Detailed information for compound 1456058

Basic information

Technical information
  • TDR Targets ID: 1456058
  • Name: 4-[5-[(Z)-[1-[(4-fluorophenyl)methyl]-2,5-dio xoimidazolidin-4-ylidene]methyl]furan-2-yl]-3 -methylbenzoic acid
  • MW: 420.39 | Formula: C23H17FN2O5
  • H donors: 2 H acceptors: 4 LogP: 3.51 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)CN1C(=O)N/C(=C\c2ccc(o2)c2ccc(cc2C)C(=O)O)/C1=O
  • InChi: 1S/C23H17FN2O5/c1-13-10-15(22(28)29)4-8-18(13)20-9-7-17(31-20)11-19-21(27)26(23(30)25-19)12-14-2-5-16(24)6-3-14/h2-11H,12H2,1H3,(H,25,30)(H,28,29)/b19-11-
  • InChiKey: ZCLCEOWKKQHMNP-ODLFYWEKSA-N  

Network

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Synonyms

  • 4-[5-[(Z)-[1-[(4-fluorophenyl)methyl]-2,5-dioxo-imidazolidin-4-ylidene]methyl]-2-furyl]-3-methyl-benzoic acid
  • 4-[5-[(Z)-[1-[(4-fluorophenyl)methyl]-2,5-dioxo-4-imidazolidinylidene]methyl]-2-furyl]-3-methylbenzoic acid
  • 4-[5-[(Z)-[1-(4-fluorobenzyl)-2,5-diketo-imidazolidin-4-ylidene]methyl]-2-furyl]-3-methyl-benzoic acid
  • 4-[5-[(Z)-[1-[(4-fluorophenyl)methyl]-2,5-dioxo-imidazolidin-4-ylidene]methyl]furan-2-yl]-3-methyl-benzoic acid
  • MLS000762407
  • SMR000415989
  • STOCK4S-04299
  • 4-{5-[1-(4-Fluoro-benzyl)-2,5-dioxo-imidazolidin-(4Z)-ylidenemethyl]-furan-2-yl}-3-methyl-benzoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0338 0.1
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0665 0.1844
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.26 0.2598
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0819 0.0817
Trypanosoma brucei unspecified product 0.0032 0.0184 0.0543
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1818 0.6369
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0261 0.0689
Leishmania major GTP-binding protein, putative 0.0026 0.0115 0.0337
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0665 0.1973
Brugia malayi Importin beta-1 subunit 0.0035 0.0213 0.0586
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1375 0.3625
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0423 0.1251
Schistosoma mansoni inositol monophosphatase 0.0041 0.0273 0.0346
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0134 0.0392
Echinococcus granulosus GPCR family 2 0.0065 0.0535 0.0533
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.0134 0.0132
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.1697 1
Leishmania major mitochondrial DNA polymerase beta 0.0331 0.3364 1
Onchocerca volvulus 0.0053 0.0405 0.1611
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0338 0.1
Mycobacterium ulcerans putative regulatory protein 0.0078 0.0671 0.3639
Mycobacterium ulcerans hypothetical protein 0.0174 0.1697 1
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0333 0.0331
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0044 0.0116
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0084 0.0244
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0535 0.0533
Trichomonas vaginalis conserved hypothetical protein 0.0261 0.2613 0.9156
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0134 0.0392
Echinococcus granulosus tar DNA binding protein 0.0062 0.0501 0.0499
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0233 0.0231
Schistosoma mansoni DNA polymerase eta 0.0077 0.0665 0.0843
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.069 0.2047
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0027 0.0134 0.0462
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1818 0.6369
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0819 0.0817
Brugia malayi hypothetical protein 0.0134 0.1271 0.3529
Echinococcus granulosus dna polymerase kappa 0.0047 0.0338 0.0336
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0044 0.0056
Onchocerca volvulus 0.0078 0.0671 0.3191
Loa Loa (eye worm) hypothetical protein 0.0055 0.0423 0.1114
Brugia malayi jmjC domain containing protein 0.0019 0.0044 0.0117
Echinococcus multilocularis transfer RNA-Lys 0.0078 0.0671 0.0669
Echinococcus multilocularis musashi 0.0029 0.0149 0.0147
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1818 0.6369
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0819 0.2157
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2854 1
Brugia malayi TAR-binding protein 0.0062 0.0501 0.1387
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0116
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0044 0.0056
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0261 0.026
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0889 0.9297 0.9297
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0044 0.0056
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0405 0.1121
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0261 0.0721
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0115 0.0337
Brugia malayi hypothetical protein 0.0037 0.0233 0.0642
Brugia malayi Inositol-1 0.0041 0.0273 0.0754
Schistosoma mansoni hypothetical protein 0.0065 0.0535 0.0678
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0027 0.0134 0.0462
Loa Loa (eye worm) hypothetical protein 0.0027 0.0134 0.0352
Toxoplasma gondii exonuclease III APE 0.0023 0.0084 0.0315
Onchocerca volvulus Huntingtin homolog 0.0134 0.1271 0.6752
Schistosoma mansoni ap endonuclease 0.0023 0.0084 0.0107
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0044 0.0042
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0273 0.1039
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0084 0.0244
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0598 0.0596
Echinococcus granulosus intermediate filament protein 0.0029 0.0149 0.0147
