TDR Targets

Basic information

Technical information

TDR Targets ID: 1453689
Name: N-[2-(tert-butylamino)-1-furan-2-yl-2-oxoethy l]-5-(morpholin-4-ylmethyl)-N-phenylfuran-2-c arboxamide
MW: 465.541 | Formula: C26H31N3O5
H donors: 1 H acceptors: 2 LogP: 2.96 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(N(C(=O)c1ccc(o1)CN1CCOCC1)c1ccccc1)c1ccco1)NC(C)(C)C
InChi: 1S/C26H31N3O5/c1-26(2,3)27-24(30)23(21-10-7-15-33-21)29(19-8-5-4-6-9-19)25(31)22-12-11-20(34-22)18-28-13-16-32-17-14-28/h4-12,15,23H,13-14,16-18H2,1-3H3,(H,27,30)
InChiKey: AFYQIALDFZHPAZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(tert-butylamino)-1-(2-furyl)-2-oxo-ethyl]-5-(morpholinomethyl)-N-phenyl-furan-2-carboxamide
N-[2-(tert-butylamino)-1-(2-furyl)-2-oxoethyl]-5-(morpholinomethyl)-N-phenyl-2-furancarboxamide
N-[2-(tert-butylamino)-1-(2-furyl)-2-keto-ethyl]-5-(morpholinomethyl)-N-phenyl-2-furamide
N-[2-(tert-butylamino)-1-furan-2-yl-2-oxo-ethyl]-5-(morpholin-4-ylmethyl)-N-phenyl-furan-2-carboxamide
SMR000002679
5-Morpholin-4-ylmethyl-furan-2-carboxylic acid (tert-butylcarbamoyl-furan-2-yl-methyl)-phenyl-amide
MLS000889509
ASN 03859921
MLS000030267

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania braziliensis	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma congolense	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	IPR015063,Domain of unknown function DUF1873,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Leishmania donovani	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei gambiense	ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium parvum	ubiquitin C-terminal hydrolase of the cysteine proteinase fold	Get druggable targets OG5_127431	All targets in OG5_127431
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus multilocularis	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania infantum	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium hominis	ubiquitin specific protease 66	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus granulosus	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	ubiquitin-specific protease	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	ubiquitin specific protease, putative	ubiquitin specific peptidase 2	362 aa	378 aa	25.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	endoplasmin	0.0045	0.0152	0.0801
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.131	0.1237
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0082	0.0338	0.1028
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0017	0.0015	0.0047
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0146	0.0063
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0083	0.0025
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0137	0.0612	0.9401
Plasmodium falciparum	endoplasmin, putative	0.0033	0.0091	0.0032
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0083	0.0254
Echinococcus multilocularis	FTZ F1 alpha	0.0017	0.0015	0.0047
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0146	0.0063
Onchocerca volvulus		0.0031	0.0083	0.0368
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0015	0.0047
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0083	0.0025
Trypanosoma brucei	oxidoreductase-like protein	0.0145	0.0649	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0137	0.0612	0.0533
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0083	0.0254
Trichomonas vaginalis	heat shock protein, putative	0.0033	0.0091	0.0032
Mycobacterium ulcerans	short chain dehydrogenase	0.0137	0.0612	0.0533
Loa Loa (eye worm)	hypothetical protein	0.035	0.1669	0.8789
Trichomonas vaginalis	aldo/keto reductase, putative	0.0031	0.0083	0.0025
Onchocerca volvulus		0.0031	0.0083	0.0368
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0083	0.0025
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0061	0.0274
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0083	0.044
Echinococcus multilocularis	ecdysone induced protein 78C	0.0017	0.0015	0.0047
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0015	0.0047
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0083	0.0254
Onchocerca volvulus		0.0137	0.0612	0.3169
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0.0152	0.9901
Echinococcus multilocularis	carbonyl reductase 1	0.002	0.0029	0.009
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.2026	1	1
Echinococcus granulosus	tar DNA binding protein	0.0076	0.031	0.0944
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0017	0.0015	0.0082
Schistosoma mansoni	dihydropteridine reductase	0.0137	0.0612	0.1863
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0015	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0767
