Detailed information for compound 1455097

Basic information

Technical information
  • TDR Targets ID: 1455097
  • Name: methyl 2-[(6-acetamido-1,3-benzothiazol-2-yl) sulfanyl]acetate
  • MW: 296.365 | Formula: C12H12N2O3S2
  • H donors: 1 H acceptors: 3 LogP: 2.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CSc1nc2c(s1)cc(cc2)NC(=O)C
  • InChi: 1S/C12H12N2O3S2/c1-7(15)13-8-3-4-9-10(5-8)19-12(14-9)18-6-11(16)17-2/h3-5H,6H2,1-2H3,(H,13,15)
  • InChiKey: TYXZJDHELRGQTC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(6-acetamido-1,3-benzothiazol-2-yl)thio]acetic acid methyl ester
  • methyl 2-[(6-acetamido-1,3-benzothiazol-2-yl)sulfanyl]ethanoate
  • SMR000013103
  • STK079676
  • ZINC00330787
  • (6-Acetylamino-benzothiazol-2-ylsulfanyl)-acetic acid methyl ester
  • MLS000031735

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.004 0.0185 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0024 0.0084 0.0135
Brugia malayi Cyclic-nucleotide gated cation channel 0.0024 0.0084 0.0074
Echinococcus granulosus bloom syndrome protein 0.0024 0.0081 0.0129
Plasmodium falciparum cGMP-dependent protein kinase 0.0024 0.0084 0.0134
Brugia malayi regulator of G-protein signaling egl-10 0.0056 0.0291 0.0281
Echinococcus multilocularis segment polarity protein dishevelled 0.0056 0.0291 0.0517
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0024 0.0084 0.0134
Echinococcus granulosus patatin phospholipase domain containing protein 0.0024 0.0084 0.0135
Echinococcus granulosus hyperpolarization activated cyclic 0.0024 0.0084 0.0135
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0024 0.0084 0.0135
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.004 0.0185 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0168 0.4756
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0024 0.0084 0.2437
Treponema pallidum catabolite gene activator 0.0024 0.0084 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0024 0.002
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0081 0.0129
Mycobacterium ulcerans hypothetical protein 0.0024 0.0084 0.3878
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0062 0.0336 1
Brugia malayi N-terminal motif family protein 0.004 0.0185 0.0175
Brugia malayi RasGEF domain containing protein 0.004 0.0185 0.0175
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0039 0.1171
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.0084 0.4207
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0003 0.0005
Loa Loa (eye worm) RecQ helicase 0.0024 0.0081 0.0078
Trypanosoma cruzi protein kinase A regulatory subunit 0.0024 0.0084 0.2437
Brugia malayi MH2 domain containing protein 0.0034 0.0149 0.0138
Schistosoma mansoni hypothetical protein 0.0482 0.3111 0.4567
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0097 0.2886
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0024 0.0084 0.0074
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0081 0.2334
Echinococcus granulosus hyperpolarization activated cyclic 0.0024 0.0084 0.0135
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0011 0.0576
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0024 0.0024
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.004 0.0185 1
Brugia malayi Isocitrate dehydrogenase 0.0062 0.0336 0.0326
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0081 0.0078
Entamoeba histolytica hypothetical protein 0.004 0.0185 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0084 0.0081
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0081 0.4356
Onchocerca volvulus 0.0023 0.0076 0.0071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0482 0.3111 0.571
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.004 0.0185 1
Leishmania major protein kinase, putative 0.0024 0.0084 0.0134
Loa Loa (eye worm) hypothetical protein 0.0024 0.0084 0.0081
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.004 0.0185 1
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0024 0.0084 0.0134
Treponema pallidum catabolite gene activator (Crp) 0.0024 0.0084 1
Schistosoma mansoni tar DNA-binding protein 0.071 0.4622 0.6786
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0024 0.0084 0.4207
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0011 0.0576
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Echinococcus granulosus segment polarity protein dishevelled 0.0056 0.0291 0.0517
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0024 0.0084 0.0135
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0024 0.0084 0.0135
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0084 0.2136
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0062 0.0336 0.0599
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0024 0.0084 0.0124
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0149 0.0219
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0024 0.0084 0.2136
Schistosoma mansoni Smad4 0.0034 0.0149 0.0219