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1509 0.4483
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0149 0.0392
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0273 0.1173
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0819 0.2271
Entamoeba histolytica hypothetical protein 0.0037 0.0233 0.0885
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0134 0.0462
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0143 0.0494
Loa Loa (eye worm) hypothetical protein 0.0134 0.1271 0.3349
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0501 0.0635
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0084 0.0222
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0084 0.0315
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0103 0.0101
Brugia malayi hypoxia-induced factor 1 0.0326 0.3307 0.9191
Entamoeba histolytica transcription factor BTF3, putative 0.0261 0.2613 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.069 0.0688
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0338 0.1288
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2854 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0273 0.1039
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.03 0.038
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0338 0.1575
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1818 0.6369
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0184 0.0543
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0228 1
Echinococcus multilocularis neuropeptide receptor A26 0.0955 1 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0273 1
Leishmania major hypothetical protein, conserved 0.0055 0.0423 0.1251
Entamoeba histolytica hypothetical protein 0.0261 0.2613 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0338 0.1575
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0134 0.0392
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0134 0.0392
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0044 0.0125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0084 0.0244
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0044 0.0161
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0044 0.0042
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0338 0.1179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0819 0.1038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0535 0.0533
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0143 0.0494
Schistosoma mansoni hypothetical protein 0.0348 0.3543 0.4492
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0331 0.3364 1
Loa Loa (eye worm) inositol-1 0.0041 0.0273 0.072
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0338 0.1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0084 0.0082
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0501 0.0499
Leishmania major basic transcription factor 3a, putative 0.0261 0.2613 0.7767
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0338 0.0336
Entamoeba histolytica hypothetical protein 0.0037 0.0233 0.0885
Trypanosoma cruzi transcription factor btf3, putative 0.0261 0.2613 0.7767
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0535 0.141
Brugia malayi jmjC domain containing protein 0.0019 0.0044 0.0117
Schistosoma mansoni survival motor neuron protein 0.0053 0.0405 0.0513
Schistosoma mansoni lamin 0.0029 0.0149 0.0189
Brugia malayi Calcitonin receptor-like protein seb-1 0.0206 0.2031 0.5641
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0084 0.2443
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0535 0.0533
Brugia malayi jmjC domain containing protein 0.0071 0.0598 0.1657
Giardia lamblia DINP protein human, muc B family 0.0047 0.0338 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0446 0.1321
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1925 0.6742
Loa Loa (eye worm) RNA binding protein 0.0062 0.0501 0.132
Schistosoma mansoni ran 0.0026 0.0115 0.0146
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0338 0.1
Brugia malayi PAS domain containing protein 0.0105 0.0962 0.267
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0338 0.1
Brugia malayi follicle stimulating hormone receptor 0.0256 0.2566 0.713
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0598 0.0758
Entamoeba histolytica Ran family GTPase 0.0026 0.0115 0.0433
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.069 0.1819
Loa Loa (eye worm) hypothetical protein 0.0034 0.0206 0.0543
Brugia malayi hypothetical protein 0.0259 0.26 0.7223
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0115 0.0433
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0143 0.0494
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0044 0.0116
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0134 0.0462
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.1338 0.3716
Echinococcus multilocularis lamin dm0 0.0029 0.0149 0.0147
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0392
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0501 0.132
Leishmania major protein kinase, putative 0.0027 0.0134 0.0392
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0115 0.0303
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0501 0.1387
Loa Loa (eye worm) hypothetical protein 0.0028 0.0143 0.0377
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0115 0.0337
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0002 0.0002
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0134 0.0462
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0044 0.0125
Leishmania major DNA polymerase eta, putative 0.0077 0.0665 0.1973
Echinococcus multilocularis transcription factor btf3 0.0261 0.2613 0.2612
