Detailed information for compound 145646

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 641.472 | Formula: C22H21BrN6O8S2
  • H donors: 6 H acceptors: 8 LogP: 1.24 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCO/N=C(\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)CNC(=O)c1cc(O)c(c(c1)Br)O)/c1csc(n1)N
  • InChi: 1S/C22H21BrN6O8S2/c1-2-37-28-13(11-7-39-22(24)26-11)18(33)27-14-19(34)29-15(21(35)36)9(6-38-20(14)29)5-25-17(32)8-3-10(23)16(31)12(30)4-8/h3-4,7,14,20,30-31H,2,5-6H2,1H3,(H2,24,26)(H,25,32)(H,27,33)(H,35,36)/b28-13-/t14-,20-/m1/s1
  • InChiKey: IOGGFTWXFOZWBX-QDUDRHGOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0125 0.1065 0.1065
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0049 0.0211 0.0257
Loa Loa (eye worm) MH2 domain-containing protein 0.0063 0.0362 0.0362
Schistosoma mansoni heat shock protein 0.0147 0.1308 0.1475
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0125 0.1065 0.1201
Schistosoma mansoni hypothetical protein 0.0071 0.0456 0.0514
Onchocerca volvulus 0.0125 0.1065 0.1901
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0125 0.1065 0.1332
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0751 0.0751
Loa Loa (eye worm) hypothetical protein 0.0225 0.2181 0.2181
Loa Loa (eye worm) glutathione reductase 0.0257 0.2545 0.2545
Schistosoma mansoni neuropeptide receptor 0.0125 0.1065 0.1201
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0125 0.1065 0.1901
Onchocerca volvulus 0.017 0.1564 0.2873
Toxoplasma gondii hexokinase 0.017 0.1564 0.2643
Echinococcus granulosus g protein coupled receptor 0.0125 0.1065 0.1332
Echinococcus multilocularis serotonin receptor 0.0125 0.1065 0.1332
Trypanosoma brucei hexokinase, putative 0.017 0.1564 0.6145
Loa Loa (eye worm) hexokinase 0.0053 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Echinococcus granulosus allatostatin A receptor 0.0125 0.1065 0.1332
Schistosoma mansoni hypothetical protein 0.0125 0.1065 0.1201
Schistosoma mansoni growth hormone secretagogue receptor 0.0125 0.1065 0.1201
Schistosoma mansoni neuropeptide receptor 0.0125 0.1065 0.1201
Echinococcus granulosus somatostatin receptor 0.0125 0.1065 0.1332
Leishmania major heat shock protein, putative 0.0098 0.0754 0.051
Treponema pallidum hexokinase (hxk) 0.017 0.1564 1
Echinococcus multilocularis g protein coupled receptor 0.0125 0.1065 0.1332
Loa Loa (eye worm) hexokinase 0.0106 0.0853 0.0853
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0049 0.0211 0.0257
Schistosoma mansoni tar DNA-binding protein 0.013 0.1121 0.1264
Echinococcus multilocularis hexokinase 0.017 0.1564 0.1959
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Brugia malayi hypothetical protein 0.0202 0.1922 0.1922
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.0047
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0125 0.1065 0.1065
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0089 0.0658 0.0658
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0098 0.0754 0.0941
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0225 0.2181 0.2181
Echinococcus multilocularis neuropeptide receptor A26 0.0125 0.1065 0.1332
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Trypanosoma brucei heat shock protein, putative 0.0147 0.1308 0.514
Brugia malayi Protein cec-1. 0.0039 0.009 0.009
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0039 0.009 0.0151
Leishmania major hexokinase, putative 0.017 0.1564 0.4802
Schistosoma mansoni adenoreceptor 0.0125 0.1065 0.1201
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0586 0.6243 0.8837
Plasmodium vivax ataxin-2 like protein, putative 0.011 0.0891 0.1505
Schistosoma mansoni biogenic amine (5HT) receptor 0.0125 0.1065 0.1201
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Trypanosoma brucei hexokinase 0.017 0.1564 0.6145
Brugia malayi G-protein coupled receptor 0.0125 0.1065 0.1065
Trypanosoma cruzi heat shock protein 90, putative 0.0126 0.107 0.3284
Echinococcus granulosus g protein coupled receptor 0.0125 0.1065 0.1332
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0652 0.6978 1
Echinococcus granulosus Chromobox protein 3 0.0039 0.009 0.0105
Plasmodium vivax hypothetical protein, conserved 0.0039 0.009 0.0151
Echinococcus multilocularis G protein coupled receptor 139 0.0125 0.1065 0.1332
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Brugia malayi Thioredoxin reductase 0.0257 0.2545 0.2545
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0039 0.009 0.0101
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0127 0.1089 0.1089
Trypanosoma cruzi Heat shock protein 83, putative 0.0147 0.1308 0.437
Plasmodium falciparum glutathione reductase 0.0089 0.0658 0.1111
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Echinococcus multilocularis Chromo domain 0.0039 0.009 0.0105
Echinococcus multilocularis hexokinase 0.017 0.1564 0.1959
Loa Loa (eye worm) hypothetical protein 0.0094 0.0708 0.0708
Entamoeba histolytica hypothetical protein 0.0202 0.1922 0.2781
Loa Loa (eye worm) hypothetical protein 0.0132 0.1139 0.1139
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0658 0.1409
Trypanosoma cruzi heat shock protein 85, putative 0.0126 0.107 0.3284
Echinococcus granulosus Smad4 0.0063 0.0362 0.0447
Brugia malayi neuropeptide F receptor 0.0125 0.1065 0.1065
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.009
Onchocerca volvulus 0.0333 0.3401 0.6454
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Schistosoma mansoni opsin-like receptor 0.0125 0.1065 0.1201
