococcus multilocularis	g-protein coupled receptor	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0185	0.0545
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0013	0.0186	0.1452
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0095	0.2727	0.5287
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.1981	0.6874
Echinococcus granulosus	peptidase Clp S14 family	0.0055	0.1487	0.2857
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.2727	0.5287
Loa Loa (eye worm)	RecQ helicase	0.0026	0.0574	0.0574
Schistosoma mansoni	biogenic amine receptor	0.0095	0.2727	0.5287
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.2727	0.5287
Trichomonas vaginalis	DNA helicase recq1, putative	0.0026	0.0574	0.5062
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Brugia malayi	sulfakinin receptor protein	0.0095	0.2727	0.2705
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0043	0.1106	0.379
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0691	0.233
Echinococcus granulosus	hypothetical protein	0.0095	0.2727	0.5287
Trichomonas vaginalis	protein disulfide isomerase, putative	0.0008	0.003	0.0003
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.1056	0.2011
Brugia malayi	larval opioid receptor	0.0095	0.2727	0.2705
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.1056	0.0865
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.1056	0.3614
Echinococcus granulosus	g protein coupled receptor	0.0095	0.2727	0.5287
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0055	0.1487	0.4744
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.1056	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0095	0.2727	0.5287
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0095	0.2727	0.5287
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0011	0.0102	0.0141
Brugia malayi	hypothetical protein	0.0095	0.2727	0.2705
Onchocerca volvulus		0.0095	0.2727	0.1868
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0023	0.0477	0.1893
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Mycobacterium leprae	Probable lipase LipE	0.0041	0.1056	0.2231
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0095	0.2727	0.5287
Echinococcus granulosus	orexin receptor type 2	0.0095	0.2727	0.5287
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.2727	0.5287
Brugia malayi	Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1	0.0013	0.0186	0.0156
Onchocerca volvulus		0.0328	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0095	0.2727	0.5287
Brugia malayi	Melatonin receptor type 1A	0.0095	0.2727	0.2705
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.04	0.04
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0017	0.0314	0.1203
Toxoplasma gondii	ABC1 family protein	0.0041	0.1056	0.4347
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0029	0.0673	0.2724
Giardia lamblia	DNA damage repair protein	0.0013	0.0185	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1056	0.1056
Trypanosoma cruzi	DNA damage repair protein, putative	0.0013	0.0185	0.0545
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0095	0.2727	0.5287
Echinococcus multilocularis	somatostatin receptor	0.0095	0.2727	0.5287
Toxoplasma gondii	exonuclease III APE	0.002	0.04	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0013	0.0186	0.0306
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0084	0.2389	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Plasmodium falciparum	DNA repair protein REV1, putative	0.0013	0.0185	0.0656
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0095	0.2727	0.1868
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.04	0.3441
Echinococcus granulosus	neuropeptide receptor	0.0095	0.2727	0.5287
Echinococcus granulosus	transcription factor Dp 1	0.0041	0.105	0.2
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0084	0.2389	0.4626
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0017	0.0308	0.1176
Schistosoma mansoni	neuropeptide receptor	0.0095	0.2727	0.5287
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.04	0.0371
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0095	0.2727	0.5287
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Brugia malayi	hypothetical protein	0.0095	0.2727	0.2705
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Echinococcus multilocularis	neuropeptide receptor A26	0.0095	0.2727	0.5287
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0095	0.2727	0.2705
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Mycobacterium tuberculosis	Conserved protein	0.0041	0.1056	0.0865
Echinococcus multilocularis	g protein coupled receptor	0.0095	0.2727	0.5287
Onchocerca volvulus		0.0095	0.2727	0.1868
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0084	0.2389	1
Echinococcus multilocularis	serotonin receptor	0.0095	0.2727	0.5287
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0071	0.1981	0.3825
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0095	0.2727	0.2727
