Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.1968 | 0.1265 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0805 | 0.0311 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4154 | 0.3642 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.1968 | 0.1537 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0805 | 0.0311 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0403 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0403 | 0.5 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0403 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1968 | 0.1968 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0403 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5058 | 0.5058 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.1968 | 0.1537 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1968 | 0.1968 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0403 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.1968 | 0.1537 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5058 | 0.4637 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0403 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.1968 | 0.1283 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0403 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.1968 | 0.1537 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0403 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0403 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0403 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0403 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8491 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4154 | 0.4154 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5058 | 0.4626 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.443 | 0.4131 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0403 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.443 | 0.443 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1968 | 0.1968 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7722 | 0.7527 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7722 | 0.7522 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0403 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4154 | 0.3655 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0509 | 0.0509 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0403 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0403 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0403 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.443 | 0.4131 |
Onchocerca volvulus | 0.0035 | 0.4154 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1968 | 0.1968 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.1968 | 0.1537 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7722 | 0.7527 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1968 | 0.1265 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0403 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0403 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.1968 | 0.1537 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7722 | 0.7522 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.959 | 0.959 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.1968 | 0.1283 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.443 | 0.443 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.