Toxoplasma gondii	heat shock protein 75, putative	0.003	0.0077	0.0011
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0137	0.0612	0.0533
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0048	0.0167	0.2311
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0045	0.0152	1
Echinococcus multilocularis	jun protein	0.0082	0.0338	0.1028
Trichomonas vaginalis	heat shock protein, putative	0.0045	0.0152	0.0094
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0137	0.0612	0.0533
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0146	0.1962
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0083	0.0025
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0137	0.0612	0.0533
Brugia malayi	bHLH-PAS transcription factor	0.0136	0.0607	0.3595
Trypanosoma brucei	heat shock protein, putative	0.0045	0.0152	0.1307
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0028	0.0067	0.0707
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0146	0.0791
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0048	0.0167	0.0109
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.003	0.0077	0.0236
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0146	0.0087
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0031	0.0083	0.0283
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0137	0.0612	0.0533
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0083	0.0413
Echinococcus granulosus	neuroglian	0.0015	0.0002	0.0007
Echinococcus multilocularis	microtubule associated protein 2	0.0675	0.3283	1
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0031	0.0083	0.0045
Onchocerca volvulus		0.0396	0.1899	1
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0049	0.0175	0.0534
Onchocerca volvulus		0.0031	0.0083	0.0368
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0145	0.0649	0.057
Wolbachia endosymbiont of Brugia malayi	acyl carrier protein	0.0051	0.0182	0.0044
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0152	0.2056
Mycobacterium leprae	POSSIBLE OXIDOREDUCTASE	0.0137	0.0612	0.0575
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0017	0.0015	0.0082
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0137	0.0612	0.0533
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0083	0.0254
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0109	0.0331
Trypanosoma cruzi	heat shock protein, putative	0.003	0.0077	0.0873
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0348	0.1661	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0017	0.0015	0.0047
Schistosoma mansoni	aryl hydrocarbon receptor	0.0534	0.2585	0.7874
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0152	0.0798
Echinococcus multilocularis	carbonyl reductase 1	0.0028	0.0067	0.0204
Schistosoma mansoni	hypothetical protein	0.0071	0.0283	0.0863
Trypanosoma brucei	heat shock protein, putative	0.0045	0.0152	0.1307
Trypanosoma cruzi	heat shock protein 90, putative	0.0045	0.0152	0.2066
Entamoeba histolytica	aldose reductase, putative	0.0031	0.0083	0.0113
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0017	0.0015	0.0047
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0.0152	0.1452
Echinococcus granulosus	endoplasmin	0.0042	0.0139	0.0422
Trypanosoma cruzi	heat shock protein 85, putative	0.0045	0.0152	0.2066
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0083	0.0254
Mycobacterium leprae	3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI	0.0137	0.0612	0.0575
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.0102	0.0311
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0146	0.0444
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0038	0.012	0.5319
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0083	0.0254
Brugia malayi	bZIP transcription factor family protein	0.0082	0.0338	0.1957
Schistosoma mansoni	coup transcription factor	0.0017	0.0015	0.0047
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0109	0.0331
Trypanosoma brucei	aldo-keto reductase, putative	0.0031	0.0083	0.0105
Schistosoma mansoni	hypothetical protein	0.0166	0.0753	0.2294
Onchocerca volvulus		0.0043	0.0146	0.0697
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0167	0.0109
Leishmania major	oxidoreductase-like protein	0.0145	0.0649	1
Echinococcus granulosus	aldehyde reductase	0.0022	0.0039	0.0118
Echinococcus granulosus	FTZ F1 alpha	0.0017	0.0015	0.0047
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0146	0.0063
Trypanosoma brucei	heat shock protein, putative	0.0045	0.0152	0.1307
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.051	0.2683
Entamoeba histolytica	hypothetical protein	0.0071	0.0283	0.3857
Loa Loa (eye worm)	steroid hormone receptor	0.0017	0.0015	0.0082
Echinococcus multilocularis	heat shock protein	0.0045	0.0152	0.0464