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.04	0.1897
Plasmodium falciparum	NLI interacting factor-like phosphatase, putative	0.0013	0.0186	0.066
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0013	0.0185	0.0656
Trypanosoma cruzi	DNA damage repair protein, putative	0.0013	0.0185	0.0545
Schistosoma mansoni	growth hormone secretagogue receptor	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Loa Loa (eye worm)	G-protein coupled receptor	0.0095	0.2727	0.2727
Trichomonas vaginalis	DNA polymerase eta, putative	0.0043	0.1106	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.013	0.3817	0.3817
Echinococcus multilocularis	transcription factor Dp 1	0.0041	0.105	0.2
Leishmania major	DNA polymerase eta, putative	0.0099	0.2868	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Loa Loa (eye worm)	hypothetical protein	0.0084	0.2389	0.2389
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.04	0.3443
Schistosoma mansoni	neuropeptide F-like receptor	0.0095	0.2727	0.5287
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0095	0.2727	0.2705
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.1056	0.3614
Brugia malayi	hypothetical protein	0.0095	0.2727	0.2705
Echinococcus granulosus	g-protein coupled receptor	0.0095	0.2727	0.5287
Brugia malayi	Serotonin receptor	0.0095	0.2727	0.2705
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Leishmania major	hypothetical protein, conserved	0.0041	0.1056	0.3614
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.1056	0.3614
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0095	0.2727	0.5287
Schistosoma mansoni	hypothetical protein	0.0095	0.2727	0.5287
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0095	0.2727	0.5287
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0095	0.2727	0.2727
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0071	0.1981	0.6874
Brugia malayi	G-protein coupled receptor	0.0095	0.2727	0.2705
Echinococcus multilocularis	neuropeptides capa receptor	0.0095	0.2727	0.5287
Mycobacterium ulcerans	hypothetical protein	0.0041	0.1056	0.3951
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.04	0.1569
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2868	0.2868
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0084	0.2389	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0084	0.2389	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0095	0.2727	0.2727
Brugia malayi	Bloom's syndrome protein homolog	0.0026	0.0574	0.0546
Onchocerca volvulus		0.0095	0.2727	0.1868
Onchocerca volvulus		0.0095	0.2727	0.1868
Schistosoma mansoni	DNA helicase recq1	0.0011	0.0102	0.0141
Trypanosoma brucei	hypothetical protein, conserved	0.0013	0.0185	0.0545
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.2727	0.5287
Echinococcus granulosus	sex peptide receptor	0.0095	0.2727	0.5287
Trichomonas vaginalis	esterase, putative	0.0041	0.1056	0.9536
Brugia malayi	Dopamine receptor protein 1	0.0095	0.2727	0.2705
Echinococcus multilocularis	Carboxy terminal domain RNA polymerase II	0.0013	0.0186	0.0306
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0055	0.1487	0.1433
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.1056	0.0865
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Echinococcus granulosus	geminin	0.0172	0.513	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.2727	0.5287
Loa Loa (eye worm)	G-protein coupled receptor	0.0095	0.2727	0.2727
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Trypanosoma cruzi	DNA polymerase eta, putative	0.0099	0.2868	1
Echinococcus granulosus	g protein coupled receptor	0.0095	0.2727	0.5287
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0095	0.2727	0.5287
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0095	0.2727	0.5287
Brugia malayi	beta-lactamase	0.0041	0.1056	0.1029
Brugia malayi	ORL1-like opioid receptor	0.0095	0.2727	0.2705
Schistosoma mansoni	amine GPCR	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Trichomonas vaginalis	dullard protein, putative	0.0013	0.0186	0.1452
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.2727	0.5287
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0095	0.2727	0.2705
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Echinococcus granulosus	neuropeptide FF receptor 2	0.0095	0.2727	0.5287
Echinococcus granulosus	bloom syndrome protein	0.0026	0.0574	0.1067
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.1056	0.2011
Schistosoma mansoni	opsin-like receptor	0.0095	0.2727	0.5287
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0055	0.1487	0.2857
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1056	0.1056
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Mycobacterium ulcerans	lipase LipD	0.0041	0.1056	0.3951
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0095	0.2727	0.2705
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0095	0.2727	0.5287
