Detailed information for compound 1456144

Basic information

Technical information
  • TDR Targets ID: 1456144
  • Name: NCGC00101932-01
  • MW: 412.416 | Formula: C20H16N2O6S
  • H donors: 3 H acceptors: 6 LogP: 2.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c2ccc(c3c2c(c1=O)ccc3)S(=O)(=O)Nc1ccc(c(c1)C(=O)O)O
  • InChi: 1S/C20H16N2O6S/c1-2-22-15-7-9-17(12-4-3-5-13(18(12)15)19(22)24)29(27,28)21-11-6-8-16(23)14(10-11)20(25)26/h3-10,21,23H,2H2,1H3,(H,25,26)
  • InChiKey: JYUYTYXHBKSMML-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-{[(1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)sulfonyl]amino}-2-hydroxybenzoic acid
  • AQ-390/42869127

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens growth factor, augmenter of liver regeneration Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Brugia malayi Augmenter of liver regeneration Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis human hepatopoietin-like protein, putative Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum FAD-linked sulfhydryl oxidase ALR, putative Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hepatopoietin HPO2 Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cpg binding protein 0.0037 0.0639 0.0639
Plasmodium falciparum transporter, putative 0.0022 0.0337 0.4569
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Onchocerca volvulus Peroxidasin homolog 0.0128 0.2515 0.9952
Trichomonas vaginalis ran, putative 0.0021 0.0322 0.0484
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0061 0.0091
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.009 0.0136
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.009 0.009
Plasmodium vivax hypothetical protein, conserved 0.0007 0.0023 0.0318
Brugia malayi serpin 0.0006 0.0006 0.0009
Brugia malayi steroid hormone receptor 0.001 0.009 0.0136
Leishmania major hypothetical protein, conserved 0.0041 0.0737 0.1431
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.009 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.009 0.0136
Loa Loa (eye worm) hypothetical protein 0.0146 0.2876 0.4327
Schistosoma mansoni ran 0.0021 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0506
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0477 0.0928
Onchocerca volvulus 0.0022 0.0337 0.1311
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0061 0.0118
Onchocerca volvulus 0.0128 0.2515 0.9952
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0065 0.0065
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.009 0.009
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0022 0.0337 0.0337
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0061 0.0523
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0206 0.0309
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0475 0.0629
Loa Loa (eye worm) hypothetical protein 0.0012 0.0134 0.0201
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0061 0.0523
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0322 0.0322
Echinococcus granulosus FTZ F1 alpha 0.001 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0129 0.2527 0.3803
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0061 0.0523
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Schistosoma mansoni smad 0.001 0.009 0.009
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0322 0.0601
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.009 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0061 0.0091
Onchocerca volvulus 0.001 0.009 0.0334
Loa Loa (eye worm) steroid hormone receptor 0.001 0.009 0.0136
Onchocerca volvulus 0.0008 0.0061 0.0217
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.009 0.0136
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0337 0.4569
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.5148 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0049 0.0074
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0491 0.666
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0494 0.0936
Onchocerca volvulus 0.0129 0.2527 1
Loa Loa (eye worm) Erv1/Alr family protein 0.0007 0.0023 0.0035
Brugia malayi serpin 0.0006 0.0006 0.0009
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0477 0.0928
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Schistosoma mansoni hypothetical protein 0.0307 0.6175 0.6175
Brugia malayi hypothetical protein 0.0128 0.2515 0.3784
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0134 0.0134
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0061 0.0118
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0134 0.0201
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0327 0.6334
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0061 0.0523
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0303 0.5811
Brugia malayi Blistered cuticle protein 3 0.0128 0.2515 0.3784
Onchocerca volvulus Peroxidase homolog 0.0128 0.2515 0.9952
Loa Loa (eye worm) hypothetical protein 0.0021 0.0327 0.0491
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.009 0.0136
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0494 0.0658
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1234 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0477 0.0718
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0506
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Loa Loa (eye worm) Smad1 0.001 0.009 0.0135
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Echinococcus multilocularis Smad4 0.001 0.009 0.009
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0061 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0049 0.0074
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.009 0.009
Loa Loa (eye worm) serpin 0.0006 0.0006 0.0009
Trypanosoma cruzi quiescin sulfhydryl oxidase, putative 0.0007 0.0023 0.0019
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.2728
Brugia malayi hypothetical protein 0.0006 0.0006 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0475 0.0714
Mycobacterium ulcerans hypothetical protein 0.0029 0.0475 0.0629
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.009 0.009
Echinococcus granulosus cpg binding protein 0.0037 0.0639 0.0639