Mycobacterium ulcerans	short chain dehydrogenase	0.0137	0.0612	0.0533
Echinococcus granulosus	twitchin	0.0015	0.0002	0.0007
Toxoplasma gondii	heat shock protein HSP90	0.0045	0.0152	0.0086
Leishmania major	aldo-keto reductase-like protein	0.0031	0.0083	0.0283
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0061	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0015	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0572
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0017	0.0015	0.0047
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0137	0.0612	0.322
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.0137	0.0612	0.0533
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0146	0.0063
Trypanosoma cruzi	aldo/keto reductase, putative	0.0031	0.0083	0.0969
Echinococcus multilocularis	lamin	0.0026	0.0061	0.0185
Loa Loa (eye worm)	acyl carrier protein	0.0051	0.0182	0.0959
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0137	0.0612	0.0533
Echinococcus granulosus	PP-binding domain containing protein	0.0037	0.0115	0.035
Echinococcus multilocularis	neuroglian	0.0015	0.0002	0.0007
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0048	0.0167	0.2311
Mycobacterium ulcerans	short chain dehydrogenase	0.0137	0.0612	0.0533
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0015	0.0047
Echinococcus granulosus	aldo keto reductase	0.0031	0.0083	0.0254
Entamoeba histolytica	heat shock protein 90, putative	0.0045	0.0152	0.1399
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0188	0.0865	0.4555
Onchocerca volvulus		0.0036	0.0109	0.0502
Trypanosoma brucei	heat shock protein, putative	0.0045	0.0152	0.1307
Mycobacterium tuberculosis	Probable oxidoreductase	0.0145	0.0649	0.057
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.051	0.2683
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0152	0.0093
Echinococcus granulosus	lamin	0.0026	0.0061	0.0185
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0152	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0396	0.1899	1
Chlamydia trachomatis	oxoacy-ACP reductase	0.0137	0.0612	0.0437
Echinococcus multilocularis	lamin dm0	0.0026	0.0061	0.0185
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0072	0.0287	0.0875
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0083	0.0254
Echinococcus multilocularis	roundabout 2	0.0018	0.0021	0.0064
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0137	0.0612	0.0556
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0083	0.044
Onchocerca volvulus		0.0043	0.0146	0.0697
Schistosoma mansoni	heat shock protein	0.003	0.0077	0.0236
Echinococcus multilocularis	heat shock protein 90	0.0045	0.0152	0.0464
Brugia malayi	Hsp90 protein	0.003	0.0077	0.0377
Plasmodium falciparum	enoyl-acyl carrier reductase	0.2026	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0767
Onchocerca volvulus		0.0138	0.0615	0.3188
Schistosoma mansoni	jun-related protein	0.0067	0.0261	0.0796
Mycobacterium tuberculosis	Meromycolate extension acyl carrier protein AcpM	0.0051	0.0182	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0767
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0.0152	0.1386
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0015	0.0047
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0137	0.0612	0.0533
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0146	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0015	0.0082
Trichomonas vaginalis	aldo/keto reductase, putative	0.0031	0.0083	0.0025
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Echinococcus granulosus	heat shock protein 90	0.0045	0.0152	0.0464
Brugia malayi	hypothetical protein	0.0064	0.025	0.1425
Mycobacterium tuberculosis	Possible oxidoreductase	0.0137	0.0612	0.0533
Schistosoma mansoni	aldo-keto reductase	0.0031	0.0083	0.0254
Schistosoma mansoni	nephrin	0.0015	0.0002	0.0007
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0137	0.0612	1
Echinococcus multilocularis	endoplasmin	0.0042	0.0139	0.0422
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0137	0.0612	0.048
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0015	0.0082
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0146	0.0087
Onchocerca volvulus		0.0031	0.0083	0.0368
Trichomonas vaginalis	heat shock protein, putative	0.0042	0.0139	0.008
Echinococcus granulosus	heat shock protein 90	0.0038	0.012	0.0366
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0083	0.0025
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.031	0.0944
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0015	0.0082
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.003	0.0077	0.0336
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0152	0.1295