Giardia lamblia Heat shock protein HSP 90-alpha 0.0126 0.107 0.6333
Brugia malayi glutathione reductase 0.0257 0.2545 0.2545
Trypanosoma brucei heat shock protein, putative 0.0147 0.1308 0.514
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Schistosoma mansoni hypothetical protein 0.0071 0.0456 0.0514
Echinococcus granulosus serotonin receptor 0.0125 0.1065 0.1332
Echinococcus granulosus GPCR family 2 0.0071 0.0456 0.0565
Brugia malayi latrophilin 2 splice variant baaae 0.0154 0.1383 0.1383
Entamoeba histolytica hypothetical protein 0.0202 0.1922 0.2781
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0125 0.1065 0.1201
Schistosoma mansoni amine GPCR 0.0125 0.1065 0.1201
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.009
Trypanosoma brucei heat shock protein, putative 0.0147 0.1308 0.514
Loa Loa (eye worm) hypothetical protein 0.0333 0.3401 0.3401
Onchocerca volvulus 0.0125 0.1065 0.1901
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0125 0.1065 0.1201
Loa Loa (eye worm) hypothetical protein 0.011 0.0891 0.0891
Brugia malayi jmjC domain containing protein 0.0113 0.0929 0.0929
Echinococcus granulosus endoplasmin 0.0138 0.1207 0.151
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Onchocerca volvulus 0.0125 0.1065 0.1901
Treponema pallidum heat shock protein 90 0.0138 0.1207 0.6059
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0306 0.3098 0.3889
Echinococcus granulosus g protein coupled receptor 0.0125 0.1065 0.1332
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0039 0.009 0.0101
Echinococcus granulosus heat shock protein 90 0.0147 0.1308 0.1638
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0658 0.1409
Onchocerca volvulus 0.0125 0.1065 0.1901
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.1065 0.1332
Loa Loa (eye worm) heat shock protein 90 0.0147 0.1308 0.1308
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0125 0.1065 0.1065
Loa Loa (eye worm) TAR-binding protein 0.013 0.1121 0.1121
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0125 0.1065 0.1065
Echinococcus granulosus G protein coupled receptor 139 0.0125 0.1065 0.1332
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Schistosoma mansoni hypothetical protein 0.0071 0.0456 0.0514
Brugia malayi hypothetical protein 0.0125 0.1065 0.1065
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0127 0.1089 0.1362
Trypanosoma brucei heat shock protein, putative 0.0147 0.1308 0.514
Loa Loa (eye worm) transcription factor SMAD2 0.0921 1 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Trypanosoma cruzi trypanothione reductase, putative 0.0089 0.0658 0.1409
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0039 0.009 0.0105
Echinococcus multilocularis somatostatin receptor 0.0125 0.1065 0.1332
Schistosoma mansoni neuropeptide F-like receptor 0.0125 0.1065 0.1201
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0125 0.1065 0.1332
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.3385 0.3385
Echinococcus granulosus hexokinase 0.017 0.1564 0.1959
Schistosoma mansoni chromobox protein 0.0039 0.009 0.0101
Echinococcus multilocularis heat shock protein 90 0.0147 0.1308 0.1638
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Echinococcus granulosus neuropeptides capa receptor 0.0125 0.1065 0.1332
Brugia malayi SET domain containing protein 0.0039 0.009 0.009
Echinococcus granulosus neuropeptide receptor 0.0125 0.1065 0.1332
Echinococcus granulosus chromobox protein 2 0.0039 0.009 0.0105
Echinococcus granulosus hexokinase type 2 0.017 0.1564 0.1959
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0039 0.009 0.0151
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Brugia malayi Serotonin receptor 0.0125 0.1065 0.1065
Brugia malayi Dopamine receptor 0.0125 0.1065 0.1065
Brugia malayi AF-10 protein 0.0031 0.0001 0.0001
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0625 0.6677 1
Entamoeba histolytica hypothetical protein 0.0202 0.1922 0.2781
Trypanosoma cruzi heat shock protein 85, putative 0.0147 0.1308 0.437
Loa Loa (eye worm) jmjC domain-containing protein 0.0113 0.0929 0.0929
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Loa Loa (eye worm) pax transcription factor protein 2 0.0495 0.522 0.522
Onchocerca volvulus 0.0106 0.0853 0.1488
Schistosoma mansoni jumonji domain containing protein 0.0243 0.239 0.2696
Echinococcus multilocularis jumonji domain containing protein 0.013 0.1119 0.14
Schistosoma mansoni transcription factor LCR-F1 0.0202 0.1922 0.2167
Schistosoma mansoni hypothetical protein 0.0739 0.7954 0.8972
Loa Loa (eye worm) RNA binding protein 0.013 0.1121 0.1121
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0586 0.6243 0.8837
Schistosoma mansoni biogenic amine receptor 0.0125 0.1065 0.1201
Brugia malayi PHD-finger family protein 0.0094 0.0708 0.0708
Trichomonas vaginalis heat shock protein, putative 0.0138 0.1207 0.1695
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Giardia lamblia Grp94/Hsp90 0.0138 0.1207 0.8441
Echinococcus granulosus geminin 0.0739 0.7954 1
Echinococcus multilocularis neuropeptide receptor 0.0125 0.1065 0.1332
Brugia malayi hypothetical protein 0.011 0.0891 0.0891
Trypanosoma cruzi PAB1-binding protein , putative 0.011 0.0891 0.2469
Trichomonas vaginalis chromobox protein, putative 0.0142 0.1252 0.1764
Toxoplasma gondii LsmAD domain-containing protein 0.011 0.0891 0.1505
Entamoeba histolytica hexokinase 2 0.017 0.1564 0.2237
