Detailed information for compound 1456302

Basic information

Technical information
  • TDR Targets ID: 1456302
  • Name: 5-(4-fluorophenyl)-3-hydroxy-4-(5-methylfuran -2-carbonyl)-1-pyrimidin-2-yl-5H-pyrrol-2-one
  • MW: 379.341 | Formula: C20H14FN3O4
  • H donors: 1 H acceptors: 5 LogP: 3.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C1N(c2ncccn2)C(=O)C(=C1C(=O)c1ccc(o1)C)O
  • InChi: 1S/C20H14FN3O4/c1-11-3-8-14(28-11)17(25)15-16(12-4-6-13(21)7-5-12)24(19(27)18(15)26)20-22-9-2-10-23-20/h2-10,16,26H,1H3
  • InChiKey: LOBJFYNPGDUUKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(4-fluorophenyl)-3-hydroxy-4-[(5-methyl-2-furyl)-oxomethyl]-1-(2-pyrimidinyl)-5H-pyrrol-2-one
  • 5-(4-fluorophenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-pyrimidin-2-yl-3-pyrrolin-2-one
  • 5-(4-fluorophenyl)-3-hydroxy-4-(5-methylfuran-2-yl)carbonyl-1-pyrimidin-2-yl-5H-pyrrol-2-one
  • Oprea1_794814
  • STOCK2S-74067
  • 5-(4-Fluoro-phenyl)-3-hydroxy-4-(5-methyl-furan-2-carbonyl)-1-pyrimidin-2-yl-1,5-dihydro-pyrrol-2-one
  • SMR000430202
  • MLS000767873

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens galactosidase, alpha Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens relaxin/insulin-like family peptide receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_127620 All targets in OG5_127620
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Glycoside hydrolase, family 27 Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative Get druggable targets OG5_127620 All targets in OG5_127620
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase precursor, putative Get druggable targets OG5_127620 All targets in OG5_127620
Brugia malayi Melibiase family protein Get druggable targets OG5_127620 All targets in OG5_127620
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii melibiase subfamily protein Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus segment polarity protein dishevelled 0.0038 0.0161 0.0395
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0594 0.696
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0102 0.0854 0.2091
Trichomonas vaginalis glutaminase, putative 0.0268 0.2625 1
Brugia malayi isocitrate dehydrogenase 0.0102 0.0854 0.0854
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0161 0.0161
Brugia malayi glutaminase DH11.1 0.0268 0.2625 0.2625
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0102 0.0854 1
Loa Loa (eye worm) TAR-binding protein 0.0404 0.4083 0.4083
Mycobacterium ulcerans glutaminase 0.0268 0.2625 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0767 0.7971 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0594 0.0594
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0594 0.5496
Loa Loa (eye worm) hypothetical protein 0.0654 0.6759 0.6759
Trypanosoma cruzi hypothetical protein 0.0027 0.0045 0.0528
Schistosoma mansoni ras GTP exchange factor 0.0027 0.0045 0.0067
Echinococcus multilocularis segment polarity protein dishevelled 0.0038 0.0161 0.0395
Schistosoma mansoni hypothetical protein 0.0303 0.2998 0.4435
Trichomonas vaginalis ran, putative 0.0026 0.0031 0.0119
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.1081 0.16
Echinococcus granulosus Protein son of sevenless 0.0027 0.0045 0.011
Leishmania major importin beta-1 subunit, putative 0.0028 0.0059 0.0693
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0027 0.0045 0.0067
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0045 0.7617
Loa Loa (eye worm) DIX domain-containing protein 0.0038 0.0161 0.0161
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0038 0.0161 0.0161
Entamoeba histolytica hypothetical protein 0.0028 0.0059 1
Echinococcus multilocularis son of sevenless 1 0.0027 0.0045 0.011
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0102 0.0854 1
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0038 0.0161 0.0146
Schistosoma mansoni dishevelled 0.0038 0.0161 0.0238
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0027 0.0045 0.0528
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0102 0.0854 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0594 0.696
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0027 0.0045 0.0172
Echinococcus granulosus GPCR family 2 0.0303 0.2998 0.7343
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0059 0.0225
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.013 0.1519
Brugia malayi RNA, U transporter 1 0.0099 0.0817 0.0817
Loa Loa (eye worm) hypothetical protein 0.0038 0.0161 0.0161
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0303 0.2998 0.7343
Loa Loa (eye worm) RasGEF domain-containing protein 0.0027 0.0045 0.0045
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0161 0.0161
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0594 0.696
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0031 0.0289
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.1081 0.16
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.1081 0.16
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0045 0.7617
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0124 0.1081 0.2648
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0404 0.4083 0.4083
