Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | polymerase (DNA directed), beta | 335 aa | 303 aa | 32.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0262 | 0.2593 | 0.1903 |
Schistosoma mansoni | tar DNA-binding protein | 0.0262 | 0.2593 | 0.1903 |
Schistosoma mansoni | tar DNA-binding protein | 0.0262 | 0.2593 | 0.1903 |
Brugia malayi | RNA binding protein | 0.0262 | 0.2593 | 0.4847 |
Echinococcus multilocularis | tar DNA binding protein | 0.0262 | 0.2593 | 0.1903 |
Echinococcus granulosus | geminin | 0.0205 | 0.1844 | 0.1085 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1844 | 0.1085 |
Schistosoma mansoni | tar DNA-binding protein | 0.0262 | 0.2593 | 0.1903 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0262 | 0.2593 | 0.4847 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0277 | 0.2781 | 0.5371 |
Schistosoma mansoni | tar DNA-binding protein | 0.0262 | 0.2593 | 0.1903 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1844 | 0.1085 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.1681 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0262 | 0.2593 | 0.1903 |
Brugia malayi | TAR-binding protein | 0.0262 | 0.2593 | 0.4847 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0405 | 0.4443 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0365 | 0.3921 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.3921 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0405 | 0.4443 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.3921 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0405 | 0.4443 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0262 | 0.2593 | 0.4847 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0262 | 0.2593 | 0.4847 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.2781 | 0.5371 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.1681 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0262 | 0.2593 | 0.4847 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.1428 | 0.3643 |
Schistosoma mansoni | hypothetical protein | 0.0277 | 0.2781 | 0.2109 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1844 | 0.1085 |
Loa Loa (eye worm) | hypothetical protein | 0.0405 | 0.4443 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 0.3921 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1458 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.