Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | pyruvate kinase, muscle | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyruvate kinase | pyruvate kinase, muscle | 605 aa | 521 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.1692 | 0.1692 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.2291 | 0.2291 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0032 | 0.1263 | 0.3981 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1402 | 0.1402 |
Echinococcus granulosus | pyruvate kinase | 0.0021 | 0.0617 | 0.1943 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.1263 | 0.3981 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.004 | 0.1692 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0028 | 0.1024 | 0.5 |
Giardia lamblia | Pyruvate kinase | 0.004 | 0.1692 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0371 | 0.0371 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 0.1692 | 0.5334 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0028 | 0.1024 | 0.1024 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.3173 | 0.3173 |
Brugia malayi | Isocitrate dehydrogenase | 0.0032 | 0.1263 | 0.1263 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.1227 | 0.3866 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 0.1692 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 0.1692 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0371 | 0.1169 |
Plasmodium vivax | pyruvate kinase, putative | 0.004 | 0.1692 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0371 | 0.1169 |
Leishmania major | pyruvate kinase | 0.004 | 0.1692 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0021 | 0.0617 | 0.1943 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3173 | 1 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.004 | 0.1692 | 0.1692 |
Mycobacterium ulcerans | pyruvate kinase | 0.004 | 0.1692 | 0.5 |
Plasmodium falciparum | pyruvate kinase | 0.004 | 0.1692 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 0.1692 | 0.5334 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0371 | 0.0371 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.3173 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0032 | 0.1263 | 0.601 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 0.1692 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1402 | 0.1402 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.1263 | 0.3981 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.1692 | 0.1692 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1402 | 0.4419 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.004 | 0.1692 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.1263 | 0.7464 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2291 | 0.2291 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.1263 | 0.3981 |
Echinococcus granulosus | pyruvate kinase | 0.0021 | 0.0617 | 0.1943 |
Schistosoma mansoni | pyruvate kinase | 0.0021 | 0.0617 | 0.1943 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.3173 | 0.3173 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.1692 | 0.1692 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.3173 | 0.3173 |
Trypanosoma brucei | pyruvate kinase 1 | 0.004 | 0.1692 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0371 | 0.0371 |
Brugia malayi | RNA binding protein | 0.0067 | 0.3173 | 0.3173 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3173 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.004 | 0.1692 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0032 | 0.1263 | 0.3981 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 0.1692 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0371 | 0.1169 |
Leishmania major | pyruvate kinase | 0.004 | 0.1692 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.2291 | 0.2291 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.1692 | 0.1692 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.1263 | 0.7464 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.2291 | 0.2291 |
Brugia malayi | isocitrate dehydrogenase | 0.0032 | 0.1263 | 0.1263 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1024 | 0.1024 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0021 | 0.0617 | 0.1943 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0371 | 0.1169 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.004 | 0.1692 | 0.1692 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1692 | 0.1692 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.004 | 0.1692 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.1692 | 0.1692 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0032 | 0.1263 | 0.3981 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.1692 | 0.5334 |
Echinococcus granulosus | pyruvate kinase | 0.004 | 0.1692 | 0.5334 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0371 | 0.0371 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0371 | 0.1169 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0371 | 0.1169 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0021 | 0.0617 | 0.3644 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.0012 | 0.0151 | 0.0151 |
Chlamydia trachomatis | pyruvate kinase | 0.004 | 0.1692 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.1692 | 0.1692 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.3173 | 0.3173 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.3173 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3173 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3173 | 1 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.3173 | 0.3173 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0032 | 0.1263 | 0.1263 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0371 | 0.1169 |
Echinococcus granulosus | pyruvate kinase | 0.004 | 0.1692 | 0.5334 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0371 | 0.1169 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0371 | 0.1169 |
Echinococcus granulosus | pyruvate kinase | 0.0021 | 0.0617 | 0.1943 |
Echinococcus multilocularis | pyruvate kinase | 0.0021 | 0.0617 | 0.1943 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0371 | 0.1169 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.1263 | 0.3981 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0032 | 0.1263 | 0.601 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.1692 | 0.5334 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3173 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.