Echinococcus multilocularis	dna polymerase kappa	0.0043	0.1106	0.2109
Schistosoma mansoni	opsin-like receptor	0.0095	0.2727	0.5287
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0095	0.2727	0.5287
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.02	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Brugia malayi	hypothetical protein	0.0095	0.2727	0.2705
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.1056	0.4347
Trichomonas vaginalis	protein disulfide isomerase, putative	0.0008	0.003	0.0003
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.1056	0.2011
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0043	0.1106	0.1106
Echinococcus multilocularis	orexin receptor type 2	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1056	0.1056
Echinococcus multilocularis	serotonin receptor	0.0095	0.2727	0.5287
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.04	0.0726
Echinococcus multilocularis	neuropeptide s receptor	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Brugia malayi	hypothetical protein	0.0095	0.2727	0.2705
Schistosoma mansoni	DNA polymerase IV / kappa	0.0013	0.0185	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0102	0.0102
Giardia lamblia	DINP protein human, muc B family	0.0043	0.1106	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0095	0.2727	0.5287
Brugia malayi	Dopamine receptor	0.0095	0.2727	0.2705
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Echinococcus granulosus	g protein coupled receptor	0.0095	0.2727	0.5287
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0186	0.0186
Onchocerca volvulus		0.0095	0.2727	0.1868
Onchocerca volvulus		0.0095	0.2727	0.1868
Trypanosoma brucei	hypothetical protein, conserved	0.0013	0.0185	0.0545
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.1056	0.0865
Schistosoma mansoni	neuropeptide receptor	0.0095	0.2727	0.5287
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Brugia malayi	neuropeptide F receptor	0.0095	0.2727	0.2705
Brugia malayi	beta-lactamase family protein	0.0041	0.1056	0.1029
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.1056	0.9536
Brugia malayi	neuropeptide F receptor	0.0095	0.2727	0.2705
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0043	0.1106	0.093
Leishmania major	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.1056	0.3951
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0013	0.0186	0.1452
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.007	0.1947	0.8126
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0071	0.1981	0.3825
Echinococcus granulosus	tm gpcr rhodopsin	0.0095	0.2727	0.5287
Brugia malayi	Dopamine receptor protein 2	0.0095	0.2727	0.2705
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0043	0.1106	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0095	0.2727	0.5287
Echinococcus granulosus	neuropeptides capa receptor	0.0095	0.2727	0.5287
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0043	0.1106	0.093
Schistosoma mansoni	amine GPCR	0.0095	0.2727	0.5287
Echinococcus granulosus	dna polymerase eta	0.0099	0.2868	0.5565
Loa Loa (eye worm)	neuropeptide F receptor	0.0095	0.2727	0.2727
Brugia malayi	hypothetical protein	0.0095	0.2727	0.2705
Schistosoma mansoni	ap endonuclease	0.002	0.04	0.0726
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.1056	0.0865
Echinococcus granulosus	7tm_1 domain containing protein	0.0095	0.2727	0.5287
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0011	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Toxoplasma gondii	hypothetical protein	0.0029	0.0673	0.2724
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0095	0.2727	0.5287
Echinococcus granulosus	allatostatin A receptor	0.0095	0.2727	0.5287
Schistosoma mansoni	neuropeptide receptor	0.0095	0.2727	0.5287
Trichomonas vaginalis	dullard protein, putative	0.0013	0.0186	0.1452
Schistosoma mansoni	hypothetical protein	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1056	0.1056
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.1056	0.1056
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Brugia malayi	G protein-coupled receptor	0.0095	0.2727	0.2705
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0084	0.2389	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0095	0.2727	0.5287
Mycobacterium ulcerans	beta-lactamase	0.0041	0.1056	0.3951
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0043	0.1106	0.2109
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.04	0.0726
Echinococcus granulosus	fmrfamide receptor	0.0095	0.2727	0.5287
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0084	0.2389	0.5
Trypanosoma brucei	Mitochondrial import inner membrane translocase subunit TIM50	0.0013	0.0186	0.0549
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0691	0.233
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0095	0.2727	0.2705
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0095	0.2727	0.5287