Brugia malayi hypothetical protein 0.0125 0.1065 0.1065
Brugia malayi MH1 domain containing protein 0.0063 0.0362 0.0362
Schistosoma mansoni smad1 5 8 and 0.0063 0.0362 0.0408
Brugia malayi ORL1-like opioid receptor 0.0125 0.1065 0.1065
Onchocerca volvulus Neuropeptide F receptor homolog 0.0125 0.1065 0.1901
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0089 0.0658 0.2583
Echinococcus multilocularis hexokinase type 2 0.017 0.1564 0.1959
Plasmodium vivax hexokinase, putative 0.017 0.1564 0.2643
Brugia malayi Calcitonin receptor-like protein seb-1 0.0225 0.2181 0.2181
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Plasmodium vivax heat shock protein 86, putative 0.0147 0.1308 0.2211
Echinococcus granulosus sex peptide receptor 0.0125 0.1065 0.1332
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0127 0.1089 0.1362
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.009
Echinococcus multilocularis g protein coupled receptor 0.0125 0.1065 0.1332
Schistosoma mansoni tar DNA-binding protein 0.013 0.1121 0.1264
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0125 0.1065 0.1332
Echinococcus granulosus peptide allatostatin:somatostatin 0.0125 0.1065 0.1332
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0039 0.009 0.009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.1065 0.1201
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0125 0.1065 0.1201
Brugia malayi N-terminal motif family protein 0.0207 0.1986 0.1986
Trichomonas vaginalis glutathione reductase, putative 0.0089 0.0658 0.0862
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0652 0.6978 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0089 0.0658 0.2583
Brugia malayi hypothetical protein 0.0125 0.1065 0.1065
Brugia malayi hypothetical protein 0.0125 0.1065 0.1065
Loa Loa (eye worm) jmjC domain-containing protein 0.0193 0.1826 0.1826
Toxoplasma gondii heat shock protein 75, putative 0.0098 0.0754 0.1274
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Loa Loa (eye worm) endoplasmin 0.0147 0.1308 0.1308
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0751 0.0846
Trichomonas vaginalis heat shock protein, putative 0.0138 0.1207 0.1695
Schistosoma mansoni chromobox protein 0.0235 0.2301 0.2595
Schistosoma mansoni hypothetical protein 0.0039 0.009 0.0101
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Loa Loa (eye worm) hypothetical protein 0.0071 0.0456 0.0456
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0089 0.0658 0.1111
Trypanosoma cruzi hexokinase, putative 0.017 0.1564 0.5534
Echinococcus granulosus heat shock protein 90 0.0126 0.107 0.1338
Echinococcus multilocularis Smad4 0.0063 0.0362 0.0447
Trypanosoma brucei heat shock protein, putative 0.0147 0.1308 0.514
Loa Loa (eye worm) hexokinase 0.017 0.1564 0.1564
Plasmodium falciparum importin beta, putative 0.0031 0.0007 0.001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.1065 0.1332
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Echinococcus granulosus heat shock protein 0.0147 0.1308 0.1638
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0039 0.009 0.0101
Brugia malayi hypothetical protein 0.0071 0.0454 0.0454
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0207 0.1986 0.3695
Schistosoma mansoni opsin-like receptor 0.0125 0.1065 0.1201
Trypanosoma brucei trypanothione reductase 0.0257 0.2545 1
Brugia malayi hexokinase 0.017 0.1564 0.1564
Echinococcus multilocularis neuropeptide Y receptor 0.0125 0.1065 0.1332
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0039 0.009 0.0105
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0586 0.6243 0.8837
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.1065 0.1201
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0125 0.1065 0.1332
Echinococcus granulosus fmrfamide receptor 0.0125 0.1065 0.1332
Brugia malayi Smad1 0.0063 0.0362 0.0362
Onchocerca volvulus Alhambra homolog 0.0094 0.0708 0.1204
Schistosoma mansoni myosin xvIII 0.0125 0.1065 0.1201
Toxoplasma gondii PHD-finger domain-containing protein 0.0094 0.0708 0.1196
Brugia malayi G protein-coupled receptor F59B2.13 0.0125 0.1065 0.1065
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0125 0.1065 0.1201
Schistosoma mansoni jumonji/arid domain-containing protein 0.0113 0.0929 0.1047
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0127 0.1089 0.1362
Trypanosoma cruzi hexokinase, putative 0.017 0.1564 0.5534
Loa Loa (eye worm) MH2 domain-containing protein 0.0921 1 1
Brugia malayi TAR-binding protein 0.013 0.1121 0.1121
Plasmodium falciparum phd finger protein, putative 0.0094 0.0708 0.1196
Trypanosoma brucei heat shock protein, putative 0.0147 0.1308 0.514
Plasmodium vivax heat shock protein, putative 0.0557 0.5914 1
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0001 0.0001
Echinococcus multilocularis neuropeptides capa receptor 0.0125 0.1065 0.1332
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0125 0.1065 0.1201
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0202 0.1922 0.241
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0751 0.0937
Brugia malayi hypothetical protein 0.0125 0.1065 0.1065
Plasmodium falciparum thioredoxin reductase 0.0089 0.0658 0.1111
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0089 0.0658 0.1409
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.1065 0.1332
Schistosoma mansoni smad1 5 8 and 0.0063 0.0362 0.0408
Schistosoma mansoni alpha-1 adrenergic receptor 0.0125 0.1065 0.1201