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0081 0.007
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0024 0.0084 0.2506
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0081 0.0129
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0024 0.0084 0.0135
Echinococcus granulosus GPCR family 2 0.0482 0.3111 0.571
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0087 0.0076
Schistosoma mansoni DNA helicase recq5 0.0024 0.0081 0.0119
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0087 0.2216
Mycobacterium tuberculosis Conserved protein 0.0024 0.0084 0.2136
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0084 0.0124
Schistosoma mansoni Smad4 0.0015 0.0024 0.0035
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0003 0.0092
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.0084 0.4207
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.1133 0.7422 1
Schistosoma mansoni tar DNA-binding protein 0.071 0.4622 0.6786
Echinococcus multilocularis Smad4 0.0034 0.0149 0.0255
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.544 0.7987
Loa Loa (eye worm) latrophilin receptor protein 2 0.0482 0.3111 0.3109
Mycobacterium leprae Conserved hypothetical protein 0.0024 0.0084 0.3878
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0081 0.4011
Brugia malayi N-terminal motif family protein 0.004 0.0185 0.0175
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0038 0.0173 0.0253
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0062 0.0336 1
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0024 0.0084 0.2506
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0024 0.0084 0.0124
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.071 0.4622 0.462
Brugia malayi Smad1 0.0034 0.0149 0.0138
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0084 0.0124
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Brugia malayi Latrophilin receptor protein 2 0.0482 0.3111 0.3104
Schistosoma mansoni smad1 5 8 and 0.0034 0.0149 0.0219
Trypanosoma brucei cAMP binding protein, putative 0.0024 0.0084 0.0134
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.0084 0.4207
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0056 0.0291 0.0362
Echinococcus granulosus son of sevenless 1 0.004 0.0185 0.0322
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0008
Toxoplasma gondii isocitrate dehydrogenase 0.0062 0.0336 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0076 0.0065
Mycobacterium ulcerans hypothetical protein 0.0024 0.0084 0.3878
Loa Loa (eye worm) hypothetical protein 0.0024 0.0081 0.0078
Brugia malayi MH2 domain containing protein 0.0015 0.0024 0.0013
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.004 0.0185 0.0322
Schistosoma mansoni dep domain containing protein 0.0056 0.0291 0.0428
Loa Loa (eye worm) hypothetical protein 0.0056 0.0291 0.0288
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0062 0.0336 0.0599
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0024 0.0084 0.0081
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0059 0.136
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0076 0.1879
Echinococcus granulosus microtubule associated protein 2 0.0833 0.544 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0062 0.0336 0.0333
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0024 0.0084 0.0074
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0084 0.0124
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0081 0.0129
Trypanosoma cruzi cAMP response protein 1, putative 0.0024 0.0084 0.2437
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.0234 0.0224
Treponema pallidum cyclic nucleotide binding protein 0.0024 0.0084 1
Schistosoma mansoni hypothetical protein 0.104 0.6811 1
Brugia malayi MH2 domain containing protein 0.0034 0.0149 0.0138
Echinococcus granulosus smad 0.0034 0.0149 0.0255
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0024 0.0084 0.0135
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.004 0.0185 0.0219
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0087 0.4065
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.0084 0.0124
Leishmania major protein kinase A regulatory subunit, putative 0.0024 0.0084 0.0134
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0087 0.2216
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0008
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0003 0.0092
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0024 0.0084 0.0074
Echinococcus multilocularis Protein son of sevenless 0.004 0.0185 0.0322
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0024 0.0084 0.2437
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0082 0.2059
Echinococcus granulosus ras GTP exchange factor 0.004 0.0185 0.0322
Trichomonas vaginalis ras GTP exchange factor, putative 0.004 0.0185 1
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0024 0.0084 0.4207