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0137	0.0612	0.0533
Trypanosoma brucei	heat shock protein 90, putative	0.0045	0.0152	0.1307
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0083	0.0254
Mycobacterium ulcerans	short chain dehydrogenase	0.0145	0.0649	0.057
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0137	0.0612	0.322
Trypanosoma brucei	heat shock protein 90, putative	0.0045	0.0152	0.1307
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0137	0.0612	0.0533
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0152	0.0462
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.0137	0.0612	0.0533
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0146	0.1962
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0083	0.0025
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0083	0.0025
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0048	0.0167	0.2311
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0146	0.0087
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0017	0.0015	0.0047
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0083	0.0254
Echinococcus granulosus	netrin receptor unc 5	0.0018	0.0018	0.0056
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0049	0.0175	0.0924
Echinococcus multilocularis	netrin receptor unc 5	0.0018	0.0018	0.0056
Trichomonas vaginalis	heat shock protein, putative	0.0038	0.012	0.0061
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0017	0.0015	0.0007
Trichomonas vaginalis	guanylate cyclase, putative	0.0048	0.0167	0.0109
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.2026	1	1
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0083	0.0254
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0137	0.0612	0.9355
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0006	0.0019
Trypanosoma brucei	heat shock protein, putative	0.0045	0.0152	0.1307
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0083	0.0025
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.031	0.1631
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0137	0.0612	0.0533
Mycobacterium tuberculosis	Possible oxidoreductase	0.0137	0.0612	0.0533
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0146	0.0767
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0137	0.0612	0.0533
Toxoplasma gondii	aldose reductase, putative	0.0031	0.0083	0.0017
Mycobacterium ulcerans	short chain dehydrogenase	0.0137	0.0612	0.0533
Schistosoma mansoni	carbonyl reductase	0.0028	0.0067	0.0204
Echinococcus granulosus	acyl carrier protein mitochondrial	0.0051	0.0182	0.0555
Plasmodium falciparum	acyl carrier protein	0.0051	0.0182	0.0124
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0137	0.0612	0.1863
Schistosoma mansoni	microtubule-associated protein tau	0.0675	0.3283	1
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0028	0.0067	0.0707
Mycobacterium ulcerans	acyl carrier protein	0.0051	0.0182	0.0099
Brugia malayi	Pre-SET motif family protein	0.0251	0.1179	0.7068
Onchocerca volvulus		0.0017	0.0015	0.0007
Schistosoma mansoni	carbonyl reductase	0.002	0.0029	0.009
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.2026	1	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0137	0.0612	0.0533
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0048	0.0167	0.0109
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0137	0.0612	0.0533
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0398	0.1907	0.581
Brugia malayi	hypothetical protein	0.0048	0.0167	0.0924
Entamoeba histolytica	hypothetical protein	0.0071	0.0283	0.3857
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0767
Brugia malayi	heat shock protein 90	0.0045	0.0152	0.0831
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0146	0.0444
Mycobacterium leprae	Possible regulatory protein	0.0048	0.0167	0.0129
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0146	0.0107
Mycobacterium ulcerans	heat shock protein 90	0.0042	0.0139	0.0056
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0045	0.0152	0.0462
Trypanosoma cruzi	heat shock protein 90, putative	0.0038	0.012	0.1553
Plasmodium vivax	heat shock protein 86, putative	0.0045	0.0152	0.0075
Echinococcus multilocularis	ubiquitin specific protease 41	0.0045	0.0152	0.0462
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.2026	1	1
Brugia malayi	MH2 domain containing protein	0.0117	0.051	0.3002
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0083	0.0025
Brugia malayi	beta-lactamase family protein	0.0043	0.0146	0.0791
Echinococcus granulosus	jun protein	0.0082	0.0338	0.1028
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0137	0.0612	0.9355
Plasmodium vivax	heat shock protein, putative	0.017	0.0773	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0058	0.0306