Brugia malayi MH1 domain containing protein 0.0035 0.0047 0.0047
Echinococcus granulosus peregrin 0.0094 0.0708 0.0882
Onchocerca volvulus 0.0125 0.1065 0.1901
Brugia malayi G-protein coupled receptor 0.0125 0.1065 0.1065
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Plasmodium falciparum heat shock protein 90 0.0147 0.1308 0.2211
Schistosoma mansoni tar DNA-binding protein 0.013 0.1121 0.1264
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0751 0.0751
Echinococcus granulosus chromobox protein 1 0.0235 0.2301 0.2887
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0089 0.0658 0.1409
Brugia malayi CHD4 protein 0.0039 0.009 0.009
Plasmodium falciparum heat shock protein 90, putative 0.0085 0.0617 0.1042
Trichomonas vaginalis heat shock protein, putative 0.0126 0.107 0.1487
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.1065 0.1201
Echinococcus granulosus alpha 1A adrenergic receptor 0.0125 0.1065 0.1332
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.1065 0.1201
Schistosoma mansoni heat shock protein 0.0098 0.0754 0.085
Loa Loa (eye worm) hexokinase type II 0.017 0.1564 0.1564
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0751 0.0937
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0202 0.1922 0.241
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Echinococcus multilocularis orexin receptor type 2 0.0125 0.1065 0.1332
Echinococcus granulosus neuropeptides capa receptor 0.0125 0.1065 0.1332
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0125 0.1065 0.1332
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0125 0.1065 0.1065
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Trypanosoma brucei heat shock protein, putative 0.0147 0.1308 0.514
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0089 0.0658 0.2583
Loa Loa (eye worm) thioredoxin reductase 0.0257 0.2545 0.2545
Loa Loa (eye worm) neuropeptide F receptor 0.0125 0.1065 0.1065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.1065 0.1201
Brugia malayi Hexokinase family protein 0.0106 0.0853 0.0853
Echinococcus multilocularis allatostatin A receptor 0.0125 0.1065 0.1332
Brugia malayi chromobox protein homolog 3 0.0132 0.1139 0.1139
Echinococcus granulosus thioredoxin glutathione reductase 0.0257 0.2545 0.3194
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0071 0.0456 0.0565
Onchocerca volvulus 0.0125 0.1065 0.1901
Onchocerca volvulus Hexokinase homolog 0.0106 0.0853 0.1488
Echinococcus multilocularis mothers against decapentaplegic 5 0.0063 0.0362 0.0447
Schistosoma mansoni jumonji/arid domain-containing protein 0.0113 0.0929 0.1047
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0089 0.0658 0.2583
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0125 0.1065 0.1332
Onchocerca volvulus 0.0125 0.1065 0.1901
Loa Loa (eye worm) PHD-finger family protein 0.0094 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0089 0.0658 0.1111
Schistosoma mansoni importin beta-1 0.0031 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Onchocerca volvulus 0.0125 0.1065 0.1901
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0039 0.009 0.0151
Brugia malayi putative neuropeptide receptor 0.0125 0.1065 0.1065
Onchocerca volvulus 0.0125 0.1065 0.1901
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0039 0.009 0.0151
Brugia malayi Hexokinase family protein 0.017 0.1564 0.1564
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Trichomonas vaginalis chromobox protein, putative 0.0142 0.1252 0.1764
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0586 0.6243 0.8727
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0039 0.009 0.0151
Trypanosoma cruzi trypanothione reductase, putative 0.0257 0.2545 1
Brugia malayi AKH receptor 0.0125 0.1065 0.1065
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0089 0.0658 0.1111
Schistosoma mansoni hypothetical protein 0.0202 0.1922 0.2167
Onchocerca volvulus 0.0125 0.1065 0.1901
Loa Loa (eye worm) hypothetical protein 0.0054 0.0264 0.0264
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0063 0.0362 0.0408
Schistosoma mansoni histamine h1 receptor 0.0125 0.1065 0.1201
Plasmodium falciparum hexokinase 0.017 0.1564 0.2643
Echinococcus multilocularis Chromobox protein 3 0.0039 0.009 0.0105
Plasmodium vivax heat shock protein 90, putative 0.0098 0.0754 0.1274
Echinococcus granulosus tachykinin peptides receptor 99D 0.0125 0.1065 0.1332
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0125 0.1065 0.1332
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0127 0.1089 0.1228
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0625 0.6677 1
Mycobacterium tuberculosis Probable reductase 0.0586 0.6243 0.8837
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0089 0.0658 0.1111
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0039 0.009 0.0105
Brugia malayi putative neuropeptide receptor NPR1 0.0125 0.1065 0.1065
Toxoplasma gondii thioredoxin reductase 0.0257 0.2545 0.4302
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.1065 0.1201
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Schistosoma mansoni hypothetical protein 0.0332 0.3385 0.3818
Schistosoma mansoni biogenic amine receptor 0.0125 0.1065 0.1201
Giardia lamblia PHD finger protein 15 0.0094 0.0708 0.0767
Brugia malayi M-phase phosphoprotein, mpp8 0.0039 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.009
Schistosoma mansoni smad 0.0063 0.0362 0.0408
Trypanosoma brucei heat shock protein 84, putative 0.0098 0.0754 0.2962
