Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.256 | 0.2431 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0134 | 0.256 | 0.2431 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0236 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0289 | 0.6556 | 0.6611 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0236 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0265 | 0.5951 | 0.5951 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.6556 | 0.6473 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0265 | 0.5951 | 0.5853 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0485 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0485 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.256 | 0.2431 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0422 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0134 | 0.256 | 0.256 |
Schistosoma mansoni | tar DNA-binding protein | 0.0415 | 0.9797 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0485 | 0.0255 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0236 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0236 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.256 | 0.2431 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.6272 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0236 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0415 | 0.9797 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0415 | 0.9797 | 1 |
Brugia malayi | TAR-binding protein | 0.0415 | 0.9797 | 0.9797 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0415 | 0.9797 | 0.9797 |
Schistosoma mansoni | tar DNA-binding protein | 0.0415 | 0.9797 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0134 | 0.256 | 0.2431 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0134 | 0.256 | 0.238 |
Echinococcus granulosus | tar DNA binding protein | 0.0415 | 0.9797 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0485 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0236 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0265 | 0.5951 | 0.5853 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0236 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0236 | 0.5 | |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0134 | 0.256 | 0.2431 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0236 | 0.0236 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0134 | 0.256 | 0.2431 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0236 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.256 | 0.2431 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0289 | 0.6556 | 0.6556 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0236 | 0.0236 |
Echinococcus granulosus | GPCR family 2 | 0.0134 | 0.256 | 0.2431 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0485 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0236 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0236 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0415 | 0.9797 | 0.9792 |
Brugia malayi | RNA binding protein | 0.0415 | 0.9797 | 0.9797 |
Loa Loa (eye worm) | TAR-binding protein | 0.0415 | 0.9797 | 0.9792 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0134 | 0.256 | 0.2431 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0236 | 0.0236 |
Loa Loa (eye worm) | RNA binding protein | 0.0415 | 0.9797 | 0.9792 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.0485 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0134 | 0.256 | 0.256 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0236 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.0485 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0415 | 0.9797 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.256 | 0.238 |
Onchocerca volvulus | 0.0043 | 0.0236 | 0.5 | |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.0485 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0415 | 0.9797 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0236 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0422 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.0485 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0236 | 0.0236 |
Onchocerca volvulus | 0.0043 | 0.0236 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0053 | 0.0485 | 0.0485 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0236 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.7079 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.