Brugia malayi latrophilin 2 splice variant baaae 0.0654 0.6759 0.6759
Loa Loa (eye worm) hypothetical protein 0.0957 1 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0102 0.0854 0.0854
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0031 0.0366
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.13 0.13
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0594 0.696
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0031 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0027 0.0045 0.0067
Brugia malayi RasGEF domain containing protein 0.0027 0.0045 0.0045
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.13 0.13
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0102 0.0854 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0027 0.0045 0.0045
Echinococcus granulosus son of sevenless 1 0.0027 0.0045 0.011
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0059 0.0693
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0031 0.0366
Schistosoma mansoni tar DNA-binding protein 0.0404 0.4083 0.6041
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0045 0.7617
Echinococcus granulosus Pleckstrin G protein interacting region 0.0038 0.0161 0.0395
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.013 0.1199
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0045 0.7617
Schistosoma mansoni tar DNA-binding protein 0.0404 0.4083 0.6041
Leishmania major hypothetical protein, conserved 0.0078 0.0594 0.696
Loa Loa (eye worm) hypothetical protein 0.0082 0.064 0.064
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0045 0.7617
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3737 0.3737
Echinococcus multilocularis snurportin 1 0.0372 0.3737 0.9152
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0045
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0124 0.1081 0.2648
Loa Loa (eye worm) glutaminase 2 0.0268 0.2625 0.2625
Onchocerca volvulus 0.0038 0.0161 0.0146
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0 0.5
Echinococcus multilocularis tar DNA binding protein 0.0404 0.4083 1
Brugia malayi hypothetical protein 0.0038 0.0161 0.0161
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.064 0.0947
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0161 0.0395
Echinococcus granulosus tar DNA binding protein 0.0404 0.4083 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0031 0.0031
Brugia malayi Importin beta-1 subunit 0.0035 0.013 0.013
Brugia malayi RasGEF domain containing protein 0.0027 0.0045 0.0045
Echinococcus multilocularis GPCR, family 2 0.0303 0.2998 0.7343
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0102 0.0854 0.2091
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0102 0.0854 1
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0027 0.0045 0.011
Toxoplasma gondii isocitrate dehydrogenase 0.0102 0.0854 0.7896
Schistosoma mansoni hypothetical protein 0.0654 0.6759 1
Toxoplasma gondii isocitrate dehydrogenase 0.0102 0.0854 0.7896
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0594 0.696
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0038 0.0161 0.0395
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0045 0.7617
Schistosoma mansoni hypothetical protein 0.0303 0.2998 0.4435
Loa Loa (eye worm) RasGEF domain-containing protein 0.0027 0.0045 0.0045
Brugia malayi hypothetical protein 0.0038 0.0161 0.0161
Loa Loa (eye worm) latrophilin receptor protein 2 0.0303 0.2998 0.2998
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0045 0.7617
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0038 0.0161 0.0161
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0031 0.0076
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0161 0.0238
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0045 0.7617
Trypanosoma cruzi hypothetical protein 0.0027 0.0045 0.0528
Plasmodium vivax importin-beta 2, putative 0.0035 0.013 0.1519
Schistosoma mansoni importin beta-1 0.0035 0.013 0.0192
Schistosoma mansoni hypothetical protein 0.0035 0.0132 0.0196
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0 0.5
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0102 0.0854 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0102 0.0854 1
Brugia malayi Isocitrate dehydrogenase 0.0102 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0038 0.0161 0.0161
Echinococcus granulosus segment polarity protein dishevelled 0.0038 0.0161 0.0395
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.013 0.1519
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0303 0.2998 0.2998
Brugia malayi RasGEF domain containing protein 0.0027 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0303 0.2998 0.2998
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0045 0.7617
Schistosoma mansoni tar DNA-binding protein 0.0404 0.4083 0.6041
Leishmania major GTP-binding protein, putative 0.0026 0.0031 0.0366
Toxoplasma gondii hypothetical protein 0.0038 0.0161 0.149
Brugia malayi MH2 domain containing protein 0.0144 0.13 0.13
Echinococcus granulosus ras GTP exchange factor 0.0027 0.0045 0.011
Echinococcus granulosus importin subunit beta 1 0.0035 0.013 0.0318
Schistosoma mansoni dep domain containing protein 0.0038 0.0161 0.0238