Echinococcus multilocularis	fmrfamide receptor	0.0095	0.2727	0.5287
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0013	0.0186	0.1452
Trypanosoma brucei	DNA polymerase eta, putative	0.0099	0.2868	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0095	0.2727	0.5287
Loa Loa (eye worm)	beta-lactamase	0.0041	0.1056	0.1056
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0095	0.2727	0.5287
Onchocerca volvulus		0.0095	0.2727	0.1868
Brugia malayi	beta-lactamase family protein	0.0041	0.1056	0.1029
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0011	0.0102	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0084	0.2389	0.4626
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Loa Loa (eye worm)	TYRA-2 protein	0.0095	0.2727	0.2727
Brugia malayi	G-protein coupled receptor	0.0095	0.2727	0.2705
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.1056	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Echinococcus granulosus	CTD small phosphatase protein like	0.0013	0.0186	0.0306
Schistosoma mansoni	hypothetical protein	0.0172	0.513	1
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.02	0.0598
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0102	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Echinococcus multilocularis		0.0013	0.0186	0.0306
Schistosoma mansoni	biogenic amine receptor	0.0095	0.2727	0.5287
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0102	0.0306
Trichomonas vaginalis	DNA helicase recq, putative	0.0014	0.02	0.1581
Brugia malayi	putative neuropeptide receptor	0.0095	0.2727	0.2705
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0095	0.2727	0.1868
Trypanosoma brucei	unspecified product	0.0043	0.1106	0.379
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Echinococcus granulosus	somatostatin receptor	0.0095	0.2727	0.5287
Loa Loa (eye worm)	transglutaminase	0.0008	0.003	0.003
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.04	0.3443
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.04	0.1304
Brugia malayi	hypothetical protein	0.0095	0.2727	0.2705
Echinococcus granulosus	serotonin receptor	0.0095	0.2727	0.5287
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0071	0.1981	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0102	0.0072
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.1056	0.0865
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Onchocerca volvulus		0.0095	0.2727	0.1868
Trichomonas vaginalis	protein disulfide isomerase, putative	0.0008	0.003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0185	0.0185
Trypanosoma cruzi	hypothetical protein, conserved	0.0013	0.0186	0.0549
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0095	0.2727	0.5287
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0043	0.1106	0.5513
Echinococcus granulosus	7TM GPCR rhodopsin	0.0095	0.2727	0.5287
Schistosoma mansoni	neuropeptide receptor	0.0095	0.2727	0.5287
Trypanosoma brucei	chrX additional, unordered contigs	0.0013	0.0185	0.0545
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.1056	0.9536
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0084	0.2389	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0095	0.2727	0.5287
Loa Loa (eye worm)	protein disulfide isomerase	0.0008	0.003	0.003
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.1056	0.3951
Onchocerca volvulus		0.0095	0.2727	0.1868
Echinococcus multilocularis	dro:myosuppressin receptor	0.0095	0.2727	0.5287
Schistosoma mansoni	hypothetical protein	0.0013	0.0181	0.0295
Schistosoma mansoni	hypothetical protein	0.0095	0.2727	0.5287
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0013	0.0186	0.1452
Trypanosoma brucei	DNA polymerase IV, putative	0.0043	0.1106	0.379
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Trichomonas vaginalis	DNA helicase recq, putative	0.0026	0.0574	0.5062
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0084	0.2389	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.1056	0.1029
Echinococcus multilocularis	neuropeptide Y receptor	0.0095	0.2727	0.5287
Echinococcus granulosus	G protein coupled receptor 139	0.0095	0.2727	0.5287
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1056	0.1056
Brugia malayi	hypothetical protein	0.0095	0.2727	0.2705
Echinococcus granulosus	biogenic amine 5HT receptor	0.0095	0.2727	0.5287
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0043	0.1106	0.2109
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1056	0.1056
Brugia malayi	follicle stimulating hormone receptor	0.0095	0.2727	0.2705
Echinococcus multilocularis	geminin	0.0172	0.513	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.04	0.1304
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.04	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.1056	0.2231
Echinococcus granulosus	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Echinococcus granulosus	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Schistosoma mansoni	neuropeptide f receptor 76f	0.0095	0.2727	0.5287