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.004 0.0185 0.0272
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0029 0.0862
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0084 0.0124
Trypanosoma cruzi hypothetical protein 0.0013 0.0011 0.0228
Loa Loa (eye worm) hypothetical protein 0.0056 0.0291 0.0288
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0024 0.0084 0.2506
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.004 0.0185 0.0322
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0081 0.0129
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0005 0.0161
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.004 0.0185 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0024 0.0084 0.0124
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0056 0.0291 0.0517
Echinococcus multilocularis isocitrate dehydrogenase 0.0062 0.0336 0.0599
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0062 0.0336 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0011 0.0576
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0097 0.2535
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Trypanosoma cruzi hypothetical protein 0.0013 0.0011 0.0228
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0059 0.2064
Mycobacterium ulcerans thioesterase 0.0021 0.0059 0.2064
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0011 0.0576
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0081 0.4011
Echinococcus granulosus segment polarity protein dishevelled 0.0056 0.0291 0.0517
Onchocerca volvulus 0.0024 0.0084 0.0082
Loa Loa (eye worm) hypothetical protein 0.1522 1 1
Toxoplasma gondii isocitrate dehydrogenase 0.0062 0.0336 1
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0062 0.0336 0.0599
Brugia malayi MH1 domain containing protein 0.0019 0.0048 0.0037
Schistosoma mansoni dishevelled 0.0056 0.0291 0.0428
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0087 0.4065
Mycobacterium ulcerans hypothetical protein 0.0024 0.0084 0.3878
Onchocerca volvulus 0.004 0.0185 0.0219
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0024 0.0084 0.2136
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0024 0.0084 0.0124
Brugia malayi hypothetical protein 0.0056 0.0291 0.0281
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0024 0.0084 0.0081
Brugia malayi RNA recognition motif domain containing protein 0.071 0.4622 0.4616
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0059 0.2064
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.0084 0.0124
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0081 0.2404
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0011 0.0576
Loa Loa (eye worm) RNA binding protein 0.071 0.4622 0.462
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0024 0.0084 0.0135
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0024 0.0024
Echinococcus multilocularis hyperpolarization activated cyclic 0.0024 0.0084 0.0135
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0024 0.0084 0.2136
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0024 0.0084 0.0124
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0149 0.0146
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0084 0.0124
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0024 0.0084 0.0135
Loa Loa (eye worm) hypothetical protein 0.0024 0.0084 0.0081
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0011 0.0576
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0024 0.0084 0.0135
Loa Loa (eye worm) TAR-binding protein 0.071 0.4622 0.462
Echinococcus multilocularis son of sevenless 1 0.004 0.0185 0.0322
Schistosoma mansoni ral guanine nucleotide exchange factor with pH domain and sh3 binding motif ralgps 0.0013 0.0011 0.0016
Echinococcus multilocularis tar DNA binding protein 0.071 0.4622 0.8493
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.004 0.0185 1
Leishmania major hypothetical protein, conserved 0.0024 0.0084 0.0134
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.004 0.0185 0.0272
Trypanosoma brucei protein kinase A regulatory subunit 0.0024 0.0084 0.0134
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Trypanosoma brucei cAMP response protein 1, putative 0.0024 0.0084 0.0134
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0482 0.3111 0.571
Echinococcus multilocularis regulator of G protein signaling 7 0.0056 0.0291 0.0517
Leishmania major hypothetical protein, unknown function 0.0024 0.0084 0.0134
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0097 0.481
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0024 0.0084 0.0124
Loa Loa (eye worm) fatty acid synthase 0.0025 0.0085 0.0082
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.002
Brugia malayi MH2 domain containing protein 0.0502 0.3248 0.324
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0024 0.0084 0.0074
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0024 0.0084 0.0135
