TDR Targets

Basic information

Technical information

TDR Targets ID: 1455344
Name: N-(3-ethylphenyl)-2-[6-(4-methylpiperidin-1-y l)sulfonyl-2-oxoquinolin-1-yl]acetamide
MW: 467.58 | Formula: C25H29N3O4S
H donors: 1 H acceptors: 4 LogP: 3.65 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCc1cccc(c1)NC(=O)Cn1c(=O)ccc2c1ccc(c2)S(=O)(=O)N1CCC(CC1)C
InChi: 1S/C25H29N3O4S/c1-3-19-5-4-6-21(15-19)26-24(29)17-28-23-9-8-22(16-20(23)7-10-25(28)30)33(31,32)27-13-11-18(2)12-14-27/h4-10,15-16,18H,3,11-14,17H2,1-2H3,(H,26,29)
InChiKey: LNNPZZQTQBWRHA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-ethylphenyl)-2-[6-[(4-methyl-1-piperidyl)sulfonyl]-2-oxo-1-quinolyl]acetamide
N-(3-ethylphenyl)-2-[6-[(4-methyl-1-piperidinyl)sulfonyl]-2-oxo-1-quinolyl]acetamide
N-(3-ethylphenyl)-2-[2-keto-6-[(4-methyl-1-piperidyl)sulfonyl]-1-quinolyl]acetamide
N-(3-ethylphenyl)-2-[6-(4-methylpiperidin-1-yl)sulfonyl-2-oxo-quinolin-1-yl]ethanamide
G853-0235
NCGC00135385-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nuclear receptor nhr 48	0.0046	0.0231	0.0318
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0098	0.0695	0.0694
Echinococcus granulosus	caspase 2	0.0061	0.036	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0231	0.0239
Schistosoma mansoni	retinoic acid receptor RXR	0.0098	0.0695	0.0936
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0098	0.0695	0.0955
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.0231	0.0318
Leishmania major	trypanothione reductase	0.0046	0.0233	0.2042
Schistosoma mansoni	pyruvate kinase	0.0034	0.0119	0.0143
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0098	0.0695	0.0955
Echinococcus multilocularis	pyruvate kinase	0.0066	0.0406	0.0557
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0057	0.0332	0.0435
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0647	0.5608	0.7704
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0015	0.0021
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0098	0.0695	0.0955
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.0342	0.0469
Schistosoma mansoni	hypothetical protein	0.0031	0.0095	0.011
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.013	0.0982	0.1022
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0098	0.0695	0.0955
Onchocerca volvulus	Cell death protein 3 homolog	0.0061	0.036	0.2774
Loa Loa (eye worm)	jmjC domain-containing protein	0.0119	0.0879	0.0915
Plasmodium vivax	pyruvate kinase, putative	0.0066	0.0406	1
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0233	0.0241
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0098	0.0695	0.0694
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0098	0.0695	0.0955
Brugia malayi	hypothetical protein	0.0046	0.0231	0.0229
Brugia malayi	conserved hypotetical protein	0.0046	0.0231	0.0229
Schistosoma mansoni	hypothetical protein	0.0031	0.0095	0.011
Loa Loa (eye worm)	hypothetical protein	0.0234	0.1911	0.1992
Onchocerca volvulus	Pyruvate kinase homolog	0.0066	0.0406	0.3755
Echinococcus multilocularis	nuclear receptor nhr 48	0.0046	0.0231	0.0318
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.013	0.0982	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0695	0.0723
Leishmania major	pyruvate kinase	0.0066	0.0406	0.388
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0098	0.0695	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0228	0.0235
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0233	0.0241
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0098	0.0695	0.0723
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.0342	0.0469
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0046	0.0231	0.0229
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0098	0.0695	0.0694
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0231	0.0239
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0098	0.0695	0.0955
Echinococcus multilocularis	peregrin	0.006	0.0352	0.0484
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0098	0.0695	0.0694
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.0765	0.8342
Brugia malayi	Bromodomain containing protein	0.0038	0.0154	0.0152
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0098	0.0695	0.0723
Trypanosoma brucei	pyruvate kinase 1, putative	0.0066	0.0406	0.388
Loa Loa (eye worm)	jmjC domain-containing protein	0.0071	0.0457	0.0474
Schistosoma mansoni	hypothetical protein	0.0031	0.0095	0.011
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.0765	0.8342
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0281	0.0291
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.728	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0046	0.0231	0.0318
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0052	0.0281	0.0366
Schistosoma mansoni	pyruvate kinase	0.0066	0.0406	0.0537
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0046	0.0231	0.0318
Schistosoma mansoni	nuclear receptor	0.0046	0.0231	0.0298
Brugia malayi	hypothetical protein	0.0046	0.0231	0.0229
Loa Loa (eye worm)	hypothetical protein	0.004	0.0175	0.0181
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0046	0.0231	0.0239
Schistosoma mansoni	pyruvate kinase	0.0066	0.0406	0.0537
Onchocerca volvulus		0.0048	0.0244	0.0277
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.013	0.0982	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0095	0.0131
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0233	0.5263
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.728	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0098	0.0695	0.0723
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0098	0.0695	0.0723