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0125 0.1065 0.1065
Echinococcus multilocularis peregrin 0.0094 0.0708 0.0882
Schistosoma mansoni hypothetical protein 0.0739 0.7954 0.8972
Loa Loa (eye worm) hypothetical protein 0.0054 0.0264 0.0264
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0306 0.3098 0.3889
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.1065 0.1201
Echinococcus multilocularis thioredoxin glutathione reductase 0.0257 0.2545 0.3194
Onchocerca volvulus 0.0125 0.1065 0.1901
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Leishmania major hypothetical protein, conserved 0.011 0.0891 0.1234
Echinococcus granulosus neuropeptide receptor A26 0.0125 0.1065 0.1332
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0098 0.0754 0.1008
Loa Loa (eye worm) helicase 0.0039 0.009 0.009
Schistosoma mansoni hexokinase 0.017 0.1564 0.1763
Loa Loa (eye worm) melatonin receptor type 1A 0.0125 0.1065 0.1065
Schistosoma mansoni biogenic amine receptor 0.0125 0.1065 0.1201
Loa Loa (eye worm) CHromoDomain protein family member 0.0039 0.009 0.009
Onchocerca volvulus 0.0103 0.0819 0.1421
Trypanosoma cruzi heat shock protein 90, putative 0.0147 0.1308 0.437
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0138 0.1207 0.2909
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0138 0.1207 0.0868
Brugia malayi Dopamine receptor protein 2 0.0125 0.1065 0.1065
Brugia malayi larval opioid receptor 0.0125 0.1065 0.1065
Onchocerca volvulus 0.0125 0.1065 0.1901
Trypanosoma brucei Heat shock protein 83, putative 0.0147 0.1308 0.514
Loa Loa (eye worm) nuclear factor I 0.0035 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0116 0.0958 0.0958
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.1065 0.1201
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0039 0.009 0.0101
Brugia malayi hexokinase type II 0.0054 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.009
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0007 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.1139 0.1593
Schistosoma mansoni smad1 5 8 and 0.0063 0.0362 0.0408
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0125 0.1065 0.1201
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.1065 0.1332
Brugia malayi Endoplasmin precursor 0.0147 0.1308 0.1308
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0751 0.0937
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0094 0.0708 0.0798
Brugia malayi heat shock protein 90 0.0147 0.1308 0.1308
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0125 0.1065 0.1201
Trichomonas vaginalis heat shock protein, putative 0.0085 0.0617 0.08
Brugia malayi sulfakinin receptor protein 0.0125 0.1065 0.1065
Echinococcus multilocularis PHD finger protein rhinoceros 0.0094 0.0708 0.0882
Plasmodium falciparum ataxin-2 like protein, putative 0.011 0.0891 0.1505
Plasmodium falciparum heat shock protein 90, putative 0.0557 0.5914 1
Trypanosoma cruzi heat shock protein, putative 0.0098 0.0754 0.1847
Echinococcus granulosus g-protein coupled receptor 0.0125 0.1065 0.1332
Toxoplasma gondii NADPH-glutathione reductase 0.0089 0.0658 0.1111
Plasmodium falciparum ataxin-2 like protein, putative 0.011 0.0891 0.1505
Echinococcus granulosus chromobox protein 1 0.0235 0.2301 0.2887
Echinococcus multilocularis neuropeptide receptor 0.0125 0.1065 0.1332
Trichomonas vaginalis endoplasmin, putative 0.0107 0.0856 0.1162
Brugia malayi RE15519p 0.0125 0.1065 0.1065
Onchocerca volvulus 0.0125 0.1065 0.1901
Mycobacterium tuberculosis Probable oxidoreductase 0.0652 0.6978 1
Schistosoma mansoni hypothetical protein 0.0125 0.1065 0.1201
Echinococcus multilocularis chromobox protein 1 0.0235 0.2301 0.2887
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0007
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0125 0.1065 0.1065
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0751 0.0846
Schistosoma mansoni hypothetical protein 0.0094 0.0708 0.0798
Echinococcus multilocularis GPCR, family 2 0.0071 0.0456 0.0565
Echinococcus multilocularis g-protein coupled receptor 0.0125 0.1065 0.1332
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Schistosoma mansoni Smad4 0.0063 0.0362 0.0408
Schistosoma mansoni chromobox protein 0.0235 0.2301 0.2595
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Mycobacterium ulcerans heat shock protein 90 0.0138 0.1207 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0751 0.0937
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.1065 0.1332
Brugia malayi hypothetical protein 0.0125 0.1065 0.1065
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0125 0.1065 0.1332
Plasmodium vivax importin-beta 2, putative 0.0031 0.0007 0.001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0225 0.2181 0.2181
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0125 0.1065 0.1332
Toxoplasma gondii PHD-finger domain-containing protein 0.0094 0.0708 0.1196
Brugia malayi Hsp90 protein 0.0098 0.0754 0.0754
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0132 0.1139 0.2046
Schistosoma mansoni amine GPCR 0.0125 0.1065 0.1201
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0098 0.0754 0.0941
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0125 0.1065 0.1332
Schistosoma mansoni hypothetical protein 0.0125 0.1065 0.1201
Trypanosoma cruzi PAB1-binding protein , putative 0.011 0.0891 0.2469
Brugia malayi hypothetical protein 0.0125 0.1065 0.1065
Entamoeba histolytica heat shock protein 90, putative 0.0147 0.1308 0.1849