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0024 0.0084 0.2506
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0482 0.3111 0.571
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0097 0.2535
Schistosoma mansoni ras GTP exchange factor 0.004 0.0185 0.0272
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0149 0.0146
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0024 0.0084 0.2136
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.004 0.0185 0.0272
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0024 0.0084 0.0135
Leishmania major hypothetical protein, conserved 0.0024 0.0084 0.0134
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0056 0.0291 0.0281
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0055 0.172
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0024 0.002
Loa Loa (eye worm) DIX domain-containing protein 0.0056 0.0291 0.0288
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.004 0.0185 0.0322
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Leishmania major cyclic nucleotide-binding protein-like protein 0.0024 0.0084 0.0134
Schistosoma mansoni tar DNA-binding protein 0.071 0.4622 0.6786
Mycobacterium ulcerans polyketide synthase 0.0025 0.0087 0.4065
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.004 0.0185 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.004 0.0185 0.0182
Schistosoma mansoni hypothetical protein 0.0482 0.3111 0.4567
Echinococcus multilocularis ras GTP exchange factor 0.004 0.0185 0.0322
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0003 0.0166
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0084 0.0124
Echinococcus granulosus cGMP dependent protein kinase 0.0024 0.0084 0.0135
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0024 0.0084 0.0135
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0024 0.0084 1
Brugia malayi RasGEF domain containing protein 0.004 0.0185 0.0175
Leishmania major protein kinase, putative 0.0024 0.0084 0.0134
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0024 0.0084 0.0135
Brugia malayi Egg laying defective protein 4 0.0024 0.0084 0.0074
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.004 0.0185 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0087 0.4065
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0024 0.0084 0.0124
Loa Loa (eye worm) hypothetical protein 0.004 0.0185 0.0182
Schistosoma mansoni tar DNA-binding protein 0.071 0.4622 0.6786
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0084 0.2437
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0024 0.0084 0.5
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0024 0.0084 0.0135
Echinococcus multilocularis expressed conserved protein 0.0024 0.0084 0.0135
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0024 0.0084 0.0135
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1522 1 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.004 0.0185 1
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0024 0.0084 0.0135
Entamoeba histolytica RasGEF domain containing protein 0.0013 0.0011 0.0576
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0055 0.172
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0149 0.0255
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0082 0.2059
Schistosoma mansoni dishevelled 0.0056 0.0291 0.0428
Loa Loa (eye worm) transcription factor SMAD2 0.0502 0.3248 0.3246
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.544 1
Brugia malayi TAR-binding protein 0.071 0.4622 0.4616
Loa Loa (eye worm) Smad1 0.0034 0.0149 0.0146
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0024 0.0084 0.0081
Loa Loa (eye worm) RasGEF domain-containing protein 0.0013 0.0011 0.0008
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Toxoplasma gondii hypothetical protein 0.0056 0.0291 0.8673
Brugia malayi N-terminal motif family protein 0.1133 0.7422 0.7419
Echinococcus multilocularis voltage gated potassium channel 0.0024 0.0084 0.0135
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0087 0.4065
Trypanosoma cruzi hypothetical protein 0.004 0.0185 0.5478
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0062 0.0336 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.0084 0.4207
Echinococcus granulosus tar DNA binding protein 0.071 0.4622 0.8493
Trypanosoma cruzi cAMP response protein 1 0.0024 0.0084 0.2437
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0087 0.2216
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0024 0.0084 0.0074
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0024 0.0084 0.0124
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Loa Loa (eye worm) RasGEF domain-containing protein 0.004 0.0185 0.0182
Echinococcus multilocularis segment polarity protein dishevelled 0.0056 0.0291 0.0517
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.004 0.0185 1
Trypanosoma cruzi cAMP binding protein, putative 0.0024 0.0084 0.2437