Loa Loa (eye worm)	heat shock protein 75	0.003	0.0077	0.0408
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0109	0.0331
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Echinococcus multilocularis	carbonyl reductase 1	0.0028	0.0067	0.0204
Mycobacterium ulcerans	short chain dehydrogenase	0.0137	0.0612	0.0533
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0083	0.0025
Leishmania major	prostaglandin f synthase, putative	0.0031	0.0083	0.0283
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0137	0.0612	0.3622
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.031	0.0944
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0048	0.0167	0.0109
Schistosoma mansoni	netrin receptor unc5	0.0018	0.0018	0.0056
Onchocerca volvulus		0.0021	0.0034	0.0107
Trypanosoma brucei	Heat shock protein 83, putative	0.0045	0.0152	0.1307
Schistosoma mansoni	single-minded	0.0184	0.0845	0.2575
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0083	0.0254
Schistosoma mansoni	endoplasmin	0.0045	0.0152	0.0464
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Echinococcus granulosus	geminin	0.0166	0.0753	0.2294
Onchocerca volvulus		0.0026	0.0061	0.0246
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0048	0.0167	0.2311
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0033
Echinococcus multilocularis	transfer RNA-Lys	0.0136	0.0607	0.185
Echinococcus granulosus	aryl hydrocarbon receptor	0.0398	0.1907	0.581
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0031	0.0083	0.0025
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.031	0.0944
Echinococcus multilocularis	carbonyl reductase 1	0.002	0.0029	0.009
Echinococcus granulosus	carbonyl reductase 1	0.0028	0.0067	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0767
Mycobacterium ulcerans	short chain dehydrogenase	0.0137	0.0612	0.0533
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0146	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0061	0.0319
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0145	0.0649	0.0586
Giardia lamblia	Grp94/Hsp90	0.0042	0.0139	0.801
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0152	0.2056
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.1179	0.6206
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0017	0.0015	0.0047
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0109	0.0042
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0083	0.0254
Entamoeba histolytica	heat shock protein 90, putative	0.0045	0.0152	0.1399
Schistosoma mansoni	acyl carrier protein	0.0051	0.0182	0.0555
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Trichomonas vaginalis	esterase, putative	0.0043	0.0146	0.0087
Trypanosoma cruzi	heat shock protein 85, putative	0.0038	0.012	0.1553
Trypanosoma cruzi	aldo-keto reductase	0.0031	0.0083	0.0969
Trichomonas vaginalis	adenylate cyclase, putative	0.0048	0.0167	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0021	0.0111
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0152	0.0462
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.0283	0.0863
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0146	0.0063
Schistosoma mansoni	heat shock protein	0.0045	0.0152	0.0464
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0061	0.0319
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0083	0.044
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0137	0.0612	0.9401
Plasmodium vivax	endoplasmin, putative	0.0045	0.0152	0.0075
Trichomonas vaginalis	aldo/keto reductase, putative	0.0031	0.0083	0.0025
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0137	0.0612	0.0533
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0031	0.0083	0.0025
Schistosoma mansoni	RAR-like nuclear receptor	0.0017	0.0015	0.0047
Echinococcus multilocularis	aldehyde reductase	0.0022	0.0039	0.0118
Onchocerca volvulus	Protein ultraspiracle homolog	0.0017	0.0015	0.0007
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0072	0.0287	0.0875
Trichomonas vaginalis	heat shock protein, putative	0.0042	0.0139	0.008
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0137	0.0612	0.0533
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0083	0.0254
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0083	0.0254
Schistosoma mansoni	heat shock protein	0.0045	0.0152	0.0464
Schistosoma mansoni	pol-related	0.0031	0.0083	0.0254
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0017	0.0015	0.0047
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0146	0.0063
Brugia malayi	intermediate filament protein	0.0026	0.0061	0.0274
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0137	0.0612	0.1863