Brugia malayi	Steroid receptor seven-up type 2	0.0098	0.0695	0.0694
Schistosoma mansoni	nuclear hormone receptor	0.0046	0.0231	0.0298
Brugia malayi	nuclear hormone receptor	0.0046	0.0231	0.0229
Schistosoma mansoni	RAR-like nuclear receptor	0.0098	0.0695	0.0936
Brugia malayi	Bromodomain containing protein	0.006	0.0352	0.035
Schistosoma mansoni	nuclear hormone receptor	0.0046	0.0231	0.0298
Plasmodium vivax	pyruvate kinase 2, putative	0.0034	0.0119	0.2158
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0233	0.032
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0695	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0061	0.036	0.0374
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0015	0.0021
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0118	0.0871	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0234	0.1911	0.2625
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0098	0.0695	0.0694
Onchocerca volvulus	Bile acid receptor homolog	0.0098	0.0695	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0118	0.0871	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0098	0.0695	0.0955
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0098	0.0695	0.0955
Brugia malayi	hypothetical protein	0.0025	0.004	0.0038
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0233	0.2042
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0231	0.0239
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0133	0.0183
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0066	0.0406	0.388
Onchocerca volvulus		0.0098	0.0695	1
Brugia malayi	jmjC domain containing protein	0.0188	0.1502	0.15
Echinococcus granulosus	peregrin	0.006	0.0352	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0332	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0154	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0231	0.0239
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0098	0.0695	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.0697	0.0725
Echinococcus granulosus	pyruvate kinase	0.0034	0.0119	0.0164
Toxoplasma gondii	pyruvate kinase PyK1	0.0066	0.0406	1
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0061	0.036	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0695	0.0723
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0133	0.0183
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0118	0.0871	1
Schistosoma mansoni	coup transcription factor	0.0098	0.0695	0.0936
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0351	0.3296
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0133	0.0183
Brugia malayi	Thioredoxin reductase	0.0046	0.0233	0.0231
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0095	0.0131
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0119	0.0164
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0233	0.5263
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0231	0.0239
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0046	0.0231	0.0298
Schistosoma mansoni	hypothetical protein	0.0549	0.473	0.649
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0098	0.0695	0.0936
Brugia malayi	Bromodomain containing protein	0.0074	0.0476	0.0474
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0046	0.0231	0.0318
Echinococcus multilocularis	jumonji domain containing protein	0.008	0.0533	0.0732
Mycobacterium tuberculosis	Probable reductase	0.0106	0.0765	0.8342
Brugia malayi	nuclear receptor NHR-88	0.0046	0.0231	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0231	0.0239
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0046	0.0231	0.0239
Giardia lamblia	PHD finger protein 15	0.0057	0.0332	0.7411
Schistosoma mansoni	bromodomain containing protein	0.0062	0.0373	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0695	0.0723
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0418	0.0416
Schistosoma mansoni	hypothetical protein	0.0057	0.0332	0.0435
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0095	0.0131
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0052	0.0281	0.0386
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0046	0.0231	0.0318
Plasmodium falciparum	pyruvate kinase	0.0066	0.0406	1
Brugia malayi	hypothetical protein	0.0035	0.0133	0.0131
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0188	0.1502	0.2063
Toxoplasma gondii	pyruvate kinase PyKII	0.0034	0.0119	0.2158
Echinococcus granulosus	thyroid hormone receptor alpha	0.0046	0.0231	0.0318
Echinococcus multilocularis	transcription factor Dp 1	0.0075	0.0491	0.0675
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0046	0.0231	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0231	0.0239
Brugia malayi	Nuclear hormone receptor-like 1	0.1091	0.9586	0.9586
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0231	0.0239
Echinococcus granulosus	pyruvate kinase	0.0066	0.0406	0.0557
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0119	0.0164
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0098	0.0695	0.0936
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0119	0.0164
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0098	0.0695	0.0955
Brugia malayi	PHD-finger family protein	0.0057	0.0332	0.033
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0046	0.0231	0.0298
Loa Loa (eye worm)	pyruvate kinase	0.0066	0.0406	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0695	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0231	0.0239
Schistosoma mansoni	jumonji domain containing protein	0.0149	0.1156	0.157
Echinococcus granulosus	GPCR family 2	0.0031	0.0095	0.0131
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0098	0.0695	0.0694