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0149 0.0255
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0168 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0081 0.2404
Echinococcus granulosus regulator of G protein signaling 7 0.0056 0.0291 0.0517
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0081 0.0129
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.0084 0.0124
Schistosoma mansoni DNA helicase recq1 0.0024 0.0081 0.0119
Schistosoma mansoni hypothetical protein 0.0482 0.3111 0.4567
Loa Loa (eye worm) RasGEF domain-containing protein 0.004 0.0185 0.0182
Echinococcus multilocularis GPCR, family 2 0.0482 0.3111 0.571
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.004 0.0185 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.0084 0.4207
Echinococcus multilocularis hyperpolarization activated cyclic 0.0024 0.0084 0.0135
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0013 0.0011 0.0016
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0024 0.0084 0.0135
Schistosoma mansoni hypothetical protein 0.0482 0.3111 0.4567
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0024 0.0084 0.0134
Trypanosoma cruzi hypothetical protein 0.004 0.0185 0.5478
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.004 0.0185 1
Echinococcus granulosus Protein son of sevenless 0.004 0.0185 0.0322
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0024 0.0084 0.0124
Echinococcus granulosus regulator of G protein signaling 7 0.0056 0.0291 0.0517
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0062 0.0336 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0081 0.007
Echinococcus multilocularis regulator of G protein signaling 7 0.0056 0.0291 0.0517
Echinococcus multilocularis smad 0.0034 0.0149 0.0255
Mycobacterium ulcerans polyketide synthase 0.0026 0.0097 0.481
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0024 0.0084 0.0124
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0097 0.481
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0011 0.0576
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0087 0.4065
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0097 0.481
Schistosoma mansoni z-protein (S1r protein) 0.0056 0.0291 0.0428
Brugia malayi MH1 domain containing protein 0.0034 0.0149 0.0138
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0055 0.172
Echinococcus granulosus voltage gated potassium channel 0.0024 0.0084 0.0135
Brugia malayi Calcitonin receptor-like protein seb-1 0.1522 1 1
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0097 0.2535
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.004 0.0185 0.5478
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0011 0.0576
Onchocerca volvulus Fatty acid synthase homolog 0.0045 0.0219 0.0264
Loa Loa (eye worm) hypothetical protein 0.0042 0.0199 0.0196
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0024 0.0084 0.2506
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0045
Brugia malayi isocitrate dehydrogenase 0.0062 0.0336 0.0326
Schistosoma mansoni regulator of G protein signaling 0.0056 0.0291 0.0428
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0024 0.0084 0.2506
Brugia malayi DIX domain containing protein 0.0056 0.0291 0.0281
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0084 0.2136
Loa Loa (eye worm) hypothetical protein 0.1133 0.7422 0.7421
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0024 0.0084 0.0081
Leishmania major hypothetical protein, conserved 0.0024 0.0084 0.0134
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.004 0.077
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0056 0.0291 0.0281
Schistosoma mansoni pdz domain containing guanine nucleotide exchange factor pdz-gef 0.0013 0.0011 0.0016
Schistosoma mansoni ral guanine nucleotide dissociation stimulator ralgds 0.0013 0.0011 0.0016
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0011 0.0576
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.0084 0.0124
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0062 0.0336 1
Trypanosoma cruzi Flagellar Member 6 0.0024 0.0084 0.2437
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0076 0.0073
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0024 0.0084 0.0135
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.004 0.0185 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0024 0.0024
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0482 0.3111 0.571
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.000000000065367
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0024 0.0084 0.2506
Schistosoma mansoni Smad4 0.0015 0.0024 0.0035
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.004 0.0185 0.0322
Brugia malayi hypothetical protein 0.0056 0.0291 0.0281
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0097 0.481
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0024 0.0084 0.2437