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.2026	1	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0017	0.0015	0.0047
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0109	0.0331
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0054	0.02	0.0018
Treponema pallidum	acyl carrier protein	0.0051	0.0182	1
Echinococcus multilocularis	heat shock protein 90	0.0038	0.012	0.0366
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.0283	0.0863
Leishmania major	hypothetical protein, conserved	0.0043	0.0146	0.1351
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0048	0.0167	0.2311
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0083	0.0413
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.0152	0.0826
Schistosoma mansoni	endoplasmin	0.0045	0.0152	0.0464
Mycobacterium ulcerans	short chain dehydrogenase	0.0137	0.0612	0.0533
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0137	0.0612	0.9355
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Onchocerca volvulus		0.0145	0.0649	0.3368
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0083	0.044
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0145	0.0649	0.057
Trypanosoma brucei	heat shock protein, putative	0.0045	0.0152	0.1307
Brugia malayi	beta-lactamase	0.0043	0.0146	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0015	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0767
Brugia malayi	beta-lactamase family protein	0.0043	0.0146	0.0791
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0146	0.0063
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0083	0.0254
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0137	0.0612	0.0533
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0146	0.1193
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0083	0.0254
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0152	0.0462
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.2026	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0145	0.0649	0.057
Trypanosoma brucei	heat shock protein, putative	0.0045	0.0152	0.1307
Trypanosoma cruzi	Acyl carrier protein, mitochondrial, putative	0.0051	0.0182	0.2544
Onchocerca volvulus	Bile acid receptor homolog	0.0017	0.0015	0.0007
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0017	0.0015	0.0082
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.031	0.1631
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0137	0.0612	0.0548
Echinococcus multilocularis	Acyl carrier protein, mitochondrial	0.0051	0.0182	0.0555
Schistosoma mansoni	lamin	0.0026	0.0061	0.0185
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Brugia malayi	Pre-SET motif family protein	0.0036	0.0109	0.0567
Plasmodium falciparum	heat shock protein 90, putative	0.017	0.0773	0.0719
Trichomonas vaginalis	guanylate cyclase, putative	0.0048	0.0167	0.0109
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0048	0.0167	0.0109
Mycobacterium ulcerans	short chain dehydrogenase	0.0137	0.0612	0.0533
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0083	0.044
Schistosoma mansoni	cell adhesion molecule	0.0015	0.0006	0.0019
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0188	0.0865	0.5162
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0152	0.0462
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0031	0.0083	0.0025
Entamoeba histolytica	aldose reductase, putative	0.0031	0.0083	0.0113
Schistosoma mansoni	thyroid hormone receptor	0.0017	0.0015	0.0047
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0152	0.0093
Mycobacterium ulcerans	short chain dehydrogenase	0.0137	0.0612	0.0533
Onchocerca volvulus		0.0064	0.025	0.1251
Echinococcus granulosus	aldo keto reductase	0.0031	0.0083	0.0254
Echinococcus granulosus	single minded 2	0.0136	0.0607	0.185
Leishmania major	pteridine reductase 1	0.0145	0.0649	1
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Loa Loa (eye worm)	hypothetical protein	0.008	0.0326	0.1719
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0042	0.0139	0.0056
Brugia malayi	acyl carrier protein, mitochondrial precursor, putative	0.0051	0.0182	0.1012
Schistosoma mansoni	thyroid hormone receptor	0.0017	0.0015	0.0047
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0146	0.0087
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0042	0.0139	0.01
Entamoeba histolytica	aldose reductase, putative	0.0031	0.0083	0.0113
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0083	0.0254
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Loa Loa (eye worm)	RNA binding protein	0.0076	0.031	0.1631
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.003	0.0077	0.0236
Brugia malayi	RNA binding protein	0.0076	0.031	0.1788
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0137	0.0612	0.0548
