Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0072 | 0.0137 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.3135 | 0.5938 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0052 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0072 | 0.0076 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0174 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0174 | 0.0183 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0072 | 0.0072 |
Onchocerca volvulus | 0.0052 | 0 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0072 | 0.0171 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0174 | 0.0174 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0515 | 0.95 | 0.95 |
Echinococcus granulosus | geminin | 0.0205 | 0.3135 | 0.743 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0072 | 0.0137 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0072 | 0.0137 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0174 | 0.0174 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.3135 | 0.5938 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0072 | 0.0171 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.3135 | 0.5938 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0515 | 0.95 | 0.95 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0072 | 0.0137 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0258 | 0.4219 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0258 | 0.4219 | 0.7992 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0309 | 0.528 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0072 | 0.0137 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0258 | 0.4219 | 0.7992 |
Loa Loa (eye worm) | hypothetical protein | 0.0512 | 0.944 | 0.9937 |
Schistosoma mansoni | thyroid hormone receptor | 0.0309 | 0.528 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0309 | 0.528 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.4635 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0515 | 0.95 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.