Loa Loa (eye worm) hypothetical protein 0.0056 0.0291 0.0288
Schistosoma mansoni smad1 5 8 and 0.0034 0.0149 0.0219
Schistosoma mansoni smad1 5 8 and 0.0034 0.0149 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0084 0.0124
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0024 0.0024
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0084 0.0124
Trypanosoma brucei Flagellar Member 6 0.0024 0.0084 0.0134
Onchocerca volvulus 0.0043 0.0209 0.025
Loa Loa (eye worm) hypothetical protein 0.0482 0.3111 0.3109
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0011 0.0576
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0081 0.4011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0482 0.3111 0.3104
Loa Loa (eye worm) AGC/PKG protein kinase 0.0024 0.0084 0.0081
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.004 0.0185 0.0272
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0057 0.128
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.0084 0.4207
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0024 0.0084 0.0135
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0008
Brugia malayi MH1 domain containing protein 0.0034 0.0149 0.0138
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0024 0.0084 0.0135
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0056 0.0291 0.0288
Trichomonas vaginalis ras GTP exchange factor, putative 0.004 0.0185 1
Schistosoma mansoni tar DNA-binding protein 0.071 0.4622 0.6786
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0011 0.0576
Loa Loa (eye worm) hypothetical protein 0.104 0.6811 0.681
Schistosoma mansoni smad 0.0015 0.0024 0.0035
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0081 0.007
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0062 0.0336 0.0599
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0062 0.0336 0.0599
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0168 0.4756
Echinococcus granulosus Smad4 0.0034 0.0149 0.0255
Schistosoma mansoni hypothetical protein 0.0024 0.0084 0.0124
Echinococcus granulosus cGMP dependent protein kinase 1 0.0024 0.0084 0.0135
Mycobacterium ulcerans regulatory protein 0.0024 0.0084 0.3878
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0097 0.481
Loa Loa (eye worm) hypothetical protein 0.004 0.0185 0.0182
Brugia malayi RNA binding protein 0.071 0.4622 0.4616
Brugia malayi RasGEF domain containing protein 0.004 0.0185 0.0175
Brugia malayi MH1 domain containing protein 0.0019 0.0048 0.0037
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0168 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0084 0.4207
Loa Loa (eye worm) nuclear factor I 0.0019 0.0048 0.0045
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0011 0.0576
Onchocerca volvulus 0.0056 0.0291 0.0362
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0024 0.0084 0.0124
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0011
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0149 0.0255
Mycobacterium ulcerans hypothetical protein 0.0024 0.0084 0.3878
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0024 0.0084 0.0124
Loa Loa (eye worm) MH2 domain-containing protein 0.0502 0.3248 0.3246
Leishmania major regulatory subunit of protein kinase a-like protein 0.0024 0.0084 0.0134
Echinococcus granulosus cGMP dependent protein kinase 1 0.0024 0.0084 0.0135
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0149 0.0255
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0024 0.0084 0.2506
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0024 0.0084 0.0135
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.004 0.0185 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0062 0.0336 1
Mycobacterium ulcerans transcriptional regulatory protein 0.0024 0.0084 0.3878
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0062 0.0336 0.0493
Mycobacterium ulcerans transmembrane transport protein 0.0024 0.0084 0.3878
Treponema pallidum cyclic nucleotide binding protein 0.0024 0.0084 1
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0576
Schistosoma mansoni smad 0.0034 0.0149 0.0219
Echinococcus granulosus Pleckstrin G protein interacting region 0.0056 0.0291 0.0517
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0024 0.0084 0.0135
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0024 0.0084 0.0135
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0087 0.4065
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0056 0.0291 0.0428
Brugia malayi latrophilin 2 splice variant baaae 0.104 0.6811 0.6808
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0024 0.0013
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0062 0.0336 1
Schistosoma mansoni hypothetical protein 0.0013 0.0011 0.0016
Onchocerca volvulus 0.0024 0.0084 0.0082

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1585 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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