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0146	0.0107
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0146	0.0063
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.0109	0.0331
Onchocerca volvulus		0.0031	0.0083	0.0368
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0017	0.0015	0.0082
Brugia malayi	Endoplasmin precursor	0.0045	0.0152	0.0831
Echinococcus granulosus	microtubule associated protein 2	0.0675	0.3283	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0137	0.0612	0.0533
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0083	0.0025
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0146	0.0444
Trichomonas vaginalis	endoplasmin, putative	0.0033	0.0091	0.0032
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0017	0.0015	0.0047
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0017	0.0015	0.0047
Trypanosoma brucei	Acyl carrier protein, mitochondrial	0.0051	0.0182	0.1831
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0109	0.0331
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0137	0.0612	0.3622
Trypanosoma brucei	prostaglandin f synthase	0.0031	0.0083	0.0105
Leishmania major	protein kinase, putative	0.0048	0.0167	0.1726
Brugia malayi	hypothetical protein	0.0071	0.0283	0.1628
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0083	0.0254
Toxoplasma gondii	heat shock protein 90, putative	0.0045	0.0152	0.0086
Echinococcus granulosus	ecdysone induced protein 78C	0.0017	0.0015	0.0047
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0015	0.0047
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0083	0.0254
Leishmania major	acyl carrier protein, putative	0.0051	0.0182	0.1977
Onchocerca volvulus		0.0286	0.1352	0.7097
Echinococcus granulosus	carbonyl reductase 1	0.002	0.0029	0.009
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0017	0.0015	0.0047
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0031	0.0083	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0612	0.322
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0018	0.0017
Schistosoma mansoni	lamin	0.0026	0.0061	0.0185
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0017	0.0015	0.0082
Echinococcus granulosus	PP-binding domain containing protein	0.0037	0.0115	0.035
Schistosoma mansoni	hypothetical protein	0.0166	0.0753	0.2294
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.0283	0.0863
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0145	0.0649	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0045	0.0152	0.2066
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0083	0.0025
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0083	0.0254
Plasmodium falciparum	heat shock protein 90	0.0045	0.0152	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0021	0.0111
Echinococcus granulosus	hypothetical protein	0.0031	0.0083	0.0254
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0038	0.012	0.0366
Mycobacterium ulcerans	short chain dehydrogenase	0.0137	0.0612	0.0533
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0017	0.0015	0.0082
Entamoeba histolytica	hypothetical protein	0.0071	0.0283	0.3857
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0017	0.0015	0.0047
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0048	0.0167	0.0109
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0061	0.0185
Echinococcus granulosus	carbonyl reductase 1	0.0028	0.0067	0.0204
Leishmania major	protein kinase, putative	0.0048	0.0167	0.1726
Onchocerca volvulus		0.0031	0.0083	0.0368
Echinococcus multilocularis	musashi	0.0026	0.0061	0.0185
Plasmodium vivax	acyl carrier protein, putative	0.0051	0.0182	0.0105
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0146	0.0069
Echinococcus granulosus	lamin dm0	0.0026	0.0061	0.0185
Loa Loa (eye worm)	oxidoreductase	0.0137	0.0612	0.322
Echinococcus granulosus	aldo keto reductase	0.0031	0.0083	0.0254
Onchocerca volvulus		0.0173	0.0788	0.4106
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0017	0.0015	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0015	0.0082
Trichomonas vaginalis	hypothetical protein	0.2026	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0017	0.0015	0.0047
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0083	0.0254
Toxoplasma gondii	acyl carrier protein ACP	0.0051	0.0182	0.0116
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0167	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0167	0.0109
Mycobacterium ulcerans	short chain dehydrogenase	0.0137	0.0612	0.0533
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0048	0.0167	0.1726
Schistosoma mansoni	aldo-keto reductase	0.0031	0.0083	0.0254
Brugia malayi	TAR-binding protein	0.0076	0.031	0.1788
Schistosoma mansoni	carbonyl reductase	0.0028	0.0067	0.0204
