Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purine nucleoside phosphorylase | Starlite/ChEMBL | References |
Plasmodium falciparum | purine nucleoside phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | purine nucleoside phosphorylase | 289 aa | 255 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 1 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0211 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0186 | 0.7117 | 0.5 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0186 | 0.7117 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 1 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0211 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0211 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0211 | 1 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 0.5 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0211 | 1 | 0.5 |
Brugia malayi | purine nucleoside phosphorylase I, inosine and guanosine-specific family protein | 0.0186 | 0.7117 | 0.5 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0186 | 0.7117 | 0.5 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0211 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 1 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0211 | 1 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0186 | 0.7117 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0211 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0186 | 0.7117 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.