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1818 0.6369
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0819 0.0817
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2854 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0115 0.0433
Trypanosoma brucei transcription factor BTF3, putative 0.0261 0.2613 0.7767
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0273 0.0951
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0598 0.0596
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0338 0.0336
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0103 0.0101
Brugia malayi hypothetical protein 0.0055 0.0423 0.117
Entamoeba histolytica hypothetical protein 0.0037 0.0233 0.0885
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2854 1
Echinococcus multilocularis microtubule associated protein 2 0.0757 0.7889 0.7888
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0044 0.0042
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0423 0.1611
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0598 0.0758
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0007 0.0013
Brugia malayi hypothetical protein 0.0353 0.3598 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.069 0.2047
Plasmodium vivax basic transcription factor 3b, putative 0.0261 0.2613 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0027 0.0134 0.0132
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0283 0.2854 0.793
Brugia malayi jmjC domain containing protein 0.0019 0.0044 0.0117
Leishmania major DNA polymerase kappa, putative 0.0047 0.0338 0.1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0338 0.0891
Brugia malayi RNA, U transporter 1 0.0099 0.0895 0.2484
Schistosoma mansoni ran 0.0026 0.0115 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1925 0.6742
Schistosoma mansoni hypothetical protein 0.0053 0.0405 0.0513
Leishmania major hypothetical protein, conserved 0.0019 0.0044 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0338 0.1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0115 0.0337
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0338 0.1
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0338 0.1179
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0338 0.0336
Echinococcus granulosus geminin 0.0348 0.3543 0.3542
Loa Loa (eye worm) hypothetical protein 0.0065 0.0535 0.141
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0044 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0338 0.1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1375 0.3625
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0273 0.0807
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0338 0.1575
Brugia malayi bHLH-PAS transcription factor 0.0078 0.0671 0.1861
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0338 0.0999
Echinococcus multilocularis GPCR, family 2 0.0065 0.0535 0.0533
Leishmania major importin beta-1 subunit, putative 0.0028 0.0143 0.0419
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0044 0.0125
Plasmodium vivax JmjC domain containing protein 0.0019 0.0044 0.0161
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0819 0.0817
Loa Loa (eye worm) hypothetical protein 0.0077 0.0665 0.1753
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0233 0.0231
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0134 0.0462
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0213 0.0627
Echinococcus granulosus lamin dm0 0.0029 0.0149 0.0147
Schistosoma mansoni hypothetical protein 0.0065 0.0535 0.0678
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0423 0.1611
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.069 0.2636
Brugia malayi jmjC domain containing protein 0.0071 0.0598 0.1657
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0134 0.0392
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0134 0.0462
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0819 0.1038
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0002 0.0002
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0044 0.0042
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0665 0.1973
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0184 0.0543
Trypanosoma cruzi transcription factor btf3, putative 0.0261 0.2613 0.7767
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0084 0.0315
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0044 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0501 0.0635
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0134 0.0392
Onchocerca volvulus Huntingtin homolog 0.0134 0.1271 0.6752
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0007 0.0018
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0338 0.0935
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0233 0.0295
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.1509 0.4483
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0234 0.0813
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0501 0.0635
Loa Loa (eye worm) hypothetical protein 0.0259 0.26 0.6851
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0228 0.0893
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0338 0.1
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2854 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0338 0.0999
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0115 0.0113
Brugia malayi jmjC domain containing protein 0.0019 0.0044 0.0117
Trichomonas vaginalis adenylate cyclase, putative 0.0027 0.0134 0.0462
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.2566 0.6763
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0598 0.0596
Brugia malayi RNA binding protein 0.0062 0.0501 0.1387