Onchocerca volvulus 0.017 0.1564 0.2873
Plasmodium vivax heterochromatin protein 1, putative 0.0039 0.009 0.0151
Mycobacterium tuberculosis Probable dehydrogenase 0.0586 0.6243 0.8837
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0125 0.1065 0.1201
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0089 0.0658 0.0741
Echinococcus granulosus neuropeptide Y receptor 0.0125 0.1065 0.1332
Schistosoma mansoni tar DNA-binding protein 0.013 0.1121 0.1264
Toxoplasma gondii Hsp90 domain-containing protein 0.0557 0.5914 1
Brugia malayi MH1 domain containing protein 0.0035 0.0047 0.0047
Plasmodium falciparum heterochromatin protein 1 0.0039 0.009 0.0151
Schistosoma mansoni amine GPCR 0.0125 0.1065 0.1201
Schistosoma mansoni amine GPCR 0.0125 0.1065 0.1201
Brugia malayi Serotonin receptor 0.0125 0.1065 0.1065
Echinococcus granulosus mothers against decapentaplegic 5 0.0063 0.0362 0.0447
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0125 0.1065 0.1065
Plasmodium vivax endoplasmin, putative 0.0147 0.1308 0.2211
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0089 0.0658 0.5
Plasmodium falciparum endoplasmin, putative 0.0107 0.0856 0.1446
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0658 0.1409
Loa Loa (eye worm) TYRA-2 protein 0.0125 0.1065 0.1065
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0126 0.107 0.1338
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0125 0.1065 0.1332
Echinococcus granulosus neuropeptide s receptor 0.0125 0.1065 0.1332
Schistosoma mansoni opsin-like receptor 0.0125 0.1065 0.1201
Brugia malayi MH2 domain containing protein 0.0063 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Echinococcus granulosus hexokinase 0.017 0.1564 0.1959
Loa Loa (eye worm) hypothetical protein 0.0154 0.1383 0.1383
Echinococcus granulosus hypothetical protein 0.0125 0.1065 0.1332
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Echinococcus granulosus smad 0.0063 0.0362 0.0447
Brugia malayi Hexokinase family protein 0.0053 0.0247 0.0247
Brugia malayi hypothetical protein 0.0333 0.3401 0.3401
Echinococcus multilocularis tar DNA binding protein 0.013 0.1121 0.1403
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.1065 0.1201
Brugia malayi G protein-coupled receptor 0.0125 0.1065 0.1065
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0127 0.1089 0.1089
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Onchocerca volvulus 0.0125 0.1065 0.1901
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Brugia malayi hypothetical protein 0.0125 0.1065 0.1065
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0065 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0138 0.1207 1
Trypanosoma cruzi heat shock protein 85, putative 0.0147 0.1308 0.437
Echinococcus granulosus tar DNA binding protein 0.013 0.1121 0.1403
Giardia lamblia Heat shock protein HSP 90-alpha 0.0147 0.1308 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.1065 0.1201
Loa Loa (eye worm) hypothetical protein 0.0207 0.1986 0.1986
Echinococcus multilocularis endoplasmin 0.0138 0.1207 0.151
Brugia malayi Melatonin receptor type 1A 0.0125 0.1065 0.1065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.1065 0.1201
Echinococcus multilocularis neuropeptides capa receptor 0.0125 0.1065 0.1332
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Echinococcus multilocularis hexokinase 0.017 0.1564 0.1959
Echinococcus granulosus biogenic amine 5HT receptor 0.0125 0.1065 0.1332
Loa Loa (eye worm) hypothetical protein 0.016 0.1458 0.1458
Brugia malayi jmjC domain containing protein 0.0306 0.3098 0.3098
Schistosoma mansoni endoplasmin 0.0147 0.1308 0.1475
Plasmodium vivax thioredoxin reductase, putative 0.0257 0.2545 0.4302
Toxoplasma gondii heat shock protein HSP90 0.0147 0.1308 0.2211
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0071 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.009
Schistosoma mansoni endoplasmin 0.0147 0.1308 0.1475
Echinococcus multilocularis g protein coupled receptor 0.0125 0.1065 0.1332
Echinococcus granulosus snurportin 1 0.0332 0.3385 0.4251
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Echinococcus multilocularis G-protein coupled receptor, putative 0.0125 0.1065 0.1332
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0125 0.1065 0.1332
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0098 0.0754 0.1294
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Trypanosoma brucei heat shock protein 90, putative 0.0147 0.1308 0.514
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Brugia malayi Bromodomain containing protein 0.0094 0.0708 0.0708
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0125 0.1065 0.1332
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0652 0.6978 1
Entamoeba histolytica hexokinase 1 0.017 0.1564 0.2237
Brugia malayi Valyl-tRNA synthetase 0.0039 0.009 0.009
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Schistosoma mansoni neuropeptide f receptor 76f 0.0125 0.1065 0.1201
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0125 0.1065 0.1332
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.1139 0.1593
Echinococcus granulosus biogenic amine 5HT receptor 0.0125 0.1065 0.1332
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Schistosoma mansoni hypothetical protein 0.0125 0.1065 0.1201
Plasmodium falciparum thioredoxin reductase 0.0257 0.2545 0.4302
Onchocerca volvulus 0.0125 0.1065 0.1901
Entamoeba histolytica hypothetical protein 0.0202 0.1922 0.2781