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0351	0.8494
Schistosoma mansoni	hypothetical protein	0.0061	0.036	0.0475
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0233	0.5263
Brugia malayi	nuclear hormone receptor family member odr-7	0.0046	0.0231	0.0229
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0244	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0061	0.036	0.0374
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0098	0.0695	0.0936
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0095	0.0093
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.0765	0.8342
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0066	0.0406	0.388
Toxoplasma gondii	PHD-finger domain-containing protein	0.0057	0.0332	0.7969
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0281	0.0291
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0095	0.0097
Brugia malayi	nuclear receptor NHR-88	0.0098	0.0695	0.0694
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.013	0.0982	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0133	0.0183
Mycobacterium tuberculosis	Probable oxidoreductase	0.0118	0.0871	1
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0549	0.473	0.6497
Plasmodium vivax	hypothetical protein, conserved	0.0057	0.0332	0.7969
Trypanosoma brucei	pyruvate kinase 1	0.0066	0.0406	0.388
Trichomonas vaginalis	pyruvate kinase, putative	0.0066	0.0406	0.5
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0095	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0695	0.0723
Onchocerca volvulus	Pyruvate kinase homolog	0.0066	0.0406	0.3755
Echinococcus granulosus	FTZ F1 alpha	0.0098	0.0695	0.0955
Echinococcus granulosus	PHD finger protein rhinoceros	0.0057	0.0332	0.0455
Brugia malayi	Nuclear hormone receptor E75	0.0046	0.0231	0.0229
Echinococcus multilocularis	ecdysone induced protein 78C	0.0098	0.0695	0.0955
Echinococcus multilocularis	caspase 2	0.0061	0.036	0.0495
Echinococcus multilocularis	FTZ F1 alpha	0.0098	0.0695	0.0955
Trichomonas vaginalis	pyruvate kinase, putative	0.0066	0.0406	0.5
Loa Loa (eye worm)	hypothetical protein	0.1085	0.9536	0.9948
Loa Loa (eye worm)	DR-78	0.0046	0.0231	0.0239
Giardia lamblia	Pyruvate kinase	0.0066	0.0406	1
Onchocerca volvulus	Alhambra homolog	0.0057	0.0332	0.2156
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0351	0.0462
Echinococcus granulosus	pyruvate kinase	0.0034	0.0119	0.0164
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.0765	0.8342
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0133	0.0162
Echinococcus granulosus	lysine specific demethylase 5A	0.0071	0.0457	0.0627
Schistosoma mansoni	hypothetical protein	0.0035	0.0133	0.0162
Chlamydia trachomatis	pyruvate kinase	0.0066	0.0406	0.5
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0057	0.0332	0.0455
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0046	0.0231	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0231	0.0239
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0046	0.0231	0.0229
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0046	0.0231	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0025	0.004	0.004
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0098	0.0695	0.0955
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0697	0.0725
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.0457	0.0607
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.0765	0.8342
Brugia malayi	jmjC domain containing protein	0.0071	0.0457	0.0455
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0098	0.0695	0.0694
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.013	0.0982	0.133
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0098	0.0695	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0095	0.0097
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.0697	0.0695
Brugia malayi	photoreceptor-specific nuclear receptor	0.0098	0.0695	0.0694
Onchocerca volvulus	Pyruvate kinase homolog	0.0066	0.0406	0.3755
Schistosoma mansoni	nuclear receptor	0.0046	0.0231	0.0298
Onchocerca volvulus		0.0061	0.036	0.2774
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0098	0.0695	0.0955
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0351	0.0482
Schistosoma mansoni	hypothetical protein	0.0048	0.0244	0.0315
Brugia malayi	tailless protein	0.0046	0.0231	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0695	0.0723
Brugia malayi	Nuclear hormone receptor E75	0.0046	0.0231	0.0229
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0233	0.032
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0695	0.0723
Brugia malayi	Cell death protein 3 precursor	0.0061	0.036	0.0358
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0098	0.0695	0.0955
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.0457	0.0607
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.013	0.0982	0.098
Schistosoma mansoni	nuclear hormone receptor	0.0098	0.0695	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0418	0.0434
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0106	0.0765	0.7725
Plasmodium falciparum	glutathione reductase	0.0046	0.0233	0.5263
Entamoeba histolytica	pyruvate kinase, putative	0.0046	0.0228	0.1112
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.013	0.0982	0.1349
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0188	0.1502	0.2063
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0098	0.0695	0.0694
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0699	0.0727
Loa Loa (eye worm)	pyruvate kinase	0.0066	0.0406	0.0421
Loa Loa (eye worm)	PHD-finger family protein	0.0057	0.0332	0.0344