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0095	0.2727	0.2705
Echinococcus granulosus	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0011	0.0102	0.0141
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0095	0.2727	0.5287
Onchocerca volvulus		0.0095	0.2727	0.1868
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0264	0.7982	1
Echinococcus granulosus	neuropeptides capa receptor	0.0095	0.2727	0.5287
Echinococcus multilocularis	neuropeptide receptor	0.0095	0.2727	0.5287
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0011	0.0102	0.0306
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.1056	0.9536
Schistosoma mansoni	DNA helicase recq5	0.0011	0.0102	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Trypanosoma brucei	DNA damage repair protein, putative	0.0013	0.0185	0.0545
Echinococcus granulosus	tm gpcr rhodopsin	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0181	0.0181
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0029	0.0673	0.2724
Echinococcus multilocularis	neuropeptides capa receptor	0.0095	0.2727	0.5287
Trypanosoma brucei	unspecified product	0.003	0.0691	0.233
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0084	0.2389	1
Echinococcus multilocularis	g protein coupled receptor	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Echinococcus multilocularis	allatostatin A receptor	0.0095	0.2727	0.5287
Onchocerca volvulus		0.0095	0.2727	0.1868
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0095	0.2727	0.5287
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0043	0.1106	0.2109
Trypanosoma cruzi	DNA polymerase eta, putative	0.007	0.1947	0.6755
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0095	0.2727	0.5287
Echinococcus granulosus	neuropeptide s receptor	0.0095	0.2727	0.5287
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0095	0.2727	0.5287
Echinococcus granulosus	neuropeptide Y receptor	0.0095	0.2727	0.5287
Echinococcus granulosus	biogenic amine 5HT receptor	0.0095	0.2727	0.5287
Onchocerca volvulus		0.0095	0.2727	0.1868
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0084	0.2389	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0084	0.2389	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.1056	0.2011
Trypanosoma brucei	DNA polymerase IV, putative	0.0043	0.1106	0.379
Echinococcus granulosus	dro:myosuppressin receptor	0.0095	0.2727	0.5287
Brugia malayi	AKH receptor	0.0095	0.2727	0.2705
Echinococcus multilocularis	sex peptide receptor	0.0095	0.2727	0.5287
Brugia malayi	G protein-coupled receptor F59B2.13	0.0095	0.2727	0.2705
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.04	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0095	0.2727	0.2727
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Loa Loa (eye worm)	neuropeptide F receptor	0.0095	0.2727	0.2727
Brugia malayi	polk-prov protein	0.0013	0.0185	0.0155
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0095	0.2727	0.5287
Schistosoma mansoni	peptidase Clp (S14 family)	0.0084	0.2389	0.4626
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.02	0.0598
Entamoeba histolytica	recQ family helicase, putative	0.0014	0.02	0.087
Giardia lamblia	Nuclear LIM interactor-interacting factor 1	0.0013	0.0186	0.1449
Trypanosoma brucei	DNA polymerase IV, putative	0.0043	0.1106	0.379
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0095	0.2727	0.5287
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0095	0.2727	0.5287
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0095	0.2727	0.5287
Loa Loa (eye worm)	melatonin receptor type 1A	0.0095	0.2727	0.2727
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.2727	0.5287
Schistosoma mansoni	hypothetical protein	0.0172	0.513	1
Brugia malayi	Serotonin receptor	0.0095	0.2727	0.2705
Schistosoma mansoni	opsin-like receptor	0.0095	0.2727	0.5287
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0095	0.2727	0.5287
Onchocerca volvulus		0.0095	0.2727	0.1868
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0095	0.2727	0.5287
Trypanosoma brucei	unspecified product	0.003	0.0691	0.233
Mycobacterium ulcerans	DNA polymerase IV	0.0043	0.1106	0.4177
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Schistosoma mansoni	DNA polymerase eta	0.0099	0.2868	0.5565
Echinococcus granulosus	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Brugia malayi	ImpB/MucB/SamB family protein	0.0099	0.2868	0.2847
Plasmodium vivax	DNA repair protein REV1, putative	0.0013	0.0185	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Brugia malayi	hypothetical protein	0.0095	0.2727	0.2705
Schistosoma mansoni	histamine h1 receptor	0.0095	0.2727	0.5287
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0029	0.0673	0.137
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0013	0.0186	0.0306
Brugia malayi	GnHR receptor homolog	0.0095	0.2727	0.2705