Trichomonas vaginalis glutaminase, putative 0.033 0.6646 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.009 0.0136
Loa Loa (eye worm) hepatopoietin HPO2 0.0041 0.0737 0.1108
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.009 0.009
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0049 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.009 0.0136
Brugia malayi hypothetical protein 0.0019 0.0277 0.0417
Trichomonas vaginalis helicase, putative 0.0008 0.0049 0.0074
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0475 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.009 0.009
Toxoplasma gondii hypothetical protein 0.0022 0.0337 0.2728
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0494 0.0658
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0475 0.0629
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0061 0.0492
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0494 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0475 1
Echinococcus granulosus peroxidasin 0.0128 0.2515 0.2515
Schistosoma mansoni sodium/chloride dependent transporter 0.0022 0.0337 0.0337
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Schistosoma mansoni serpin 0.0006 0.0006 0.0006
Echinococcus granulosus serine protease inhibitor 0.0006 0.0006 0.0006
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0041 0.0737 0.0737
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.009 0.0136
Loa Loa (eye worm) serpin 0.0006 0.0006 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.0029 0.0477 0.0718
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0506
Brugia malayi Animal haem peroxidase family protein 0.0128 0.2515 0.3784
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.009 0.009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0303 0.5811
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0061 0.0092
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.0737 1
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.009 0.0135
Onchocerca volvulus 0.0029 0.0475 0.1859
Brugia malayi MH1 domain containing protein 0.001 0.009 0.0135
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0327 0.0491
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0494 0.0936
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.009 0.0136
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0022 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0129 0.2527 0.3803
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0061 0.0091
Treponema pallidum sodium- and chloride- dependent transporter 0.0129 0.2527 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0022 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0506
Schistosoma mansoni nuclear hormone receptor 0.001 0.009 0.009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0134 0.1083
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0134 0.0201
Entamoeba histolytica serine protease inhibitor, putative 0.0006 0.0006 0.0127
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0366 0.0551
Brugia malayi MH2 domain containing protein 0.001 0.009 0.0135
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0206 0.04
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0477 0.0477
Plasmodium vivax importin-beta 2, putative 0.0029 0.0477 0.6482
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Brugia malayi Erv1 / Alr family protein 0.0007 0.0023 0.0035
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0061 0.0523
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0022 0.0337 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0049 0.0074
Echinococcus multilocularis smad 0.001 0.009 0.009
Schistosoma mansoni smad1 5 8 and 0.001 0.009 0.009
Brugia malayi hypothetical protein 0.0022 0.0337 0.0506
Echinococcus multilocularis Estrogen regulated protein EP45 0.0006 0.0006 0.0006
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.284 0.4273
Loa Loa (eye worm) glutaminase 0.033 0.6646 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0475 0.0629
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.6175 0.9291
Brugia malayi Animal haem peroxidase family protein 0.0128 0.2515 0.3784
Plasmodium falciparum amino acid transporter, putative 0.0022 0.0337 0.4569
Onchocerca volvulus Dual oxidase homolog 0.0128 0.2515 0.9952
Plasmodium falciparum importin beta, putative 0.0029 0.0477 0.6482
Loa Loa (eye worm) hypothetical protein 0.0021 0.0327 0.0491
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0494 0.0494
Brugia malayi ecdysteroid receptor 0.001 0.009 0.0136
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Brugia malayi serpin 0.0006 0.0006 0.0009
Leishmania major hypothetical protein, conserved 0.0257 0.5148 1
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0108 0.0163
Leishmania major importin beta-1 subunit, putative 0.0023 0.0366 0.0711
Echinococcus multilocularis FTZ F1 alpha 0.001 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0061 0.0118
Brugia malayi MH2 domain containing protein 0.001 0.009 0.0135
Brugia malayi serpin (BmSERPIN) 0.0006 0.0006 0.0009
Schistosoma mansoni thyroid hormone receptor 0.001 0.009 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.009 0.0136
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Mycobacterium ulcerans hypothetical protein 0.003 0.0494 0.0658
Schistosoma mansoni serine protease inhibitors serpins 0.0006 0.0006 0.0006
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0322 0.0484
Onchocerca volvulus 0.0128 0.2515 0.9952
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.009 0.0334
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.0737 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.009 0.009
Onchocerca volvulus 0.0128 0.2515 0.9952
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.0506
Loa Loa (eye worm) hypothetical protein 0.0007 0.0023 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0475 0.0714
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0065 0.0065
Echinococcus granulosus bloom syndrome protein 0.0029 0.0482 0.0482