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0084 0.0228
Trypanosoma brucei unspecified product 0.0047 0.0338 0.1
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0044 0.0042
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0044 0.0042
Echinococcus granulosus snurportin 1 0.0372 0.3795 0.3794
Schistosoma mansoni intermediate filament proteins 0.0029 0.0149 0.0189
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.069 0.1914
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0338 0.0429
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1818 0.6369
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0338 0.1575
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0501 0.0635
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1509 0.4483
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0184 0.0543
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0273 0.0951
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0501 0.0635
Schistosoma mansoni hypothetical protein 0.0372 0.3795 0.4811
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0535 0.1482
Schistosoma mansoni hypothetical protein 0.0348 0.3543 0.4492
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0338 0.0999
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0535 0.1482
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0598 0.0758
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0273 0.0951
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0115 0.0113
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.069 0.0875
Loa Loa (eye worm) ICD-1 protein 0.0261 0.2613 0.6886
Entamoeba histolytica hypothetical protein 0.0037 0.0233 0.0885
Schistosoma mansoni importin beta-1 0.0035 0.0213 0.027
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0044 0.0161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0116
Loa Loa (eye worm) hypothetical protein 0.0134 0.1271 0.3349
Echinococcus granulosus single minded 2 0.0082 0.071 0.0708
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.3364 1
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0423 0.1251
Echinococcus granulosus transcription factor btf3 0.0261 0.2613 0.2612
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0273 0.0807
Schistosoma mansoni hypothetical protein 0.0065 0.0535 0.0678
Brugia malayi beta-NAC-like protein 0.0261 0.2613 0.7261
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0044 0.0042
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0423 0.1611
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0206 0.2031 0.5641
Onchocerca volvulus 0.0029 0.0149 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1818 0.6369
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0423 0.1251
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.03 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0134 0.0462
Schistosoma mansoni aryl hydrocarbon receptor 0.0105 0.0962 0.122
Echinococcus granulosus neuropeptide receptor A26 0.0955 1 1
Leishmania major protein kinase, putative 0.0033 0.0189 0.0556
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0338 0.1
Loa Loa (eye worm) hypothetical protein 0.0353 0.3598 0.9482
Plasmodium falciparum basic transcription factor 3b, putative 0.0261 0.2613 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.069 0.0688
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0598 0.0596
Brugia malayi intermediate filament protein 0.0029 0.0149 0.0408
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0273 0.0807
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0027 0.0134 0.0132
Loa Loa (eye worm) hypoxia-induced factor 1 0.0326 0.3307 0.8715
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.0134 0.0132
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0535 0.0533
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0283 0.2854 0.752
Onchocerca volvulus Glucosylceramidase homolog 0.0186 0.1818 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.069 0.2047
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.0134 0.5
Schistosoma mansoni microtubule-associated protein tau 0.0757 0.7889 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.069 0.2047
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0134 0.0462
Trichomonas vaginalis conserved hypothetical protein 0.0261 0.2613 0.9156
Schistosoma mansoni hypothetical protein 0.0024 0.0103 0.013
Entamoeba histolytica hypothetical protein 0.0028 0.0143 0.054
Toxoplasma gondii NAC domain-containing protein 0.0261 0.2613 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0261 0.026
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0044 0.0042
Plasmodium falciparum importin beta, putative 0.0035 0.0213 0.0808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0819 0.1038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0116
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.3364 1
Loa Loa (eye worm) hypothetical protein 0.0206 0.2031 0.5351
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0423 0.1611
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0143 0.0419
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0149 0.0392
Onchocerca volvulus 0.0029 0.0149 0.009
Echinococcus granulosus lamin 0.0029 0.0149 0.0147
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3795 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0206 0.2031 0.5351
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0084 0.0244
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0273 0.0271
Schistosoma mansoni transcription factor btf3 0.0261 0.2613 0.3313
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0084 0.5
Echinococcus multilocularis lamin 0.0029 0.0149 0.0147