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0011	0.0102	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Echinococcus granulosus	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.04	0.1304
Brugia malayi	ImpB/MucB/SamB family protein	0.0043	0.1106	0.1079
Schistosoma mansoni	biogenic amine receptor	0.0095	0.2727	0.5287
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Echinococcus multilocularis	bloom syndrome protein	0.0026	0.0574	0.1067
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.1056	0.9536
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0095	0.2727	0.5287
Echinococcus granulosus	dna polymerase kappa	0.0043	0.1106	0.2109
Loa Loa (eye worm)	hypothetical protein	0.0328	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0095	0.2727	0.5287
Schistosoma mansoni	amine GPCR	0.0095	0.2727	0.5287
Schistosoma mansoni	hypothetical protein	0.0095	0.2727	0.5287
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0071	0.1981	0.1957
Entamoeba histolytica	NLI interacting factor-like phosphatase domain-containing protein	0.0013	0.0186	0.0799
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0095	0.2727	0.5287
Echinococcus multilocularis	neuropeptide receptor	0.0095	0.2727	0.5287
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0102	0.0072
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0071	0.1981	0.3825
Onchocerca volvulus		0.0095	0.2727	0.1868
Trichomonas vaginalis	dullard protein, putative	0.0013	0.0186	0.1452
Mycobacterium ulcerans	DNA polymerase IV	0.0043	0.1106	0.4177
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Brugia malayi	Probable ClpP-like protease	0.0084	0.2389	0.2366
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Schistosoma mansoni	amine GPCR	0.0095	0.2727	0.5287
Brugia malayi	hypothetical protein	0.0095	0.2727	0.2705
Schistosoma mansoni	neuropeptide F-like receptor	0.0095	0.2727	0.5287
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0095	0.2727	0.2727
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	0.0013	0.0186	0.066
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0691	0.233
Schistosoma mansoni	ap endonuclease	0.002	0.04	0.0726
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	0.0013	0.0186	0.066
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.1981	0.6874
Onchocerca volvulus		0.0095	0.2727	0.1868
Echinococcus granulosus	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Leishmania major	DNA damage repair protein, putative	0.0013	0.0185	0.0545
Trypanosoma cruzi	hypothetical protein, conserved	0.0013	0.0185	0.0545
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0095	0.2727	0.5287
Giardia lamblia	Sgs1 DNA helicase, putative	0.0011	0.0102	0.0671
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.2727	0.5287
Mycobacterium tuberculosis	Conserved protein	0.0041	0.1056	0.0865
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.2727	0.5287
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.1981	0.6874
Echinococcus granulosus	neuropeptide receptor	0.0095	0.2727	0.5287
Mycobacterium tuberculosis	Conserved protein	0.0041	0.1056	0.0865
Onchocerca volvulus		0.0095	0.2727	0.1868
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0055	0.1487	0.1433
Trypanosoma brucei	DNA damage repair protein, putative	0.0013	0.0185	0.0545
Leishmania major	DNA polymerase kappa, putative	0.0013	0.0185	0.0545
Leishmania major	hypothetical protein, conserved	0.0013	0.0186	0.0549
Schistosoma mansoni	amine GPCR	0.0095	0.2727	0.5287
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0095	0.2727	0.5287
Trypanosoma cruzi	hypothetical protein, conserved	0.0013	0.0185	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2727	0.2727
Echinococcus multilocularis	neuropeptide Y receptor	0.0095	0.2727	0.5287
Echinococcus multilocularis	g protein coupled receptor	0.0095	0.2727	0.5287
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0185	0.0545
Toxoplasma gondii	Dullard family phosphatase domain-containing protein	0.0013	0.0186	0.066
Echinococcus multilocularis	fmrfamide receptor	0.0095	0.2727	0.5287
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0095	0.2727	0.5287
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.1056	0.9536
Echinococcus granulosus	neuropeptide Y receptor	0.0095	0.2727	0.5287
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0013	0.0185	0.0656
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0095	0.2727	0.5287
Brugia malayi	putative neuropeptide receptor NPR1	0.0095	0.2727	0.2705
Schistosoma mansoni	myosin xvIII	0.0095	0.2727	0.5287
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.1106	0.379
Loa Loa (eye worm)	Pdia4 protein	0.0008	0.003	0.003

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 20000 nM	Inhibitory activity against human thromboxane synthetase	ChEMBL.	7199088

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 115463

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 14536