Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1743 | 0.1743 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.0441 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.0618 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0198 | 0.6638 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0279 | 1 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0079 | 0.1743 | 0.1743 |
Echinococcus granulosus | tar DNA binding protein | 0.0198 | 0.6638 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.5705 | 0.5705 |
Brugia malayi | RNA binding protein | 0.0198 | 0.6638 | 0.6638 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.5503 | 0.8291 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0115 | 0.3245 | 0.3245 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.0441 | 0.5 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.5705 | 0.5705 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.0618 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0198 | 0.6638 | 0.6638 |
Loa Loa (eye worm) | TAR-binding protein | 0.0198 | 0.6638 | 0.6638 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.0441 | 0.5 |
Schistosoma mansoni | glutaminase | 0.0279 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.0618 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0198 | 0.6638 | 0.6638 |
Trichomonas vaginalis | glutaminase, putative | 0.0279 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0198 | 0.6638 | 0.6638 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.5705 | 0.8596 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.5705 | 0.5705 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3245 | 0.3245 |
Schistosoma mansoni | tar DNA-binding protein | 0.0198 | 0.6638 | 0.6638 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0115 | 0.3245 | 0.3245 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0198 | 0.6638 | 0.6638 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0233 | 0.8105 | 0.8105 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0198 | 0.6638 | 0.6638 |
Loa Loa (eye worm) | glutaminase | 0.0279 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.0618 | 0.093 |
Brugia malayi | MH2 domain containing protein | 0.0233 | 0.8105 | 0.8105 |
Schistosoma mansoni | tar DNA-binding protein | 0.0198 | 0.6638 | 0.6638 |
Loa Loa (eye worm) | glutaminase 2 | 0.0279 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0115 | 0.3245 | 0.3245 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0233 | 0.8105 | 0.8105 |
Loa Loa (eye worm) | RNA binding protein | 0.0198 | 0.6638 | 0.6638 |
Schistosoma mansoni | tar DNA-binding protein | 0.0198 | 0.6638 | 0.6638 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.1743 | 0.1743 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (binding) | 25.1189 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.