Echinococcus granulosus	apoptotic protease activating factor 1	0.0061	0.036	0.0495
Mycobacterium ulcerans	pyruvate kinase	0.0066	0.0406	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0046	0.0231	0.0239
Echinococcus granulosus	jumonji domain containing protein	0.008	0.0533	0.0732
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0098	0.0695	0.0694
Echinococcus multilocularis	lysine specific demethylase 5A	0.007	0.044	0.0604
Toxoplasma gondii	PHD-finger domain-containing protein	0.0057	0.0332	0.7969
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0066	0.0406	0.0404
Brugia malayi	glutathione reductase	0.0046	0.0233	0.0231
Schistosoma mansoni	hypothetical protein	0.0048	0.0246	0.0318
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.0231	0.0318
Schistosoma mansoni	thyroid hormone receptor	0.0647	0.5608	0.7699
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0095	0.0093
Echinococcus granulosus	survival motor neuron protein 1	0.0234	0.1911	0.2625
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0098	0.0695	0.0955
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0052	0.0281	0.0366
Plasmodium falciparum	phd finger protein, putative	0.0057	0.0332	0.7969
Echinococcus multilocularis	pyruvate kinase	0.0066	0.0406	0.0557
Schistosoma mansoni	hypothetical protein	0.0031	0.0095	0.011
Loa Loa (eye worm)	pyruvate kinase-PB	0.0046	0.0228	0.0235
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0098	0.0695	0.0936
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0066	0.0406	0.2712
Schistosoma mansoni	nuclear receptor nhr-48	0.0046	0.0231	0.0298
Brugia malayi	steroid hormone receptor	0.0098	0.0695	0.0694
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0098	0.0695	0.0694
Brugia malayi	nuclear receptor NHR-67	0.0046	0.0231	0.0229
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0351	0.185
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0095	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0406	0.0421
Trypanosoma brucei	trypanothione reductase	0.0046	0.0233	0.2042
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.013	0.0982	1
Leishmania major	pyruvate kinase	0.0066	0.0406	0.388
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.0697	0.0695
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0233	0.5263
Brugia malayi	hypothetical protein	0.0052	0.0281	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0192	0.0198
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.728	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0351	0.0482
Echinococcus multilocularis	pyruvate kinase	0.0052	0.0282	0.0387
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0098	0.0695	0.0694
Schistosoma mansoni	caspase-7 (C14 family)	0.0061	0.036	0.0475
Brugia malayi	orphan nuclear receptor NR2E1	0.0046	0.0231	0.0229
Echinococcus granulosus	pyruvate kinase	0.0034	0.0119	0.0164
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0098	0.0695	0.0723
Brugia malayi	PHD-finger family protein	0.0024	0.0036	0.0034
Schistosoma mansoni	zinc finger protein	0.0046	0.0231	0.0298
Brugia malayi	ecdysone receptor	0.0046	0.0231	0.0229
Echinococcus granulosus	ecdysone induced protein 78C	0.0098	0.0695	0.0955
Loa Loa (eye worm)	steroid hormone receptor	0.0098	0.0695	0.0723
Brugia malayi	hypothetical protein	0.0234	0.1911	0.191
Schistosoma mansoni	thyroid hormone receptor	0.0647	0.5608	0.7699
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0231	0.0239
Schistosoma mansoni	hypothetical protein	0.0067	0.0418	0.0555
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0098	0.0695	0.0936
Plasmodium falciparum	pyruvate kinase 2	0.0034	0.0119	0.2158
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0098	0.0695	0.0936
Brugia malayi	nuclear hormone receptor	0.0098	0.0695	0.0694
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0098	0.0695	0.0694
Brugia malayi	hypothetical protein	0.0061	0.036	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0439	0.0455
Echinococcus granulosus	transcription factor Dp 1	0.0075	0.0491	0.0675
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.1091	0.9586	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0098	0.0695	1
Brugia malayi	hypothetical protein	0.0052	0.0281	0.0279
Brugia malayi	Nuclear hormone receptor-like 1	0.1091	0.9586	0.9586
Brugia malayi	ecdysteroid receptor	0.0098	0.0695	0.0694
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0098	0.0695	0.0723
Brugia malayi	nuclear receptor RXR	0.0046	0.0231	0.0229
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.013	0.0982	0.1349
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0351	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0281	0.0291
Echinococcus granulosus	pyruvate kinase	0.0066	0.0406	0.0557
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0066	0.0406	0.0404
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0052	0.0281	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0231	0.0239
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0098	0.0695	0.0694
Loa Loa (eye worm)	pyruvate kinase	0.0066	0.0406	0.0421
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0244	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0281	0.0291
Brugia malayi	nuclear receptor RXR	0.0052	0.0281	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0281	0.0291
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0549	0.473	0.6497
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.013	0.0982	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (binding)	= 100 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1612516

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1455344