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.26 0.2598
Trypanosoma brucei unspecified product 0.0032 0.0184 0.0543
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0324 0.1231
Echinococcus granulosus microtubule associated protein 2 0.0757 0.7889 0.7888
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0338 0.1
Schistosoma mansoni ap endonuclease 0.0023 0.0084 0.0107
Echinococcus multilocularis snurportin 1 0.0372 0.3795 0.3794
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0338 0.1
Brugia malayi hypothetical protein 0.0035 0.0217 0.0598
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2854 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0115 0.0433
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0084 0.0288
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0134 0.0392
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0213 0.0808
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0338 0.0999
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0333 0.0331
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0044 0.0161
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0213 0.0627
Schistosoma mansoni lamin 0.0029 0.0149 0.0189
Schistosoma mansoni hypothetical protein 0.0037 0.0233 0.0295
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0598 0.1575
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0044 0.0056
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0273 0.0271
Toxoplasma gondii hypothetical protein 0.0053 0.0411 0.1565
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0084 0.0082
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0134 0.0352
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0115 0.3365
Echinococcus granulosus dna polymerase eta 0.0077 0.0665 0.0663
Loa Loa (eye worm) hypothetical protein 0.0141 0.1338 0.3527
Echinococcus multilocularis neuropeptide s receptor 0.0955 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0338 0.1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0213 0.0211
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0273 0.0807
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0338 0.1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0213 0.0561
Schistosoma mansoni single-minded 0.0105 0.0962 0.122
Plasmodium vivax importin-beta 2, putative 0.0035 0.0213 0.0808
Echinococcus multilocularis geminin 0.0348 0.3543 0.3542
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0149 0.0408
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0338 0.1
Schistosoma mansoni hypothetical protein 0.0065 0.0535 0.0678
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0134 0.0462
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0501 0.132
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0084 0.0315
Echinococcus multilocularis dna polymerase eta 0.0077 0.0665 0.0663
Schistosoma mansoni hypothetical protein 0.0141 0.1338 0.1697
Brugia malayi MH2 domain containing protein 0.0144 0.1375 0.3819
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0338 0.1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0338 0.1
Echinococcus granulosus importin subunit beta 1 0.0035 0.0213 0.0211
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0115 0.0315
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0338 0.1
Schistosoma mansoni inositol monophosphatase 0.0041 0.0273 0.0346
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0084 0.0288
Echinococcus granulosus phd:f box containing protein 0.0019 0.0044 0.0042
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0044 0.0116
Leishmania major DNA polymerase eta, putative 0.0045 0.0324 0.0956
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0324 0.0956
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0338 0.0429
Trichomonas vaginalis ran, putative 0.0026 0.0115 0.0397
Trichomonas vaginalis conserved hypothetical protein 0.0261 0.2613 0.9156
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0234 0.0813

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 190.561 um PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of Mex-5 Binding to TCR-2. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] ChEMBL. No reference
EC50 (binding) = 195.187 um PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of POS-1 Binding to mex-3-RNA. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] ChEMBL. No reference
IC50 (functional) = 3.424 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
IC50 (functional) = 20.8 uM PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493011, AID493024] ChEMBL. No reference
IC50 (functional) = 42 uM PUBCHEM_BIOASSAY: Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493011, AID493024] ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588708, AID588742] ChEMBL. No reference
Potency (functional) 3.6626 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485290, AID485312, AID504464, AID504474] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.2 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.9441 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 37.6858 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) [Related pubchem assays: 1705 (qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) ), 2324 (Probe Development Summary of Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1707 (Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Validation Assay), 2517 (qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1708 (Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV)] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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