Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2927 | 0.7211 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0793 | 0.1953 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.03 | 0.0739 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.03 | 0.0739 |
Onchocerca volvulus | 0.0043 | 0.0793 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.2927 | 0.7211 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4059 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0793 | 0.1953 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.4059 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4059 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0043 | 0.0793 | 0.0793 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0043 | 0.0793 | 0.0793 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0793 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0793 | 0.1953 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0793 | 0.1953 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.4059 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0793 | 0.1953 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0793 | 0.1953 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0793 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0793 | 0.1953 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0793 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0043 | 0.0793 | 0.0793 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0793 | 0.1953 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.4059 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0793 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0793 | 0.1953 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.03 | 0.0739 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.4059 | 1 |
Onchocerca volvulus | 0.0043 | 0.0793 | 0.5 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0793 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0793 | 0.1953 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0043 | 0.0793 | 0.0793 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0793 | 0.0793 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.03 | 0.0739 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0793 | 0.1953 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0793 | 0.1953 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1711 | 0.4215 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0043 | 0.0793 | 0.0793 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0793 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.03 | 0.0739 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0043 | 0.0793 | 0.0793 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0793 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.03 | 0.0739 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.2927 | 0.7211 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0793 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0793 | 0.0793 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0793 | 1 |
Onchocerca volvulus | 0.0043 | 0.0793 | 0.5 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0793 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.03 | 0.0739 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.03 | 0.0739 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.03 | 0.0739 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0793 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0793 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0793 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.4059 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.03 | 0.0739 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.1711 | 0.4215 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0793 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.4059 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4059 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4059 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4059 | 1 |
Brugia malayi | RNA binding protein | 0.0127 | 0.4059 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0793 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0793 | 0.1953 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0793 | 0.0793 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0793 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.03 | 0.0739 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0793 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1711 | 0.4215 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0043 | 0.0793 | 0.0793 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.2927 | 0.7211 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0793 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.03 | 0.0739 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.4059 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.03 | 0.0739 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.03 | 0.0739 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0793 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0793 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0793 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0793 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.