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0322 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.0029 0.0475 0.0714
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0475 0.9573
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0506
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0327 0.0491
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0061 0.0523
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0006 0.0013 0.002
Schistosoma mansoni serpin 0.0006 0.0006 0.0006
Schistosoma mansoni serine protease inhibitors serpins 0.0006 0.0006 0.0006
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0134 0.0201
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.009 0.0136
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0475 0.0629
Brugia malayi Peroxidasin 0.0128 0.2515 0.3784
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0022 0.0337 0.0337
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0322 0.0626
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0327 0.4433
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.009 0.0136
Echinococcus granulosus serine protease inhibitor 0.0006 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0477 0.387
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0475 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0061 0.0523
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.009 0.009
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0061 0.0091
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0482 0.0725
Schistosoma mansoni peroxidasin 0.0128 0.2515 0.2515
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0322 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.041 0.5566
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Brugia malayi Animal haem peroxidase family protein 0.0128 0.2515 0.3784
Brugia malayi hypothetical protein 0.0029 0.0491 0.0738
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.2728
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.009 0.0136
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0061 0.0523
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0129 0.2527 0.2527
Schistosoma mansoni glutaminase 0.033 0.6646 0.6646
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Brugia malayi serpin 0.0006 0.0006 0.0009
Onchocerca volvulus Peroxidase homolog 0.0128 0.2515 0.9952
Schistosoma mansoni serine protease inhibitors serpins 0.0006 0.0006 0.0006
Brugia malayi BmSERPIN 0.0006 0.0006 0.0009
Brugia malayi serpin precursor 0.0006 0.0006 0.0009
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0134 0.4038
Schistosoma mansoni cpg binding protein 0.0037 0.0639 0.0639
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0061 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0108 0.0108
Echinococcus granulosus serine protease inhibitor 0.0006 0.0006 0.0006
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0061 0.0492
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0366 0.0551
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0475 0.0629
Schistosoma mansoni sodium/chloride dependent transporter 0.0022 0.0337 0.0337
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.5148 1
Schistosoma mansoni quiescin q6-related sulfhydryl oxidase 0.0007 0.0023 0.0023
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.003 0.0494 0.0658
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0327 0.4433
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0065 0.0065
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.009 0.0136
Loa Loa (eye worm) serpin 0.0006 0.0006 0.0009
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0491 0.0953
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.2728
Echinococcus granulosus Estrogen regulated protein EP45 0.0006 0.0006 0.0006
Schistosoma mansoni Smad4 0.001 0.009 0.009
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0134 0.0134
Brugia malayi Animal haem peroxidase family protein 0.0128 0.2515 0.3784
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0475 0.0629
Echinococcus granulosus Smad4 0.001 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Echinococcus granulosus serotonin transporter 0.0129 0.2527 0.2527
Schistosoma mansoni DNA helicase recq1 0.0012 0.0134 0.0134
Schistosoma mansoni smad1 5 8 and 0.001 0.009 0.009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0366 0.0551
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.009 0.009
Brugia malayi RNA, U transporter 1 0.0082 0.1563 0.2352
Echinococcus granulosus snurportin 1 0.0307 0.6175 0.6175
Onchocerca volvulus 0.0022 0.0337 0.1311
Loa Loa (eye worm) hypothetical protein 0.0008 0.0061 0.0091
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.0506
Onchocerca volvulus Peroxidasin homolog 0.0128 0.2515 0.9952
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0061 0.0091
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0491 0.0929
Toxoplasma gondii serpin (serine proteinase inhibitor) superfamily protein 0.0006 0.0006 0.0049
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0061 0.0092
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.009 0.009
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.029 0.3935
Brugia malayi Augmenter of liver regeneration 0.0041 0.0737 0.1108
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0322 0.0484
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.0737 0.1431
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0065 0.0065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.009 0.009
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0022 0.0337 0.0337
Loa Loa (eye worm) glutaminase 2 0.033 0.6646 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0061 0.0061
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0061 0.0091
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0065 0.0065
Brugia malayi Animal haem peroxidase family protein 0.0128 0.2515 0.3784
Loa Loa (eye worm) animal heme peroxidase 0.0128 0.2515 0.3784
Brugia malayi CXXC zinc finger family protein 0.0035 0.0599 0.0901
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0134 0.1083
Schistosoma mansoni hypothetical protein 0.0013 0.0159 0.0159