Echinococcus multilocularis	carbonyl reductase 1	0.0028	0.0067	0.0204
Mycobacterium leprae	MEROMYCOLATE EXTENSION ACYL CARRIER PROTEIN ACPM	0.0037	0.0115	0.0076
Trypanosoma brucei	pteridine reductase 1	0.0137	0.0612	0.9343
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0146	0.0063
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0109	0.0331
Echinococcus multilocularis	geminin	0.0166	0.0753	0.2294
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.031	0.0944
Toxoplasma gondii	Hsp90 domain-containing protein	0.017	0.0773	0.0711
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0137	0.0612	0.0538
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Plasmodium vivax	SET domain protein, putative	0.0036	0.0109	0.0032
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0146	0.0444
Onchocerca volvulus	Tyrosine kinase homolog	0.0176	0.0803	0.4185
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.031	0.0944
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0082	0.0338	0.1028
Onchocerca volvulus		0.0043	0.0146	0.0697
Echinococcus granulosus	carbonyl reductase 1	0.0028	0.0067	0.0204
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0146	0.0767
Leishmania major	heat shock protein, putative	0.003	0.0077	0.0179
Mycobacterium ulcerans	putative regulatory protein	0.0136	0.0607	0.0528
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0137	0.0612	0.1863
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0042	0.0139	0.1228
Schistosoma mansoni	hypothetical protein	0.0067	0.0261	0.0796
Trypanosoma brucei	heat shock protein, putative	0.0045	0.0152	0.1307
Loa Loa (eye worm)	heat shock protein 90	0.0045	0.0152	0.0801
Brugia malayi	PAS domain containing protein	0.0184	0.0845	0.5041
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0045	0.0152	0.0462
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0083	0.0413
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0083	0.0254
Leishmania major	heat shock protein 83-1	0.0045	0.0152	0.1463
Entamoeba histolytica	hypothetical protein	0.0071	0.0283	0.3857
Echinococcus granulosus	ubiquitin specific protease 41	0.0045	0.0152	0.0462
Mycobacterium ulcerans	lipase LipD	0.0043	0.0146	0.0063
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0083	0.0254
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0146	0.0063
Echinococcus granulosus	roundabout 2	0.0018	0.0021	0.0064
Echinococcus granulosus	carbonyl reductase 1	0.0028	0.0067	0.0204
Mycobacterium ulcerans	oxidoreductase	0.0137	0.0612	0.0533
Onchocerca volvulus		0.0026	0.0061	0.0246
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.031	0.0944
Loa Loa (eye worm)	hypothetical protein	0.0348	0.1661	0.8747
Trypanosoma cruzi	heat shock protein 85, putative	0.0045	0.0152	0.2066
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0083	0.0413
Echinococcus granulosus	intermediate filament protein	0.0026	0.0061	0.0185
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0083	0.0254
Schistosoma mansoni	carbonyl reductase	0.0028	0.0067	0.0204
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0083	0.044
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.1351	0.13
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0167	0.0882
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0017	0.0015	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0015	0.0082
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.031	0.1788
Toxoplasma gondii	ABC1 family protein	0.0043	0.0146	0.0079
Echinococcus granulosus	heat shock protein	0.0045	0.0152	0.0464
Echinococcus multilocularis	carbonyl reductase 1	0.0028	0.0067	0.0204
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0017	0.0015	0.0047
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0049	0.0175	0.0534
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0146	0.0063
Onchocerca volvulus		0.0028	0.0067	0.028
Trypanosoma cruzi	Heat shock protein 83, putative	0.0045	0.0152	0.2066
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0146	0.0087
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0137	0.0612	0.9343
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0017	0.0015	0.0047
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0017	0.0015	0.0047
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0028	0.0067	0.0313
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0048	0.0167	0.2311
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0017	0.0015	0.0082
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0146	0.0063

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	6.5733 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1583272

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1453689