Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0562 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.056 | 0.0567 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0562 | 0.06 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0562 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0562 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0562 | 0.0569 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0562 | 0.0639 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0562 | 0.0639 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.4618 | 0.525 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0562 | 0.0639 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0275 | 0.9879 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0562 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0562 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0562 | 0.0639 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0562 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0562 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0562 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.056 | 0.0567 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0562 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.056 | 0.0645 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0562 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0562 | 0.0639 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.056 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0562 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0562 | 0.0639 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0562 | 0.0646 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0562 | 0.0569 |
Onchocerca volvulus | 0.0043 | 0.0562 | 1 | |
Onchocerca volvulus | 0.0043 | 0.0562 | 1 | |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0245 | 0.8689 | 0.8796 |
Schistosoma mansoni | thyroid hormone receptor | 0.0275 | 0.9879 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0562 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0245 | 0.8689 | 0.8796 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0562 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0562 | 0.06 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.056 | 0.0567 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.056 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0562 | 0.0569 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0562 | 0.06 |
Onchocerca volvulus | 0.0043 | 0.0562 | 1 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0562 | 0.0639 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.4618 | 0.4935 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.4618 | 0.525 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0562 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0562 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0262 | 0.9357 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.8729 | 0.9923 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0248 | 0.8796 | 0.94 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0248 | 0.8796 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0245 | 0.8689 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.056 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0275 | 0.9879 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.056 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.056 | 0.0599 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0562 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0562 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0248 | 0.8796 | 0.94 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0562 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0562 | 0.0639 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0562 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0562 | 0.06 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.122 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (binding) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.