Brugia malayi BmSERPIN, truncated 0.0006 0.0006 0.0009
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.0737 0.5971
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0049 0.0074
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0159 0.0159
Brugia malayi serpin 0.0006 0.0006 0.0009
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0007 0.0023 0.0069
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0061 0.0092
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.009 0.009
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0491 0.666
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0061 0.0492
Schistosoma mansoni sodium/chloride dependent transporter 0.0129 0.2527 0.2527
Brugia malayi Smad1 0.001 0.009 0.0135
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.009 0.009
Echinococcus granulosus Estrogen regulated protein EP45 0.0006 0.0006 0.0006
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0007 0.0023 0.0069
Entamoeba histolytica recQ family helicase, putative 0.0006 0.0009 0.0184
Echinococcus granulosus sodium and chloride dependent glycine 0.0022 0.0337 0.0337
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.009 0.0136
Echinococcus multilocularis peroxidasin 0.0128 0.2515 0.2515
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0206 0.0374
Schistosoma mansoni serine protease inhibitors serpins 0.0006 0.0006 0.0006
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0061 0.0523
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.009 0.0136
Entamoeba histolytica hypothetical protein 0.0023 0.0366 0.7712
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.0737 0.5971
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0013 0.0284
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0475 0.9573
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0061 0.0824
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0022 0.0337 0.0337
Loa Loa (eye worm) serpin 0.0006 0.0006 0.0009
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0061 0.1279
Toxoplasma gondii hypothetical protein 0.0022 0.0337 0.2728
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0206 0.4332
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.009 0.0136
Mycobacterium ulcerans hypothetical protein 0.003 0.0494 0.0658
Echinococcus granulosus plasminogen activator inhibitor 2 0.0006 0.0006 0.0006
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.0737 0.1409
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0061 0.0091
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0475 0.0922
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Onchocerca volvulus 0.0008 0.0061 0.0217
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0322 0.0601
Schistosoma mansoni cpg binding protein 0.0035 0.0599 0.0599
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.009 0.0135
Schistosoma mansoni serine protease inhibitors serpins 0.0006 0.0006 0.0006
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.009 0.009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0303 0.5811
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0482 0.0482
Schistosoma mansoni peroxidasin 0.0128 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.0506
Onchocerca volvulus Chorion peroxidase homolog 0.0128 0.2515 0.9952
Mycobacterium ulcerans glutaminase 0.033 0.6646 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0322 0.6783
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0491 0.666
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0506
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0022 0.0337 0.0337
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0061 0.0523
Onchocerca volvulus Bile acid receptor homolog 0.001 0.009 0.0334
Brugia malayi MH1 domain containing protein 0.001 0.009 0.0135
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.5148 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0129 0.2527 0.3803
Echinococcus granulosus sulfhydryl oxidase 1 0.0007 0.0023 0.0023
Echinococcus multilocularis snurportin 1 0.0307 0.6175 0.6175
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0475 0.0629
Plasmodium vivax amine transporter, putative 0.0022 0.0337 0.4569
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1395 0.1395
Loa Loa (eye worm) serpin protein 6 0.0006 0.0006 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0061 0.0091
Leishmania major GTP-binding protein, putative 0.0021 0.0322 0.0626
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0491 0.0929
Loa Loa (eye worm) hypothetical protein 0.0129 0.2527 0.3803
Schistosoma mansoni serine protease inhibitors serpins 0.0006 0.0006 0.0006
Loa Loa (eye worm) oxidoreductase 0.0008 0.0061 0.0091
Brugia malayi quiescin Q6 0.0007 0.0023 0.0035
Leishmania major hypothetical protein, conserved 0.0029 0.0491 0.0953
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0475 0.0922
Schistosoma mansoni DNA helicase recq5 0.0012 0.0134 0.0134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.009 0.0136
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0061 0.0091
Echinococcus multilocularis sulfhydryl oxidase 1 0.0007 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0061 0.0091
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.009 0.009
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0599 0.0901
Schistosoma mansoni cpg binding protein 0.0037 0.0639 0.0639
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0475 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0475 0.0714
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0482 0.0725
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.009 0.0136
Loa Loa (eye worm) norepinephrine transporter 0.0129 0.2527 0.3803
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.009 0.009
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.0737 0.1409
Loa Loa (eye worm) animal heme peroxidase 0.0128 0.2515 0.3784
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0134 0.0134
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0041 0.0737 0.0737
Schistosoma mansoni importin beta-1 0.0029 0.0477 0.0477
