Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.9658 | 0.9658 |
Schistosoma mansoni | lamin | 0.0028 | 1 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 1 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.1333 | 0.1333 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 1 | 0.5 | |
Echinococcus multilocularis | musashi | 0.0028 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0342 | 0.0342 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 1 | 0.5 | |
Schistosoma mansoni | lamin | 0.0028 | 1 | 0.5 |
Echinococcus multilocularis | lamin | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.