Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.3882 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0009 | 0.0164 | 0.0378 |
Brugia malayi | DIX domain containing protein | 0.0009 | 0.0164 | 0.0146 |
Toxoplasma gondii | hypothetical protein | 0.0009 | 0.0164 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0164 | 0.0378 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0009 | 0.0164 | 0.0146 |
Trypanosoma cruzi | hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Trypanosoma cruzi | hypothetical protein | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0006 | 0.0018 | 0.0046 |
Onchocerca volvulus | 0.0009 | 0.0164 | 0.0146 | |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0006 | 0.0018 | 0.5 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.3882 | 1 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0009 | 0.0164 | 0.0422 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0006 | 0.0018 | 0.0046 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0164 | 0.0422 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.0009 | 0.0164 | 0.0422 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0177 | 1 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3882 | 1 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Schistosoma mansoni | ras GTP exchange factor | 0.0006 | 0.0018 | 0.0046 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0164 | 0.0378 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3882 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3882 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0009 | 0.0164 | 0.0422 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0164 | 0.0422 |
Schistosoma mansoni | dep domain containing protein | 0.0009 | 0.0164 | 0.0422 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0164 | 0.0378 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0164 | 0.0378 |
Brugia malayi | RNA binding protein | 0.0072 | 0.3882 | 0.3871 |
Brugia malayi | TAR-binding protein | 0.0072 | 0.3882 | 0.3871 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 1 | 1 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0009 | 0.0164 | 0.0146 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0164 | 0.0146 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0006 | 0.0018 | 0.0046 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0009 | 0.0164 | 0.0378 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0009 | 0.0164 | 0.0146 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0164 | 0.0378 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0164 | 0.0378 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0009 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.3882 | 0.3871 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3882 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3882 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.3882 | 0.3871 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.3882 | 0.3871 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0164 | 0.0378 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0.0018 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0006 | 0.0018 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.3882 | 0.3871 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0006 | 0.0018 | 0.0046 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0164 | 0.0378 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 112.219 um | PUBCHEM_BIOASSAY: Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 1663 (Primary HTS), 1678 (Summary of Project)] | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.