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0108 0.0108
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0105 0.0159
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.009 0.009
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.0737 0.1409
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.009 0.009
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0322 0.4371
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0494 0.0494
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0322 0.4371
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0061 0.0061
Loa Loa (eye worm) animal heme peroxidase 0.0128 0.2515 0.3784
Loa Loa (eye worm) hypothetical protein 0.0029 0.0491 0.0738
Loa Loa (eye worm) serotonin transporter b 0.0129 0.2527 0.3803
Schistosoma mansoni smad1 5 8 and 0.001 0.009 0.009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0013 0.0109
Loa Loa (eye worm) RecQ helicase 0.0029 0.0482 0.0725
Brugia malayi glutaminase DH11.1 0.033 0.6646 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0022 0.0337 0.0337
Schistosoma mansoni blooms syndrome DNA helicase 0.0006 0.0013 0.0013
Loa Loa (eye worm) blistered cuticle protein 3 0.0128 0.2515 0.3784
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0506
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Echinococcus granulosus smad 0.001 0.009 0.009
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0366 0.0687
Onchocerca volvulus 0.0035 0.0599 0.235
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Loa Loa (eye worm) quiescin Q6 0.0007 0.0023 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0061 0.0091
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0061 0.0523
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.0506
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.0506
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.009 0.009
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0357 0.0357
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Loa Loa (eye worm) animal heme peroxidase 0.0128 0.2515 0.3784
Brugia malayi hypothetical protein 0.0006 0.0006 0.0009
Echinococcus granulosus sodium and chloride dependent glycine 0.0022 0.0337 0.0337
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0475 1
Brugia malayi Serpin protein 6 0.0006 0.0006 0.0009
Brugia malayi serpin 0.0006 0.0006 0.0009
Echinococcus multilocularis serotonin transporter 0.0129 0.2527 0.2527
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0159 0.0159
Onchocerca volvulus 0.0008 0.0061 0.0217
Toxoplasma gondii Erv1 / Alr family protein 0.0007 0.0023 0.019
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0021 0.0327 0.0491
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0134 0.1814
Brugia malayi serpin (BmSERPIN) 0.0006 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0061 0.0824
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.009 0.0136
Echinococcus multilocularis Estrogen regulated protein EP45 0.0006 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0475 0.0714
Echinococcus multilocularis serine protease inhibitor 0.0006 0.0006 0.0006
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0022 0.0337 0.0506
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0007 0.0023 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0049 0.0074
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0206 0.04
Trypanosoma cruzi quiescin sulfhydryl oxidase, putative 0.0007 0.0023 0.0019
Mycobacterium tuberculosis Conserved protein 0.003 0.0494 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.009 0.0136
Schistosoma mansoni ran 0.0021 0.0322 0.0322
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0022 0.0337 0.0337
Echinococcus multilocularis sodium and chloride dependent glycine 0.0022 0.0337 0.0337
Brugia malayi MH2 domain containing protein 0.0144 0.284 0.4273
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0061 0.0118
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0007 0.0023 0.0318
Toxoplasma gondii protease inhibitor PI1 0.0006 0.0006 0.0049
Onchocerca volvulus 0.0008 0.0061 0.0217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.009 0.0136
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0129 0.2527 0.3803
Echinococcus granulosus importin subunit beta 1 0.0029 0.0477 0.0477
Echinococcus multilocularis serine protease inhibitor 0.0006 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0482 0.0725
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0494 0.0744
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0327 0.0404
Schistosoma mansoni coup transcription factor 0.001 0.009 0.009
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.284 0.4273
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0061 0.0092
Brugia malayi nuclear hormone receptor 0.001 0.009 0.0136
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0322 0.261
Brugia malayi nuclear receptor NHR-88 0.001 0.009 0.0136
Schistosoma mansoni hypothetical protein 0.0494 1 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0475 0.0714
Onchocerca volvulus 0.0022 0.0337 0.1311
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0285 0.2311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.009 0.0136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0303 0.5811
Trypanosoma brucei quiescin sulfhydryl oxidase 0.0007 0.0023 0.0046
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0475 0.0922
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0006 0.0009 0.0119
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0491 0.3977
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.009 0.009
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0007 0.0023 0.0069
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0494 0.096
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.009 0.009
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0022 0.0337 0.0337

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 1.548 uM PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.9955 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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