Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.4939 | 0.4939 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4939 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4939 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.4939 | 0.4929 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4939 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0886 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0886 | 0.0886 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4939 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0886 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4939 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.002 | 0.002 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0886 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.002 | 0.002 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0886 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.4939 | 0.4929 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0.002 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0886 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0886 | 0.0867 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0886 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.4939 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.4939 | 0.4929 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.4939 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0886 | 1 |
Brugia malayi | RNA binding protein | 0.0066 | 0.4939 | 0.4939 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.4939 | 0.4939 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0886 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.