Trypanosoma brucei hexokinase 0.017 0.1564 0.6145
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0257 0.2545 0.2985
Brugia malayi hypothetical protein 0.0039 0.009 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Echinococcus multilocularis neuropeptide s receptor 0.0125 0.1065 0.1332
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0007 0.001
Brugia malayi Dopamine receptor protein 1 0.0125 0.1065 0.1065
Brugia malayi GnHR receptor homolog 0.0125 0.1065 0.1065
Trichomonas vaginalis chromobox protein, putative 0.0235 0.2301 0.3357
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0751 0.0846
Echinococcus multilocularis lysine specific demethylase 5A 0.0113 0.0929 0.116
Echinococcus granulosus PHD finger protein rhinoceros 0.0094 0.0708 0.0882
Echinococcus granulosus hexokinase 0.017 0.1564 0.1959
Echinococcus multilocularis neuropeptide FF receptor 2 0.0125 0.1065 0.1332
Toxoplasma gondii heat shock protein 90, putative 0.0147 0.1308 0.2211
Brugia malayi Associated with TFs and helicases family protein 0.0039 0.009 0.009
Schistosoma mansoni biogenic amine (5HT) receptor 0.0125 0.1065 0.1201
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0089 0.0658 0.082
Brugia malayi MH1 domain containing protein 0.0063 0.0362 0.0362
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Brugia malayi hypothetical protein 0.0125 0.1065 0.1065
Loa Loa (eye worm) G-protein coupled receptor 0.0125 0.1065 0.1065
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0127 0.1089 0.1362
Trypanosoma brucei PAB1-binding protein , putative 0.011 0.0891 0.3499
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Schistosoma mansoni tar DNA-binding protein 0.013 0.1121 0.1264
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0007 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0658 0.1409
Schistosoma mansoni neuropeptide receptor 0.0125 0.1065 0.1201
Echinococcus multilocularis fmrfamide receptor 0.0125 0.1065 0.1332
Echinococcus granulosus neuropeptide receptor 0.0125 0.1065 0.1332
Brugia malayi follicle stimulating hormone receptor 0.0125 0.1065 0.1065
Brugia malayi Tachykinin-like peptides receptor 99D 0.0125 0.1065 0.1065
Brugia malayi Latrophilin receptor protein 2 0.0071 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Echinococcus multilocularis chromobox protein 1 0.0235 0.2301 0.2887
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.009
Trypanosoma brucei heat shock protein 90, putative 0.0147 0.1308 0.514
Schistosoma mansoni neuropeptide F-like receptor 0.0125 0.1065 0.1201
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0586 0.6243 0.8837
Leishmania major hexokinase, putative 0.017 0.1564 0.4802
Trichomonas vaginalis mercuric reductase, putative 0.0089 0.0658 0.0862
Echinococcus multilocularis smad 0.0063 0.0362 0.0447
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0125 0.1065 0.1332
Echinococcus granulosus lysine specific demethylase 5A 0.0113 0.0929 0.116
Echinococcus granulosus 7tm_1 domain containing protein 0.0125 0.1065 0.1332
Echinococcus multilocularis fmrfamide receptor 0.0125 0.1065 0.1332
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0071 0.0456 0.0565
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Echinococcus granulosus Chromo domain 0.0039 0.009 0.0105
Plasmodium vivax glutathione reductase, putative 0.0257 0.2545 0.4302
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.1065 0.1201
Brugia malayi Importin beta-1 subunit 0.0031 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0103 0.0819 0.0819
Onchocerca volvulus 0.0495 0.522 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Schistosoma mansoni neuropeptide receptor 0.0125 0.1065 0.1201
Echinococcus multilocularis sex peptide receptor 0.0125 0.1065 0.1332
Echinococcus multilocularis heat shock protein 90 0.0126 0.107 0.1338
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Echinococcus multilocularis heat shock protein 0.0147 0.1308 0.1638
Onchocerca volvulus 0.0125 0.1065 0.1901
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0125 0.1065 0.1065
Schistosoma mansoni chromobox protein 0.0039 0.009 0.0101
Brugia malayi hypothetical protein 0.0125 0.1065 0.1065
Onchocerca volvulus 0.0125 0.1065 0.1901
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Schistosoma mansoni hypothetical protein 0.0071 0.0456 0.0514
Brugia malayi MH2 domain containing protein 0.0063 0.0362 0.0362
Entamoeba histolytica heat shock protein 90, putative 0.0147 0.1308 0.1849
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.1065 0.1332
Trypanosoma brucei heat shock protein, putative 0.0147 0.1308 0.514
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0039 0.009 0.0105
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Onchocerca volvulus 0.017 0.1564 0.2873
Echinococcus multilocularis dro:myosuppressin receptor 0.0125 0.1065 0.1332
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Schistosoma mansoni hypothetical protein 0.0154 0.1383 0.1559
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0125 0.1065 0.1201
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0063 0.0362 0.0447
Echinococcus granulosus dro:myosuppressin receptor 0.0125 0.1065 0.1332
Leishmania major trypanothione reductase 0.0257 0.2545 1
Echinococcus granulosus neuropeptide Y receptor 0.0125 0.1065 0.1332
Schistosoma mansoni heat shock protein 0.0147 0.1308 0.1475
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0071 0.0456 0.0565
