Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | transcription factor BTF3, putative | 0.0159 | 1 | 0.5 |
Loa Loa (eye worm) | ICD-1 protein | 0.0159 | 1 | 1 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0159 | 1 | 0.5 |
Toxoplasma gondii | NAC domain-containing protein | 0.0159 | 1 | 0.5 |
Schistosoma mansoni | transcription factor btf3 | 0.0159 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.9002 | 0.9002 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0159 | 1 | 0.5 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0159 | 1 | 0.5 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0159 | 1 | 0.5 |
Echinococcus granulosus | transcription factor btf3 | 0.0159 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0159 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0159 | 1 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.9002 | 0.9002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0159 | 1 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.9002 | 0.9002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0159 | 1 | 0.5 |
Echinococcus multilocularis | transcription factor btf3 | 0.0159 | 1 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0159 | 1 | 0.5 |
Leishmania major | basic transcription factor 3a, putative | 0.0159 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.2589 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 70.7946 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.