Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0186 | 0.9463 | 0.9397 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0195 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.1098 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0186 | 0.9463 | 0.9397 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.1098 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0186 | 0.9463 | 0.9463 |
Loa Loa (eye worm) | RNA binding protein | 0.0186 | 0.9463 | 0.9397 |
Leishmania major | hypothetical protein, conserved | 0.005 | 0.1098 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0186 | 0.9463 | 0.9463 |
Echinococcus multilocularis | tar DNA binding protein | 0.0186 | 0.9463 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.9463 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.9463 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.9463 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0186 | 0.9463 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.9463 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0062 | 0.1797 | 0.0786 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0062 | 0.1797 | 0.1797 |
Brugia malayi | hypothetical protein | 0.005 | 0.1098 | 0.1098 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.005 | 0.1098 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.005 | 0.1098 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.9463 | 1 |
Brugia malayi | RNA binding protein | 0.0186 | 0.9463 | 0.9463 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0195 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0062 | 0.1797 | 0.1797 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.1098 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.1098 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0133 | 0.6203 | 0.6203 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.6203 | 0.5735 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1797 | 0.0786 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.6203 | 0.5748 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.005 | 0.1098 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.