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0071 0.0456 0.0565
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Echinococcus granulosus TGF beta signal transducer SmadC 0.0063 0.0362 0.0447
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.1065 0.1332
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0707 0.0936
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0125 0.1065 0.1332
Brugia malayi neuropeptide F receptor 0.0125 0.1065 0.1065
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0142 0.1252 0.2265
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Echinococcus multilocularis snurportin 1 0.0332 0.3385 0.4251
Loa Loa (eye worm) MH1 domain-containing protein 0.0063 0.0362 0.0362
Brugia malayi RNA recognition motif domain containing protein 0.013 0.1121 0.1121
Brugia malayi RNA binding protein 0.013 0.1121 0.1121
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0039 0.009 0.0101
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0658 0.1409
Loa Loa (eye worm) G-protein coupled receptor 0.0125 0.1065 0.1065
Loa Loa (eye worm) hexokinase 0.017 0.1564 0.1564
Echinococcus granulosus 7TM GPCR rhodopsin 0.0125 0.1065 0.1332
Echinococcus granulosus jumonji domain containing protein 0.013 0.1119 0.14
Brugia malayi Pax transcription factor protein 2 0.0495 0.522 0.522
Trichomonas vaginalis chromobox protein, putative 0.0235 0.2301 0.3357
Loa Loa (eye worm) hypothetical protein 0.0031 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0707 0.0936
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0089 0.0658 0.1111
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0125 0.1065 0.1065
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0125 0.1065 0.1332
Echinococcus multilocularis chromobox protein 2 0.0039 0.009 0.0105
Trypanosoma cruzi heat shock protein 85, putative 0.0147 0.1308 0.437
Loa Loa (eye worm) Smad1 0.0063 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0089 0.0658 0.082
Loa Loa (eye worm) hypothetical protein 0.0125 0.1065 0.1065
Plasmodium vivax hypothetical protein, conserved 0.0094 0.0708 0.1196
Loa Loa (eye worm) latrophilin receptor protein 2 0.0071 0.0456 0.0456
Brugia malayi PHD-finger family protein 0.0031 0.0001 0.0001
Brugia malayi RNA, U transporter 1 0.0088 0.065 0.065
Plasmodium vivax hypothetical protein, conserved 0.0039 0.009 0.0151
Echinococcus multilocularis neuropeptide Y receptor 0.0125 0.1065 0.1332
Loa Loa (eye worm) heterochromatin protein 1 0.0235 0.2301 0.2301
Echinococcus granulosus orexin receptor type 2 0.0125 0.1065 0.1332
Echinococcus granulosus neuropeptide FF receptor 2 0.0125 0.1065 0.1332
Schistosoma mansoni amine GPCR 0.0125 0.1065 0.1201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0658 0.1409
Loa Loa (eye worm) neuropeptide F receptor 0.0125 0.1065 0.1065
Loa Loa (eye worm) heat shock protein 75 0.0098 0.0754 0.0754
Schistosoma mansoni hypothetical protein 0.0049 0.0211 0.0237
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.1121 0.1121
Plasmodium falciparum glutathione reductase 0.0257 0.2545 0.4302
Leishmania major heat shock protein 83-1 0.0147 0.1308 0.3447
Echinococcus multilocularis geminin 0.0739 0.7954 1
Trichomonas vaginalis heat shock protein, putative 0.0147 0.1308 0.1849
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0065 0.0392 0.0392
Trichomonas vaginalis heat shock protein, putative 0.0107 0.0856 0.1162
Brugia malayi Heterochromatin protein 1 0.0235 0.2301 0.2301
Echinococcus multilocularis serotonin receptor 0.0125 0.1065 0.1332

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 17 mg hr-1 l-1 Serum AUC in marmosets (IV dose) ChEMBL. 1635063
MIC (functional) < 0.008 ug ml-1 Compound was tested for antimicrobial activity against Escherichia coli DC0 strain (parent organism) ChEMBL. 1635063
MIC (functional) < 0.008 ug ml-1 Compound was tested for antimicrobial activity against Escherichia coli DC2 strain (permeability mutant) ChEMBL. 1635063
MIC (functional) < 0.008 ug ml-1 Compound was tested for antimicrobial activity against Escherichia coli DC0 strain (parent organism) ChEMBL. 1635063
MIC (functional) < 0.008 ug ml-1 Compound was tested for antimicrobial activity against Escherichia coli DC2 strain (permeability mutant) ChEMBL. 1635063
MIC (functional) = 0.015 ug ml-1 Compound was tested for antimicrobial activity against Enterobacter cloacae inducible type I beta-lactamase producer (P99-) strain ChEMBL. 1635063
MIC (functional) = 0.06 ug ml-1 Compound was tested for antimicrobial activity against Pseudomonas aeruginosa PU21 strain ChEMBL. 1635063
MIC (functional) = 2 ug ml-1 Compound was tested for antimicrobial activity against Staphylococcus aureus Oxford strain ChEMBL. 1635063
MIC (functional) = 4 ug ml-1 Compound was tested for antimicrobial activity against Pseudomonas aeruginosa constitutive derepressed type I beta-lactamase producer (18SH) strain ChEMBL. 1635063
MIC (functional) = 4 ug ml-1 Compound was tested for antimicrobial activity against Staphylococcus aureus penicillin sensitive S. aureus (147N) strain ChEMBL. 1635063
MIC (functional) = 8 ug ml-1 Compound was tested for antimicrobial activity against Enterobacter cloacae constitutive derepressed type I beta-lactamase producer (P99+) strain ChEMBL. 1635063
pKa = 6.9 Dissociation constant (pKa) ChEMBL. 1635063
T1/2 (ADMET) = 0.7 hr Serum T1/2 in marmosets (IV dose) ChEMBL. 1635063

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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