Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0282 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0242 | 0.8317 | 0.8317 |
Onchocerca volvulus | 0.0282 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0242 | 0.8317 | 0.8317 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.8317 | 0.8317 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0242 | 0.8317 | 0.8317 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.8317 | 0.8317 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0242 | 0.8317 | 0.8317 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0282 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.8317 | 0.8317 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0282 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0282 | 1 | 1 |
Onchocerca volvulus | 0.0282 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0242 | 0.8317 | 0.8317 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0242 | 0.8317 | 0.8317 |
Echinococcus multilocularis | peroxidasin | 0.0282 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0242 | 0.8317 | 0.8317 |
Brugia malayi | Animal haem peroxidase family protein | 0.0282 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0242 | 0.8317 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Onchocerca volvulus | 0.0282 | 1 | 1 | |
Schistosoma mansoni | peroxidasin | 0.0282 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0282 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0282 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0282 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0242 | 0.8317 | 0.8317 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 112.219 um | PUBCHEM_BIOASSAY: Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 1663 (Primary HTS), 1678 (Summary of Project)] | ChEMBL. | No reference |
Potency (functional) | 20.7865 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.