Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1489 | 0.1489 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3259 | 0.3259 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0133 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0133 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0133 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3259 | 0.3259 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3259 | 0.3259 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3259 | 0.3259 |
Brugia malayi | TAR-binding protein | 0.0133 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0133 | 1 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0133 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0133 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1489 | 0.1489 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.