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0059 0.0225
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0161 0.0395
Echinococcus multilocularis segment polarity protein dishevelled 0.0038 0.0161 0.0395
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0161 0.0238
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0031 0.0031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0957 1 1
Schistosoma mansoni tar DNA-binding protein 0.0404 0.4083 0.6041
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0303 0.2998 0.7343
Brugia malayi N-terminal motif family protein 0.0027 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0372 0.3737 0.5528
Echinococcus granulosus snurportin 1 0.0372 0.3737 0.9152
Schistosoma mansoni ran 0.0026 0.0031 0.0046
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0038 0.0161 0.0238
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0027 0.0045 0.011
Echinococcus multilocularis isocitrate dehydrogenase 0.0102 0.0854 0.2091
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0031 0.0076
Brugia malayi Latrophilin receptor protein 2 0.0303 0.2998 0.2998
Brugia malayi RNA binding protein 0.0404 0.4083 0.4083
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0027 0.0045 0.011
Brugia malayi TAR-binding protein 0.0404 0.4083 0.4083
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0027 0.0045 0.011
Brugia malayi hypothetical protein 0.0078 0.0594 0.0594
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0102 0.0854 0.2091
Loa Loa (eye worm) hypothetical protein 0.0767 0.7971 0.7971
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0059 0.0225
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0031 0.0366
Toxoplasma gondii melibiase subfamily protein 0.0124 0.1081 1
Entamoeba histolytica Ran family GTPase 0.0026 0.0031 0.5279
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0124 0.1081 0.2648
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0161 0.0395
Brugia malayi DIX domain containing protein 0.0038 0.0161 0.0161
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0594 0.696
Trichomonas vaginalis ras GTP exchange factor, putative 0.0027 0.0045 0.0172
Echinococcus multilocularis ras GTP exchange factor 0.0027 0.0045 0.011
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0027 0.0045 0.0067
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0031 0.0366
Schistosoma mansoni ran 0.0026 0.0031 0.0046
Schistosoma mansoni hypothetical protein 0.0303 0.2998 0.4435
Brugia malayi N-terminal motif family protein 0.0767 0.7971 0.7971
Loa Loa (eye worm) RNA binding protein 0.0404 0.4083 0.4083
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0303 0.2998 0.7343
Schistosoma mansoni glutaminase 0.0268 0.2625 0.3884
Brugia malayi RNA recognition motif domain containing protein 0.0404 0.4083 0.4083
Echinococcus multilocularis Protein son of sevenless 0.0027 0.0045 0.011
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0031 0.0366
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0303 0.2998 0.7343
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0038 0.0161 0.0161
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0026 0.0031 0.0046
Brugia malayi Melibiase family protein 0.0082 0.064 0.064
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0102 0.0854 0.2091
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0132 0.0324
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0102 0.0854 1
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.064 0.2438
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.064 0.0947
Schistosoma mansoni hypothetical protein 0.0303 0.2998 0.4435
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0132 0.0324
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0027 0.0045 0.0067
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0161 0.0395
Echinococcus multilocularis importin subunit beta 1 0.0035 0.013 0.0318
Entamoeba histolytica hypothetical protein 0.0027 0.0045 0.7617
Loa Loa (eye worm) glutaminase 0.0268 0.2625 0.2625
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0045 0.7617
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0404 0.4083 0.6041
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0045 0.7617
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0027 0.0045 0.0172
Brugia malayi hypothetical protein 0.005 0.0297 0.0297
Schistosoma mansoni dishevelled 0.0038 0.0161 0.0238
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.1081 0.16
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0102 0.0854 0.1263
Brugia malayi N-terminal motif family protein 0.0027 0.0045 0.0045
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0045 0.7617
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0045 0.7617
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0102 0.0854 0.2091
Brugia malayi Calcitonin receptor-like protein seb-1 0.0957 1 1
Plasmodium falciparum importin beta, putative 0.0035 0.013 0.1519
Trichomonas vaginalis ras GTP exchange factor, putative 0.0027 0.0045 0.0172

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 82.75 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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